Stroke research

• Phase I trials in volunteers
• Phase II and phase III trials in acute stroke, stroke recovery and stroke prevention
• Meta-analysis using both summary and individual patient data
• Data (safety) monitoring committees

• Remote Ischemic Conditioning After Stroke Trial (RECAST-3)
• Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage (DASH)
• LACunar Intervention-2 Trial (LACI-2)
• Rate risks and Routes to Reduction of Vacular Dementia (R4VaD)
• Nottingham Stroke

• Acute interventions
• Secondary prevention
• Recovery and rehabilitation

• Role of stem cells in post-stroke neurovascular regeneration.
• Protein Kinase C signalling pathways in hyperglycaemia - and ischaemia-induced cerebral and vascular damage.
• NADPH oxidase system and ischaemic cerebral vascular damage.
• Endothelial senescence and dysfunction - chronological ageing.
• Endothelial Progenitor Cells - inflammation, angiongenesis and neurovascular recover.
• Therapeutic hypothermia - neurovascular unit recovery.
• Diagnostic and Prognostic clinical biomarkers for stroke subtypes.

• Sprigg N, Selim, M., Hanley, DF., Steiner, T., Christensen, HK., Lafuente, J., Rodriguez, D., Keep, RF., Anderson, C., Parry-Jones, AR., Nilsson, M., Stibrant Sunnerhagen, K., Novick, E.,  Aronowski, J., Lawson, B., Chaudhary, N., Zhou-Ping, T., Zuccarello, M., Wood, D., Shoamanesh, A., Qureshi, A., Cordonnier, C., Klijn, CJM., Al-Shahi Salman, R., Gregson, B., Mendelow, AD., Gaudin, C., Pandey, AS., Ziai, W., Alcazar-Romero, PP., Montaner, J., Marti-Fabregas, J., Nilsson, S., Schenk, B., Riess, H., You, C., Gaist, D., Broderick, J., Recommendations for Clinical Trials in ICH.  The Second Hemorrhagic Stroke Academia Industry Roundtable.  Stroke, 2020
• Sprigg N, Law, ZK., Ali, A., Krishnan, K., Bischoff, A., Appleton, JP., Scutt, P., Woodhouse, L., Pszczolkowski, S., Cala, LA., Dineen, RA., England, TJ., Ozturk, S., Roffe, C., Bereczki, D., Ciccone, A., Christensen, H., Ovesen, C., Bath, PM. Noncontrast Computed Tomography Signs as Predictors of Hematoma Expansion, Clinical Outcome, and Response to Tranexamic Acid in Acute Intracerebral Hemorrhage. Stroke 2020
• Bath PM, Anderson, CS., Huang, Y., Lindley, R., Chen, X., Arima, H., Chen, G., Mbiostat, QL., Billot, L., Delcourt, C., Broderick, JP., Demchuk, AM., Donnan, GA., Durham, AC., Lavados, PM., Lee, TH., Levi, C., Martins, SO., Olavarria, VV., Pandian, JD., Parsons, MW., Pontes-Neto, OM., Ricci, S., Sato, S., Sharma, VK., Silva, F., Song, L., Thang, NH., Wardlaw, JM., Wang, JG., Wang, X., Woodward, M., Chalmers, J., Robinson, TG., Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial. The Lancet, 2019.

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  Bath PM, Woodhouse LJ, Krishnan K, Appleton JP, Anderson CS, Berge E, Cala L, Dixon M, England TJ, Godolphin PJ, Hepburn T, Mair G, Montgomery AA, Philips SJ, Potter J, Price CI, Randall M, Robinson TG, Roffe C, Rothwell PM, Sandset EC, Sanossian N, Saver JL, Siriwardena AN, Venebles G, Wardlaw JM, Sprigg N.  Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage: Data from the (RIGHT-2) Trial. Stroke, 2019
• Bath PM, Appleton, JP., Woodhouse, LJ., Bereczki, D., Berge, E., Christensen, HK., Collins, R., Gommans, J., Ntaios, G., Ozturk, S., Szatmari, S., Wardlaw, JM., Sprigg, N., Rothwell, PM. Effect of Glyceryl Trinitrate on Heodynamics in Acute Stroke. Stroke 2019

See details of more publications under individual researchers' profiles.

Safety and Efficacy of Triple Antiplatelets for reducing dependency after Ischaemic Stroke; The TARDIS randomised controlled trial.

Tranexamic acid for hyperacute primary Intracerebral Haemorrhage (TICH-2).

Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2): Assessment of safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor, and of the feasibility of a multicentre ambulance-based stroke trial.

DMT-EPC Endothelial progenitor cells: potential biomarkers for diagnosis and prognosis of ischaemic stroke.

See our other major awards from funders including the NIHR HTA and the Stroke Association.

Professor Philip Bath, head of the Stroke Research group, has been named an Emeritus Senior Investigator after the closure in March 2020 of his previous award of NIHR Senior Investigator. Senior Investigators are the NIHR’s pre-eminent researchers and include some of the nation’s most outstanding leaders of clinical   and applied health and social care research.