World-class Research at the University of Nottingham
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Inspiring peopleRita Tewari

New ways of fighting the malaria parasite
Researcher in Antimicrobials and Antimicrobial Resistance
Rita Tewari
How would you explain your research?

By learning how to disrupt the life cycle of the malaria parasite we can help develop new drugs and vaccines to block transmission of the disease. In parasites, particular proteins direct them. Some of these, like kinases, are very important – if you block them the cell cannot grow. Can we target them? At Imperial College I started this ambitious project to knock out [replace one gene with another] each of the 72 kinase genes in the genome one by one and understand the function. That was a big gamble, a very, very ambitious project. I was quite close to finishing when this job at Nottingham came up. I finished that work [the world’s first comprehensive study of the molecular switches in the malaria parasite’s life cycle] and that made me.

Now we are doing the other side of the coin, the phosphatase, which returns the protein to its silent state. That again is a big thing because nobody has studied these phosphatases at this scale.

That’s the beauty of biology: there are no boundaries if you want to ask simple questions
What drew you to this area of research?

I was always fascinated by biology. After school I wanted to do medicine but my father – who was a professor in social sciences – moved to northeastern India, a backwater, to establish a university. There were no medical colleges so I went for zoology. I started my PhD at the University of Delhi, studying genetics and sex chromosomes. I became hungry for research, wanted to see more and the only way to do that was to go abroad in good labs.

I started to study the malaria parasite at Imperial College, London, working on a group of transgenic mice.  The basic processes, whether it’s a human cell or a mouse cell or a parasite cell, are more or less the same. For me, that’s the beauty of biology: there are no boundaries if you want to ask simple questions – how does the cell divide? How can I make the cell stop? I can sit at the microscope for hours and people think – “what is there?” – but I still get excited by the same single cell because every time you see a cell it looks different, it has something else to show you.

What’s been the greatest moment of your career so far?

Getting a PhD was a big thing for my family and for myself. A big high was working for Frank Grosveld [Head of the Department of Cell Biology at the Erasmus University Medical Centre, Rotterdam] in Holland. I think Imperial exposed me to lots of challenges, and here [at The University of Nottingham] when I got this work published. I think every paper is a high and now it’s not just for me, it’s a group effort. And, of course, my recent inaugural lecture as Professor of Parasite Cell Biology, with all friends, family and mentors, was special for me.

For me the biggest part of a scientific career is learning about people, their culture, the language, and that I would have never learned if I had not taken this journey

How will your research affect the average person?

Better understanding of the malaria parasite will lead in turn to better drugs and a better quality of life for people who suffer from malaria, at least in Africa. The Indian subcontinent has improved a lot but the parasite is also mutating so you have drug resistance. Malaria will not be eradicated: I think it can be controlled. 

What advice would you give to someone starting out?

Have a passion for your work, or like what you do. For me to come on a Saturday or at four in the morning because I want to see a result is not a hardship. What drives me is that I want to know the unknown. For me, it’s not work: I love every bit of it.

What drives me is that I want to know the unknown. For me, it’s not work: I love every bit of it
What living person do you most admire?

I really admire my old boss in Holland, Professor Frank Grosveld, and Dr Tony Holder, who’s in London [at the National Institute for Medical Research]. They are both very famous scientists but the thing I admire in them is that they are both very good human beings, and they understand people. For me, that’s more important than big papers. Tony is my mentor now.

If you weren’t doing this what would you be doing?

I don’t know! Maybe I should open a restaurant – I love cooking. A world restaurant, where there would be food from every part of the world that I’ve lived in. My cooking is not

“Indian” anymore, it’s a mixture of everything. I’m a vegetarian, I mix things – it’s the same as I do in research. If you’re exposed to so many different things you can think, create.

Where would you go back in time?

I’m a person of the here and now. Go back in time? I don’t know. I would like to go to Peru. Maybe Europe, because my father was there. Back in time in India my dream was to go to Europe – it was a mystery to me. 

 

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Athena Swan Silver Award