Centre for Evidence Based Hand Surgery

HandSRev


Carpal tunnel syndrome

 

GUIDELINES

Hand Pain and Sensory Deficits: Carpal Tunnel Syndrome.
Erickson M, Lawrence M, Jansen CWS, Coker D, Amadio P, Cleary C.
J Orthop Sports Phys Ther. 2019 May;49(5):CPG1-CPG85. doi: 10.2519/jospt.2019.0301.

RCS Commissioning Guide: Treatment of Carpal Tunnel Syndrome 2017. (PDF)
British Society for Surgery of the Hand (BSSH), British Orthopaedic Association (BOA), Royal College of Surgeons of England (RCSEng).
London: Royal College of Surgeons, 2017.

The American Academy of Orthopaedic Surgeons Evidence-Based Clinical Practice Guideline on: Management of Carpal Tunnel Syndrome.
Graham B, Peljovich AE, Afra R, Cho MS, Gray R, Stephenson J, Gurman A, MacDermid J, Mlady G, Patel AT, Rempel D, Rozental TD, Salajegheh MK, Keith MW, Jevsevar DS, Shea KG, Bozic KJ, Adams J, Evans JM, Lubahn J, Ray WZ, Spinner R, Thomson G, Shaffer WO, Cummins DS, Murray JN, Mohiuddin M, Mullen K, Shores P, Woznica A, Linskey E, Martinez Y, Sevarino K.
J Bone Joint Surg Am. 2016 Oct 19;98(20):1750-1754. No abstract available.
Link to full guideline (PDF) 

Carpal tunnel syndrome: hand surgeons, hand therapists, and physical medicine and rehabilitation physicians agree on a multidisciplinary treatment guideline—results from the European HANDGUIDE Study.
Huisstede BM, Fridén J, Coert JH, Hoogvliet P; European HANDGUIDE Group.
Arch Phys Med Rehabil. 2014 Dec;95(12):2253-63. doi: 10.1016/j.apmr.2014.06.022. Epub 2014 Aug 12.

Evidence-based guideline: neuromuscular ultrasound for the diagnosis of carpal tunnel syndrome.
Cartwright MS, Hobson-Webb LD, Boon AJ, Alter KE, Hunt CH, Flores VH, Werner RA, Shook SJ, Thomas TD, Primack SJ, Walker FO; American Association of Neuromuscular and Electrodiagnostic Medicine.
Muscle Nerve. 2012 Aug;46(2):287-93. doi: 10.1002/mus.23389.

ACR–SCBT-MR–SPR–SSR Practice Parameter for the Performance of Magnetic Resonance Imaging (MRI) of the Wrist (PDF)

ACR appropriateness criteria - Chronic Wrist Pain

 
General

Use of decision analysis and economic evaluation in upper extremity surgery: A systematic review.
Safran T, Retrouvey H, Gorsky K, Baltzer HL.
Plast Reconstr Surg. 2019 May 7. doi: 10.1097/PRS.0000000000005830. [Epub ahead of print]

Quality of randomized controlled trials for surgical treatment of carpal tunnel syndrome: A systematic review.
Long C, Azad AD, desJardins-Park HE, Fox PM.
Plast Reconstr Surg. 2019 Mar;143(3):791-799. doi: 10.1097/PRS.0000000000005366.

Impact of carpal tunnel syndrome on ulnar nerve at wrist: Systematic review.
Ginanneschi F, Mondelli M, Cioncoloni D, Rossi A.
J Electromyogr Kinesiol. 2018 Jun;40:32-38. doi: 10.1016/j.jelekin.2018.03.004. Epub 2018 Mar 20.

Work-related carpal tunnel syndrome: diagnosis and treatment guideline.
Franklin GM, Friedman AS.
Phys Med Rehabil Clin N Am. 2015 Aug;26(3):523-37. doi: 10.1016/j.pmr.2015.04.003. Epub 2015 Jun 19.

Carpal tunnel syndrome.
Ashworth NL.
BMJ Clin Evid. 2014;08:1114.

 
Diagnosis & evaluation

Carpal tunnel syndrome caused by the entrapment of a bifid Lanz IIIA Type anatomical variant of median nerve: A case report and systematic literature review.
Corte E, Gelmi CAE, Acciarri N.
Surg Neurol Int. 2021 Feb 3;12:37. doi: 10.25259/SNI_765_2020. eCollection 2021.

Sonoelastography in the diagnosis of carpal tunnel syndrome: A systematic review of diagnostic values compared with the normative population.
Lee CH, Lin YT, Wu CT, Lin CH, Chen SH, Hsu CC.
Ann Plast Surg. 2021 Jan 11. doi: 10.1097/SAP.0000000000002686. Online ahead of print.

Diagnosing carpal tunnel syndrome: Diagnostic test accuracy of scales, questionnaires, and hand symptom diagrams-a systematic review.
Dabbagh A, MacDermid JC, Yong J, Macedo LG, Packham TL.
J Orthop Sports Phys Ther. 2020 Sep 16:1-47. doi: 10.2519/jospt.2020.9599. Online ahead of print.

A systematic review of the methodology of sonographic assessment of upper limb activities-associated carpal tunnel syndrome.
Fong SW, Liu BWF, Sin CL, Lee KS, Wong TM, Choi KS, Yang YP, Lin YY, Chien Y, Tarng YW, Chen CF, Lin LT.
J Chin Med Assoc. 2020 Aug 20. doi: 10.1097/JCMA.0000000000000415. Online ahead of print.

Subsynovial connective tissue thickness in carpal tunnel syndrome: A systematic review.
Robben E, Dever J, De Groef A, Degreef I, Peers K.
Clin Biomech (Bristol, Avon). 2020 May;75:105002. doi: 10.1016/j.clinbiomech.2020.105002. Epub 2020 Apr 19.

Using Carpal Tunnel Questionnaire in clinical practice: A systematic review of its measurement properties.
Mehta SP, Weinstock-Zlotnick G, Akland KL, Hanna MM, Workman KJ.
J Hand Ther. 2020 Mar 6. pii: S0894-1130(20)30010-7. doi: 10.1016/j.jht.2019.12.011. [Epub ahead of print]

Screening for carpal tunnel syndrome in patients with mucopolysaccharidosis.
Patel P, Antoniou G, Clark D, Ketteridge D, Williams N.
J Child Neurol. 2020 Mar 11:883073820904481. doi: 10.1177/0883073820904481. [Epub ahead of print]

Ultrasound elastography in the evaluation of peripheral neuropathies: a systematic review of the literature.
Zakrzewski J, Zakrzewska K, Pluta K, Nowak O, Miłoszewska-Paluch A.
Pol J Radiol. 2019 Dec 21;84:e581-e591. doi: 10.5114/pjr.2019.91439. eCollection 2019.

Utility of ultrasound elastography in evaluation of carpal tunnel syndrome: A systematic review and meta-analysis.
Lin CP, Chen IJ, Chang KV, Wu WT, Özçakar L.
Ultrasound Med Biol. 2019 Aug 9. pii: S0301-5629(19)31099-3. doi: 10.1016/j.ultrasmedbio.2019.07.409. [Epub ahead of print]

Ultrasound elastography for the evaluation of peripheral nerves: A systematic review.
Wee TC, Simon NG.
Muscle Nerve. 2019 Jul 3. doi: 10.1002/mus.26624. [Epub ahead of print]

The sensitivity and specificity of nerve conduction studies for diagnosis of carpal tunnel syndrome: A systematic review.
Demino C, Fowler JR.
Hand (N Y). 2019 Jun 17:1558944719855442. doi: 10.1177/1558944719855442. [Epub ahead of print]

Work-related carpal tunnel syndrome: diagnosis and treatment guideline.
Franklin GM, Friedman AS.
Phys Med Rehabil Clin N Am. 2015 Aug;26(3):523-37. doi: 10.1016/j.pmr.2015.04.003. Epub 2015 Jun 19.

 
Epidemiology - outcomes

Carpal tunnel syndrome caused by the entrapment of a bifid Lanz IIIA Type anatomical variant of median nerve: A case report and systematic literature review.
Corte E, Gelmi CAE, Acciarri N.
Surg Neurol Int. 2021 Feb 3;12:37. doi: 10.25259/SNI_765_2020. eCollection 2021.

Outcome metrics in the treatment of carpal tunnel syndrome: A systematic review.
Mertz K, Lindsay SE, Morris A, Kamal RN.
Hand (N Y). 2020 Oct 19:1558944720949951. doi: 10.1177/1558944720949951. Online ahead of print.

Does diabetes mellitus change the carpal tunnel release outcomes? Evidence from a systematic review and meta-analysis.
Moradi A, Sadr A, Ebrahimzadeh MH, Hassankhani GG, Mehrad-Majd H.
J Hand Ther. 2020 Mar 7. pii: S0894-1130(20)30023-5. doi: 10.1016/j.jht.2020.01.003. [Epub ahead of print]

Sickness absence after carpal tunnel release: a systematic review of the literature.
Newington L, Stevens M, Warwick D, Adams J, Walker-Bone K.
Scand J Work Environ Health. 2018 Nov 1;44(6):557-567. doi: 10.5271/sjweh.3762. Epub 2018 Aug 12.

Linking hand therapy outcome measures used after carpal tunnel release to the International Classification of Functioning, Disability and Health: A systematic review.
Cantero-Téllez R, Naughton N, Algar L, Valdes K.
J Hand Ther. 2018 Jul 12. pii: S0894-1130(17)30272-7. doi: 10.1016/j.jht.2018.02.006. [Epub ahead of print]

The incidence of complex regional pain syndrome in simultaneous surgical treatment of carpal tunnel syndrome and Dupuytren contracture.
Buller M, Schulz S, Kasdan M, Wilhelmi BJ.
Hand (N Y). 2018 Jul;13(4):391-394. doi: 10.1177/1558944717718345. Epub 2017 Jul 8.

The effect of psychological factors on the outcomes of carpal tunnel release: a systematic review.
Park JW, Gong HS, Rhee SH, Kim J, Lee YH, Baek GH.
J Hand Surg Asian Pac Vol. 2017 Jun;22(2):131-137. doi: 10.1142/S0218810417300029.

Complications of surgical release\break of carpal tunnel syndrome: A systematic review.
Faucher GK, Daruwalla JH, Seiler JG 3rd.
J Surg Orthop Adv. 2017 Spring;26(1):18-24.

Outcomes following carpal tunnel release in patients receiving workers' compensation: A systematic review.
Dunn JC, Kusnezov NA, Koehler LR, Vanden Berge D, Genco B, Mitchell J, Orr JD, Pallis M.
Hand (N Y). 2018 Mar;13(2):137-142. doi: 10.1177/1558944717701240. Epub 2017 Apr 7.

Surgical site infection after hand surgery outside the operating theatre: a systematic review.
Jagodzinski NA, Ibish S, Furniss D.
J Hand Surg Eur Vol. 2017 Mar;42(3):289-294. doi: 10.1177/1753193416676408.

Prognostic factors for return-to-work following surgery for carpal tunnel syndrome: a systematic review.
Peters S, Johnston V, Hines S, Ross M, Coppieters M.
JBI Database System Rev Implement Rep. 2016 Sep;14(9):135-216.

A systematic review of the literature on the outcomes of treatment for recurrent and persistent carpal tunnel syndrome.
Soltani AM, Allan BJ, Best MJ, Mir HS, Panthaki ZJ.
Plast Reconstr Surg. 2013 Jul;132(1):114-21. doi: 10.1097/PRS.0b013e318290faba.

Long-term outcomes of carpal tunnel release: a critical review of the literature.
Louie D, Earp B, Blazar P.
Hand (N Y). 2012 Sep;7(3):242-6. doi: 10.1007/s11552-012-9429-x.

Surgical techniques and return to work following carpal tunnel release: a systematic review and meta-analysis.
Sanati KA, Mansouri M, Macdonald D, Ghafghazi S, Macdonald E, Yadegarfar G.
J Occup Rehabil. 2011 Dec;21(4):474-81. doi: 10.1007/s10926-011-9310-8.

 
Epidemiology - association with trigger digits

Coincidence or complication? A systematic review of trigger digit after carpal tunnel release.
Lin FY, Wu CI, Cheng HT.
J Plast Surg Hand Surg. 2018 Apr;52(2):67-73. doi: 10.1080/2000656X.2017.1345751. Epub 2017 Jul 7.

Is carpal tunnel release associated with trigger finger?
Le Guillou A, Despreaux T, Descatha A.
Chir Main. 2015 Jun;34(3):149-50. doi: 10.1016/j.main.2015.03.003Shen L. Epub 2015 May 11. No abstract available.

 
Epidemiology - work-related risk factors

Strategies for the prevention of carpal tunnel syndrome in the workplace: A systematic review.
Trillos-Chacón MC, Castillo-M JA, Tolosa-Guzman I, Sánchez Medina AF, Ballesteros SM.
Appl Ergon. 2021 Jan 13;93:103353. doi: 10.1016/j.apergo.2020.103353. Online ahead of print.

Associations of screen work with neck and upper extremity symptoms: a systematic review with meta-analysis.
Coenen P, van der Molen HF, Burdorf A, Huysmans MA, Straker L, Frings-Dresen MH, van der Beek AJ.
Occup Environ Med. 2019 Mar 20. pii: oemed-2018-105553. doi: 10.1136/oemed-2018-105553. [Epub ahead of print]

Prevalence of work-related musculoskeletal disorders among surgeons and interventionalists: A systematic review and meta-analysis.
Epstein S, Sparer EH, Tran BN, Ruan QZ, Dennerlein JT, Singhal D, Lee BT.
JAMA Surg. 2018 Feb 21;153(2):e174947. doi: 10.1001/jamasurg.2017.4947. Epub 2018 Feb 21.

Hand-arm vibration and the risk of vascular and neurological diseases - A systematic review and meta-analysis.
Nilsson T, Wahlström J, Burström L.
PLoS One. 2017 Jul 13;12(7):e0180795. doi: 10.1371/journal.pone.0180795. eCollection 2017.

Association between work-related biomechanical risk factors and the occurrence of carpal tunnel syndrome: an overview of systematic reviews and a meta-analysis of current research.
Kozak A, Schedlbauer G, Wirth T, Euler U, Westermann C, Nienhaus A.
BMC Musculoskelet Disord. 2015 Sep 1;16:231. doi: 10.1186/s12891-015-0685-0.

Computer use and carpal tunnel syndrome: A meta-analysis.
Shiri R, Falah-Hassani K.
J Neurol Sci. 2015 Feb 15;349(1-2):15-9. doi: 10.1016/j.jns.2014.12.037. Epub 2015 Jan 2.

Is carpal tunnel syndrome related to computer exposure at work? A review and meta-analysis.
Mediouni Z, de Roquemaurel A, Dumontier C, Becour B, Garrabe H, Roquelaure Y, Descatha A.
J Occup Environ Med. 2014 Feb;56(2):204-8. doi: 10.1097/JOM.0000000000000080.

Meta-analysis: association between wrist posture and carpal tunnel syndrome among workers.
You D, Smith AH, Rempel D.
Saf Health Work. 2014 Mar;5(1):27-31. doi: 10.1016/j.shaw.2014.01.003. Epub 2014 Jan 31.

[Metaanalysis for the evaluation of risk factors for carpal tunnel syndrome (CTS) Part II. Occupational risk factors].
Spahn G, Wollny J, Hartmann B, Schiele R, Hofmann GO.
Z Orthop Unfall. 2012 Oct;150(5):516-24. doi: 10.1055/s-0032-1315346. Epub 2012 Oct 17. German.

Carpal tunnel syndrome and its relationship to occupation: a meta-analysis.
Barcenilla A, March LM, Chen JS, Sambrook PN.
Rheumatology (Oxford). 2012 Feb;51(2):250-61. doi: 10.1093/rheumatology/ker108. Epub 2011 May 17.

 
Epidemiology - other risk factors

Does diabetes mellitus change the carpal tunnel release outcomes? Evidence from a systematic review and meta-analysis.
Moradi A, Sadr A, Ebrahimzadeh MH, Hassankhani GG, Mehrad-Majd H.
J Hand Ther. 2020 Mar 7. pii: S0894-1130(20)30023-5. doi: 10.1016/j.jht.2020.01.003. [Epub ahead of print]

Histoplasmosis of the upper extremities: clinical case, treatment algorithm, and systematic review.
Huayllani MT, Restrepo DJ, Boczar D, Sisti A, Rinker BD, Manrique OJ, Perdikis G, Forte AJ.
Hand (N Y). 2020 Mar 22:1558944720911212. doi: 10.1177/1558944720911212. [Epub ahead of print]

Systematic review and pooled analysis of the rate of carpal tunnel syndrome after prophylactic carpal tunnel release in patients with a distal radius fracture.
Al-Amin Z, Senyürek SA, Van Lieshout EMM, Wijffels MME.
Hand Surg Rehabil. 2018 Jun;37(3):155-159. doi: 10.1016/j.hansur.2018.02.004. Epub 2018 Mar 24.

Psychosocial risk factors and the association with carpal tunnel syndrome: a systematic review.
Mansfield M, Thacker M, Sandford F.
Hand (N Y). 2018 Sep;13(5):501-508. doi: 10.1177/1558944717736398. Epub 2017 Oct 27.

Is there a relationship between impaired median nerve excursion and carpal tunnel syndrome? A systematic review.
Ellis R, Blyth R, Arnold N, Miner-Williams PhD W.
J Hand Ther. 2016 Sep 28. pii: S0894-1130(16)30131-4. doi: 10.1016/j.jht.2016.09.002.

Arthritis as a risk factor for carpal tunnel syndrome: a meta-analysis.
Shiri R.
Scand J Rheumatol. 2016 Oct;45(5):339-46. doi: 10.3109/03009742.2015.1114141. Epub 2016 Mar 29.

Diabetes as a risk factor for carpal tunnel syndrome: a systematic review and meta-analysis.
Pourmemari MH, Shiri R.
Diabet Med. 2016 Jan;33(1):10-6. doi: 10.1111/dme.12855. Epub 2015 Aug 18.

The effect of excess body mass on the risk of carpal tunnel syndrome: a meta-analysis of 58 studies.
Shiri R, Pourmemari MH, Falah-Hassani K, Viikari-Juntura E.
Obes Rev. 2015 Dec;16(12):1094-104. doi: 10.1111/obr.12324. Epub 2015 Sep 23.

A square-shaped wrist as a predictor of carpal tunnel syndrome: A meta-analysis.
Shiri R.
Muscle Nerve. 2015 Nov;52(5):709-13. doi: 10.1002/mus.24761. Epub 2015 Jul 24.

Comparison of risk of carpal tunnel syndrome in patients with distal radius fractures after 7 treatments.
Zhao HL, Wang GB, Jia YQ, Zhu SC, Zhang FF, Liu HM.
Med Sci Monit. 2015 Sep 22;21:2837-44. doi: 10.12659/MSM.894075.

Hypothyroidism and carpal tunnel syndrome: a meta-analysis.
Shiri R.
Muscle Nerve. 2014 Dec;50(6):879-83. doi: 10.1002/mus.24453. Epub 2014 Oct 30.

Smoking and carpal tunnel syndrome: a meta-analysis.
Pourmemari MH, Viikari-Juntura E, Shiri R.
Muscle Nerve. 2014 Mar;49(3):345-50. doi: 10.1002/mus.23922. Epub 2013 Jul 8.

Influence of compensation status on time off work after carpal tunnel release and rotator cuff surgery: a meta-analysis.
de Moraes VY, Godin K, Dos Santos JB, Faloppa F, Bhandari M, Belloti JC.
Patient Saf Surg. 2013 Jan 2;7(1):1. doi: 10.1186/1754-9493-7-1.

Neurologic involvement in scleroderma: a systematic review.
Amaral TN, Peres FA, Lapa AT, Marques-Neto JF, Appenzeller S.
Semin Arthritis Rheum. 2013 Dec;43(3):335-47. doi: 10.1016/j.semarthrit.2013.05.002. Epub 2013 Jul 1.

The association of Raynaud's syndrome with carpal tunnel syndrome: a meta-analysis.
Hartmann P, Mohokum M, Schlattmann P.
Rheumatol Int. 2012 Mar;32(3):569-74. doi: 10.1007/s00296-011-2122-5. Epub 2011 Sep 7.

[Metaanalysis for the evaluation of risk factors for carpal tunnel syndrome (CTS) Part I. General factors].
Spahn G, Wollny J, Hartmann B, Schiele R, Hofmann GO.
Z Orthop Unfall. 2012 Oct;150(5):503-15. doi: 10.1055/s-0032-1315345. Epub 2012 Oct 17. German.

 
Treatments - non-surgical

Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome.
Choi GH, Wieland LS, Lee H, Sim H, Lee MS, Shin BC.
Cochrane Database Syst Rev. 2018 Dec 2;12:CD011215. doi: 10.1002/14651858.CD011215.pub2.

Rehabilitation following carpal tunnel release.
Peters S, Page MJ, Coppieters MW, Ross M, Johnston V.
Cochrane Database Syst Rev. 2016 Feb 17;2:CD004158. doi: 10.1002/14651858.CD004158.pub3.

Therapeutic ultrasound for carpal tunnel syndrome.
Page MJ, O'Connor D, Pitt V, Massy-Westropp N.
Cochrane Database Syst Rev. 2013 Mar 28;3:CD009601. doi: 10.1002/14651858.CD009601.pub2.

Splinting for carpal tunnel syndrome.
Page MJ, Massy-Westropp N, O'Connor D, Pitt V.
Cochrane Database Syst Rev. 2012 Jul 11;7:CD010003. doi: 10.1002/14651858.CD010003.

Exercise and mobilisation interventions for carpal tunnel syndrome.
Page MJ, O'Connor D, Pitt V, Massy-Westropp N.
Cochrane Database Syst Rev. 2012 Jun 13;6:CD009899. doi: 10.1002/14651858.CD009899.

Ergonomic positioning or equipment for treating carpal tunnel syndrome.
O'Connor D, Page MJ, Marshall SC, Massy-Westropp N.
Cochrane Database Syst Rev. 2012 Jan 18;1:CD009600. doi: 10.1002/14651858.CD009600.

Local corticosteroid injection for carpal tunnel syndrome.
Marshall S, Tardif G, Ashworth N.
Cochrane Database Syst Rev. 2007 Apr 18;(2):CD001554.

Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome.
O'Connor D, Marshall S, Massy-Westropp N.
Cochrane Database Syst Rev. 2003;(1):CD003219.

Effect of platelet-rich plasma injection on mild or moderate carpal tunnel syndrome: an updated systematic review and meta-analysis of randomized controlled trials.
Dong C, Sun Y, Qi Y, Zhu Y, Wei H, Wu D, Li C.
Biomed Res Int. 2020 Nov 14;2020:5089378. doi: 10.1155/2020/5089378. eCollection 2020.

Extracorporeal shock wave therapy versus local corticosteroid injection for the treatment of carpal tunnel syndrome: a meta-analysis.
Li W, Dong C, Wei H, Xiong Z, Zhang L, Zhou J, Wang Y, Song J, Tan M.
J Orthop Surg Res. 2020 Nov 23;15(1):556. doi: 10.1186/s13018-020-02082-x.

The utilization of joint mobilization as part of a comprehensive program to manage carpal tunnel syndrome: A systematic review.
Sault JD, Jayaseelan DJ, Mischke JJ, Post AA.
J Manipulative Physiol Ther. 2020 Aug 26:S0161-4754(20)30057-9. doi: 10.1016/j.jmpt.2020.02.001. Online ahead of print.

Effects of shock wave therapy in patients with carpal tunnel syndrome: a systematic review and meta-analysis.
Xie Y, Zhang C, Liang B, Wang J, Wang L, Wan T, Xu F, Lei L.
Disabil Rehabil. 2020 May 18:1-12. doi: 10.1080/09638288.2020.1762769. [Epub ahead of print]

Regenerative injections including 5% dextrose and platelet-rich plasma for the treatment of carpal tunnel syndrome: A systematic review and network meta-analysis.
Lin CP, Chang KV, Huang YK, Wu WT, Özçakar L.
Pharmaceuticals (Basel). 2020 Mar 18;13(3). pii: E49. doi: 10.3390/ph13030049.

Effectiveness of low-level laser therapy compared to ultrasound in patients with carpal tunnel syndrome: A systematic review and meta-analysis.
Rayegani SM, Moradi-Joo M, Raeissadat SA, Bahrami MH, Seyed-Nezhad M, Heidari S.
J Lasers Med Sci. 2019 Fall;10(Suppl 1):S82-S89. doi: 10.15171/jlms.2019.S15. Epub 2019 Dec 1.

Low-level laser therapy for carpal tunnel syndrome: systematic review and network meta-analysis.
Cheung WKW, Wu IXY, Sit RWS, Ho RST, Wong CHL, Wong SYS, Chung VCH.
Physiotherapy. 2020 Mar;106:24-35. doi: 10.1016/j.physio.2019.06.005. Epub 2019 Jun 20.

Effectiveness of platelet rich plasma injections for non-surgical management of carpal tunnel syndrome: a systematic review and meta-analysis of randomized controlled trials.
Catapano M, Catapano J, Borschel G, Alavania SM, Robinson LR, Mittal N.
Arch Phys Med Rehabil. 2019 Dec 7. pii: S0003-9993(19)31436-4. doi: 10.1016/j.apmr.2019.10.193. [Epub ahead of print]

Acupuncture and related interventions for carpal tunnel syndrome: systematic review.
Wu IX, Lam VC, Ho RS, Cheung WK, Sit RW, Chou LW, Zhang Y, Leung TH, Chung VC.
Clin Rehabil. 2019 Sep 26:269215519877511. doi: 10.1177/0269215519877511. [Epub ahead of print]

Effect of extracorporeal shockwave therapy on carpal tunnel syndrome: A systematic review and meta-analysis of randomized controlled trials.
Kim JC, Jung SH, Lee SU, Lee SY.
Medicine (Baltimore). 2019 Aug;98(33):e16870. doi: 10.1097/MD.0000000000016870.

The effects of needling therapies on muscle force production: A systematic review and meta-analysis.
Mansfield C, VanEtten L, Willy R, Di Stasi S, Magnussen R, Briggs M.
J Orthop Sports Phys Ther. 2019 Mar;49(3):154-170. doi: 10.2519/jospt.2019.8270. Epub 2018 Nov 30.

Electromyographic biofeedback in motor function recovery after peripheral nerve injury: An integrative review of the literature.
Duarte-Moreira RJ, Castro KV, Luz-Santos C, Martins JVP, Sá KN, Baptista AF.
Appl Psychophysiol Biofeedback. 2018 Dec;43(4):247-257. doi: 10.1007/s10484-018-9403-7.

Platelet-rich plasma injections for carpal tunnel syndrome: a systematic and comprehensive review.
Malahias MA, Chytas D, Mavrogenis AF, Nikolaou VS, Johnson EO, Babis GC.
Eur J Orthop Surg Traumatol. 2019 Jan;29(1):1-8. doi: 10.1007/s00590-018-2278-8. Epub 2018 Jul 18.

The effectiveness of oral pain medication and corticosteroid injections for carpal tunnel syndrome – A systematic review.
Huisstede BM, Randsdorp MS, van den Brink J, Franke TP, Koes BW, Hoogvliet P.
Arch Phys Med Rehabil. 2018 Aug;99(8):1609-1622.e10. doi: 10.1016/j.apmr.2018.03.003. Epub 2018 Apr 5.

The use of neurodynamic techniques in the conservative treatment of carpal tunnel syndrome - A critical appraisal of the literature.
Wolny T.
Ortop Traumatol Rehabil. 2017 Oct 31;19(5):427-440.

Carpal tunnel syndrome: Effectiveness of physical therapy and electrophysical modalities. An updated systematic review of randomized controlled trials.
Huisstede BMA, Hoogvliet P, Franke TPC, Randsdorp MS, Koes BW.
Arch Phys Med Rehabil. 2018 Aug;99(8):1623-1634.e23. doi: 10.1016/j.apmr.2017.08.482. Epub 2017 Sep 20.

Ultrasound-guided versus landmark-guided local corticosteroid injection for carpal tunnel syndrome: A systematic review and meta-analysis of randomized controlled clinical trials.
Babaei-Ghazani A, Roomizadeh P, Forogh B, Moeini-Taba SM, Abedini A, Kadkhodaie M, Jahanjoo F, Eftekharsadat B.
Arch Phys Med Rehabil. 2018 Apr;99(4):766-775. doi: 10.1016/j.apmr.2017.08.484. Epub 2017 Sep 21.

Median nerve mobilization techniques in the treatment of carpal tunnel syndrome: A systematic review.
Lim YH, Chee DY, Girdler S, Lee HC.
J Hand Ther. 2017 Oct - Dec;30(4):397-406. doi: 10.1016/j.jht.2017.06.019. Epub 2017 Jul 29.

Interventions for neuropathic pain: An overview of systematic reviews.
Dosenovic S, Jelicic Kadic A, Miljanovic M, Biocic M, Boric K, Cavar M, Markovina N, Vucic K, Puljak L.
Anesth Analg. 2017 Aug;125(2):643-652. doi: 10.1213/ANE.0000000000001998.

The effectiveness of neural mobilization for neuro-musculoskeletal conditions: A systematic review and meta-analysis.
Basson A, Olivier B, Ellis R, Coppieters M, Stewart A, Mudzi W.
J Orthop Sports Phys Ther. 2017 Sep;47(9):593-615. doi: 10.2519/jospt.2017.7117. Epub 2017 Jul 13.

The effectiveness of surgical and post-surgical interventions for carpal tunnel syndrome-A systematic review.
Huisstede BM, van den Brink J, Randsdorp MS, Geelen SJ, Koes BW.
Arch Phys Med Rehabil. 2018 Aug;99(8):1660-1680.e21. doi: 10.1016/j.apmr.2017.04.024. Epub 2017 May 31.

Efficacy of low-level laser therapy in carpal tunnel syndrome management: a systematic review and meta-analysis.
Bekhet AH, Ragab B, Abushouk AI, Elgebaly A, Ali OI.
Lasers Med Sci. 2017 Aug;32(6):1439-1448. doi: 10.1007/s10103-017-2234-6. Epub 2017 Jun 5.

Do patients with carpal tunnel syndrome benefit from low-level laser therapy? A systematic review of randomized controlled trials.
Franke TPC, Koes BW, Geelen SJG, Huisstede BMA.
Arch Phys Med Rehabil. 2018 Aug;99(8):1650-1659.e15. doi: 10.1016/j.apmr.2017.06.002. Epub 2017 Jun 16.

The effectiveness of low-level laser therapy on pain, self-reported hand function, and grip strength compared to placebo or "sham" treatment for adults with carpal tunnel syndrome: A systematic review.
Burger M, Kriel R, Damon A, Abel A, Bansda A, Wakens M, Ernstzen D.
Physiother Theory Pract. 2017 Mar;33(3):184-197. doi: 10.1080/09593985.2017.1282999. Epub 2017 Mar 8.

Acupuncture for the treatment of peripheral neuropathy: a systematic review and meta-analysis.
Dimitrova A, Murchison C, Oken B.
J Altern Complement Med. 2017 Mar;23(3):164-179. doi: 10.1089/acm.2016.0155. Epub 2017 Jan 23.

Clinical effectiveness of low-level laser treatment on peripheral somatosensory neuropathy.
Fallah A, Mirzaei A, Gutknecht N, Demneh AS.
Lasers Med Sci. 2017 Apr;32(3):721-728. doi: 10.1007/s10103-016-2137-y. Epub 2017 Jan 10.

Effectiveness of occupational therapy interventions for adults with musculoskeletal conditions of the forearm, wrist, and hand: A systematic review.
Roll SC, Hardison ME.
Am J Occup Ther. 2017 Jan/Feb;71(1):7101180010p1-7101180010p12. doi: 10.5014/ajot.2017.023234.

Effectiveness of nerve gliding exercises on carpal tunnel syndrome: a systematic review.
Ballestero-Pérez R, Plaza-Manzano G, Urraca-Gesto A, Romo-Romo F, Atín-Arratibel ML, Pecos-Martín D, Gallego-Izquierdo T, Romero-Franco N.
J Manipulative Physiol Ther. 2017 Jan;40(1):50-59. doi: 10.1016/j.jmpt.2016.10.004. Epub 2016 Nov 11.

Effectiveness of low-level laser on carpal tunnel syndrome: A meta-analysis of previously reported randomized trials.
Li ZJ, Wang Y, Zhang HF, Ma XL, Tian P, Huang Y.
Medicine (Baltimore). 2016 Aug;95(31):e4424. doi: 10.1097/MD.0000000000004424.

Conservative treatment in patients with mild to moderate carpal tunnel syndrome: A systematic review.
Jiménez Del Barrio S, Bueno Gracia E, Hidalgo García C, Estébanez de Miguel E, Tricás Moreno JM, Rodríguez Marco S, Ceballos Laita L.
Neurologia. 2016 Jul 22. pii: S0213-4853(16)30094-9. doi: 10.1016/j.nrl.2016.05.018. [Epub ahead of print] English, Spanish.

Effectiveness of acupuncture therapies to manage musculoskeletal disorders of the extremities: A systematic review.
Cox J, Varatharajan S, Côté P, Optima Collaboration.
J Orthop Sports Phys Ther. 2016 Jun;46(6):409-29. doi: 10.2519/jospt.2016.6270. Epub 2016 Apr 26.

A Bayesian network meta-analysis: Comparing the clinical effectiveness of local corticosteroid injections using different treatment strategies for carpal tunnel syndrome.
Chen PC, Chuang CH, Tu YK, Bai CH, Chen CF, Liaw M.
BMC Musculoskelet Disord. 2015 Nov 19;16(1):363. doi: 10.1186/s12891-015-0815-8.

Clinical course and prognostic factors in conservatively managed carpal tunnel syndrome: A systematic review.
Burton CL, Chesterton LS, Chen Y, van der Windt DA.
Arch Phys Med Rehabil. 2016 May;97(5):836-852.e1. doi: 10.1016/j.apmr.2015.09.013. Epub 2015 Oct 9.

Efficacy of tendon and nerve gliding exercises for carpal tunnel syndrome: a systematic review of randomized controlled trials.
Kim SD.J Phys Ther Sci. 2015 Aug;27(8):2645-8. doi: 10.1589/jpts.27.2645. Epub 2015 Aug 21.

Acupuncture for carpal tunnel syndrome: a systematic review of randomized controlled trials.
Sim H, Shin BC, Lee MS, Jung A, Lee H, Ernst E.
J Pain. 2011 Mar;12(3):307-14. doi: 10.1016/j.jpain.2010.08.006. Epub 2010 Nov 19.

 
Treatments - surgical vs non-surgical treatments

Surgical versus non-surgical treatment for carpal tunnel syndrome.
Verdugo RJ, Salinas RA, Castillo JL, Cea JG.
Cochrane Database Syst Rev. 2008 Oct 8;(4):CD001552. doi: 10.1002/14651858.CD001552.pub2.

Effectiveness of surgical versus conservative treatment for carpal tunnel syndrome: A systematic review, meta-analysis and qualitative analysis.
Klokkari D, Mamais I.
Hong Kong Physiother J. 2018 Dec;38(2):91-114. doi: 10.1142/S1013702518500087. Epub 2018 Jul 2.

Comparison of the short-term and long-term effects of surgery and nonsurgical intervention in treating carpal tunnel syndrome: A systematic review and meta-analysis.
Shi Q, Bobos P, Lalone EA, Warren L, MacDermid JC.
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Effectiveness of surgical and post-surgical interventions for carpal tunnel syndrome-A systematic review.
Huisstede BM, van den Brink J, Randsdorp MS, Geelen SJ, Koes BW.
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Is surgical intervention more effective than non-surgical treatment for carpal tunnel syndrome? A systematic review.
Shi Q, MacDermid JC.
J Orthop Surg Res. 2011 Apr 11;6:17. doi: 10.1186/1749-799X-6-17.

RETRACTED ARTICLE (DUE TO ERROR IN ANAYSIS):
Efficacy, safety, and cost of surgical versus nonsurgical treatment for carpal tunnel syndrome: A systematic review and meta-analysis.
Ren YM, Wang XS, Wei ZJ, Fan BY, Lin W, Zhou XH, Feng SQ.
Medicine (Baltimore). 2016 Oct;95(40):e4857.

Retraction: Medicine (Baltimore). 2017 Apr;96(16):e6778.

 
Treatments - surgical: endoscopic vs. open release

Endoscopic release for carpal tunnel syndrome.
Vasiliadis HS, Georgoulas P, Shrier I, Salanti G, Scholten RJ.
Cochrane Database Syst Rev. 2014 Jan 31;1:CD008265. doi: 10.1002/14651858.CD008265.pub2.

Open versus endoscopic carpal tunnel release: a systematic review and meta-analysis of randomized controlled trials.
Li Y, Luo W, Wu G, Cui S, Zhang Z, Gu X.
BMC Musculoskelet Disord. 2020 Apr 27;21(1):272. doi: 10.1186/s12891-020-03306-1.

The effectiveness of surgical and post-surgical interventions for carpal tunnel syndrome-A systematic review.
Huisstede BM, van den Brink J, Randsdorp MS, Geelen SJ, Koes BW.
Arch Phys Med Rehabil. 2018 Aug;99(8):1660-1680.e21. doi: 10.1016/j.apmr.2017.04.024. Epub 2017 May 31.

Complications of surgical release\break of carpal tunnel syndrome: A systematic review.
Faucher GK, Daruwalla JH, Seiler JG 3rd.
J Surg Orthop Adv. 2017 Spring;26(1):18-24.

Intraindividual comparison between open and endoscopic release in bilateral carpal tunnel syndrome: a meta-analysis of randomized controlled trials.
Hu K, Zhang T, Xu W.
Brain Behav. 2016 Feb 16;6(3):e00439. doi: 10.1002/brb3.439. eCollection 2016 Mar.

Endoscopic and open release similarly safe for the treatment of carpal tunnel syndrome. a systematic review and meta-analysis.
Vasiliadis HS, Nikolakopoulou A, Shrier I, Lunn MP, Brassington R, Scholten RJ, Salanti G.
PLoS One. 2015 Dec 16;10(12):e0143683. doi: 10.1371/journal.pone.0143683. eCollection 2015.

Endoscopic versus open carpal tunnel release for idiopathic carpal tunnel syndrome: a meta-analysis of randomized controlled trials.
Zuo D, Zhou Z, Wang H, Liao Y, Zheng L, Hua Y, Cai Z.
J Orthop Surg Res. 2015 Jan 28;10:12. doi: 10.1186/s13018-014-0148-6.

Open versus endoscopic carpal tunnel release: a meta-analysis of randomized controlled trials.
Sayegh ET, Strauch RJ.
Clin Orthop Relat Res. 2015 Mar;473(3):1120-32. doi: 10.1007/s11999-014-3835-z. Epub 2014 Aug 19.

Effectiveness and safety of endoscopic versus open carpal tunnel decompression.
Chen L, Duan X, Huang X, Lv J, Peng K, Xiang Z.
Arch Orthop Trauma Surg. 2014 Apr;134(4):585-93. doi: 10.1007/s00402-013-1898-z. Epub 2014 Jan 12.

Outcomes of open and endoscopic carpal tunnel release: a meta-analysis.
Kohanzadeh S, Herrera FA, Dobke M.
Hand (N Y). 2012 Sep;7(3):247-51. doi: 10.1007/s11552-012-9413-5.

 
Treatments - surgical: other

Absorbable versus non-absorbable sutures for skin closure after carpal tunnel decompression surgery.
Wade RG, Wormald JC, Figus A.
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Surgical treatment options for carpal tunnel syndrome.
Scholten RJ, Mink van der Molen A, Uitdehaag BM, Bouter LM, de Vet HC.
Cochrane Database Syst Rev. 2007 Oct 17;(4):CD003905.

Carpal tunnel release without a tourniquet: A systematic review and meta-analysis.
Olaiya OR, Alagabi AM, Mbuagbaw L, McRae MH.
Plast Reconstr Surg. 2020 Mar;145(3):737-744. doi: 10.1097/PRS.0000000000006549.

The comparison of limited-incision versus standard-incision in treatment of carpal tunnel syndrome: A meta-analysis of randomized controlled trials.
Li G, Kong L, Kou N, Wang Y, Yu K, Bai J, Tian D.
Medicine (Baltimore). 2019 May;98(18):e15372. doi: 10.1097/MD.0000000000015372.

Upper-extremity nerve decompression under local anesthesia: A systematic review of methods for reduction of postoperative pain and opioid consumption.
Chocron Y, Aljerian A, Thibaudeau S.
Hand (N Y). 2019 Apr 15:1558944719843635. doi: 10.1177/1558944719843635. [Epub ahead of print]

Quality of randomized controlled trials for surgical treatment of carpal tunnel syndrome: A systematic review.
Long C, Azad AD, desJardins-Park HE, Fox PM.
Plast Reconstr Surg. 2019 Mar;143(3):791-799. doi: 10.1097/PRS.0000000000005366.

Carpal tunnel release with versus without flexor retinaculum reconstruction for carpal tunnel syndrome at short- and long-term follow up - A meta-analysis of randomized controlled trials.
Lai S, Zhang K, Li J, Fu W.
PLoS One. 2019 Jan 28;14(1):e0211369. doi: 10.1371/journal.pone.0211369. eCollection 2019.

A meta-analysis of surgical decompression in the treatment of diabetic peripheral neuropathy.
Zhu CL, Zhao WY, Qiu XD, Zhao SW, Zhong LZ, He N.
Medicine (Baltimore). 2018 Sep;97(37):e12399. doi: 10.1097/MD.0000000000012399.

The incidence of complex regional pain syndrome in simultaneous surgical treatment of carpal tunnel syndrome and Dupuytren contracture.
Buller M, Schulz S, Kasdan M, Wilhelmi BJ.
Hand (N Y). 2018 Jul;13(4):391-394. doi: 10.1177/1558944717718345. Epub 2017 Jul 8.

The effectiveness of surgical and post-surgical interventions for carpal tunnel syndrome-A systematic review.
Huisstede BM, van den Brink J, Randsdorp MS, Geelen SJ, Koes BW.
Arch Phys Med Rehabil. 2018 Aug;99(8):1660-1680.e21. doi: 10.1016/j.apmr.2017.04.024. Epub 2017 May 31.

Surgical site infection after hand surgery outside the operating theatre: a systematic review.
Jagodzinski NA, Ibish S, Furniss D.
J Hand Surg Eur Vol. 2017 Mar;42(3):289-294. doi: 10.1177/1753193416676408.

Surgical decompression in the treatment of diabetic peripheral neuropathy: A systematic review and meta-analysis.
Tu Y, Lineaweaver WC, Chen Z, Hu J, Mullins F, Zhang F.
J Reconstr Microsurg. 2017 Mar;33(3):151-157. doi: 10.1055/s-0036-1594300. Epub 2016 Nov 28.

The Camitz transfer and its modifications: a review.
Rymer B, Thomas PB.
J Hand Surg Eur Vol. 2016 Jul;41(6):632-7. doi: 10.1177/1753193415625605. Epub 2016 Jan 14.

Revision decompression and collagen nerve wrap for recurrent and persistent compression neuropathies of the upper extremity.
Soltani AM, Allan BJ, Best MJ, Mir HS, Panthaki ZJ.
Ann Plast Surg. 2014 May;72(5):572-8. doi: 10.1097/SAP.0b013e3182956475.

Surgical techniques and return to work following carpal tunnel release: a systematic review and meta-analysis.
Sanati KA, Mansouri M, Macdonald D, Ghafghazi S, Macdonald E, Yadegarfar G.
J Occup Rehabil. 2011 Dec;21(4):474-81. doi: 10.1007/s10926-011-9310-8.

 

 

 

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Centre for Evidence Based Hand Surgery

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