Snow Stolnik

Contact

• workRoom D10 Boots Science Building
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 8466074
• fax0115 9515102
• Snow.Stolnik@nottingham.ac.uk

Biography

I received Dipl. Eng. degree in Pharmacy from the School of Pharmacy and Biochemistry, University of Zagreb, Croatia. I worked for my master degree in Pharmaceutical Technology at Pharmacology and Therapeutics Department, McGill University, Montreal, Canada. I obtained PhD (Doctorate Medicine-Pharmacy) from University of Zagreb, Croatia for work completed under supervision of Prof SS Davis and Prof L Illum at the School of Pharmacy, University of Nottingham, UK.

Following PhD, I took up postdoctoral position at the School of Pharmacy at Nottingham, and was subsequently appointed Lecturer, Associate Professor in Advanced Drug Delivery, and promoted to Professor in Pharmaceutics at School of Pharmacy, University of Nottingham.

I held the Royal Society Industry Fellowship in 2007-2009.

I was Director of EPSRC Centre for Doctoral Training in Advanced Therapeutics and Nanomedicines, PI and Director of 2018 funded Centre for Doctoral Training in Transformative Pharmaceutical Technologies at University of Nottingham, University College London, SSPC Centre for Pharmaceuticals in Ireland, and a consortium of pharmaceutical and healthcare industry partners. I am also CI and co-Director of 2024 funded EPSRC Centre for Doctoral Training in Accelerated Medicines Design and Development, at University of Nottingham and UCL, and a consortium of pharmaceutical industrial partners.

http://www.transpharmtech-dtc.ac.uk/

Expertise Summary

My research lies at the interface of physicochemical characterisation and biological performance of drug delivery systems. Representative recent examples include studies on transport of nanoparticles into/across cells, and events at epithelium and at cell membrane (Molecular Pharmaceutics 2014, 2019, Scientific Reports 2018, Biochimica et Biophysica Acta-Bioenergetics 2019, Journal of Controlled Release 2022), ligand mediated delivery of colloidal polymeric systems (J Controlled Release 2012, 2013, 2020, Small 2013, Science Advances 2015, Advanced Therapeutics 2021) and 'cells in matrices' (J Biotechnology 2009, Bioconjugate Chemistry 2019, J of Pathology 2021).

https://orcid.org/0000-0002-2345-5062

Snow Stolnik Google Scholar

My research funding also includes a portfolio of industry-sponsored projects with NittoDenko Japan, UCB Celltech, Biocompatibles, AstraZeneca, MedImmune, Baxter, Critical Pharmaceuticals, Archimedes, Honda, and GSK.

Teaching Summary

Pharmaceutics lead on Gastrointestinal and liver diseases, and Central nervous system modules of MPharm course, and Advanced drug delivery, and Science in industry modules of MSci course.

Research Summary

My research lies at the interface of physicochemical characterisation and biological performance of drug delivery systems. Representative recent examples include studies on transport of nanoparticles… read more

Recent Publications

• ALI ALAZZO, NURCAN GUMUS, PRATIK GURNANI, SNJEZANA STOLNIK, RUMAN RAHMAN, KEITH SPRIGGS and CAMERON ALEXANDER, 2022. Investigating histidinylated highly branched poly(lysine) for siRNA delivery J. Mater. Chem. B. 10(2), 236-246
• SULAIMAN, SARAH, GERSHKOVICH, PAVEL, HOAD, CAROLINE L., CALLADINE, MATTHEW, SPILLER, ROBIN C., STOLNIK, SNOW and MARCIANI, LUCA, 2022. Application of In Vivo MRI Imaging to Track a Coated Capsule and Its Disintegration in the Gastrointestinal Tract in Human Volunteers PHARMACEUTICS. 14(2),
• CONTE, C., MONTEIRO, P.F., GURNANI, P., STOLNIK, S., UNGARO, F., QUAGLIA, F., CLARKE, P., GRABOWSKA, A.M., KAVALLARIS, M. and ALEXANDER, C., 2021. Multi-component bioresponsive nanoparticles for synchronous delivery of Docetaxel and TUBB3 siRNA to lung cancer cells Nanoscale. 13, 11414-11426
• LINKE, FRANZISKA, ALDIGHIERI, MACHA, LOURDUSAMY, ANBARASU, GRABOWSKA, ANNA M., STOLNIK, SNOW, KERR, IAN D., MERRY, CATHERINE L. R. and COYLE, BETH, 2021. 3D hydrogels reveal medulloblastoma subgroup differences and identify extracellular matrix subtypes that predict patient outcome JOURNAL OF PATHOLOGY. 253(3), 326-338

• View all publications

Current Research

My research lies at the interface of physicochemical characterisation and biological performance of drug delivery systems. Representative recent examples include studies on transport of nanoparticles into/across cells, and events at epithelium and at cell membrane (Molecular Pharmaceutics 2014, 2019, Scientific Reports 2018, Biochimica et Biophysica Acta-Bioenergetics 2019, Journal of Controlled Release 2022), ligand mediated delivery of colloidal polymeric systems (J Controlled Release 2012, 2013, 2020, Small 2013, Science Advances 2015, Advanced Therapeutics 2021) and 'cells in matrices' (J Biotechnology 2009, Bioconjugate Chemistry 2019, J of Pathology 2021).

https://orcid.org/0000-0002-2345-5062

Snow Stolnik Google Scholar

My research funding also includes a portfolio of industry-sponsored projects with NittoDenko Japan, UCB Celltech, Biocompatibles, AstraZeneca, MedImmune, Baxter, Critical Pharmaceuticals, Archimedes, Honda, and GSK.

• ALI ALAZZO, NURCAN GUMUS, PRATIK GURNANI, SNJEZANA STOLNIK, RUMAN RAHMAN, KEITH SPRIGGS and CAMERON ALEXANDER, 2022. Investigating histidinylated highly branched poly(lysine) for siRNA delivery J. Mater. Chem. B. 10(2), 236-246
• SULAIMAN, SARAH, GERSHKOVICH, PAVEL, HOAD, CAROLINE L., CALLADINE, MATTHEW, SPILLER, ROBIN C., STOLNIK, SNOW and MARCIANI, LUCA, 2022. Application of In Vivo MRI Imaging to Track a Coated Capsule and Its Disintegration in the Gastrointestinal Tract in Human Volunteers PHARMACEUTICS. 14(2),
• CONTE, C., MONTEIRO, P.F., GURNANI, P., STOLNIK, S., UNGARO, F., QUAGLIA, F., CLARKE, P., GRABOWSKA, A.M., KAVALLARIS, M. and ALEXANDER, C., 2021. Multi-component bioresponsive nanoparticles for synchronous delivery of Docetaxel and TUBB3 siRNA to lung cancer cells Nanoscale. 13, 11414-11426
• LINKE, FRANZISKA, ALDIGHIERI, MACHA, LOURDUSAMY, ANBARASU, GRABOWSKA, ANNA M., STOLNIK, SNOW, KERR, IAN D., MERRY, CATHERINE L. R. and COYLE, BETH, 2021. 3D hydrogels reveal medulloblastoma subgroup differences and identify extracellular matrix subtypes that predict patient outcome JOURNAL OF PATHOLOGY. 253(3), 326-338
• CATANIA, ROSA, MASTROTTO, FRANCESCA, MOORE, CHRIS J., BOSQUILLON, CYNTHIA, FALCONE, FRANCO H., HUETT, ALAN, MANTOVANI, GIUSEPPE and STOLNIK, SNOW, 2021. Study on Significance of Receptor Targeting in Killing of Intracellular Bacteria with Membrane-Impermeable Antibiotics ADVANCED THERAPEUTICS.
• JEWELL, ADELAIDE, WILLIAMS, HANNAH, HOAD, CAROLINE L., GELLERT, PAUL R., ASHFORD, MARIANNE B., BUTLER, JAMES, STOLNIK, SNOW, SCURR, DAVID, STOCKS, MICHAEL J., MARCIANI, LUCA, GOWLAND, PENNY A. and GERSHKOVICH, PAVEL, 2021. Assessing Lymphatic Uptake of Lipids Using Magnetic Resonance Imaging: A Feasibility Study in Healthy Human Volunteers with Potential Application for Tracking Lymph Node Delivery of Drugs and Formulation Excipients PHARMACEUTICS. 13(9),
• CONTE, CLAUDIA, MONTEIRO, PATRICIA F., GURNANI, PRATIK, STOLNIK, SNOW, UNGARO, FRANCESCA, QUAGLIA, FABIANA, CLARKE, PHILIP, GRABOWSKA, ANNA, KAVALLARIS, MARIA and ALEXANDER, CAMERON, 2021. Multi-component bioresponsive nanoparticles for synchronous delivery of docetaxel and TUBB3 siRNA to lung cancer cells NANOSCALE. 13(26), 11414-11426
• PARASKEVOPOULOU, VASILIKI, SCHIMPL, MARIANNE, OVERMAN, ROSS C., STOLNIK, SNOW, CHEN, YAJIE, NGUYEN, LINH, WINKLER, G. SEBASTIAAN, GELLERT, PAUL, KLASSEN, JOHN S. and FALCONE, FRANCO H., 2021. Structural and binding characterization of the LacdiNAc-specific adhesin (LabA; HopD) exodomain from Helicobacter pylori CURRENT RESEARCH IN STRUCTURAL BIOLOGY. 3, 19-29
• ALQAHTANI, SAFAR, ROBERTS, CLIVE J, STOLNIK, SNJEZANA and BOSQUILLON, CYNTHIA, 2020. Development of an In Vitro System to Study the Interactions of Aerosolized Drugs with Pulmonary Mucus. Pharmaceutics. 12(2), 145
• ALQAHTANI, SAFAR, ROBERTS, CLIVE J., STOLNIK, SNJEZANA and BOSQUILLON, CYNTHIA, 2020. Development of an In Vitro System to Study the Interactions of Aerosolized Drugs with Pulmonary Mucus PHARMACEUTICS. 12(2),
• ALAZZO, ALI, AL-NATOUR, MOHAMMAD AHMAD, SPRIGGS, KEITH, STOLNIK, SNJEZANA, GHAEMMAGHAMI, AMIR, KIM, DONG-HYUN and ALEXANDER, CAMERON, 2019. Investigating the intracellular effects of hyperbranched polycation-DNA complexes on lung cancer cells using LC-MS-based metabolite profiling MOLECULAR OMICS. 15(1), 77-87
• VASILIKI PARASKEVOPOULOU, VERONICA GARCIA ARTIAGA, RACHEL ROWLINSON, G. SEBASTIAAN WINKLER, PAUL GELLERT, SNOW STOLNIK, ROSS OVERMAN and FRANCO H. FALCONE, 2019. Introduction of a C-terminal hexa-lysine tag increases thermal stability of the LacDiNac binding adhesin (LabA) exodomain from Helicobacter pylori Protein Expression and Purification. 163, 105446
• SHERMAN, HARRY G., HICKS, JACQUELINE M., JAIN, AKHIL, TITMAN, JEREMY J., ALEXANDER, CAMERON, STOLNIK, SNOW and RAWSON, FRANKIE J., 2019. Mammalian-Cell-Driven Polymerisation of Pyrrole CHEMBIOCHEM. 20(8), 1008-1013
• CAVANAGH RJ, SMITH PA and STOLNIK S, 2019. Exposure to a Nonionic Surfactant Induces a Response Akin to Heat-Shock Apoptosis in Intestinal Epithelial Cells: Implications for Excipients Safety. Molecular Pharmaceutics. 16(2), 618-631
• SHERMAN, HARRY G., JOVANOVIC, CAROLYN, ABUAWAD, ALAA, KIM, DONG-HYUN, COLLINS, HILARY, DIXON, JAMES E., CAVANAGH, ROBERT, MARKUS, ROBERT, STOLNIK, SNOW and RAWSON, FRANKIE J., 2019. Mechanistic insight into heterogeneity of trans-plasma membrane electron transport in cancer cell types BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 1860(8), 628-639
• PARASKEVOPOULOU, VASILIKI, ARTIAGA, VERONICA GARCIA, ROWLINSON, RACHEL, WINKLER, G. SEBASTIAAN, GELLERT, PAUL, STOLNIK, SNOW, OVERMAN, ROSS and FALCONE, FRANCO H., 2019. Introduction of a C-terminal hexa-lysine tag increases thermal stability of the LacDiNac binding adhesin (LabA) exodomain from Helicobacter pylori PROTEIN EXPRESSION AND PURIFICATION. 163,
• CINGOLANI, EMANUELA, ALQAHTANI, SAFAR, SADLER, ROBYN C., PRIME, DAVID, STOLNIK, SNJEZANA and BOSQUILLON, CYNTHIA, 2019. In vitro investigation on the impact of airway mucus on drug dissolution and absorption at the air-epithelium interface in the lungs EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 141, 210-220
• LI, HUITONG LUCY, NIETO-ORELLANA, ALEJANDRO, FALCONE, FRANCO H., BOSQUILLON, CYNTHIA, KEEGAN, GEMMA, CHILDERHOUSE, NICK, MANTOVANI, GIUSEPPE and STOLNIK, SNOW, 2019. TARGETED PEG-POLY(GLUTAMIC ACID) POLYMERS FOR THE DELIVERY OF PROTEINS INTO THE LUNG EPITHELIUM JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY. 32(2), A21-A21
• TCHORYK, ALEKSANDRA, TARESCO, VINCENZO, ARGENT, RICHARD H., ASHFORD, MARIANNE, GELLERT, PAUL R., STOLNIK, SNOW, GRABOWSKA, ANNA and GARNETT, MARTIN C., 2019. Penetration and Uptake of Nanoparticles in 3D Tumor Spheroids BIOCONJUGATE CHEMISTRY. 30(5), 1371-1384
• CAVANAGH, ROBERT J., SMITH, PAUL A. and STOLNIK, SNOW, 2019. Exposure to a Nonionic Surfactant Induces a Response Akin to Heat-Shock Apoptosis in Intestinal Epithelial Cells: Implications for Excipients Safety MOLECULAR PHARMACEUTICS. 16(2), 618-631
• VICTORIA CAPEL, DRITON VLLASALIU, PETER WATTS, PHILIP A CLARKE, DOMINIC LUXTON, ANNA M GRABOWSKA, GIUSEPPE MANTOVANI and SNJEZANA STOLNIK, 2018. Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of SiRNA Drug Delivery. 25(1), 644-653
• HARRY SHERMAN, CAROLYN JOVANOVIC, SNOW STOLNIK and FRANKIE RAWSON, 2018. Electrochemical System for the Study of Trans-Plasma Membrane Electron Transport in Whole Eukaryotic Cells Analytical Chemistry: Anal Chem. 90(4), 2780–2786
• NIETO-ORELLANA, ALEJANDRO, COGHLAN, DAVID, ROTHERY, MALCOLM, FALCONE, FRANCO H., BOSQUILLON, CYNTHIA, CHILDERHOUSE, NICK, MANTOVANI, GIUSEPPE and STOLNIK, SNOW, 2018. Dry-powder formulations of non-covalent protein complexes with linear or miktoarm copolymers for pulmonary delivery INTERNATIONAL JOURNAL OF PHARMACEUTICS. 540(1-2), 78-88
• CONTE, CLAUDIA, MASTROTTO, FRANCESCA, TARESCO, VINCENZO, TCHORYK, ALEKSANDRA, QUAGLIA, FABIANA, STOLNIK, SNJEZANA and ALEXANDER, CAMERON, 2018. Enhanced uptake in 2D-and 3D-lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra- and intracellular environments JOURNAL OF CONTROLLED RELEASE. 277, 126-141
• HARRY SHERMAN, SNOW STOLNIK, KIM BARONIAN, ALISON J. DOWNARD and FRANKIE J. RAWSON, 2018. New Perspectives on Iron Uptake in Eukaryotes Frontiers in Molecular Biosciences.
• LOVATO, TATIANA, TARESCO, VINCENZO, ALAZZO, ALI, SANSONE, CATERINA, STOLNIK, SNJEZANA, ALEXANDER, CAMERON and CONTE, CLAUDIA, 2018. Rapid formulation of redox-responsive oligo-aminoester polyplexes with siRNA via jet printing JOURNAL OF MATERIALS CHEMISTRY B. 6(41), 6550-6558
• LUCARINI, SIMONE, FAGIOLI, LAURA, CAVANAGH, ROBERT, LIANG, WANLING, PERINELLI, DIEGO ROMANO, CAMPANA, MARIO, STOLNIK, SNJEZANA, LAM, JENNY K. W., CASETTARI, LUCA and DURANTI, ANDREA, 2018. Synthesis, Structure-Activity Relationships and In Vitro Toxicity Profile of Lactose-Based Fatty Acid Monoesters as Possible Drug Permeability Enhancers PHARMACEUTICS. 10(3),
• SHERMAN, HARRY G., JOVANOVIC, CAROLYN, STOLNIK, SNOW, BARONIAN, KIM, DOWNARD, ALISON J. and RAWSON, FRANKIE J., 2018. New Perspectives on Iron Uptake in Eukaryotes FRONTIERS IN MOLECULAR BIOSCIENCES. 5,
• LOVATO, TATIANA, TARESCO, VINCENZO, ALAZZO, ALI, SANSONE, CATERINA, STOLNIK, SNJEZANA, ALEXANDER, CAMERON and CONTE, CLAUDIA, 2018. Rapid formulation of redox-responsive oligo--aminoester polyplexes with siRNA via jet printing JOURNAL OF MATERIALS CHEMISTRY B. 6(41), 6550-6558
• LINKE, FRANZISKA, MERRY, CATHERINE L. R., GRABOWSKA, ANNA M., STOLNIK-TRENKIC, SNOW, KERR, IAN D. and COYLE, BETH, 2018. MODELLING MEDULLOBLASTOMA INVASION AND CHEMORESISTANCE IN A 3D HYALURONAN HYDROGEL SYSTEM NEURO-ONCOLOGY. 20, 137-137
• VLLASALIU, DRITON, THANOU, MAYA, STOLNIK, SNJEZANA and FOWLER, ROBYN, 2018. Recent advances in oral delivery of biologics: nanomedicine and physical modes of delivery EXPERT OPINION ON DRUG DELIVERY. 15(8), 759-770
• ALSHEHRI, ABDULLAH, GRABOWSKA, ANNA and STOLNIK, SNOW, 2018. Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells (vol 8, 3748, 2018) SCIENTIFIC REPORTS. 8,
• CAPEL, VICTORIA, VLLASALIU, DRITON, WATTS, PETER, CLARKE, PHILIP A., LUXTON, DOMINIC, GRABOWSKA, ANNA M., MANTOVANI, GIUSEPPE and STOLNIK, SNJEZANA, 2018. Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA DRUG DELIVERY. 25(1), 644-653
• ALSHEHRI, ABDULLAH, GRABOWSKA, ANNA and STOLNIK, SNOW, 2018. Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells SCIENTIFIC REPORTS. 8,
• MADEIRA, J. DO O., MASTROTTO, F., FRANCINI, N., ALLEN, S., VAN DER WALLE, C. F., STOLNIK, S. and MANTOVANI, G., 2018. Synthetic glycopolymers as modulators of protein aggregation: influences of chemical composition, topology and concentration JOURNAL OF MATERIALS CHEMISTRY B. 6(7), 1044-1054
• SHERMAN, HARRY G., JOVANOVIC, CAROLYN, STOLNIK, SNOW and RAWSON, FRANKIE J., 2018. Electrochemical System for the Study of Trans-Plasma Membrane Electron Transport in Whole Eukaryotic Cells ANALYTICAL CHEMISTRY. 90(4), 2780-2786
• ALEJANDRO NIETO-ORELLANA, MARCO DI ANTONIO, CLAUDIA CONTE, FRANCO H FALCONE, CYNTHIA BOSQUILLON, NICK CHILDERHOUSE, GIUSEPPE MANOTVANI and SNOW STOLNIK, 2017. Effect of polymer topology on non-covalent polymer–protein complexation: miktoarm versus linear mPEG-poly(glutamic acid) copolymers Polymer Chemistry. 8, 2210-2220
• PARASKEVOPOULOU, V., HAGE, N., HOWARD, T., PHILLIPS, C., BRASSINGTON, C., OVERMAN, R., DEBRECZENI, J., GELLERT, P., MOHAMMED, A., ALISSA, M., WINKLER, G. S., STOLNIK, S., ROBINSON, K., FRANCINI, N., GOTTESMANN, M., HENSEL, A. and FALCONE, F., 2017. Hanging on for dear life: New molecular insights into how Helicobacter pylori adheres to the gastric epithelium HELICOBACTER. 22,
• NIETO-ORELLANA, A., COGHLAN, D., ROTHERY, M., BOSQUILLON, C., CHILDERHOUSE, N., MANTOVANI, G. and STOLNIK, S., 2017. POLYMER-PROTEIN-BASED DRY POWDER FOR EFFICIENT PULMONARY PROTEIN DELIVERY JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY. 30(4), A8-A8
• NIETO-ORELLANA, ALEJANDRO, DI ANTONIO, MARCO, CONTE, CLAUDIA, FALCONE, FRANCO H., BOSQUILLON, CYNTHIA, CHILDERHOUSE, NICK, MANTOVANI, GIUSEPPE and STOLNIK, SNOW, 2017. Effect of polymer topology on non-covalent polymer-protein complexation: miktoarm versus linear mPEG-poly(glutamic acid) copolymers POLYMER CHEMISTRY. 8(14), 2210-2220
• CAPEL V, VLLASALIU D, WATTS P and STOLNIK S, 2016. Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency. Biochemical and biophysical research communications. 477(2), 260-5
• SHUBBER S, VLLASALIU D, RAUCH C, JORDAN F, ILLUM L and STOLNIK S, 2015. Mechanism of Mucosal Permeability Enhancement of CriticalSorb® (Solutol® HS15) Investigated In Vitro in Cell Cultures. Pharmaceutical research. 32(2), 516-27
• NAIM HAGE, TINA HOWARD, CHRIS PHILLIPS, CLAIRE BRASSINGTON, ROSS OVERMAN, JUDIT DEBRECZENI, PAUL GELLERT, SNOW STOLNIK, G SEBASTIAAN WINKLER and F FALCONE, 2015. Structural basis of Lewisb antigen binding by the Helicobacter pylori adhesin BabA Science Advances. 1(e1500315),
• ALPESH MISTRY, SNJEZANA STOLNIK and L ILLUM, 2015. Nose-to-Brain Delivery: Investigation of the Transport of Nanoparticles with Different Surface Characteristics and Sizes in Excised Porcine Olfactory Epithelium Molecular Pharmaceutics. 12, 2755-2766
• GERARD D BYRNE, DRITON VLLASALIU, FRANCO H FALCONE and MICHEAL G SOMEKH, 2015. Live imaging of cellular internalization of single colloidal particle by combined label-free and fluorescence total internal reflection microscopy Molecular Pharmaceutics. 12(11), 862
• HAGE N, HOWARD T, PHILLIPS C, BRASSINGTON C, OVERMAN R, DEBRECZENI J, GELLERT P, STOLNIK S, WINKLER GS and FALCONE FH, 2015. Structural basis of Lewis(b) antigen binding by the Helicobacter pylori adhesin BabA. Science Advances. 1(7), e1500315
• VLLASALIU D, FALCONE FH, STOLNIK S and GARNETT M, 2014. Basement membrane influences intestinal epithelial cell growth and presents a barrier to the movement of macromolecules. Experimental cell research. 323(1), 218-31
• VLLASALIU D, FOWLER R and STOLNIK S, 2014. PEGylated nanomedicines: recent progress and remaining concerns. Expert opinion on drug delivery. 11(1), 139-54
• BANNUNAH, AZZAH M., VLLASALIU DRITON, LORD JENNIE and STOLNIK SNJEZANA, 2014. The Mechanisms of nanoparticle internalization and transport across an intestinal epithelial cell model: effect of size and surface charge. Molecular Pharmaceutics. 11, 4363-4373
• FOWLER, R., VLLASALIU, D., TRILLO, F.F., GARNETT, M., ALEXANDER, C., HORSLEY, H., SMITH, B., WHITCOMBE, I., EATON, M. and STOLNIK, S., 2013. Nanoparticle transport in epithelial cells: pathway switching through bioconjugation Small. 9(19), 3282-3294
• VLLASALIU, DRITON, SHUBBER, SAIF, FOWLER, ROBYN, GARNETT, MARTIN, ALEXANDER, CAMERON and STOLNIK, SNOW, 2013. Epithelial toxicity of alkylglycoside surfactants JOURNAL OF PHARMACEUTICAL SCIENCES. 102(1), 114-125
• VLLASALIU, D., ALEXANDER, C., GARNETT, M., EATON, M. and STOLNIK, S., 2012. Fc-mediated transport of nanoparticles across airway epithelial cell layers Journal of Controlled Release. 158(3), 479–486
• VLLASALIU D, SHUBBER S, GARNETT M, ALEXANDER C, EATON M and STOLNIK S, 2012. Evaluation Of Calcium Depletion As A Strategy For Enhancement Of Mucosal Absorption Of Macromolecules. Biochemical And Biophysical Research Communications. 418(1), 128-33
• MORADI, E., VLLASALIU, D., GARNETT, M., FALCONE, F. and STOLNIK, S., 2012. Ligand density and clustering effects on endocytosis of folate modified nanoparticles RSC Advances. 2(7), 3025-3033
• VIJAYARAGHAVAN M, STOLNIK S, HOWDLE SM and ILLUM L, 2012. Suitability of polymer materials for production of pulmonary microparticles using a pgss supercritical fluid technique: thermodynamic behaviour of fatty acids, pegs and peg-fatty acids. International journal of pharmaceutics. 438(1-2), 225-31
• VLLASALIU D, CASETTARI L, FOWLER R, EXPOSITO-HARRIS R, GARNETT M, ILLUM L and STOLNIK S, 2012. Absorption-promoting effects of chitosan in airway and intestinal cell lines: a comparative study. International journal of pharmaceutics. 430(1-2), 151-60
• BAYOUSSEF Z, DIXON JE, STOLNIK S and SHAKESHEFF KM, 2012. Aggregation promotes cell viability, proliferation, and differentiation in an in vitro model of injection cell therapy. Journal of tissue engineering and regenerative medicine. 6(10), e61-73
• VLLASALIU D, SHUBBER S, FOWLER R, GARNETT M, ALEXANDER C and STOLNIK S, 2012. Epithelial toxicity of alkylglycoside surfactants. Journal of pharmaceutical sciences. (In Press.)
• CASETTARI, L., VLLASALIU, D., CASTAGNINO, E., STOLNIK, S., HOWDLE, S. and ILLUM, L., 2012. PEGylated chitosan derivatives: Synthesis, charactierzations and pharmaceutical applications Progress in Polymer Science. 37, 659-685
• SAEED, A.O., MAGNUSSON, J.P., MORADI, E., SOLIMAN, M., WANG, W., STOLNIK, S., THURECHT, K.J., HOWDLE, S.M. and ALEXANDER, C., 2011. Modular construction of multifunctional bioresponsive cell-targeted nanoparticles for gene delivery Bioconjugate Chemistry. 22(2), 156-168
• LAM, JENNY K W, ARMES, STEVE P and STOLNIK, SNJEZANA, 2011. The involvement of microtubules and actin filaments in the intracellular transport of non-viral gene delivery system. Journal of drug targeting. 19(1), 56-66
• KAUR, I., SCHRAMM, G., EVERTS, B., SCHOLZEN, T., KINDLE, K.B., BEETZ, C., MONTIEL-DUARTE, C., BLINDOW, S., JONES, A.T., HAAS, H., STOLNIK, S., HEERY, D.M. and FALCONE, F.H., 2011. Interleukin-4 inducing principle from Schistosoma mansoni eggs contains a functional C-terminal nuclear localization signal necessary for nuclear translocation in mammalian cells but not for its uptake Infection and Immunity. 79(4), 1779-1788
• VLLASALIU D, FOWLER R, GARNETT M, EATON M and STOLNIK S, 2011. Barrier Characteristics Of Epithelial Cultures Modelling The Airway And Intestinal Mucosa: A Comparison. Biochemical And Biophysical Research Communications. 415(4), 579-85
• CASETTARI, L, CASTAGNINO, E, STOLNIK, S, LEWIS, A, HOWDLE, SM and ILLUM, L, 2011. Surface Characterisation Of Bioadhesive Plga/Chitosan Microparticles Produced By Supercritical Fluid Technology Pharmaceutical Research. 28(7), 1668-1682
• VLLASALIU, DRITON, EXPOSITO-HARRIS, RUTH, HERAS, ANGELES, CASETTARI, LUCA, GARNETT, MARTIN, ILLUM, LISBETH and STOLNIK, SNOW, 2010. Tight junction modulation by chitosan nanoparticles: comparison with chitosan solution. International journal of pharmaceutics. 400(1-2), 183-93
• CASETTARI, L., VLLASALIU, D., MANTOVANI, G., HOWDLE, S.M., STOLNIK, S. and ILLUM, L., 2010. Effect of PEGylation on the toxicity and permeability enhancement of chitosan Biomacromolecules. 11(11), 2854-2865
• ADAMS, G.G, BUTTERY, L and STOLNIK, S. AND WANG, N., 2010. Stem Cells: The Therapeutic Role In The Treatment Of Diabetes Mellitus Biotechnology and Genetic Engineering Reviews. 27, 285-304.
• STOLNIK, S. and SHAKESHEFF, K., 2009. Formulations for delivery of therapeutic proteins Biotechnology Letters. 31, 1-11
• MISTRY, ALPESH, GLUD, SYS ZOFFMANN, KJEMS, JØRGEN, RANDEL, JENS, HOWARD, KENNETH ALAN, STOLNIK, SNJEZANA and ILLUM, LISBETH, 2009. Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium. Journal of drug targeting. 17(7), 543-52
• LAM, J K W, ARMES, S P, LEWIS, A L and STOLNIK, S, 2009. Folate conjugated phosphorylcholine-based polycations for specific targeting in nucleic acids delivery. Journal of drug targeting. 17(7), 512-23
• MISTRY, A., STOLNIK, S. and ILLUM, L., 2009. Nanoparticles for direct nose-to-brain delivery of drugs. VOL 379(NUMBER 1), 146-157
• WANG, N., ADAMS, G., BUTTERY, L., FALCONE, F.H. and STOLNIK, S., 2009. Alginate encapsulation technology supports embryonic stem cells differentiation into insulin-producing cells Journal of Biotechnology. 144(4), 304-312
• BYRNE, G.D., PITTER, M.C., ZHANG, J., FALCONE, F.H., STOLNIK, S. and SOMEKH, M.G., 2008. Total internal reflection microscopy for live imaging of cellular uptake of sub-micron non-fluorescent particles Journal of Microscopy. 231(1), 168-179
• KAUR, I., STOLNIK, S. and KINDLE, K. ET AL, 2008. IPSE, a glycoprotein released from schistosoma mansoni eggs as a novel gene-delivery vector Journal of Pharmacy and Pharmacology. 60, 54
• DAVIES, O.R., HEAD, L., ARMITAGE, D., PEARSON, E.A., DAVIES, M.C., MARLOW, M. and STOLNIK, S., 2008. Surface modification of microspheres with steric stabilising and cationic polymers for gene delivery Langmuir. 24, 7138-7146
• DAVIES, OR, MARLOW, M and STOLNIK, S, 2008. Macroporous Surface Modified Microparticles Soft Matter. 4(8), 1597-1601
• CARNALLY, STEWART, BARROW, KATHARINE, ALEXANDER, MORGAN R, HAYES, CHRISTOPHER J, STOLNIK, SNJEZANA, TENDLER, SAUL J B, WILLIAMS, PHILIP M and ROBERTS, CLIVE J, 2007. Ultra-resolution imaging of a self-assembling biomolecular system using robust carbon nanotube AFM probes. Langmuir. 23(7), 3906-11
• WANG, N., BUTTERY, L., STOLNIK, S. and ADAMS, G., 2006. In-vitro differentiation of mouse embryonic stem cells into pancreatic insulin producing cells JOURNAL OF PHARMACY AND PHARMACOLOGY. VOL 58(NUMB 10), 140
• STOLNIK, S., HEALD, C. R., GARNETT, M. G., ILLUM, L. and DAVIS, S. S., 2005. Differences in the adsorption behaviour of poly(ethylene oxide) copolymers onto model polystyrene nanoparticles assessed by isothermal titration microcalorimetry correspond to the biological differences Journal of Drug Targeting. VOL 13(ISSU 8/9), 449-458
• WINTER, J. A., DAVIES, O. R., BROWN, A. P., GARNETT, M. C., STOLNIK, S. and PRITCHARD, D. I., 2005. The assessment of hookworm calreticulin as a potential vaccine for necatoriasis Parasite Immunology. 27(4), 139-146
• CHIM, Y.T.A., LAM, J.K.W., MA, Y., ARMES, S.P., LEWIS, A.L., ROBERTS, C.J., STOLNIK, S., TENDLER, S.J.B. and DAVIES, M.C., 2005. Structural study of DNA condensation induced by novel phosphorylcholine-based copolymers for gene delivery and relevance to DNA protection Langmuir. 21(8), 3591-3598
• WHITAKER, M.J., HAO, J., DAVIES, O.R., SERHATKULU, G., STOLNIK-TRENKIC, S., HOWDLE, S.M. and SHAKESHEFF, K.M., 2005. The production of protein-loaded microparticles by supercritical fluid enhanced mixing and spraying Journal of Controlled Release. 101(1-3), 85-92
• AMBROSI, M., CAMERON, N.R., DAVIS, B.G. and STOLNIK, S., 2005. Investigation of the interaction between peanut agglutinin and synthetic glycopolymeric multivalent ligands Organic & Biomolecular Chemistry. 3(8), 1476-1480
• PROMPRUK, K, GOVENDER, T, ZHANG, S, XIONG, C D and STOLNIK, S, 2005. Synthesis of a novel PEG-block-poly(aspartic acid-stat-phenylalanine) copolymer shows potential for formation of a micellar drug carrier. International Journal of Pharmaceutics. 297(1-2), 242-53
• DESHPANDE, M.C., DAVIES, M.C., GARNETT, M.C., WILLIAMS, P.M., ARMITAGE, D., BAILEY, L., VAMVAKAKI, M., ARMES, S.P. and STOLNIK, S., 2004. The effect of poly(ethylene glycol) molecular architecture on cellular interaction and uptake of DNA complexes Journal of Controlled Release. 97(1), 143-156
• LAM, J.K.W., MA, Y., ARMES, S.P., LEWIS, A.L., BALDWIN, T. and STOLNIK, S., 2004. Phosphorylcholine-polycation diblock copolymers as synthetic vectors for gene delivery. Journal of Controlled Release. 100(2), 293-312
• HEALD, C.R., STOLNIK, S., DE MATTEIS, C., GARNETT, M.C., ILLUM, L., DAVIS, S.S. and LEERMAKERS, F.A.M., 2003. Characterisation of poly(lactic acid):poly(ethyleneoxide) (PLA:PEG) nanoparticles using the self-consistent theory modelling approach Colloids and Surfaces A: Physicochemical and Engineering Aspects. 212(1), 57-64
• RUNGSARDTHONG,U., EHTEZAZI,T., BAILEY,L., ARMES,S.P., GARNETT,M.C. and STOLNIK-TRENKIC,S., 2003. Effect of polymer ionization on the interaction with DNA in non-viral gene delivery systems Biomacromolecules. 4(3), 683-690
• RILEY, T., HEALD, C. R., STOLNIK, S., GARNETT, M. C., ILLUM, L., DAVIS, S. S., KING, S. M., HEENAN, R. K., PURKISS, S. C. and BARLOW, R. J., 2003. Core-Shell Structure of PLA-PEG Nanoparticles Used for Drug Delivery Langmuir. VOL 19(PART 20), 8428-8435
• SALEM, A.K., ROSE, F.R.A.J., OREFFO, R.O.C., YANG, X., DAVIES, M.C., MITCHELL, J.R., ROBERTS, C.J., STOLNIK-TRENKIC, S., TENDLER, S.J.B., WILLIAMS, P.M. and SHAKESHEFF, K.M., 2003. Porous polymer and cell composites that self-assemble in situ Advanced Materials. 15(3), 210-213
• PETERSEN, H., KUNATH, K., KISSEL, T., MARTIN, A.L., STOLNIK, S., ROBERTS, C.J. and DAVIES, M.C., 2003. Star-shaped poly(ethylene glycol)-block-polyethylenimine copolymers enhance dna condensation of low molecular weight polyethylenimines Journal of Controlled Release. 87(1-3), 286-287
• EHTEZAZI, T., RUNGSARDTHONG, U. and STOLNIK, S., 2003. Thermodynamic analysis of polycation-DNA interaction applying titration microcalorimetry Langmuir. 19(22), 9387-9394
• RACKSTRAW, B.J., STOLNIK, S., DAVIS, S.S., BIGNOTTI, F. and GARNETT, M.C., 2002. Development of multicomponent DNA delivery systems based upon poly(amidoamine)—PEG co-polymers Biochimica et Biophysica Acta: Gene Structure and Expression. 1576(3), 269-286
• HEALD,C.R., STOLNIK-TRENKIC,S., KUJAWINSKI,K.S., DEMATTEIS,C., GARNETT,M.C., ILLUM,L., DAVIS,S.S., PURKISS,S.C., BARLOW,R.J. and GELLERT,P.R., 2002. Poly(lactic acid)-poly(ethylene oxide) (PLA-PEG) nanoparticles: NMR studies of the central solidlike PLA core and the liquid PEG corona Langmuir. 18(9), 3669-3675
• RILEY, T., STOLNIK, S., GARNETT, M. C., ILLUM, L., DAVIS, S. S., TAYLOR, P. and TADROS, T. F., 2002. Use of Viscoelastic Measurements for Investigating Interparticle Interactions in Dispersions of Micellar-like Poly(lactic acid)-Poly(ethylene glycol) Nanoparticles Langmuir. VOL 18(PART 20), 7663-7668
• DESHPANDE, MANGESH C, GARNETT, MARTIN C, VAMVAKAKI, M, BAILEY, LINDSEY, ARMES, STEVEN P and STOLNIK, SNJEZANA, 2002. Influence of polymer architecture on the structure of complexes formed by PEG-tertiary amine methacrylate copolymers and phosphorothioate oligonucleotide. Journal of Controlled Release. 81(1-2), 185-99
• PETERSEN, H., FECHNER, P.M., MARTIN, A.L., KUNATH, K., STOLNIK, S., ROBERTS, C.J., FISCHER, D., DAVIES, M.C. and KISSEL, T., 2002. Polyethylenimine-graft-poly(ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery system Bioconjugate Chemistry. 13(4), 845-854
• PETERSEN, H., MARTIN, A.L., STOLNIK, S., ROBERTS, C.J., DAVIES, M.C. and KISSEL, T., 2002. The macrostopper route: a new synthesis concept leading exclusively to diblock copolymers with enhanced DNA condensation potential Macromolecules. 35(27), 9854-9856
• PETERSEN, HOLGER, KUNATH, KLAUS, MARTIN, ALISON L, STOLNIK, SNJEZANA, ROBERTS, CLIVE J, DAVIES, MARTYN C and KISSEL, THOMAS, 2002. Star-shaped poly(ethylene glycol)-block-polyethylenimine copolymers enhance DNA condensation of low molecular weight polyethylenimines. Biomacromolecules. 3(5), 926-36
• HEALD, C.R., STOLNIK, S., DE MATTEIS, C., GARNETT, M.C., ILLUM, L., DAVIS, S.S. and LEERMAKERS, F.A.M., 2001. Self-consistent field modelling of poly(lactic acid)-poly(ethylene glycol) particles Colloids and Surfaces A: Physicochemical and Engineering Aspects. 179(1), 79-91
• RILEY,T., STOLNIK-TRENKIC,S., HEALD,C.R., XIONG,C.D., GARNETT,M.C., ILLUM,L., DAVIS,S.S., PURKISS,S.C., BARLOW,R.J. and GELLERT,P.R., 2001. Physicochemical evaluation of nanoparticles assembled from poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) block copolymers as drug delivery vehicles Langmuir. 17(11), 3168-3174
• STOLNIK-TRENKIC,S., DAUDALI,B., ARIEN,A., WHETSTONE,J., HEALD,C.R., GARNETT,M.C., DAVIS,S.S. and ILLUM,L., 2001. The effect of surface coverage and conformation of poly(ethylene oxide) (PEO) chains of poloxamer 407 on the biological fate of model colloidal drug carriers Biochimica et Biophysica Acta. 1514(2), 261-279
• STOLNIK, S., HEALD, C. R., NEAL, J., GARNETT, M. C., DAVIS, S. S., ILLUM, L., PURKIS, S. C., BARLOW, R. J. and GELLERT, P. R., 2001. Polylactide-poly(ethylene Glycol) Micellar-like Particles as Potential Drug Carriers: Production, Colloidal Properties and Biological Performance Journal of Drug Targeting. VOL 9(PART 5), 361-378
• RUNGSARDTHONG, U, DESHPANDE, M, BAILEY, L, VAMVAKAKI, M, ARMES, S P, GARNETT, M C and STOLNIK, S, 2001. Copolymers of amine methacrylate with poly(ethylene glycol) as vectors for gene therapy. Journal of Controlled Release. 73(2-3), 359-80
• RACKSTRAW, B.J., MARTIN, A.L., STOLNIK, S., ROBERTS, C.J., GARNETT, M.C., DAVIES, M.C. and TENDLER, S.J.B., 2001. Microscopic investigations into PEG-cationic polymer-induced DNA condensation Langmuir. 17(11), 3185-3193
• GOVENDER, T., STOLNIK, S., XIONG, C., ZHANG, S., ILLUM, L. and DAVIS, S. S., 2001. Drug-polyionic block copolymer interactions for micelle formation: physicochemical characterisation Journal of Controlled Release. VOL 75(NUMBER 3), 249-258
• GOVENDER, T., RILEY, T., EHTEZAZI, T., GARNETT, M. C., STOLNIK, S., ILLUM, L. and DAVIS, S. S., 2000. Defining the drug incorporation properties of PLA-PEG nanoparticles International Journal of Pharmaceutics. VOL 199(NUMBER 1), 95 - 110
• MCGURK, S.L., SANDERS, G.H.W., DAVIES, M.C., DAVIS, S.S., ILLUM, L., ROBERTS, C.J., STOLNIK, S., TENDLER, S.J.B. and WILLIAMS, P.M., 2000. A high resolution atomic force microscopy study of poly(lactic acid-co-ethylene glycol) Polymer Journal. 32(5), 444-446
• MARTIN, A.L., DAVIES, M.C., RACKSTRAW, B.J., ROBERTS, C.J., STOLNIK, S., TENDLER, S.J. and WILLIAMS, P.M., 2000. Observation of DNA-polymer condensate formation in real time at a molecular level FEBS Letters. 480(2-3), 106-112
• JONES, N. A., HILL, I. R., STOLNIK, S., BIGNOTTI, F., DAVIS, S. S. and GARNETT, M. C., 2000. Polymer chemical structure is a key determinant of physicochemical and colloidal properties of polymer-DNA complexes for gene delivery Biochimica et Biophysica Acta. VOL 1517(NUMBER 1), 1-18
• EHTEZAZI, T, GOVENDER, T and STOLNIK, S, 2000. Hydrogen bonding and electrostatic interaction contributions to the interaction of a cationic drug with polyaspartic acid. Pharmaceutical Research. 17(7), 871-8
• GARNETT, M.C., STOLNIK, S., DUNN, S.E., ARMSTRONG, I., LIN, W., SCHACHT, E., FERUTTI, P., VERT, M., DAVIES, M.C. and ILIUM, L., 1999. Application of novel biomaterials in colloidal drug delivery systems MRS Bulletin. 24(5), 49-56
• GOVENDER,T., STOLNIK,S., GARNETT,M.C., ILLUM,L. and DAVIS,S.S., 1999. PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug Journal of Controlled Release. 57(2), 171-185
• RILEY, T., GOVENDER, T., STOLNIK, S., XIONG, C.D., GARNETT, M.C., ILLUM, L. and DAVIS, S.S., 1999. Colloidal stability and drug incorporation aspects of micellar-like PLA-PEG nanoparticles Colloids and Surfaces B: Biointerfaces. VOL 16(NUMBER 1-4), 147 - 159
• GOVENDER, T, EHTEZAZI, T, STOLNIK, S, ILLUM, L and DAVIS, S S, 1999. Complex formation between the anionic polymer (PAA) and a cationic drug (procaine HCI): characterization by microcalorimetric studies. Pharmaceutical Research. 16(7), 1125-31
• NEAL, J. C., STOLNIK, S., SCHACHT, E., EL RAFAIE KENAWY, GARNETT, M. C., DAVIS, S. S. and ILLUM, L., 1998. In Vitro Displacement by Rat Serum of Adsorbed Radiolabeled Poloxamer and Poloxamine Copolymers from Model and Biodegradable Nanospheres Journal of Pharmaceutical Sciences. VOL 87(NUMBER 10), 1242-1248
• NEAL, J C, STOLNIK, S, GARNETT, M C, DAVIS, S S and ILLUM, L, 1998. Modification of the copolymers poloxamer 407 and poloxamine 908 can affect the physical and biological properties of surface modified nanospheres. Pharmaceutical Research. 15(2), 318-24
• VANDORPE, J., SCHACHT, E., DUNN, S., HAWLEY, A., STOLNIK, S., DAVIS, S.S., GARNETT, M.C., DAVIES, M.C. and ILLUM, L., 1997. Long circulating biodegradable poly(phosphazene) nanoparticles surface modified with poly(phosphazene)-poly(ethylene oxide) copolymer Biomaterials. 18(17), 1147-1152
• STOLNIK, S., FELUMB, N. C., HEALD, C. R., GARNETT, M. C., ILLUM, L. and DAVIS, S. S., 1997. Adsorption behaviour and conformation of selected poly(ethylene oxide) copolymers on the surface of a model colloidal drug carrier Colloids and Surfaces A: Physicochemical and Engineering Aspects. VOL 122(NUMBER 1/3), 151-159
• RAFATI, H., LAVELLE, E. C., COOMBES, A. G. A., STOLNIK, S., HOLLAND, J. and DAVIS, S. S., 1997. The immune response to a model antigen associated with PLG microparticles prepared using different surfactants Vaccine. VOL 15(NUMBER 17/18), 1888-1897