Claire Gibson

Contact

• workPsychology Building
  University Park
  Nottingham
  NG7 2RD
  UK
• Claire.Gibson@nottingham.ac.uk

Biography

I graduated from the University of Sheffield with a BSc (Hons) in Neuroscience and then obtained my PhD, also in Neuroscience, from the University of Newcastle. I held research positions at the Universities of Newcastle and Nottingham before taking up my first academic postion as a lecturer in Psychology at the University of Leicester. During my time at Leicester I was Head of the School for Psychology (2013-2017) and deputy Head of the College of Life Sciences before moving to the University of Nottingham in 2018. I lead a basic neuroscience research group which is primarily interested in investigating mechanims of injury following CNS injury and disease.

Teaching Summary

Teaching within the School of Psychology - typical topics may include biological psychology, neurological and psychiatric disorders, cognitive changes across the lifespan and research perspectives in… read more

Research Summary

My research career is focused on investigating the mechanisms of brain function and dysfunction through a range of imaging, behavioural and molecular biology approaches utilising experimental models… read more

Recent Publications

• TROTMAN-LUCAS, MELISSA, KELLY, MICHAEL E., JANUS, JUSTYNA and GIBSON, CLAIRE L., 2019. Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.
• BAYLISS, MICHAELA, TROTMAN-LUCAS, MELISSA, JANUS, JUSTYNA, KELLY, MICHAEL E. and GIBSON, CLAIRE L., 2018. Pre-stroke surgery is not beneficial to normotensive rats undergoing sixty minutes of transient focal cerebral ischemia PLOS ONE. 13(12),
• AKINGBADE, OLUWATOMI E. S., GIBSON, CLAIRE, KALARIA, RAJ N. and MUKAETOVA-LADINSKA, ELIZABETA B., 2018. Platelets: Peripheral Biomarkers of Dementia? JOURNAL OF ALZHEIMERS DISEASE. 63(4), 1235-1259
• PERCIE DU SERT N, ALFIERI A, ALLAN SM, CARSWELL HV, DEUCHAR GA, FARR TD, FLECKNELL P, GALLAGHER L, GIBSON CL, HALEY MJ, MACLEOD MR, MCCOLL BW, MCCABE C, MORANCHO A, MOON LD, O'NEILL MJ, PÉREZ DE PUIG I, PLANAS A, RAGAN CI, ROSELL A, ROY LA, RYDER KO, SIMATS A, SENA ES, SUTHERLAND BA, TRICKLEBANK MD, TRUEMAN RC, WHITFIELD L, WONG R and MACRAE IM, 2017. The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments). Journal of cerebral blood flow and metabolism. 37(11), 3488-3517

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Teaching within the School of Psychology - typical topics may include biological psychology, neurological and psychiatric disorders, cognitive changes across the lifespan and research perspectives in neuroscience.

Current Research

My research career is focused on investigating the mechanisms of brain function and dysfunction through a range of imaging, behavioural and molecular biology approaches utilising experimental models of CNS injury. I am particularly interested in developing novel MRI methodologies for examining brain function, investigating the role of sex and steroid hormones in ischaemic stroke/cognitive decline and increasing the translational relevance of experimental models of CNS injury and disease.

• TROTMAN-LUCAS, MELISSA, KELLY, MICHAEL E., JANUS, JUSTYNA and GIBSON, CLAIRE L., 2019. Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.
• BAYLISS, MICHAELA, TROTMAN-LUCAS, MELISSA, JANUS, JUSTYNA, KELLY, MICHAEL E. and GIBSON, CLAIRE L., 2018. Pre-stroke surgery is not beneficial to normotensive rats undergoing sixty minutes of transient focal cerebral ischemia PLOS ONE. 13(12),
• AKINGBADE, OLUWATOMI E. S., GIBSON, CLAIRE, KALARIA, RAJ N. and MUKAETOVA-LADINSKA, ELIZABETA B., 2018. Platelets: Peripheral Biomarkers of Dementia? JOURNAL OF ALZHEIMERS DISEASE. 63(4), 1235-1259
• PERCIE DU SERT N, ALFIERI A, ALLAN SM, CARSWELL HV, DEUCHAR GA, FARR TD, FLECKNELL P, GALLAGHER L, GIBSON CL, HALEY MJ, MACLEOD MR, MCCOLL BW, MCCABE C, MORANCHO A, MOON LD, O'NEILL MJ, PÉREZ DE PUIG I, PLANAS A, RAGAN CI, ROSELL A, ROY LA, RYDER KO, SIMATS A, SENA ES, SUTHERLAND BA, TRICKLEBANK MD, TRUEMAN RC, WHITFIELD L, WONG R and MACRAE IM, 2017. The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments). Journal of cerebral blood flow and metabolism. 37(11), 3488-3517
• GIBSON, C. L., BATH, P. M. W. and ALTAEE, R., 2017. Stroke Sex Differences: From Basic Research to Clinical Trials: Neuroprotective Therapy for Stroke and Ischemic Disease
• TROTMAN-LUCAS, M., KELLY, M. E., JANUS, J., FERN, R. and GIBSON, C. L., 2017. An alternative surgical approach reduces variability following filament induction of experimental stroke in mice Disease Models & Mechanisms. 10(7), 931-938
• GIBSON, C. L. and ATTWOOD, L., 2016. The impact of gender on stroke pathology and treatment. Neuroscience and Biobehavioral Reviews. 67, 119-124
• GIBSON, C. L. and BATH, P. M., 2016. Feasibility of progesterone treatment for ischaemic stroke Journal of Cerebral Blood Flow and Metabolism. 36(3), 487-491
• SUBIROS, N., PEREZ-SAAD, H., ALDANA, L., GIBSON, C. L., BORGNAKKE, W. S. and GARCIA-DEL-BARCO, D., 2016. Neuroprotective effect of epidermal growth factor plus growth hormone-releasing peptide-6 resembles hypothermia in experimental stroke Neurological Research. 38(11), 950-958
• SUBIROS, N., PEREZ-SAAD, H. M., BERLANGA, J. A., ALDANA, L., GARCIA-ILLERA, G., GIBSON, C. L. and GARCIA-DEL-BARCO, D., 2016. Assessment of dose-effect and therapeutic time window in preclinical studies of rhEGF and GHRP-6 coadministration for stroke therapy Neurological Research. 38(3), 187-195
• GIBSON CL and BATH PM, 2015. Feasibility of progesterone treatment for ischaemic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 36(3), 487-91
• TROTMAN, M., VERMEHREN, P., GIBSON, C. L. and FERN, R., 2015. The dichotomy of memantine treatment for ischemic stroke: dose-dependent protective and detrimental effects Journal of Cerebral Blood Flow and Metabolism. 35(2), 230-239
• WONG, RAYMOND, GIBSON, CLAIRE L., KENDALL, DAVID A. and BATH, PHILIP M. W., 2014. Evaluating the translational potential of progesterone treatment following transient cerebral ischaemia in male mice BMC NEUROSCIENCE. 15,
• GIBSON, CLAIRE L., SRIVASTAVA, KIRTIMAN, SPRIGG, NIKOLA, BATH, PHILIP M. W. and BAYRAKTUTAN, ULVI, 2014. inhibition of rho kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidtive stress and tight junctions JOURNAL OF NEUROCHEMISTRY. 129(5), 816-826
• AKRAM, A., GIBSON, C. L. and GRUBB, B. D., 2013. Neuroprotection mediated by the EP4 receptor avoids the detrimental side effects of COX-2 inhibitors following ischaemic injury Neuropharmacology. 65, 165-172
• CHAUHAN, N. K., YOUNG, A. M. J., GIBSON, C. L. and DAVIDSON, C., 2013. Inhibition of pre-ischeamic conditioning in the mouse caudate brain slice by NMDA- or adenosine A(1) receptor antagonists. European Journal of Pharmacology. 698(1-3), 322-329
• GIBSON, C. L., 2013. Cerebral ischemic stroke: is gender important? Journal of Cerebral Blood Flow and Metabolism. 33(9), 1355-1361
• PRADOS, J., ALVAREZ, B., HOWARTH, J., STEWART, K., GIBSON, C. L., HUTCHINSON, C. V., YOUNG, A. M. J. and DAVIDSON, C., 2013. Cue competition effects in the planarian Animal Cognition. 16(2), 177-186
• SHAH, D. S., PRADOS, J., GAMBLE, J., DE LILLO, C. and GIBSON, C. L., 2013. Sex differences in spatial memory using serial and search tasks. Behavioural Brain Research. 257, 90-99
• WONG, R., RENTON, C., GIBSON, C. L., MURPHY, S. J., KENDALL, D. A., BATH, P. M. W. and PROGESTERONE PRECLINICAL, STROKE, 2013. Progesterone treatment for experimental stroke: an individual animal meta-analysis. Journal of Cerebral Blood Flow and Metabolism. 33(9), 1362-1372
• WONG, R., BATH, P. M. W., KENDALL, D. and GIBSON, C. L., 2013. Progesterone and Cerebral Ischaemia: The Relevance of Ageing. Journal of Neuroendocrinology. 25(11), 1088-1094
• GIBSON, C. L., MURPHY, A. N. and MURPHY, S. P., 2012. Stroke outcome in the ketogenic state - a systematic review of the animal data. Journal of Neurochemistry. 123, 52-57
• KNIGHT, S. R., DAVIDSON, C., YOUNG, A. M. J. and GIBSON, C. L., 2012. Allopregnanolone Protects Against Dopamine-Induced Striatal Damage After In Vitro Ischaemia via Interaction at GABAA Receptors Journal of Neuroendocrinology. 24(8), 1135-1143
• RADLEY, E., AKRAM, A., GRUBB, B. D. and GIBSON, C. L., 2012. Investigation of the mechanisms of progesterone protection following oxygen-glucose deprivation in organotypic hippocampal slice cultures. Neuroscience Letters. 506(1), 131-135
• DAVIDSON, C., CHAUHAN, N. K., KNIGHT, S., GIBSON, C. L. and YOUNG, A. M. J., 2011. Modelling ischaemia in vitro: Effects of temperature and glucose concentration on dopamine release evoked by oxygen and glucose depletion in a mouse brain slice. Journal of Neuroscience Methods. 202(2), 165-172
• DAVIDSON, C., COOMBER, B., GIBSON, C. L. and YOUNG, A. M. J., 2011. Effect of pre-ischaemic conditioning on hypoxic depolarization of dopamine efflux in the rat caudate brain slice measured in real-time with fast cyclic voltammetry Neurochemistry International. 59(5), 714-721
• DAVIDSON, C., PRADOS, J., GIBSON, C. L., YOUNG, A. M. J., BARNES, D., SHERLOCK, R. and HUTCHINSON, C. V., 2011. Shedding light on photosensitive behaviour in brown planaria (Dugesia Tigrina) Perception. 40(6), 743-746
• GIBSON, C. L., COOMBER, B. and MURPHY, S. P., 2011. Progesterone is neuroprotective following cerebral ischaemia in reproductively ageing female mice Brain. 134, 2125-2133
• GIBSON, CLAIRE L, BATH, PHILIP M W and MURPHY, SEAN P, 2010. G-CSF administration is neuroprotective following transient cerebral ischemia even in the absence of a functional NOS-2 gene. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 30(4), 739-43
• COOMBER, B. and GIBSON, C. L., 2010. Sustained levels of progesterone prior to the onset of cerebral ischemia are not beneficial to female mice Brain Research. 1361, 124-132
• GIBSON, C. L., BATH, P. M. W. and MURPHY, S. P., 2010. G-CSF administration is neuroprotective following transient cerebral ischemia even in the absence of a functional NOS-2 gene. Journal of Cerebral Blood Flow and Metabolism. 30(4), 739-743
• GIBSON, C. L. and MURPHY, S. P., 2010. Benefits of histone deacetylase inhibitors for acute brain injury: a systematic review of animal studies Journal of Neurochemistry. 115(4), 806-813
• ENGLAND, T.J., GIBSON, C.L. and BATH, P.M.W., 2009. Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: a systematic review Brain Research Reviews. 62(1), 71-82
• GIBSON, C. L., COOMBER, B. and RATHBONE, J., 2009. Is Progesterone a Candidate Neuroprotective Factor for Treatment following Ischemic Stroke? Neuroscientist. 15(4), 324-332
• GIBSON, C.L., GRAY, L.J., BATH, P.M.W. and MURPHY, S.P., 2008. Progesterone for the treatment of experimental brain injury; a systematic review Brain. 131(2), 318-328
• SUN, Y, ALEXANDER, S P H, GARLE, M J, GIBSON, C L, HEWITT, K, MURPHY, S P, KENDALL, D A and BENNETT, A J, 2007. Cannabinoid activation of PPARalpha; a novel neuroprotective mechanism. British Journal of Pharmacology. 152(5), 734-43
• MURPHY, S. and GIBSON, C. L., 2007. Nitric oxide, ischaemia and brain inflammation. Biochemical Society Transactions. 35, 1133-1137
• GIBSON, CLAIRE L, GRAY, LAURA J, MURPHY, SEAN P and BATH, PHILIP M W, 2006. Estrogens and experimental ischemic stroke: a systematic review. Journal of Cerebral Blood Flow and Metabolism. 26(9), 1103-13
• GIBSON, C. L., JONES, N. C., PRIOR, M. J. W., BATH, P. M. W. and MURPHY, S. P., 2005. G-CSF suppresses edema formation and reduces interleukin-1beta expression after cerebral ischemia in mice Journal of Neuropathology and Experimental Neurology. 64(9), 763-769
• GIBSON, CLAIRE L, CONSTANTIN, DESPINA, PRIOR, MALCOLM J W, BATH, PHILIP M W and MURPHY, SEAN P, 2005. Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia. Experimental Neurology. 193(2), 522-30
• GIBSON, C.L., BATH, P.M.W. and MURPHY, S.P, 2005. G-CSF reduces infarct volume and improves functional outcome after transient focal cerebral ischemia in mice. Journal of Cerebral Blood Flow and Metabolism. 25(4), 431-439
• GIBSON, C. L., COUGHLAN, T. C. and MURPHY, S. P., 2005. Glial nitric oxide and ischemia. Glia. 50(4), 417-426
• GIBSON, C. L., JONES, N. C., PRIOR, M. J. W., BATH, P. M. W. and MURPHY, S. P., 2005. G-CSF suppresses edema formation and reduces interleukin-1 beta expression after cerebral ischemia in mice. Journal of Neuropathology and Experimental Neurology. 64(9), 763-769
• CLOWRY, G. J., DAVIES, B. M., UPILE, N. S., GIBSON, C. L. and BRADLEY, P. M., 2004. Spinal cord plasticity in response to unilateral inhibition of the rat motor cortex during development: changes to gene expression, muscle afferents and the ipsilateral corticospinal projection. European Journal of Neuroscience. 20(10), 2555-2566
• GIBSON, C. L. and MURPHY, S. P., 2004. Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice. Journal of Cerebral Blood Flow and Metabolism. 24(7), 805-813
• JONES, N. C., CONSTANTIN, D., GIBSON, C. L., PRIOR, M. J. W., MORRIS, P. G., MARSDEN, C. A. and MURPHY, S., 2004. A detrimental role for nitric oxide synthase-2 in the pathology resulting from acute cerebral injury. Journal of Neuropathology and Experimental Neurology. 63(7), 708-720
• GIBSON, C. L. and CLOWRY, G. J., 2003. The effect on motor cortical neuronal development of focal lesions to the sub-cortical white matter in the neonatal rat: a model for periventricular leukomalacia. International Journal of Developmental Neuroscience. 21(4), 171-182
• GIBSON, C. L., BATH, P. M. W., COUGHLAN, T. C. and MURPHY, S. P., 2003. Progesterone and G - CSF enhance functional recovery in mice following focal cerebral ischemia. Society for Neuroscience Abstract Viewer and Itinerary Planner. 2003, Abstract No. 741.12
• GIBSON, C. L. and CLOWRY, G. J., 2001. N-methyl-D-aspartate receptor blockade during development induces short-term but not long-term changes in c-Jun and parvalbumin expression in the rat cervical spinal cord. Experimental Neurology. 170(2), 380-384
• GIBSON, C. L., ARNOTT, G. A. and CLOWRY, G. J., 2000. Plasticity in the rat spinal cord seen in response to lesions to the motor cortex during development but not to lesions in maturity. Experimental Neurology. 166(2), 422-434
• GIBSON, C. L., ARNOTT, G. A. and CLOWRY, G. J., 2000. Muscle afferent inputs to soma and primary dendrites of homoymous forlimb motoneurones are eliminated during rat postnatal development European Journal of Neuroscience. 12, 300-300
• GIBSON, C. L. and CLOWRY, G. J., 1999. Transient expression of calcitonin gene-related peptide immunoreactivity in the ventral horn of the post-natal rat cervical spinal cord Developmental Brain Research. 115(1), 93-96
• GIBSON, C. L. and CLOWRY, G. J., 1999. Retraction of muscle afferents from the rat ventral horn during development Neuroreport. 10(2), 231-235