Centre of Evidence Based Dermatology

Systematic reviews on acne vulgaris

March 2021: This resource is now archived and no longer being updated.

We recommend the Epistemonikos database as a comprehensive, searchable database of systematic reviews. 

This page is a mapping by topic of systematic reviews on acne vulgaris (common acne) published since 1999 (the last search date of the 2001 AHRQ review Management of acne). The systematic reviews were found in the searches for our Annual Evidence Updates and CEBD Evidence Updates. Links are given to the PubMed abstract, or the original publication if not in PubMed.

Acne

Acne vulgaris (© Professor Hywel Williams)

 

Copyright © 2021 The University of Nottingham, on behalf of the Centre of Evidence Based Dermatology. ALL RIGHTS RESERVED.
Please reference this resource (as a web page citation) if you use it for research or publications.

 

Epidemiology and aetiology

Prevalence
 
Aetiology
 
Risk factors
 
Diagnosis, evaluation & outcomes
 
Disease impact & treatment cost-effectiveness

2021 Views and experiences of people with acne vulgaris and healthcare professionals about treatments: systematic review and thematic synthesis of qualitative research

2020 Identifying the impacts of acne and the use of questionnaires to detect these impacts: A systematic literature review

2020 Acne vulgaris and risk of depression and anxiety: A meta-analytic review

2019 Acne from the young patient's perspective

2019 Issues in Transgender Dermatology: a systematic review of the literature

2018 Is acne in adolescence associated with prostate cancer risk? Evidence from a meta-analysis

2017 Global skin disease morbidity and mortality: An update from the Global Burden of Disease Study 2013

2016 Content validity of patient-reported outcome instruments used with pediatric patients with facial differences: A systematic review

2016 Women and acne: any difference from males? A review of the literature

2015 Quality of life impact of childhood skin conditions measured using the Children's Dermatology Life Quality Index (CDLQI): a meta-analysis

2014 The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions

2013 Epidemiology of acne vulgaris

2013 Evidence-based recommendations for the diagnosis and treatment of pediatric acne (US Guideline)

2012 European evidence-based (S3) guidelines for the treatment of acne (EDF Guideline)

2011 Acne in adolescents: quality of life, self-esteem, mood, and psychological disorders

2011 Adolescent’s acne: Scarring inside out!

2010 [Pharmacoeconomy in acne--evaluation of benefit and economics] (in German)

 
Trial methodology
 

 

Prevention

Dietary (for prevention)
 
Hygiene
 
Sunlight
 

 

Topical treatments

Topical retinoids
 
Topical antibiotics

2020 Comparative efficacy of pharmacological and nonpharmacological interventions for acne vulgaris: A network meta-analysis

2020 Amzeeq (minocycline topical foam): A new drug for the treatment of acne

2016 Guidelines of care for the management of acne vulgaris (AAD Guideline)

2016 Systematic review of antibiotic resistance in acne: an increasing topical and oral threat

2015 [Bacterial resistance in acne? A meta-analysis of the controversy] (In Spanish)

2014 Tolerability of topical antimicrobials in treatment of acne vulgaris

2013 Evidence-based recommendations for the diagnosis and treatment of pediatric acne (US Guideline)

2013 Side effects of common acne treatments

2012 Topical antimicrobial treatment of acne vulgaris: an evidence-based review

2012 European evidence-based (S3) guidelines for the treatment of acne (EDF Guideline)

2011 Acne vulgaris (BMJ Clinical Evidence)

2011 Meta-analysis of randomized controlled trials using 5% benzoyl peroxide and clindamycin versus 2.5% benzoyl peroxide and clindamycin topical treatments in acne

2010 Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne

2005 Treatment of acne with topical antibiotics: lessons from clinical studies

2004 Treatment of acne vulgaris

2003 Is antibiotic resistance in cutaneous propionibacteria clinically relevant? : implications of resistance for acne patients and prescribers

2001 Management of acne

 
Azelaic acid
 
Benzoyl peroxide

2020 Comparative efficacy of pharmacological and nonpharmacological interventions for acne vulgaris: A network meta-analysis

2020 Topical benzoyl peroxide for acne (Cochrane Review)

2016 How much do we know about maintaining treatment response after successful acne therapy? systematic review on the efficacy and safety of acne maintenance therapy

2016 Guidelines of care for the management of acne vulgaris (AAD Guideline)

2015 Evaluating clinical trial design: systematic review of randomized vehicle-controlled trials for determining efficacy of benzoyl peroxide topical therapy for acne

2014 Tolerability of topical antimicrobials in treatment of acne vulgaris

2014 Systematic review on the rapidity of the onset of action of topical treatments in the therapy of mild-to-moderate acne vulgaris

2013 A systematic review of benzoyl peroxide for acne vulgaris

2013 Topical dose justification: benzoyl peroxide concentrations

2013 Evidence-based recommendations for the diagnosis and treatment of pediatric acne (US Guideline)

2013 Side effects of common acne treatments

2012 Topical antimicrobial treatment of acne vulgaris: an evidence-based review

2012 European evidence-based (S3) guidelines for the treatment of acne (EDF Guideline)

2011 Meta-analysis of randomized controlled trials using 5% benzoyl peroxide and clindamycin versus 2.5% benzoyl peroxide and clindamycin topical treatments in acne

2011 Acne vulgaris (BMJ Clinical Evidence)

2010 Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne

2009 Advancement in benzoyl peroxide-based acne treatment: methods to increase both efficacy and tolerability

2004 Treatment of acne vulgaris

2001 Management of acne

 
Cleansers
 
Combination therapies

2020 Comparative efficacy of pharmacological and nonpharmacological interventions for acne vulgaris: A network meta-analysis

2016 How much do we know about maintaining treatment response after successful acne therapy? systematic review on the efficacy and safety of acne maintenance therapy

2016 Guidelines of care for the management of acne vulgaris (AAD Guideline)

2014 Systematic review on the rapidity of the onset of action of topical treatments in the therapy of mild-to-moderate acne vulgaris

2014 Effects of adapalene-benzoyl peroxide combination gel in treatment or maintenance therapy of moderate or severe acne vulgaris: a meta-analysis

2013 A systematic review of benzoyl peroxide for acne vulgaris

2013 Evidence-based recommendations for the diagnosis and treatment of pediatric acne (US Guideline)

2012 Topical antimicrobial treatment of acne vulgaris: an evidence-based review

2012 European evidence-based (S3) guidelines for the treatment of acne (EDF Guideline)

2011 Meta-analysis of randomized controlled trials using 5% benzoyl peroxide and clindamycin versus 2.5% benzoyl peroxide and clindamycin topical treatments in acne

2011 Evidence-based review: fixed-combination therapy and topical retinoids in the treatment of acne

2011 Acne vulgaris (BMJ Clinical Evidence)

2010 Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne

2004 Treatment of acne vulgaris

2001 Management of acne

 
Other topical treatments

2021 Clascoterone: A novel topical androgen receptor inhibitor for the treatment of acne

2020 Efficacy and safety of topical clascoterone cream for treatment of acne vulgaris: A systematic review and meta-analysis of randomized placebo-controlled trials

2020 Comparative efficacy of pharmacological and nonpharmacological interventions for acne vulgaris: A network meta-analysis

2020 Evidence-based topical treatments (azelaic acid, salicylic acid, nicotinamide, sulfur, zinc, and fruit acid) for acne: an abridged version of a Cochrane systematic review

2020 Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne (Cochrane Review)

2019 Topical antiandrogen therapies for androgenetic alopecia and acne vulgaris

2019 Essential oils as topical anti-infective agents: A systematic review and meta-analysis

2018 Chemical peels for acne vulgaris: a systematic review of randomised controlled trials

2018 The efficacy and safety of non-pharmacological therapies for the treatment of acne vulgaris: A systematic review and best-evidence synthesis

2017 Efficacy and safety of superficial chemical peeling in treatment of active acne vulgaris

2017 The role of nicotinamide in acne treatment

2016 Green tea and other tea polyphenols: Effects on sebum production and acne vulgaris

2016 Guidelines of care for the management of acne vulgaris (AAD Guideline)

2015 Polyphenols as novel treatment options for dermatological diseases: A systematic review of clinical trials

2015 Cosmetics for acne: indications and recommendations for an evidence-based approach

2014 Tolerability of topical antimicrobials in treatment of acne vulgaris

2013 Evidence-based recommendations for the diagnosis and treatment of pediatric acne (US Guideline)

2013 The clinical effects of zinc as a topical or oral agent on the clinical response and pathophysiologic mechanisms of acne: a systematic review of the literature

2012 Topical antimicrobial treatment of acne vulgaris: an evidence-based review

2012 European evidence-based (S3) guidelines for the treatment of acne (EDF Guideline)

2011 Expert opinion: efficacy of superficial chemical peels in active acne management--what can we learn from the literature today? Evidence-based recommendations

2001 Management of acne

 

 

Systemic treatments

Oral tetracyclines

2020 Comparative efficacy of pharmacological and nonpharmacological interventions for acne vulgaris: A network meta-analysis

2020 Oral tetracyclines and acne: A systematic review for dermatologists

2019 The safe management of acne vulgaris in lupus erythematosus: A systematic review with evidence-based treatment recommendations

2019 Sarecycline review

2018 Comparison of the efficacy of azithromycin versus doxycycline in acne vulgaris: A meta-analysis of randomized controlled trials

2017 Oral antibacterial therapy for acne vulgaris: An evidence-based review

2016 How much do we know about maintaining treatment response after successful acne therapy? systematic review on the efficacy and safety of acne maintenance therapy

2016 Guidelines of care for the management of acne vulgaris (AAD Guideline)

2014 Meta-analysis comparing efficacy of antibiotics versus oral contraceptives in acne vulgaris

2013 Evidence-based recommendations for the diagnosis and treatment of pediatric acne (US Guideline)

2013 Side effects of common acne treatments

2012 Minocycline for acne vulgaris: efficacy and safety (Cochrane Review)

2012 European evidence-based (S3) guidelines for the treatment of acne (EDF Guideline)

2011 Acne vulgaris (BMJ Clinical Evidence)

2008 Efficacy of tetracyclines in the treatment of acne vulgaris: a review

2006 Systemic antibiotic therapy of acne vulgaris

2005 Safety of doxycycline and minocycline: a systematic review

2005 Use of macrolides and tetracyclines for chronic inflammatory diseases

2004 Treatment of acne vulgaris

2003 Acne: comparing hormonal approaches to antibiotics and isotretinoin

2001 Management of acne

2000 Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data

2000 Minocycline-induced lupus. A systematic review

 
Other oral antibiotics
 
Antibiotic resistance
 
Oral isotretinoin

2020 Systematic review of low-dose isotretinoin for treatment of acne vulgaris: Focus on indication, dosage, regimen, efficacy, safety, satisfaction and follow up, based on clinical studies

2020 Risk management of teratogenic medicines: A systematic review

2020 Concomitant use of isotretinoin and lasers with implications for future guidelines: An updated systematic review

2020 Effects of isotretinoin on glucose metabolism in patients with acne: A systematic review and meta-analysis

2020 Community pharmacist's' knowledge and practice toward oral isotretinoin prescription: a systemic review

2019 Isotretinoin-induced sacroiliitis: Case series of four patients and a systematic review of the literature

2019 A state-of-the-art review highlighting medical overuse in dermatology, 2017-2018: A systematic review

2019 The safe management of acne vulgaris in lupus erythematosus: A systematic review with evidence-based treatment recommendations

2019 The effects of isotretinoin therapy on serum homocysteine, folate and vitamin B12 levels in patients with acne: A meta-analysis and meta-regression

2019 Homocysteine, folic acid, and vitamin B12 levels in patients on isotretinoin therapy for acne vulgaris: A meta-analysis

2019 Psychiatric and developmental effects of isotretinoin (retinoid) treatment for acne vulgaris

2019 Issues in Transgender Dermatology: a systematic review of the literature

2019 Use of isotretinoin and risk of depression in patients with acne: a systematic review and meta-analysis

2018 Oral isotretinoin for acne (Cochrane Review)

2018 Isotretinoin; A review on the utilization pattern in pregnancy

2018 Efficacy and adverse events of oral isotretinoin for acne: a systematic review

2017 Psychiatric disorders with systemic retinoids: a systematic review of case reports

2017 Isotretinoin and timing of procedural interventions: A systematic review With consensus recommendations

2017 A systematic review on oral isotretinoin therapy and clinically observable wound healing in acne patients

2017 No evidence for increased anxiety in acne patients treated with isotretinoin

2017 Isotretinoin treatment for acne and risk of depression: A systematic review and meta-analysis

2016 Not every patient needs triglyceride check, but all can get pancreatitis: A systematic review and clinical characterization of isotretinoin associated pancreatitis

2016 How much do we know about maintaining treatment response after successful acne therapy? systematic review on the efficacy and safety of acne maintenance therapy

2016 Laboratory monitoring during isotretinoin therapy for acne: a systematic review and meta-analysis

2016 Does exposure to isotretinoin increase the risk for the development of inflammatory bowel disease? A meta-analysis

2016 Evaluation of evidence for acne remission with oral isotretinoin cumulative dosing of 120-150 mg/kg

2016 Guidelines of care for the management of acne vulgaris (AAD Guideline)

2016 Non-psychotropic medication and risk of suicide or attempted suicide: a systematic review

2013 Isotretinoin and risk for inflammatory bowel disease: a nested case-control study and meta-analysis of published and unpublished data

2013 Evidence-based recommendations for the diagnosis and treatment of pediatric acne (US Guideline)

2013 Side effects of common acne treatments

2012 Retinoic acid and affective disorders: the evidence for an association

2012 European evidence-based (S3) guidelines for the treatment of acne (EDF Guideline)

2011 Compliance with pregnancy prevention programmes of isotretinoin in Europe: a systematic review

2011 Acne vulgaris (BMJ Clinical Evidence)

2011 Acne in adolescents: quality of life, self-esteem, mood, and psychological disorders

2010 [Pharmacoeconomy in acne--evaluation of benefit and economics] (in German)

2009 Isotretinoin and psychopathology: a review

2005 Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review
(republished in 2007 in a "best of" compilation in the same journal)

2005 Isotretinoin, depression and suicide: a review of the evidence

2004 Treatment of acne vulgaris

2003 Acne: comparing hormonal approaches to antibiotics and isotretinoin

2001 Management of acne

1999 The cost-effectiveness of isotretinoin in the treatment of acne. Part 1. A meta-analysis of effectiveness literature

 
Oral contraceptives & insulin-sensitising drugs

2020 Metformin therapy for acne in patients with polycystic ovary syndrome: A systematic review and meta-analysis

2020 Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome (Cochrane Review)

2020 Eligibility criteria related to hormone therapy in acne clinical trials: A systematic review

2019 The safe management of acne vulgaris in lupus erythematosus: A systematic review with evidence-based treatment recommendations

2017 A review of hormone-based therapies to treat adult acne vulgaris in women

2016 Metformin or oral contraceptives for adolescents with polycystic ovarian syndrome: a meta-analysis

2016 Guidelines of care for the management of acne vulgaris (AAD Guideline)

2014 Meta-analysis comparing efficacy of antibiotics versus oral contraceptives in acne vulgaris

2013 Evidence-based recommendations for the diagnosis and treatment of pediatric acne (US Guideline)

2013 Side effects of common acne treatments

2012 Combined oral contraceptive pills for treatment of acne (Cochrane Review)

2012 European evidence-based (S3) guidelines for the treatment of acne (EDF Guideline)

2010 [Hormonal antiandrogens in acne treatment] (in German)

2007 Metformin versus oral contraceptive pill in polycystic ovary syndrome: a Cochrane review

2007 Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome (Cochrane Review)

2004 Hormonal treatment of acne: review of current best evidence

2004 Treatment of acne vulgaris

2001 Management of acne

 
Anti-androgens
 
Dietary & supplements (for treatment)
 

 

Other treatments

Phototherapy
 
Photodynamic therapy
 
Laser therapy

2020 Comparative efficacy of pharmacological and nonpharmacological interventions for acne vulgaris: A network meta-analysis

2020 The efficacy of fractional CO2 laser in acne scar treatment: A meta-analysis

2020 Outcomes and adverse effects of ablative versus nonablative lasers for skin resurfacing: A systematic review of 1093 patients

2020 A meta-analysis of fractional CO2 laser combined with PRP in the treatment of acne scar

2020 Concomitant use of isotretinoin and lasers with implications for future guidelines: An updated systematic review

2019 Efficacy of autologous platelet-rich plasma combined with ablative fractional carbon dioxide laser for acne scars: A systematic review and meta-analysis

2018 The clinical effectiveness and cost-effectiveness of fractional CO2 laser in acne scars and skin rejuvenation: A meta-analysis and economic evaluation

2018 Ablative fractional CO2 laser for facial atrophic acne scars

2018 A systematic review of treatments for acne scarring. Part 2: Energy-based techniques

2018 The efficacy and safety of non-pharmacological therapies for the treatment of acne vulgaris: A systematic review and best-evidence synthesis

2017 Nonablative fractional laser resurfacing in skin of color: Evidence-based review

2017 Light therapies for acne: abridged Cochrane systematic review including GRADE assessments

2016 Light therapies for acne (Cochrane Review)

2016 Interventions for acne scars (Cochrane Review)

2016 Guidelines of care for the management of acne vulgaris (AAD Guideline)

2013 The efficacy of pulsed dye laser treatment for inflammatory skin diseases: a systematic review

2013 Side effects of common acne treatments

2012 European evidence-based (S3) guidelines for the treatment of acne (EDF Guideline)

2012 Fractional laser resurfacing for acne scars: a review

2009 Laser and other light therapies for the treatment of acne vulgaris: systematic review

2008 Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris

2001 Laser resurfacing for facial acne scars (Cochrane Review) - replaced by 2016 Interventions for acne scars

2000 Laser resurfacing of the skin for the improvement of facial acne scarring: a systematic review of the evidence

 
Treatments for acne scars

2021 Microneedling in the treatment of atrophic scars: A systematic review of randomised controlled trials

2020 Microneedling for the treatment of scars: An update for clinicians

2020 The efficacy of fractional CO2 laser in acne scar treatment: A meta-analysis

2020 Outcomes and adverse effects of ablative versus nonablative lasers for skin resurfacing: A systematic review of 1093 patients

2020 A meta-analysis of fractional CO2 laser combined with PRP in the treatment of acne scar

2020 Platelet-rich plasma in noninvasive procedures for atrophic acne scars: A systematic review and meta-analysis

2019 A meta-analysis of the evidence for assisted therapy with platelet-rich plasma for atrophic acne scars

2019 Combination therapy with microneedling and platelet-rich plasma for acne scarring: A systematic review and meta-analysis

2019 Microneedling as a treatment for acne scarring: A systematic review

2019 Platelet-rich plasma and its utility in the treatment of acne scars - A systematic review

2019 Efficacy of autologous platelet-rich plasma combined with ablative fractional carbon dioxide laser for acne scars: A systematic review and meta-analysis

2018 A systematic review of treatments for acne scarring. Part 2: Energy-based techniques

2018 Acne scarring management: Systematic review and evaluation of the evidence

2018 The efficacy and safety of non-pharmacological therapies for the treatment of acne vulgaris: A systematic review and best-evidence synthesis

2018 The clinical effectiveness and cost-effectiveness of fractional CO2 laser in acne scars and skin rejuvenation: A meta-analysis and economic evaluation

2018 Ablative fractional CO2 laser for facial atrophic acne scars

2017 A systematic review of treatments for acne scarring. Part 1: Non-energy-based techniques

2017 Nonablative fractional laser resurfacing in skin of color: Evidence-based review

2017 Microneedling: Where do we stand now? A systematic review of the literature

2017 The efficacy and safety of the fractional radiofrequency technique for the treatment of atrophic acne scar in asians: A meta-analysis

2016 Interventions for acne scars (Cochrane Review)

2016 Fractional radiofrequency treatment in acne scars: Systematic review of current evidence

2015 Systematic review of the use of platelet-rich plasma in aesthetic dermatology

2012 Fractional laser resurfacing for acne scars: a review

2001 Laser resurfacing for facial acne scars (replaced by 2016 Interventions for acne scars)

2000 Laser resurfacing of the skin for the improvement of facial acne scarring: a systematic review of the evidence

 
Grenz rays
 
Psychological & educational
 
Complementary & alternative therapies

2020 Comparative efficacy of pharmacological and nonpharmacological interventions for acne vulgaris: A network meta-analysis

2020 The effects of green tea on acne vulgaris: A systematic review and meta-analysis of randomized clinical trials

2020 External application of herbal medicines for acne vulgaris: A systematic review and meta analysis

2019 Essential oils as topical anti-infective agents: A systematic review and meta-analysis

2019 Fire needle therapy for moderate-severe acne: A PRISMA systematic review and meta-analysis of randomized controlled trials

2018 [Efficacy and safety of autohemotherapy at acupoint for acne: systematic review] (in Chinese)

2018 Acupuncture for acne vulgaris: A systematic review and meta-analysis

2016 Guidelines of care for the management of acne vulgaris (AAD Guideline)

2015 Complementary therapies for acne vulgaris (Cochrane Review)

2015 [Analysis of therapeutic regularities and characteristics of blood-letting therapy for acne patients based on data mining] (in Chinese)

2015 Acupuncture as a treatment modality in dermatology: A systematic review

2014 Botanical and phytochemical therapy of acne: a systematic review

2013 Acupoint stimulation for acne: a systematic review of randomized controlled trials

2012 An updated review of the efficacy of cupping therapy

2010 Botanicals in dermatology: an evidence-based review

2009 [Evaluation of therapeutic effect and safety for clinical randomized and controlled trials of treatment of acne with acupuncture and moxibustion] (in Chinese)

2006 Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context

2000 Tea tree oil: a systematic review of randomized clinical trials

 

 

Centre of Evidence Based Dermatology

The University of Nottingham
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telephone: +44 (0) 115 84 68631
email: cebd@nottingham.ac.uk