Recent Publications
JE Dixon, A Simpson, N Mistry, N Evangelou and PG Morris. 2013. Optimisation of T(2)(*)-weighted MRI for the detection of small veins in multiple sclerosis at 3T and 7T. Eur J Radiol. 82, 719-772
A Ismail, J Cooper-Knock, JR Highley, A Milano, J Kirby, E Goodall, J Lowe, I Scott, CS Constantinescu, SJ Walters, S Price, CJ McDermott, S Sawcer, DA Compston, B Sharrack and PJ Shaw. 2013. Concurrence of multiple sclerosis and amyotrophic lateral sclerosis in patients with hexanucleotide repeat expansions of C9ORF72. J Neurol Neurosurg Psychiatry. 84, 79-87.
L Matthews, R Marasco, M Jenkinson, W Kuker, S Luppe, MI Leite, A Giorgio, N De Stefano, N Robertson, H Johansen-Berg, N Evangelou and J Palace. 2013. Distinction of seropositive NMO spectrum disorder and MS brain lesion distribution. Neurology. 80, 1330-1337.
N Mistry, J Dixon, E Tallantyre, C Tench, R Abdel-Fahim, T Jaspan, PS Morgan, P Morris and N Evangelou. 2013. Central Veins in Brain Lesions Visualized With High-Field Magnetic Resonance Imaging: A Pathologically Specific Diagnostic Biomarker for Inflammatory Demyelination in the Brain. JAMA neurology. 1-6.
G Niepel, RH Bibani, J Vilisaar, RW Langley, CM Bradshaw, E Szabadi and CS Constantinescu. 2013. Association of a deficit of arousal with fatigue in multiple sclerosis: effect of modafinil. Neuropharmacology. 64, 380-388.
T Owens, N Evangelou and DK Whynes. 2013. Rationing and deprivation: disease-modifying therapies for multiple sclerosis in the United Kingdom. The European journal of health economics : HEPAC : health economics in prevention and care. 14, 315-321.
AM Al-Radaideh, SJ Wharton, SY Lim, CR Tench, PS Morgan, RW Bowtell, CS Constantinescu and PA Gowland. 2012. Increased iron accumulation occurs in the earliest stages of demyelinating disease: an ultra-high field susceptibility mapping study in Clinically Isolated Syndrome. Mult Scler.
RA Dineen, CM Bradshaw, CS Constantinescu and DP Auer. 2012. Extra-hippocampal subcortical limbic involvement predicts episodic recall performance in multiple sclerosis. PLoS One. 7, e44942.
N Evangelou. 2012. The only way to manage neurodegeneration in MS is to prevent it with effective anti-inflammatory therapy: Yes. Mult Scler. 18, 1680-1681.
M Filippi, MA Rocca, F Barkhof, W Bruck, JT Chen, G Comi, G DeLuca, N De Stefano, BJ Erickson, N Evangelou, F Fazekas, JJ Geurts, C Lucchinetti, DH Miller, D Pelletier, BF Popescu and H Lassmann. 2012. Association between pathological and MRI findings in multiple sclerosis. Lancet Neurol. 11, 349-360.
I Induruwa, CS Constantinescu and B Gran. 2012. Fatigue in multiple sclerosis - a brief review. J Neurol Sci. 323, 9-15.
SA Jagessar, B Gran, N Heijmans, J Bauer, JD Laman, BA t Hart and CS Constantinescu. 2012. Discrepant effects of human interferon-gamma on clinical and immunological disease parameters in a novel marmoset model for multiple sclerosis. J Neuroimmune Pharmacol. 7, 253-265.
K Kawabe, D Lindsay, M Braitch, AJ Fahey, L Showe and CS Constantinescu. 2012. IL-12 inhibits glucocorticoid-induced T cell apoptosis by inducing GMEB1 and activating PI3K/Akt pathway. Immunobiology. 217, 118-123.
A Manouchehrinia and CS Constantinescu. 2012. Cost-effectiveness of disease-modifying therapies in multiple sclerosis. Curr Neurol Neurosci Rep. 12, 592-600.
G Podda and CS Constantinescu. 2012. Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis. Expert Opin Biol Ther. 12, 1517-1531.
R Tanasescu, B Gran and CS Constantinescu. 2012. The endocannabinoid system: a revolving plate in neuro-immune interaction in health and disease. Amino Acids.
TR Taylor, N Evangelou, H Porter and R Lenthall. 2012. Primary care direct access MRI for the investigation of chronic headache. Clin Radiol. 67, 24-27.
C Volpi, F Fallarino, R Bianchi, C Orabona, A De Luca, C Vacca, L Romani, B Gran, U Grohmann, P Puccetti and ML Belladonna. 2012. A GpC-rich oligonucleotide acts on plasmacytoid dendritic cells to promote immune suppression. J Immunol. 189, 2283-2289.
Y Yan, X Ding, K Li, B Ciric, S Wu, H Xu, B Gran, A Rostami and GX Zhang. 2012. CNS-specific therapy for ongoing EAE by silencing IL-17 pathway in astrocytes. Mol Ther. 20, 1338-1348.
J Yang, Y Yan, CG Ma, T Kang, N Zhang, B Gran, H Xu, K Li, B Ciric, A Zangaladze, M Curtis, A Rostami and GX Zhang. 2012. Accelerated and enhanced effect of CCR5-transduced bone marrow neural stem cells on autoimmune encephalomyelitis. Acta Neuropathol. 124, 491-503.
CS Constantinescu, G Niepel, M Patterson, A Judd, M Braitch, AJ Fahey, S Harikrishnan, LJ Edwards, CR Tench, GW Bennett and M Ghatei. 2011. Orexin A (hypocretin-1) levels are not reduced while cocaine/amphetamine regulated transcript levels are increased in the cerebrospinal fluid of patients with multiple sclerosis: No correlation with fatigue and sleepiness. J Neurol Sci.
CS Constantinescu, N Farooqi, K O'Brien and B Gran. 2011. Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). Br J Pharmacol.
EJ Downer, E Clifford, B Gran, HJ Nel, PG Fallon and PN Moynagh. 2011. Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 activation and IFN-beta expression: relevance to therapeutic effects in models of multiple sclerosis. J Biol Chem. 286, 10316-10328.
LJ Edwards, B Sharrack, A Ismail, H Tumani and CS Constantinescu. 2011. Central inflammation versus peripheral regulation in multiple sclerosis. J Neurol.
A Katsourakis, G Noussios, I Hadjis, N Evangelou and E Chatzitheoklitos. 2011. Primary malignant fibrous histiocytoma: a rare case. Case Report Med. 2011, 134801.
NB Lincoln, F Yuill, J Holmes, AE Drummond, CS Constantinescu, S Armstrong and C Phillips. 2011. Evaluation of an adjustment group for people with multiple sclerosis and low mood: a randomized controlled trial. Mult Scler. 17, 1250-1257.
N Mistry, EC Tallantyre, JE Dixon, N Galazis, T Jaspan, PS Morgan, P Morris and N Evangelou. 2011. Focal multiple sclerosis lesions abound in 'normal appearing white matter'. Mult Scler. 17, 1313-1323.
MH Nyirenda, L Sanvito, PJ Darlington, K O'Brien, GX Zhang, CS Constantinescu, A Bar-Or and B Gran. 2011. TLR2 stimulation drives human naive and effector regulatory T cells into a Th17-like phenotype with reduced suppressive function. J Immunol. 187, 2278-2290.
L Sanvito, A Tomita, N Chihara, T Okamoto, Y Lin, M Ogawa, B Gran, T Aranami and T Yamamura. 2011. Increase of Ki-67+ natural killer cells in multiple sclerosis patients treated with interferon-beta and interferon-beta combined with low-dose oral steroids. J Neuroimmunol. 236, 111-117.
L Sanvito, CS Constantinescu and B Gran. 2011. Novel therapeutic approaches to autoimmune demyelinating disorders. Curr Pharm Des. 17, 3191-3201.
BA t Hart, B Gran and R Weissert. 2011. EAE: imperfect but useful models of multiple sclerosis. Trends Mol Med. 17, 119-125.
EC Tallantyre, JE Dixon, I Donaldson, T Owens, PS Morgan, PG Morris and N Evangelou. 2011. Ultra-high-field imaging distinguishes MS lesions from asymptomatic white matter lesions. Neurology. 76, 534-539.
R Tanasescu, D Rog and CS Constantinescu. 2011. A drug discovery case history of 'delta-9-tetrahydrocannabinol, cannabidiol'. Expert Opin Drug Discov. 6, 437-452.
M Braitch and CS Constantinescu. 2010. The role of osteopontin in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). Inflamm Allergy Drug Targets. 9, 249-256.
M Braitch, K Kawabe, M Nyirenda, LJ Gilles, RA Robins, B Gran, S Murphy, L Showe and CS Constantinescu. 2010. Expression of activity-dependent neuroprotective protein in the immune system: possible functions and relevance to multiple sclerosis. Neuroimmunomodulation. 17, 120-125.
CS Constantinescu and B Gran. 2010. Multiple sclerosis: autoimmune associations in multiple sclerosis. Nat Rev Neurol. 6, 591-592.
LJ Edwards, RA Robins and CS Constantinescu. 2010. Th17/Th1 phenotype in demyelinating disease. Cytokine. 50, 19-23.
N Farooqi, B Gran and CS Constantinescu. 2010. Are current disease-modifying therapeutics in multiple sclerosis justified on the basis of studies in experimental autoimmune encephalomyelitis? J Neurochem. 115, 829-844.
B Gran, S Yu, GX Zhang and A Rostami. 2010. Accelerated thymocyte maturation in IL-12Rbeta2-deficient mice contributes to increased susceptibility to autoimmune inflammatory demyelination. Exp Mol Pathol. 89, 126-134.
L Jean-Gilles, B Gran and CS Constantinescu. 2010. Interaction between cytokines, cannabinoids and the nervous system. Immunobiology. 215, 606-610.
RB Kavia, D De Ridder, CS Constantinescu, CG Stott and CJ Fowler. 2010. Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis. Mult Scler. 16, 1349-1359.
I Kubajewska and CS Constantinescu. 2010. Cannabinoids and experimental models of multiple sclerosis. Immunobiology. 215, 647-657.
SY Lim and CS Constantinescu. 2010. Current and future disease-modifying therapies in multiple sclerosis. Int J Clin Pract. 64, 637-650.
H Liu, D Fitzgerald, B Gran, JM Leong and KR Alugupalli. 2010. Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes. J Immunol. 184, 5859-5864.
K O'Brien, B Gran and A Rostami. 2010. T-cell based immunotherapy in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunotherapy. 2, 99-115.
K O'Brien, D Fitzgerald, A Rostami and B Gran. 2010. The TLR7 agonist, imiquimod, increases IFN-beta production and reduces the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol. 221, 107-111.
A Petzold, A Altintas, L Andreoni, A Bartos, A Berthele, MA Blankenstein, L Buee, M Castellazzi, S Cepok, M Comabella, CS Constantinescu, F Deisenhammer, G Deniz, G Erten, M Espino, E Fainardi, D Franciotta, MS Freedman, V Giedraitis, NE Gilhus, G Giovannoni, A Glabinski, P Grieb, HP Hartung, B Hemmer, SK Herukka, R Hintzen, M Ingelsson, S Jackson, S Jacobsen, N Jafari, M Jalosinski, S Jarius, E Kapaki, BC Kieseier, MJ Koel-Simmelink, J Kornhuber, J Kuhle, J Kurzepa, PH Lalive, L Lannfelt, V Lehmensiek, P Lewczuk, P Livrea, F Marnetto, D Martino, T Menge, N Norgren, E Papuc, GP Paraskevas, T Pirttila, C Rajda, K Rejdak, J Ricny, D Ripova, L Rosengren, M Ruggieri, S Schraen, G Shaw, C Sindic, A Siva, T Stigbrand, I Stonebridge, B Topcular, M Trojano, H Tumani, HA Twaalfhoven, L Vecsei, V Van Pesch, H Vanderstichele, C Vedeler, MM Verbeek, LM Villar, R Weissert, B Wildemann, C Yang, K Yao and CE Teunissen. 2010. Neurofilament ELISA validation. J Immunol Methods. 352, 23-31.
M Ravnborg, PS Sorensen, M Andersson, EG Celius, PJ Jongen, I Elovaara, E Bartholome, CS Constantinescu, K Beer, E Garde and B Sperling. 2010. Methylprednisolone in combination with interferon beta-1a for relapsing-remitting multiple sclerosis (MECOMBIN study): a multicentre, double-blind, randomised, placebo-controlled, parallel-group trial. Lancet Neurol. 9, 672-680.
AE Rolls, G Giovannoni, CS Constantinescu, D Boniface and CH Hawkes. 2010. Multiple sclerosis, lymphoma and nasopharyngeal carcinoma: the central role of Epstein-Barr virus? Eur Neurol. 63, 29-35.
W Schwaeble and CS Constantinescu. 2010. Relationship between cannabinoids and the immune system. Special Issue 8, 2010 Introduction. Immunobiology. 215, 587.
SN Sotiropoulos, L Bai and CR Tench. 2010. Fuzzy anatomical connectedness of the brain using single and multiple fibre orientations estimated from diffusion MRI. Comput Med Imaging Graph. 34, 504-513.
SN Sotiropoulos, L Bai, PS Morgan, CS Constantinescu and CR Tench. 2010. Brain tractography using Q-ball imaging and graph theory: Improved connectivities through fibre crossings via a model-based approach. Neuroimage. 49, 2444-2456.
EC Tallantyre, PS Morgan, JE Dixon, A Al-Radaideh, MJ Brookes, PG Morris and N Evangelou. 2010. 3 Tesla and 7 Tesla MRI of multiple sclerosis cortical lesions. J Magn Reson Imaging. 32, 971-977.
EC Tallantyre, L Bo, O Al-Rawashdeh, T Owens, CH Polman, JS Lowe and N Evangelou. 2010. Clinico-pathological evidence that axonal loss underlies disability in progressive multiple sclerosis. Mult Scler. 16, 406-411.
R Tanasescu and CS Constantinescu. 2010. Cannabinoids and the immune system: an overview. Immunobiology. 215, 588-597.
Y Yan, GX Zhang, B Gran, F Fallarino, S Yu, H Li, ML Cullimore, A Rostami and H Xu. 2010. IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis. J Immunol. 185, 5953-5961.