Contact

• workRoom A05 Building 42, Nottingham Clinical Trials Unit
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 8231596
• fax0115 7484092
• eleanor.mitchell@nottingham.ac.uk

Biography

Eleanor is Associate Professor of Clinical Trials and has worked in clinical research since 2002 at the University of Nottingham and in the Nottingham Clinical Trials Unit (NCTU) (https://www.nottingham.ac.uk/nctu/) since 2008. Her main research interests are maternal and newborn health and she has led studies in the UK and internationally, focussing on research in low and middle income countries. She is also interested in research methodology around how we conduct clinical trials to answer important clinical questions, specifically focussing on training of research teams. She works as part of large collaborations designing and delivering clinical trials in a range of clinical areas and is an investigator on a number of large UK-based studies in maternal and newborn health. She leads outreach work with parents interested in maternal and newborn health and leads a national Facebook group called Bump2Baby Parents' Voices, where she talks to parents and expectant parents about research, including contributing to design and conduct of studies. Prior to her current role, she led a large trial management team for a number of years, leading a broad portfolio of clinical trials. She is the NCTU Teaching and Learning Lead.

Eleanor is also the Chair of the UK Trial Manager's Network (UKTMN) Executive Group. The UKTMN (https://www.tmn.ac.uk/default.aspx) was established in 1998 and aims to provide a forum for trial management professionals in the UK to share expertise. It currently has around 1000 members in the UK. In 2018, Eleanor led the transition of the UKTMN to a new host and the Network is now hosted by the Nottingham Clinical Trials Unit. She is also a member of the UKCRC CTU Network Executive Group (https://www.ukcrc-ctu.org.uk/) and the Trials Methodology Research Partnership (TMRP) Executive Group (https://www.methodologyhubs.mrc.ac.uk/about/tmrp/). She is Chair of the 2022 International Clinical Trials Methodology Conference Education Committee.

Teaching Summary

Eleanor is the current lead of a short course designed and delivered by the Nottingham Clinical Trials Unit; "Fundamentals of Clinical Trials", where she teaches several sessions. More about the… read more

Research Summary

Eleanor is co-investigator on a number of large non-commercial UK-based trials:

A scoping study investigating impacted fetal head at Caesarean section: https://www.nottingham.ac.uk/nctu/other-research/scoping-studies.aspx

A large randomised cluster trial investigating routine testing for Group B Streptococcus in Pregnancy: https://www.gbs3trial.ac.uk/home.aspx

A large randomised trial investigating whether full milk feeds from day 1 in preterm infants reduces length of hospital stay: http://www.isrctn.com/ISRCTN89654042

In addition, she is leading a number of global health projects:

https://www.nottingham.ac.uk/nctu/other-research/global-health-research.aspx

Methodology studies, focussed on improving how we run randomised controlled trials, include:

A Study Within a Trial (SWAT) investigating methods for training site research staff: https://www.qub.ac.uk/sites/TheNorthernIrelandNetworkforTrialsMethodologyResearch/FileStore/Filetoupload,903517,en.pdf

And studies in low and middle income countries (LMICs) investigating methods for training research staff.

Recent Publications

• MITCHELL, ELEANOR J., BENJAMIN, SANTOSH, ONONGE, SAM, DITAI, JAMES, QURESHI, ZAHIDA, MASOOD, SHABEEN NAZ, WHITHAM, DIANE, GODOLPHIN, PETER J. and DULEY, LELIA, 2020. Identifying women giving birth preterm and care at the time of birth: a prospective audit of births at six hospitals in India, Kenya, Pakistan and Uganda BMC PREGNANCY AND CHILDBIRTH. 20(1),
• CHALMERS, JOANNE R., HAINES, RACHEL H., BRADSHAW, LUCY E., MONTGOMERY, ALAN A., THOMAS, KIM S., BROWN, SARA J., RIDD, MATTHEW J., LAWTON, SANDRA, SIMPSON, ERIC L., CORK, MICHAEL J., SACH, TRACEY H., FLOHR, CARSTEN, MITCHELL, ELEANOR J., SWINDEN, RICHARD, TARR, STELLA, DAVIES-JONES, SUSAN, JAY, NICOLA, KELLEHER, MAEVE M., PERKIN, MICHAEL R., BOYLE, ROBERT J. and WILLIAMS, HYWEL C., 2020. Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial LANCET. 395(10228), 962-972
• BRADSHAW L, SAWYER A, ARMSTRONG-BUISSERET L, MITCHELL E, AYERS S and DULEY L, 2019. Cord pilot trial, comparing alternative policies for timing of cord clamping before 32 weeks gestation: follow-up for women up to one year. BMC pregnancy and childbirth. 19(1), 78
• BRADSHAW L, SAWYER A, MITCHELL E, ARMSTRONG-BUISSERET L, AYERS S and DULEY L, 2019. Women's experiences of participating in a randomised trial comparing alternative policies for timing of cord clamping at very preterm birth: a questionnaire study. Trials. 20(1), 225

• View all publications

Eleanor is the current lead of a short course designed and delivered by the Nottingham Clinical Trials Unit; "Fundamentals of Clinical Trials", where she teaches several sessions. More about the course can be found at: https://www.nottingham.ac.uk/nctu/short-courses/index.aspx

• MITCHELL, ELEANOR J., BENJAMIN, SANTOSH, ONONGE, SAM, DITAI, JAMES, QURESHI, ZAHIDA, MASOOD, SHABEEN NAZ, WHITHAM, DIANE, GODOLPHIN, PETER J. and DULEY, LELIA, 2020. Identifying women giving birth preterm and care at the time of birth: a prospective audit of births at six hospitals in India, Kenya, Pakistan and Uganda BMC PREGNANCY AND CHILDBIRTH. 20(1),
• CHALMERS, JOANNE R., HAINES, RACHEL H., BRADSHAW, LUCY E., MONTGOMERY, ALAN A., THOMAS, KIM S., BROWN, SARA J., RIDD, MATTHEW J., LAWTON, SANDRA, SIMPSON, ERIC L., CORK, MICHAEL J., SACH, TRACEY H., FLOHR, CARSTEN, MITCHELL, ELEANOR J., SWINDEN, RICHARD, TARR, STELLA, DAVIES-JONES, SUSAN, JAY, NICOLA, KELLEHER, MAEVE M., PERKIN, MICHAEL R., BOYLE, ROBERT J. and WILLIAMS, HYWEL C., 2020. Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial LANCET. 395(10228), 962-972
• BRADSHAW L, SAWYER A, ARMSTRONG-BUISSERET L, MITCHELL E, AYERS S and DULEY L, 2019. Cord pilot trial, comparing alternative policies for timing of cord clamping before 32 weeks gestation: follow-up for women up to one year. BMC pregnancy and childbirth. 19(1), 78
• BRADSHAW L, SAWYER A, MITCHELL E, ARMSTRONG-BUISSERET L, AYERS S and DULEY L, 2019. Women's experiences of participating in a randomised trial comparing alternative policies for timing of cord clamping at very preterm birth: a questionnaire study. Trials. 20(1), 225
• OJHA S, MITCHELL E, MONTGOMERY A and DORLING J, 2019. Full Milk Feeds from Day 1. Neonatology. 116(1), 67
• WAKE, E. V., BATCHELOR, J., LAWTON, S., THOMAS, K. S., HARRISON, E. F. and COWDELL, F. C., 2018. The views of children and young people on the use of silk garments for the treatment of eczema: a nested qualitative study within the CLOTHing for the relief of Eczema Symptoms (CLOTHES) randomized controlled trial BRITISH JOURNAL OF DERMATOLOGY. 178(1), 183-190
• MCKEEVER T, MORTIMER K, WILSON A, WALKER S, BRIGHTLING C, SKEGGS A, PAVORD I, PRICE D, DULEY L, THOMAS M, BRADSHAW L, HIGGINS B, HAYDOCK R, MITCHELL E, DEVEREUX G and HARRISON T, 2018. Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations. The New England journal of medicine. 378(10), 902-910
• HAINES RH, THOMAS KS, MONTGOMERY AA, RAVENSCROFT JC, AKRAM P, CHALMERS JR, WHITHAM D, DULEY L, ELEFTHERIADOU V, MEAKIN G, MITCHELL EJ, WHITE J, ROGERS A, SACH T, SANTER M, TAN W, HEPBURN T, WILLIAMS HC and BATCHELOR J, 2018. Home interventions and light therapy for the treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomised controlled trial. BMJ open. 8(4), e018649
• ARMSTRONG-BUISSERET, LINDSAY, MITCHELL, ELEANOR, HEPBURN, TRISH, DULEY, LELIA, THORNTON, JIM G., ROBERTS, TRACY E., STOREY, CLAIRE, SMYTH, REBECCA and HEAZELL, ALEXANDER E. P., 2018. Reduced fetal movement intervention Trial-2 (ReMIT-2): protocol for a pilot randomised controlled trial of standard care informed by the result of a placental growth factor (PlGF) blood test versus standard care alone in women presenting with reduced fetal movement at or after 36(+0) weeks gestation TRIALS. 19,
• PATSKO E, GODOLPHIN PJ, THOMAS KS, HEPBURN T, MITCHELL EJ, CRAIG FE, BATH PM and MONTGOMERY AA, 2017. Investigating the effect of independent, blinded digital image assessment on the STOP GAP trial. Trials. 18(1), 53
• THOMAS KS, BRADSHAW LE, SACH TH, COWDELL F, BATCHELOR JM, LAWTON S, HARRISON EF, HAINES RH, AHMED A, DEAN T, BURROWS NP, POLLOCK I, BUCKLEY HK, WILLIAMS HC, LLEWELLYN J, CRANG C, GRUNDY JD, GUINESS J, GRIBBIN A, WAKE EV, MITCHELL EJ, BROWN SJ and MONTGOMERY AA, 2017. Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: the CLOTHES trial. Health technology assessment (Winchester, England). 21(16), 1-260
• THOMAS KS, BRADSHAW LE, SACH TH, BATCHELOR JM, LAWTON S, HARRISON EF, HAINES RH, AHMED A, WILLIAMS HC, DEAN T, BURROWS NP, POLLOCK I, LLEWELLYN J, CRANG C, GRUNDY JD, GUINESS J, GRIBBIN A, MITCHELL EJ, COWDELL F, BROWN SJ, MONTGOMERY AA and , 2017. Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial). PLoS medicine. 14(4), e1002280
• CHALMERS JR, HAINES RH, MITCHELL EJ, THOMAS KS, BROWN SJ, RIDD M, LAWTON S, SIMPSON EL, CORK MJ, SACH TH, BRADSHAW LE, MONTGOMERY AA, BOYLE RJ and WILLIAMS HC, 2017. Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial. Trials. 18(1), 343
• DULEY L, DORLING J, PUSHPA-RAJAH A, ODDIE SJ, YOXALL CW, SCHOONAKKER B, BRADSHAW L, MITCHELL EJ, FAWKE J ON BEHALF OF THE CORD PILOT TRIAL COLLABORATIVE GROUP, 2017. Randomised trial of cord clamping and initial stabilisation at very preterm birth: Archives of Diseases in Childhood, Fetal and Neonatal edition Archives of Diseases in Childhood, Fetal and Neonatal edition.
• MASON, J M, THOMAS, K S, ORMEROD, A D, CRAIG, F E, MITCHELL, E, NORRIE, J and WILLIAMS, H C, 2017. Ciclosporin compared with prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial. The British journal of dermatology.
• BRADSHAW, LUCY, HEPBURN, TRISH, MONTGOMERY, ALAN A., HARRISON, ELEANOR F., MITCHELL, ELEANOR J., HOWELLS, LAURA and THOMAS, KIM S., 2017. Frequency of data collection in a randomised controlled trial for long term eczema management in children TRIALS. 18,
• HAYDOCK, REBECCA, HARRISON, TIM, BRADSHAW, LUCY, DULEY, LELIA, SKEGGS, ANDREW and MITCHELL, ELEANOR, 2017. Evolution of a recruitment strategy between secondary and primary care during the recruitment phase of the fourfold asthma (FAST) trial TRIALS. 18,
• HEPBURN, TRISH, BRADSHAW, LUCY E., MONTGOMERY, ALAN A., HARRISON, ELEANOR F., MITCHELL, ELEANOR J. and THOMAS, KIM S., 2017. Waiting list control designs in trials of non-pharmacological interventions for eczema TRIALS. 18,
• BRADSHAW, LUCY, DORLING, JON, DULEY, LELIA, ARMSTRONG-BUISSERET, LINDSAY, FAWKE, JOE, SCHOONAKKER, BERNARD, MITCHELL, ELEANOR and DINEEN, ROB, 2017. Intra and inter-observer agreement in the interpretation of preterm neonatal cranial ultrasound scans TRIALS. 18,
• WILKES SR, WILLIAMS HC, ORMEROD AD, CRAIG FE, GREENLAW N, NORRIE J, MITCHELL EJ, MASON JM, THOMAS KS and , 2016. Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum? Journal of the American Academy of Dermatology. 75(6), 1216-1220
• THOMAS KS, ORMEROD AD, CRAIG FE, GREENLAW N, NORRIE J, MITCHELL E, MASON JM, JOHNSTON GA, WAHIE S, WILLIAMS HC and , 2016. Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. Journal of the American Academy of Dermatology. 75(5), 940-949
• SKEGGS A, MCKEEVER T, DULEY L, MITCHELL E, BRADSHAW L, MORTIMER K, WALKER S, PARROTT S, WILSON A, PAVORD I, BRIGHTLING C, THOMAS M, PRICE D, DEVEREUX G, HIGGINS B, HARRISON T and HAYDOCK R, 2016. FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations. Trials. 17(1), 499
• THOMAS, K. S., BATCHELOR, J. M., BATH-HEXTALL, F., CHALMERS, J. R., CLARKE, T., CROWE, S., DELAMERE, F. M., ELEFTHERIADOU, V., EVANS, N., FIRKINS, L., GREENLAW, N., LANSBURY, L., LAWTON, S., LAYFIELD, C., LEONARDI-BEE, J., MASON, J., MITCHELL, E., NANKERVIS, H., NORRIE, J., NUNN, A., ORMEROD, A. D., PATEL, R., PERKINS, W., RAVENSCROFT, J. C., SCHMITT, J., SIMPSON, E., WHITTON, M. E. and WILLIAMS, H. C., 2016. A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease Programme Grants Appl Res. 4(18),
• HARRISON EF, HAINES RH, COWDELL F, SACH TH, DEAN T, POLLOCK I, BURROWS NP, BUCKLEY H, BATCHELOR J, WILLIAMS HC, LAWTON S, BROWN SJ, BRADSHAW LE, AHMED A, MONTGOMERY AA, MITCHELL EJ and THOMAS KS, 2015. A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial. Trials. 16(1), 390
• ORMEROD AD, THOMAS KS, CRAIG FE, MITCHELL E, GREENLAW N, NORRIE J, MASON JM, WALTON S, JOHNSTON GA, WILLIAMS HC and UK DERMATOLOGY CLINICAL TRIALS NETWORK’S STOP GAP TEAM, 2015. Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial. BMJ (Clinical research ed.). 350, h2958
• BRADSHAW, LUCY E., PUSHPA-RAJAH, ANGELA, DORLING, JON, MITCHELL, ELEANOR J. and DULEY, LELIA, 2015. Cord pilot trial: update to randomised trial protocol TRIALS. 16,
• LELIA DULEY, ANGELA PUSHPA-RAJAH, LUCY BRADSHAW, JON DORLING, ELEANOR MITCHELL, 2015. When an external pilot is successful, should it be possible to transform it into an internal pilot by continuing recruitment into the full trial is ready? A case study of the cord pilot trial Trials.
• SPRANGE, KIRSTY, MITCHELL, ELEANOR, HULL, MARK and BUMPHREY, GILL, 2015. No drug, no trial? Think again! TRIALS. 16,
• 2014. Immediate versus deferred cord clamping for very preterm birth (before 32 weeks gestation): study protocol for a randomized controlled trial. Trials. 15:258,
• MITCHELL E ET AL, 2013. Impact of training for site staff recruiting into trials of rare skin diseases: experiences from stop gap and blister Trials.
• CRAIG, F.F., THOMAS, K.S., MITCHELL, E.J., WILLIAMS, H.C., NORRIE, J., MASON, J.M. and ORMEROD, A.D., 2012. UK Dermatology Clinical Trials Network's STOP GAP Trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial Trials. 13(April), 51
• MITCHELL, E., 2010. RCT of treatments for pyoderma gangrenosum: time to get involved Wounds UK. 6(4), 27-32
• MITCHELL, E., 2010. Do you see patients with pyoderma gangrenosum? If so, consider referral to STOP GAP trial Leg Ulcer Forum Journal. 2010(24), 46-48 (In Press.)