James Dowden

Contact

• workRoom C24 School of Chemistry
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 9513566
• fax0115 9513564
• james.dowden@nottingham.ac.uk

Biography

Dr. Dowden gained a B.Sc in Chemistry from the University of Sheffield in 1993, then moved to the University of Southampton and completed a PhD under the supervision of Prof. J. D. Kilburn in 1996. He then worked as a postdoc with Professors N. J. Turner and S. L. Flitsch at the Edinburgh Centre for Protein Technology within the Chemistry Department, University of Edinburgh for two and a half years. In 1999 he was appointed as Lecturer in Medicinal Chemistry at the University of Bath. In 2005 he moved to his present position of Lecturer in Chemical Biology at the University of Nottingham.

Research Summary

Development of expedient synthesis of natural products. Developments of new synthetic methods, especially utilising pyridinium salts or beta-lactams.

Design and synthesis of new enyzyme inhibitors. Especially development of novel inhibitors for protein methyltransferases.

Design and synthesis of chemical probes for biological systems; Divergent synthesis; Synthesis and evaluation of signalling nucleotides and analogues; Characterisation and modulation of Protein-Protein Interactions; Protein Tyrosine Phosphatases; Developmental Biology.

Selected Publications

• DAY, JONATHAN, MCKEEVER-ABBAS, BEN and DOWDEN, JAMES, 2016. Stereoselective Synthesis of Tetrahydroindolizines through the Catalytic Formation of Pyridinium Ylides from Diazo Compounds ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 55(19), 5809-5813

• View all publications

• DAY, JONATHAN, MCKEEVER-ABBAS, BEN and DOWDEN, JAMES, 2016. Stereoselective Synthesis of Tetrahydroindolizines through the Catalytic Formation of Pyridinium Ylides from Diazo Compounds ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 55(19), 5809-5813
• HANSON-HEINE, MAGNUS W. D., WRIGLESWORTH, ALISDAIR, UROOS, MALIHA, CALLADINE, JAMES A., MURPHY, THOMAS S., HAMILTON, MICHELLE, CLARK, IAN P., TOWRIE, MICHAEL, DOWDEN, JAMES, BESLEY, NICHOLAS A. and GEORGE, MICHAEL W., 2015. Calculating singlet excited states: Comparison with fast time-resolved infrared spectroscopy of coumarins JOURNAL OF CHEMICAL PHYSICS. 142(15),
• YOU, B., HAMER, K., LEWIS, W. and DOWDEN, J., 2013. An unusual silicon mediated transannular cyclopropanation Chemical Communications. 49(8), 795-797
• DAY, JONATHAN, UROOS, MALIHA, CASTLEDINE, RICHARD A, LEWIS, WILLIAM, MCKEEVER-ABBAS, BEN and DOWDEN, JAMES, 2013. Alkaloid inspired spirocyclic oxindoles from 1,3-dipolar cycloaddition of pyridinium ylides. Organic & biomolecular chemistry. 11(38), 6502-9
• DOWDEN, J., PIKE, R.A., PARRY, R.V., HONG, W., MUHSEN, U.A. and WARD, S.G., 2011. Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1 Organic and Biomolecular Chemistry. 9(22), 7814-7821
• STEVENSON, B., LEWIS, W. and DOWDEN, J., 2010. Expedient Route to an Amine Precursor of Halichlorine and Pinnaic Acid from Nitrocyclopent-1-ene Synlett. NUMB 4, 672-674
• DOWDEN, J., HONG, W., PARRY, R.V., PIKE, R.A. and WARD, S.G., 2010. Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases Bioorganic and Medicinal Chemistry Letters. 20(7), 2103–2105
• DAMMERMANN, W., ZHANG, B., NEBEL, M., CORDIGLIERI, C., ODOARDI, F., KIRCHBERGER, T., KAWAKAMI, N., DOWDEN, J., SCHMID, F., DORNMAIR, K., HOHENEGGER, M., FLÜGEL, A., GUSE, A.H. and POTTER, B.V.L., 2009. NAADP-mediated Ca²⁺ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist Proceedings of the National Academy of Sciences of the United States of America. 106(26), 10678-10683
• PARKESH, R., LEWIS, A.M., ALEY, P.K., ARREDOUANI, A., ROSSI, S., TAVARES, R., VASUDEVAN, S.R., ROSEN, D., GALIONE, A., DOWDEN, J. and CHURCHILL, G.C., 2008. Cell-permeant NAADP: a novel chemical tool enabling the study of Ca²⁺ signalling in intact cells Cell Calcium. 43(6), 531–538
• FOSTER, S.R., PEARCE, A., BLAKE, A.J., WELHAM, M.J. and DOWDEN, J., 2007. Novel octavalent cross-linker displays efficient trapping of protein–protein interactions Chemical Communications. 24, 2512-2514
• ANDERSON, C., BARTLETT, S.J., GANSNER, J.M., WILSON, D., HE, L., GITLIN, J.D., KELSH, R.N. and DOWDEN, J., 2007. Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis Molecular BioSystems. 3(1), 51-59
• PARKESH, RAMAN, VASUDEVAN, SRIDHAR R, BERRY, ALEXANDRA, GALIONE, ANTONY, DOWDEN, JAMES and CHURCHILL, GRANT C, 2007. Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP(+)). Organic and Biomolecular Chemistry. 5(3), 441-3
• DOWDEN, J., BERRIDGE, G., MOREAU, C., YAMASAKI, M., CHURCHILL, G.C., POTTER, B.V.L. and GALIONE, A., 2006. Cell-permeant small-molecule modulators of NAADP-mediated Ca²⁺ release Chemistry & Biology. 13(6), 659-665
• YIAKOUVAKI, A., SAVOVIĆ, J., AL-QENAEI, A., DOWDEN, J. and POURZAND, C., 2006. Caged-iron chelators a novel approach towards protecting skin cells against UVA-induced necrotic cell death Journal of Investigative Dermatology. 126(10), 2287-2295
• POTTER,B.V.L., DOWDEN,J. and GALIONE,A., 2005. Therapeutics WO2005054198-A2 06/01/2005 00:00:00
• DOWDEN,J., BROWN,R.S., MOREAU,C., GALIONE,A. and POTTER,B.V., 2005. Chemical synthesis of the novel Ca²⁺ messenger NAADP. Nucleosides, Nucleotides and Nucleic Acids. 24(5-7), 513-518
• DOWDEN, J., MOREAU, C., BROWN, R.S., BERRIDGE, G., GALIONE, A. and POTTER, B.V.L., 2004. Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate Angewandte Chemie International Edition. 43(35), 4637-4640
• GALIONE, A., PARRINGTON, J. and DOWDEN, J., 2004. The NAADP receptor: commentary on Billington et al British Journal of Pharmacology. VOL 142(PART 8), 1203-1208
• WARD,S., SOTSIOS,Y., DOWDEN,J., BRUCE,I. and FINAN,P., 2003. Therapeutic potential of phosphoinositide 3-kinase inhibitors Chemistry & Biology. 10(3), 207-213
• BROWN, R. S., DOWDEN, J., MOREAU, C. and POTTER, B. V., 2002. A concise route to tiazofurin Tetrahedron Letters. VOL 43(NUMBER 37), 6561 - 6562
• YANG, J., DOWDEN, J., TATIBOUET, A., HATANAKA, Y. and HOLMAN, G. D., 2002. Development of high-affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5 Biochemical Journal. VOL 367(PART 2), 533-539
• DOWDEN, J. and SAVOVIĆ, J., 2001. Olefin metathesis in non-degassed solvent using a recyclable, polymer supported alkylideneruthenium Chemical Communications. 1, 37-38
• DOWDEN,J. and WARD,S.G., 2001. Inhibitors of p56(lck): assessing their potential as tools for manipulating T-lymphocyte activation Expert Opinion on Therapeutic Patents. 11(2), 295-306