Mark Humphries

Contact

• workSchool of Psychology
  University Park
  Nottingham
  NG7 2RD
  UK
• Mark.Humphries@nottingham.ac.uk
• https://www.humphries-lab.org/

Research Summary

I'm a systems neuroscientist who happens to use computational and statistical models rather than animal models to study the brain. Our research interrogates how the joint activity of many neurons… read more

Selected Publications

• BRUNO AM, FROST WN and HUMPHRIES MD, 2017. A spiral attractor network drives rhythmic locomotion. eLife. 6,
• MARK D HUMPHRIES, 2017. Dynamical networks: finding, measuring, and tracking neural population activity using network science Network Neuroscience. 1, 324-338
• BRUNO AM, FROST WN and HUMPHRIES MD, 2015. Modular deconstruction reveals the dynamical and physical building blocks of a locomotion motor program. Neuron. 86(1), 304-18
• GURNEY KN, HUMPHRIES MD and REDGRAVE P, 2015. A new framework for cortico-striatal plasticity: behavioural theory meets in vitro data at the reinforcement-action interface. PLoS biology. 13(1), e1002034

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Current Research

I'm a systems neuroscientist who happens to use computational and statistical models rather than animal models to study the brain. Our research interrogates how the joint activity of many neurons encodes the past, present, and future in order to guide behaviour. To do this, we drive the development of widely-applicable data analysis techniques, and use them to analyse recordings of hundreds or thousands of neurons, recordings across different tasks, brain circuits, species, and phyla. And we develop theoretical and computational models for how this joint activity arises from neural circuits.

• HUMPHRIES MD, OBESO JA and DREYER JK, 2018. Insights into Parkinson's disease from computational models of the basal ganglia. Journal of Neurology, Neurosurgery, and Psychiatry. 89, 1181-1188
• CABALLERO JA, HUMPHRIES MD and GURNEY KN, 2018. A probabilistic, distributed, recursive mechanism for decision-making in the brain. PLoS computational biology. 14(4), e1006033
• MAGGI S, PEYRACHE A and HUMPHRIES MD, 2018. An ensemble code in medial prefrontal cortex links prior events to outcomes during learning. Nature Communications. 9(1), 2204
• BRUNO AM, FROST WN and HUMPHRIES MD, 2017. A spiral attractor network drives rhythmic locomotion. eLife. 6,
• MARK D HUMPHRIES, 2017. Dynamical networks: finding, measuring, and tracking neural population activity using network science Network Neuroscience. 1, 324-338
• HUMPHRIES MD, 2016. The Goldilocks zone in neural circuits. eLife. 5,
• BRUNO AM, FROST WN and HUMPHRIES MD, 2015. Modular deconstruction reveals the dynamical and physical building blocks of a locomotion motor program. Neuron. 86(1), 304-18
• SINGH A and HUMPHRIES MD, 2015. Finding communities in sparse networks. Scientific reports. 5, 8828
• GURNEY KN, HUMPHRIES MD and REDGRAVE P, 2015. A new framework for cortico-striatal plasticity: behavioural theory meets in vitro data at the reinforcement-action interface. PLoS biology. 13(1), e1002034
• CARRON R, FILIPCHUK A, NARDOU R, SINGH A, MICHEL FJ, HUMPHRIES MD and HAMMOND C, 2014. Early hypersynchrony in juvenile PINK1(-)/(-) motor cortex is rescued by antidromic stimulation. Frontiers in systems neuroscience. 8, 95
• HUMPHRIES MD, 2014. Slaves to the rhythm: coupling of the subthalamic nucleus-globus pallidus network in Parkinsonian oscillations. The Journal of physiology. 592(7), 1427-8
• TOMKINS A, VASILAKI E, BESTE C, GURNEY K and HUMPHRIES MD, 2014. Transient and steady-state selection in the striatal microcircuit. Frontiers in computational neuroscience. 7, 192
• BESTE C, HUMPHRIES M and SAFT C, 2014. Striatal disorders dissociate mechanisms of enhanced and impaired response selection - Evidence from cognitive neurophysiology and computational modelling. NeuroImage. Clinical. 4, 623-34
• CAZE, ROMAIN DANIEL, HUMPHRIES, MARK and GUTKIN, BORIS, 2013. Passive Dendrites Enable Single Neurons to Compute Linearly Non-separable Functions PLOS COMPUTATIONAL BIOLOGY. 9(2),
• KHAMASSI M and HUMPHRIES MD, 2012. Integrating cortico-limbic-basal ganglia architectures for learning model-based and model-free navigation strategies. Frontiers in behavioral neuroscience. 6, 79
• WOHRER A, HUMPHRIES MD and MACHENS CK, 2012. Population-wide distributions of neural activity during perceptual decision-making. Progress in neurobiology. 103, 156-93
• HUMPHRIES MD and GURNEY K, 2012. Network effects of subthalamic deep brain stimulation drive a unique mixture of responses in basal ganglia output. The European journal of neuroscience. 36(2), 2240-51
• HUMPHRIES MD, KHAMASSI M and GURNEY K, 2012. Dopaminergic Control of the Exploration-Exploitation Trade-Off via the Basal Ganglia. Frontiers in neuroscience. 6, 9
• DEHORTER N, MICHEL FJ, MARISSAL T, ROTROU Y, MATROT B, LOPEZ C, HUMPHRIES MD and HAMMOND C, 2011. Onset of Pup Locomotion Coincides with Loss of NR2C/D-Mediated Cortico-Striatal EPSCs and Dampening of Striatal Network Immature Activity. Frontiers in cellular neuroscience. 5, 24
• HUMPHRIES MD, 2011. Spike-train communities: finding groups of similar spike trains. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(6), 2321-36
• HUMPHRIES MD, WOOD R and GURNEY K, 2010. Reconstructing the three-dimensional GABAergic microcircuit of the striatum. PLoS computational biology. 6(11), e1001011
• HUMPHRIES MD, LEPORA N, WOOD R and GURNEY K, 2009. Capturing dopaminergic modulation and bimodal membrane behaviour of striatal medium spiny neurons in accurate, reduced models. Frontiers in computational neuroscience. 3, 26
• HUMPHRIES MD and PRESCOTT TJ, 2009. The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward. Progress in neurobiology. 90(4), 385-417
• HUMPHRIES MD, WOOD R and GURNEY K, 2009. Dopamine-modulated dynamic cell assemblies generated by the GABAergic striatal microcircuit. Neural networks : the official journal of the International Neural Network Society. 22(8), 1174-88
• FOX C, HUMPHRIES M, MITCHINSON B, KISS T, SOMOGYVARI Z and PRESCOTT T, 2009. Technical integration of hippocampus, Basal Ganglia and physical models for spatial navigation. Frontiers in neuroinformatics. 3, 6
• LOWE, ROBERT, HUMPHRIES, MARK and ZIEMKE, TOM, 2009. The dual-route hypothesis: evaluating a neurocomputational model of fear conditioning in rats CONNECTION SCIENCE. 21(1), 15-37
• HUMPHRIES MD and GURNEY K, 2008. Network 'small-world-ness': a quantitative method for determining canonical network equivalence. PloS one. 3(4), e0002051
• HUMPHRIES MD and GURNEY K, 2007. Solution methods for a new class of simple model neurons. Neural computation. 19(12), 3216-25
• HUMPHRIES MD, GURNEY K and PRESCOTT TJ, 2007. Is there a brainstem substrate for action selection? Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 362(1485), 1627-39
• HUMPHRIES, M. D. and GURNEY, K., 2007. A means to an end: Validating models by fitting experimental data NEUROCOMPUTING. 70(10-12), 1892-1896
• HUMPHRIES MD, STEWART RD and GURNEY KN, 2006. A physiologically plausible model of action selection and oscillatory activity in the basal ganglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(50), 12921-42
• HUMPHRIES MD, GURNEY K and PRESCOTT TJ, 2006. The brainstem reticular formation is a small-world, not scale-free, network. Proceedings. Biological sciences. 273(1585), 503-11
• HUMPHRIES, MARK and PRESCOTT, TONY, 2006. Distributed action selection by a brainstem neural substrate: An embodied evaluation FROM ANIMALS TO ANIMATS 9, PROCEEDINGS. 4095, 199-210
• PRESCOTT TJ, MONTES GONZÁLEZ FM, GURNEY K, HUMPHRIES MD and REDGRAVE P, 2005. A robot model of the basal ganglia: behavior and intrinsic processing. Neural networks : the official journal of the International Neural Network Society. 19(1), 31-61
• HUMPHRIES, M, GURNEY, K and PRESCOTT, T, 2005. Is there an integrative center in the vertebrate brain-stem? A robotic evaluation of a model of the reticular formation viewed as an action selection device ADAPTIVE BEHAVIOR. 13(2), 97-113
• GURNEY KN, HUMPHRIES M, WOOD R, PRESCOTT TJ and REDGRAVE P, 2004. Testing computational hypotheses of brain systems function: a case study with the basal ganglia. Network (Bristol, England). 15(4), 263-90
• HUMPHRIES, MD and GURNEY, KN, 2002. The role of intra-thalamic and thalamocortical circuits in action selection NETWORK-COMPUTATION IN NEURAL SYSTEMS. 13(1), 131-156
• HUMPHRIES MD and GURNEY KN, 2001. A pulsed neural network model of bursting in the basal ganglia. Neural networks : the official journal of the International Neural Network Society. 14(6-7), 845-63