Alvaro Mata

Contact

• workRoom C214e BDI
  University Park
  Nottingham
  NG7 2RD
  UK
• A.Mata@nottingham.ac.uk
• www.mataresearch.com

Biography

Alvaro Mata is Professor in Biomedical Engineering and Biomaterials in the School of Pharmacy and the Department of Chemical and Environmental Engineering at the University of Nottingham. He holds a Bachelor's Degree from the University of Kansas, a Master's Degree from the University of Strathclyde, and a Doctor of Engineering Degree from Cleveland State University working with Prof. Shuvo Roy at the Cleveland Clinic. He conducted his postdoctoral training with Prof. Samuel Stupp at Northwestern University.

His group works at the interface of supramolecular chemistry, structural biology, biofabrication, and engineering to develop bioinspired approaches to design and fabricate innovative materials and devices for tissue engineering and regenerative medicine. For example, by utilizing biological processes such as protein disorder-to-order transitions, compartmentalization, or diffusion-reaction processes as predictive steps of biofabrication methods, it is possible to grow functional structures that exhibit structural and functional properties of biological systems.

His work has led to seven patents or patent applications; publications in journals including Nature Chemistry, Nature Communications, Science Advances, and Advanced Functional Materials; and awards such as a Ramon y Cajal Fellowship and an ERC Staring Grant. More information can be found at: www.mataresearch.com/, https://twitter.com/mata_lab.

Alvaro Mata is part of the Advanced Materials Research group.

Expertise Summary

Our Lab's research and expertise: https://www.mataresearch.com/research

Our Lab's publications: https://www.mataresearch.com/publications

Research Summary

Our group integrates supramolecular chemistry, structural biology, biofabrication, and engineering to develop new ways to build with biomolecules. Our aim is to create functional materials, devices,… read more

Recent Publications

• MARTÍNEZ-ESPUGA, M., MATA, A. and ORDÓÑEZ-MORÁN, P., 2023. Intestinal Cell Differentiation and Phenotype in 2D and 3D Cell Culture Models. In: Methods in Molecular Biology 2650. 235-243
• HILL, J., WILDMAN, R. and MATA, A., 2022. Exploiting the fundamentals of biological organization for the advancement of biofabrication: Current Opinion in Biotechnology Current Opinion in Biotechnology. 74, 42-54
• BU, W. H., WU, Y. H., GHAEMMAGHAMI, A. M., SUN, H. C. and MATA, A., 2022. Rational design of hydrogels for immunomodulation: Regenerative Biomaterials Regenerative Biomaterials. 9,
• WU, Y., YANG, J., VAN TEIJLINGEN, A., BERARDO, A., CORRIDORI, I., FENG, J., XU, J., TITIRICI, M. M., RODRIGUEZ-CABELLO, J. C., PUGNO, N. M., SUN, J., WANG, W., TUTTLE, T. and MATA, A., 2022. Disinfector-Assisted Low Temperature Reduced Graphene Oxide-Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma: Advanced Functional Materials Advanced Functional Materials.

• View all publications

Current Research

Our group integrates supramolecular chemistry, structural biology, biofabrication, and engineering to develop new ways to build with biomolecules. Our aim is to create functional materials, devices, and fabrication processes that tackle and overcome major challenges in tissue engineering and regenerative medicine. We use biological phenomena such as protein order-disorder synergies, molecular self-assembly, compartmentalization, and diffusion-reaction processes in combination with techniques such as bioprinting and microfabrication. These methodologies are being used for the regeneration of a variety of soft and hard tissues as well as the engineering of more effective in vitro models. Our aim is to transform sophisticated molecular design into engineering functionality with societal impact and, in this effort, our work expands from answering fundamental questions to developing translatable technologies.

Learn more about our research: https://www.mataresearch.com/research

Learn more about our publications: https://www.mataresearch.com/publications

Future Research

His group works at the interface of supramolecular chemistry, structural biology, biofabrication, and engineering to develop bioinspired approaches to design and fabricate innovative materials and devices for tissue engineering and regenerative medicine. For example, by utilizing biological processes such as protein disorder-to-order transitions, compartmentalization, or diffusion-reaction processes as predictive steps of biofabrication methods, it is possible to grow functional structures that exhibit structural and functional properties of biological system

• MARTÍNEZ-ESPUGA, M., MATA, A. and ORDÓÑEZ-MORÁN, P., 2023. Intestinal Cell Differentiation and Phenotype in 2D and 3D Cell Culture Models. In: Methods in Molecular Biology 2650. 235-243
• HILL, J., WILDMAN, R. and MATA, A., 2022. Exploiting the fundamentals of biological organization for the advancement of biofabrication: Current Opinion in Biotechnology Current Opinion in Biotechnology. 74, 42-54
• BU, W. H., WU, Y. H., GHAEMMAGHAMI, A. M., SUN, H. C. and MATA, A., 2022. Rational design of hydrogels for immunomodulation: Regenerative Biomaterials Regenerative Biomaterials. 9,
• WU, Y., YANG, J., VAN TEIJLINGEN, A., BERARDO, A., CORRIDORI, I., FENG, J., XU, J., TITIRICI, M. M., RODRIGUEZ-CABELLO, J. C., PUGNO, N. M., SUN, J., WANG, W., TUTTLE, T. and MATA, A., 2022. Disinfector-Assisted Low Temperature Reduced Graphene Oxide-Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma: Advanced Functional Materials Advanced Functional Materials.
• WU, Y. H., OKESOLA, B. O., CONNELLY, J., OREFFO, R. O. C., RODRIGUEZ-CABELLO, J. C., VOZZI, G., AZEVEDO, H. S., PUGNO, N. M. and MATA, A., 2022. INTEGRATING MOLECULAR SELF-ASSEMBLY AND ADDITIVE MANUFACTURING FOR THE BIOFABRICATION OF MICROFLUIDIC DEVICES WITH BIOLOGICALLY RELEVANT PROPERTIES: Tissue Engineering Part A Tissue Engineering Part A. 28, S282-S282
• HASAN, A., MARSHALL, K., WOJCIECHOWSKI, J., ELSHARKAWY, S., EGLIN, D., OREFFO, R., STEVENS, M. and MATA, A., 2022. HIERARCHICALLY MINERALIZING 3D PRINTED SCAFFOLDS FOR HARD TISSUE REGENERATION: Tissue Engineering Part A Tissue Engineering Part A. 28, S350-S351
• MATA, A., 2022. SUPRAMOLECULAR BIOFABRICATION: FROM MOLECULAR CONTROL TO MACROSCOPIC FUNCTIONALITY: Tissue Engineering Part A Tissue Engineering Part A. 28, S4-S4
• HASAN, A., BAGNOL, R., OWEN, R., LATIF, A., ROSTAM, H. M., ELSHARKAWY, S., ROSE, FRAJ, RODRIGUEZ-CABELLO, J. C., GHAEMMAGHAMI, A. M., EGLIN, D. and MATA, A., 2022. Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration: Frontiers in Bioengineering and Biotechnology Frontiers in Bioengineering and Biotechnology. 10,
• MAJKOWSKA, A., INOSTROZA-BRITO, K. E., GONZALEZ, M., REDONDO-GÓMEZ, C., RICE, A., RODRIGUEZ-CABELLO, J. C., DEL RIO HERNANDEZ, A. E. and MATA, A., 2022. Peptide-Protein Coassemblies into Hierarchical and Bioactive Tubular Membranes: Biomacromolecules Biomacromolecules.
• SENNETT, M. L., FRIEDMAN, J. M., ASHLEY, B. S., STOECKL, B. D., PATEL, J. M., ALINI, M., CUCCHIARINI, M., EGLIN, D., MADRY, H., MATA, A., SEMINO, C., STODDART, M. J., JOHNSTONE, B., MOUTOS, F. T., ESTES, B. T., GUILAK, F., MAUCK, R. L. and DODGE, G. R., 2021. Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model: European cells & materials European cells & materials. 41, 40-51
• PRIMO, G. A. and MATA, A., 2021. 3D Patterning within Hydrogels for the Recreation of Functional Biological Environments: Advanced Functional Materials Advanced Functional Materials.
• WU, Y. H., FORTUNATO, G. M., OKESOLA, B. O., DI BROCCHETTI, F. L. P., SUNTORNNOND, R., CONNELLY, J., DE MARIA, C., RODRIGUEZ-CABELLO, J. C., VOZZI, G., WANG, W. and MATA, A., 2021. An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability: Biofabrication Biofabrication. 13(3), 14
• DENG, X., HASAN, A., ELSHARKAWY, S., TEJEDA-MONTES, E., TARAKINA, N. V., GRECO, G., NIKULINA, E., STORMONTH-DARLING, J. M., CONVERY, N., RODRIGUEZ-CABELLO, J. C., BOYDE, A., GADEGAARD, N., PUGNO, N. M., AL-JAWAD, M. and MATA, A., 2021. Topographically guided hierarchical mineralization: Materials Today Bio Materials Today Bio. 11,
• OKESOLA, B. O., MENDOZA-MARTINEZ, A. K., CIDONIO, G., DERKUS, B., BOCCORH, D. K., OSUNA DE LA PEÑA, D., ELSHARKAWY, S., WU, Y., DAWSON, J. I., WARK, A. W., KNANI, D., ADAMS, D. J., OREFFO, R. O. C. and MATA, A., 2021. De Novo Design of Functional Coassembling Organic-Inorganic Hydrogels for Hierarchical Mineralization and Neovascularization ACS Nano. 15(7), 11202–11217
• AJOVALASIT, A., REDONDO-GOMEZ, C., SABATINO, M. A., OKESOLA, B. O., BRAUN, K., MATA, A. and DISPENZA, C., 2021. Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing: Regenerative Biomaterials Regenerative Biomaterials. 8(5),
• SHI, Y., WAREHAM, D. W., YUAN, Y., DENG, X., MATA, A. and AZEVEDO, H. S., 2021. Polymyxin B-Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy: Advanced Healthcare Materials Advanced Healthcare Materials.
• OSUNA DE LA PEÑA, D., TRABULO, S. M. D., COLLIN, E., LIU, Y., SHARMA, S., TATARI, M., BEHRENS, D., ERKAN, M., LAWLOR, R. T., SCARPA, A., HEESCHEN, C., MATA, A. and LOESSNER, D., 2021. Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology: Nature Communications Nature Communications. 12(1),
• MENDOZA-MARTINEZ, A. K., LOESSNER, D., MATA, A. and AZEVEDO, H. S., 2021. Modeling the tumor microenvironment of ovarian cancer: The application of self-assembling biomaterials: Cancers Cancers. 13(22),
• WU, Y., OKESOLA, B. O., XU, J., KOROTKIN, I., BERARDO, A., CORRIDORI, I., DI BROCCHETTI, F. L. P., KANCZLER, J., FENG, J., LI, W., SHI, Y., FARAFONOV, V., WANG, Y., THOMPSON, R. F., TITIRICI, M. M., NERUKH, D., KARABASOV, S., OREFFO, R. O. C., CARLOS RODRIGUEZ-CABELLO, J., VOZZI, G., AZEVEDO, H. S., PUGNO, N. M., WANG, W. and MATA, A., 2020. Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices: Nature Communications Nature Communications. 11(1),
• DERKUS, B., OKESOLA, B. O., BARRETT, D. W., D'ESTE, M., CHOWDHURY, T. T., EGLIN, D. and MATA, A., 2020. Multicomponent hydrogels for the formation of vascularized bone-like constructs in vitro: Acta Biomaterialia Acta Biomaterialia.
• HEDEGAARD, C. L. and MATA, A., 2020. Integrating self-assembly and biofabrication for the development of structures with enhanced complexity and hierarchical control: Biofabrication Biofabrication. 12(3), 22
• MAJKOWSKA, A., REDONDO-GÓMEZ, C., RICE, A., GONZALEZ, M., INOSTROZA-BRITO, K. E., COLLIN, E. C., RODRIGUEZ-CABELLO, J. C., DEL RIO HERNANDEZ, A. E., SOLITO, E. and MATA, A., 2020. Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures: Frontiers in Materials Frontiers in Materials. 7,
• REDONDO-GOMEZ, C., PADILLA-LOPATEGUI, S., AZEVEDO, H. S. and MATA, A., 2020. Host-Guest-Mediated Epitope Presentation on Self-Assembled Peptide Amphiphile Hydrogels: Acs Biomaterials Science & Engineering Acs Biomaterials Science & Engineering. 6(9), 4870-4880
• BARRETT, D. W., OKESOLA, B. O., COSTA, E., THRASIVOULOU, C., BECKER, D. L., MATA, A., DEPREST, J. A., DAVID, A. L. and CHOWDHURY, T. T., 2020. Potential sealing and repair of human FM defects after trauma with peptide amphiphiles and Cx43 antisense: Prenatal Diagnosis Prenatal Diagnosis.
• HEDEGAARD, C. L., REDONDO-GÓMEZ, C., TAN, B. Y., NG, K. W., LOESSNER, D. and MATA, A., 2020. Peptide-protein coassembling matrices as a biomimetic 3d model of ovarian cancer: Science Advances Science Advances. 6(40),
• REDONDO-GOMEZ, C., PADILLA-LOPATEGUI, S., MATA, A. and AZEVEDO, H. S., Peptide Amphiphile Hydrogels Based on Homoternary Cucurbit 8 uril Host-Guest Complexes: Bioconjugate Chemistry Bioconjugate Chemistry.
• GHOSH, M., MAJKOWSKA, A., MIRSA, R., BERA, S., RODRIGUEZ-CABELLO, J. C., MATA, A. and ADLER-ABRAMOVICH, L., Disordered Protein Stabilization by Co-Assembly of Short Peptides Enables Formation of Robust Membranes: Acs Applied Materials & Interfaces ACS applied materials & interfaces.