The Division of Regenerative Medicine and Cellular Therapies is one of the leading research groups in the UK with a worldwide reputation for excellence in our field. Collectively we have extensive expertise in materials science including biomaterials design, fabrication and analysis and work with both natural and synthetic polymers. We produce an array of scaffolds, hydrogels and microparticles with controlled size, shape, controlled release profiles, and topography.
In addition, we develop materials that are stimuli responsive, self-assemble and with functional biointerfaces. We lead the UK Research Council Regenerative Medicine Platform - Acellular Hub which coordinates the UK’s research effort in producing materials for regenerative medicine applications for a range of tissues. In addition to scaffold fabrication, we are experts in mammalian cell biology, including stem cells, cellular programming/reprogramming technologies and in cell/biomaterial interaction.
We have interests in immunomodulation and the immune response to biomaterials. In addition, we have expertise in developing electrochemical nano-systems for studying and controlling cellular processes which is being applied to the generation of new electroceutics. Our technologies include 3D bioprinting with a particular interest in liver, bone and cartilage, label free 3D chemical analysis of cells and surface & interface analysis, peptide delivery of DNA, mRNA and proteins to control tissue regeneration, electrospinning to form scaffolds that mimic the extraceullar matrix, and in the use of optical tweezers to manipulate the arrangement of cells to form controlled cell niches. We use these technologies and expertise not only for regenerative medicine but for the production of in vitro models for the study of tissue biology, disease and for drug and toxicity screening.
Our established research laboratories are located within the multidisciplinary Centre for Biomolecular Sciences and the Boots Science Building. We have an extensive network of collaborators within the UK including (but not exclusively) the Universities of Loughborough, Keele, Imperial, Southampton, Glasgow, and Birmingham, the Interface and Surface Analysis Centre (ISAC) and National Physical Laboratory (NPL). Worldwide collaborators include QUT in Australia, the McGowan Institute of Regenerative Medicine, Pittsburgh USA, and MIT USA amongst many others.