2012 Publications

Highlights | 2016 | 2015 | 2014 | 2013 | 2012 | Archived

International Association for the Study of Lung Cancer Computed Tomography Screening Workshop 2011 Report. John K. Field, Robert A. Smith, Denise R. Aberle, Matthijs Oudkerk, David R. Baldwin, et al. Journal of Thoracic Oncology. 2012;7(1):10-19.

The prognostic significance of lymphovascular invasion in invasive breast carcinoma. Rakha EA, Martin S, Lee AH, Morgan D, Pharoah PD, Hodi Z, Macmillan D, Ellis IO. Cancer. 2012 Aug 1;118(15):3670-80.

Safety and long term efficacy of porfimer sodium photodynamic therapy in locally advanced biliary tract carcinoma. Pereira SP, Aithal GP, Ragunath K, Devlin J, Owen F, Meadows H. Photodiagnosis Photodyn Ther. 2012;9(4):287-92. doi: 10.1016/j.pdpdt.2012.03.005.

Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity. Hole AJ, Baumli S, Shao H, Shi S, Huang S, Pepper C, Fischer PM, Wang S, Endicott JA, Noble ME. J Med Chem, 2012, in press (10.1021/jm301495v).

Three-Dimensional Pharmacophore Design Identifies Substituted 1,2,4-Triazole Compounds as Inhibitors of the Annexin A2-S100A10 Protein Interaction. Reddy TRK, Li C, Fischer PM, Dekker LV. ChemMedChem, 2012, 7, 1435-1446.

A novel synthetic lethality therapeutic approach targeting human apurinic/apyrimidinic endonucealase (APE1) in cells deficient in DNA double strand break repair. Sultana R, McNeill DR, Mohammed MZ, Abbotts R, Zdzienicka MZ, Seedhouse C, Perry C, Laughton CA, Dekker LV, Fischer PM, Patel PM, Wilson DM III, Madhusudan S. Int J Cancer, 2012, 131, 2433–2444.

Autologous and allogeneic stem-cell transplantation for transformed chronic lymphocytic leukemia (Richter's syndrome): A retrospective analysis from the chronic lymphocytic leukemia subcommittee of the chronic leukemia working party and lymphoma working party of the European Group for Blood and Marrow Transplantation. Cwynarski K, van Biezen A, de Wreede L, Stilgenbauer S, Bunjes D, Metzner B, Koza V, Mohty M, Remes K, Russell N, Nagler A, Scholten M, de Witte T, Sureda A, Dreger P. J Clin Oncol. 2012 Jun 20;30(18):2211-7.

Small molecules that bind the Mdm2 RING stabilize and activate p53. Roxburgh P, Hock A, Dickens MP, Mezna M, Fischer PM, Vousden KH. Carcinogenesis, 2012, 33, 791-798.

CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells when compared with flavopiridol. Liu X, Shi S, Lam F, Pepper C, Fischer PM, Wang S. Int J Cancer. 2012, 130, 1216-1226.

What is the most effective follow-up model for lung cancer patients? A systematic review. Schmidt-Hansen, Baldwin DR, Hasler E,. Journal of Thoracic Oncology. 2012;7:821-824.

Using socio-demographic and early clinical features in general practice to identify people with lung cancer earlier. Iyen-Omofoman B, Tata LJ, Baldwin DR, Smith CJP, Hubbard R. Thorax in press. 2012.

Clinical management of older people with non-small cell lung cancer in England. Beckett P, Callister M, Tata L, Harrison R, Peake M, Stanley R, Woolhouse I, Slade M, Hubbard RB. Thorax 67:836-839. 2012

Neutral risk of lung cancer in people with celiac disease – Nationwide cohort Study. Ludvigsson JF, West J, Hubbard RB, Card T. Lung Cancer 78:179-184. 2012.

A Proposed New Imaging Pathway for Patients with Suspected Lung Cancer. Macpherson R, Benamore R, Panakis N, Sayeed R Breen D, Bradley K, Carter R, Baldwin D, Craig J, Gleeson F. Clinical Radiology. 2012;67:564-573.

Incidence of venous thromboembolism in patients with cancer – A cohort study using linked United Kingdom databases. Walker AJ, Card TR, West J, Crooks C, Grainge MJ. Eur J Cancer. 2012.

The chemokine, CXCL12, is an independent predictor of poor survival in ovarian cancer. Popple A, Durrant LG, Spendlove I, Rolland P, Scott IV, Deen S, Ramage JM. Br J Cancer. 106:1306-13. 2012.

Clinical management of older people with non-small cell lung cancer in england. Beckett P, Callister M, Tata LJ, Harrison R, Peake MD, Stanley R, Woolhouse I, Slade M, Hubbard RB. Thorax. 67(9), 836-9. 2012.

PEGylation and biodistribution of an anti-MUC1 aptamer in MCF-7 tumour bearing mice. Da Pieve C, Blackshaw E, Missailidis S, Perkins AC. Bioconjug Chem. 2012;23(7):1377-81.

The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-Not complex. Doidge, R., S. Mittal, et al. (2012). PLoS One 7(12): e51331.

Fluoxetine counteracts the cognitive and cellular effects of 5-Fluoruracil in the rat hippocampus by a mechanism of prevention rather than recovery. Lyons L. ElBeltagy M. Bennett G. Wigmore P. 2012, PlosOne 7(1):e30010.

The effect of 5-Fluorouracil on the long term survival and proliferation of cells in the rat hippocampus. ElBeltagy M. Mustafa S. Umka J. Lyons L. Salman A. Dormon K. Allcock C. Bennett G. Wigmore P. 2012 Brain Research Bulletin 88 514-518.

The effect of systemic chemotherapy on neurogenesis, placticity and memory. Current Topics in Behavioural Neuroscience; Neurogenesis and placticity. Wigmore P. 2012, Springer.

Multicomponent synthetic polymers with viral-mimetic chemistry for nucleic acid delivery Molecular Pharmaceutics. Soliman M, Nasanit R, Abulateefeh S, Allen S, Davies MC, Briggs SS, Seymour LW, Preece J, Grabowska AM, Watson SA and Alexander C (2012). Mol Pharm 9: 1-13.

Elevated SP-1 transcription factor expression and activity drives basal and hypoxia-induced vascular endothelial growth factor (VEGF) expression in non-small cell lung cancer. Deacon K, Onion D, Kumari R, Watson SA, Knox AJ. J Biol Chem. 2012 Nov 16;287(47):39967-81. doi: 0.1074/jbc.M112.397042. Epub 2012 Sep 18. PubMed PMID: 22992725; PubMed Central PMCID: PMC3501049.

The pathological confirmation rate of lung cancer in England using the NLCA database. KHAKWANI A, RICH AL, TATA LJ, POWELL HA, STANLEY RA, BALDWIN DR and HUBBARD RB, 2012. Lung cancer (Amsterdam, Netherlands). (In Press.)

The association between smoking quantity and lung cancer in men and women. POWELL HA, IYEN-OMOFOMAN B, HUBBARD RB, BALDWIN DR and TATA LJ, 2012. Chest. (In Press.)

Application of a High Throughput Method of Biomarker Discovery to Improvement of the EarlyCDT®-Lung Test. Macdonald IK, Murray A, Healey GF, Parsy-Kowalska CB, Allen J, McElveen J, Robertson C, Sewell HF, Chapman CJ, Robertson JF. PLoS One. 2012;7(12):e51002.

Development and Validation of a High Throughput System for Discovery of Antigens for Autoantibody Detection. Macdonald IK, Murray A, Allen J, Parsy-Kowalska C, Healey G, Chapman CJ, Sewell H, Robertson JFR. PLoS ONE 2012 7(7): e40759.

EarlyCDT®-Lung test: improved clinical utility through additional autoantibody assays. Chapman CJ, Healey GF, Murray A, Boyle P, Robertson C, Peek LJ, Allen J, Thorpe AJ, Hamilton-Fairley G, Parsy-Kowalska CB, MacDonald IK, Jewell W, Maddison P, Robertson JF. Robertson J. Tumor Biol. 2012 Oct;33(5):1319-26.

Redox environment, free radical and oxidative DNA damage. S Storr, C Woolston, Y Zhang, S Martin (2012) Antioxid Redox Signal. 2012 Dec 18. [Epub ahead of print] PMID: 23249296.

The addition of the farnesyl transferase inhibitor, tipifarnib, to low dose cytarabine does not improve outcome for older patients with AML. Burnett AK, Russell NH, Culligan D, Cavanagh J, Kell J, Wheatley K, Virchis A, Hills RK, Milligan D; AML Working Group of the UK National Cancer Research Institute. Br J Haematol. 2012 Aug;158(4):519-22. doi: 10.1111/j.1365-2141.2012.09165.x. Epub 2012.

Effects of induction and maintenance plus long-term bisphosphonates on bone disease in patients with multiple myeloma: the Medical Research Council Myeloma IX Trial. Morgan GJ, Davies FE, Gregory WM, Szubert AJ, Bell SE, Drayson MT, Owen RG, Ashcroft AJ, Jackson GH, Child JA; National Cancer Research Institute Haematological Oncology Clinical Studies Group. Blood. 2012 Jun 7;119(23):5374-83. doi: 10.1182/blood-2011-11-392522. Epub 2012 Apr 12.

Mobilized peripheral blood stem cells compared with bone marrow as the stem cell source for unrelated donor allogeneic transplantation with reduced-intensity conditioning in patients with acute myeloid leukemia in complete remission: an analysis from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Nagler A, Labopin M, Shimoni A, Niederwieser D, Mufti GJ, Zander AR, Arnold R, Greinix H, Cornelissen JJ, Jackson GH, Craddock C, Bunjes DW, Ganser A, Russell NH, Kyrcz-Krzemien S, Rocha V, Mohty M. Biol Blood Marrow Transplant. 2012 Sep;18(9):1422-9. doi: 10.1016/j.bbmt.2012.02.013. Epub 2012 Mar 20.

Cyclophosphamide, thalidomide, and dexamethasone as induction therapy for newly diagnosed multiple myeloma patients destined for autologous stem-cell transplantation: MRC Myeloma IX randomized trial results. Morgan GJ, Davies FE, Gregory WM, Bell SE, Szubert AJ, Navarro Coy N, Cook G, Feyler S, Johnson PR, Rudin C, Drayson MT, Owen RG, Ross FM, Russell NH, Jackson GH, Child JA; National Cancer Research Institute Haematological Oncology Clinical Studies Group. Haematologica. 2012 Mar;97(3):442-50. doi: 10.3324/haematol.2011.043372. Epub 2011 Nov 4.

Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms. Ibrahim EE, Babaei-Jadidi R, Saadeddin A, Spencer-Dene B, Hossaini S, Abuzinadah M, Li N, Fadhil W, Ilyas M, Bonnet D, Nateri AS. Stem Cells. 2012 Oct;30(10):2076-87. PMID:22851508

Targeting XRCC1 deficiency in breast cancer for personalized therapy. Sultana R, Abdel-fatah T, Abbotts R, Chan S, Hawkes C, EA Rakha, Ball G, Ellis IO and Madhusudan S. Cancer Research. 2012 Dec 19. [Epub ahead of print]

Clinicopathological and functional significance of XRCC1 (X-ray repair cross-complementing gene 1) expression in ovarian cancer. Abdel-Fatah T, Sultana R, Abbotts R, Hawkes C, Seedhouse C, Chan S, and Madhusudan S. International Journal of Cancer. 2012 Dec 6. doi: 10.1002/ijc.27980. [Epub ahead of print]

Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer? Abdel-Fatah T, Arora A, Gorguc I, Abbotts R, Beebeejaun S, Storr S, Mohan V, Hawkes C, Soomro I, Lobo DN, Parsons SL and Madhusudan S. Antioxidant & Redox Signaling, 2012 doi:10.1089/ars.2012.4873.

Synthetic lethal targeting of DNA double strand break repair deficient cells by human apurinic/apyrimidinic endonucealase (APE1) inhibitors. Sultana R, McNeill DR, Mohammed MZ, Abbotts R, Zdzienicka MZ, , Laughton CA, Dekker LV, Fischer PM, Patel PM, Seedhouse C , Wilson DM III, Madhusudan S. International Journal of Cancer, 2012 Feb 29. doi: 10.1002/ijc.27512.

Caspase-cleaved cytokeratin-18 expression and tumour regression in patients with gastro-oesophageal adenocarcinoma treated with neo-adjuvant chemotherapy. K R Fareed, I N Soomro, K Hameed, A Arora, D N Lobo, S L Parsons and S Madhusudan. World Journal of Gastroenterology. 2012 Apr 28;18(16):1915-20.

Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla. Storr SJ, Zaitoun AM, Arora A, Durrant LG, Lobo DN, Madhusudan S, Martin SG. 2012 BMC Cancer 2012, 12:511 doi:10.1186/1471-2407-12-511.

MAGIC in Practice: Experience of peri-operative ECX(F) chemotherapy in patients with gastro-oesophageal adenocarcinomas. Reece-Smith A, Cunnell ML, Saha S, Khalid Hameed, Madhusudan S, Bessell E, Duffy J, Parsons SL. Journal of Surgical Oncology, 2012 Jun 4. doi: 10.1002/jso.23187.

Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study. Pigment cell and Melanoma Research. Davies JR, Randerson-Moor J, Kukalizch K, Harland M, Kumar R, Madhusudan S, Nagore E, Hansson J, Höiom V, Ghiorzo P, Gruis NA, Kanetsky PA, Okamoto I, Pjanova D, Puig S, Saiag P, Schadendorf D, Soufir, D, Wendt J, Affleck P, García-Casado Z, Ogbah Z, Aija Ozola, Queirolo P, Sucker A, Barrett JH, Doorn RV, Bishop T and Newton-Bishop J. 2012. May;25(3):384-394

Base excision repair factors are promising prognostic and predictive markers in cancer. Gossage L, Perry C, Abbotts R, and Madhusudan S. Current Molecular Pharmacology 2012;5:115-124

Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas. Sarah J. Storr, Xuan Pu, Dileep Lobo, Alexander M. Reece-Smith, Simon L. Parsons, Srinivasan Madhusudan, Stewart G. Martin. Journal of Gastroenterology, 2013. In Press

Survival of glioma and colorectal cancer patients using tricyclic antidepressants post-diagnosis. Alex J. Walker, Matthew Grainge, Timothy E. Bates, Tim R. Card. Cancer Causes Control, (2012)

Occupational therapy needs of patients with thoracic cancer at the time of diagnosis: findings of a dedicated rehabilitation service. Bentley R, Hussain A, Maddocks M, Wilcock A. Support Care Cancer. 2012 Dec 27. [Epub ahead of print] PMID: 23269421 [PubMed - as supplied by publisher]

Off-label prescribing in palliative care: A survey of independent prescribers. Culshaw J, Kendall D, Wilcock A. Palliat Med. 2012 Nov 21. [Epub ahead of print] PMID: 23175511 [PubMed - as supplied by publisher]

Therapeutic exercise in cancer cachexia. Maddocks M, Murton AJ, Wilcock A. Crit Rev Oncog. 2012;17(3):285-92. Review. PMID: 22831159 [PubMed - indexed for MEDLINE]

Development and testing of a cancer appetite and symptom questionnaire. Halliday V, Porock D, Arthur A, Manderson C, Wilcock A. J Hum Nutr Diet. 2012 Jun;25(3):217-24. doi: 10.1111/j.1365-277X.2012.01233.x. Epub 2012 Feb 21. PMID: 22348402 [PubMed - indexed for MEDLINE]

Exploring physical activity level in patients with thoracic cancer: implications for use as an outcome measure. Maddocks M, Wilcock A. Support Care Cancer. 2012 May;20(5):1113-6. doi: 10.1007/s00520-012-1393-z. Epub 2012 Feb 5. PMID: 22311375 [PubMed - indexed for MEDLINE

When will I get my breath back? Recovery time of exercise-induced breathlessness in patients with thoracic cancer. Maddocks M, Taylor V, Klezlova R, England R, Manderson C, Wilcock A. Lung Cancer. 2012 Apr;76(1):128-9. doi: 10.1016/j.lungcan.2012.01.003. Epub 2012 Jan 28. No abstract available. PMID: 22285531 [PubMed - indexed for MEDLINE]

Exploring autonomic nervous system dysfunction in patients with cancer cachexia: a pilot study. Chauhan A, Sequeria A, Manderson C, Maddocks M, Wasley D, Wilcock A. Auton Neurosci. 2012 Jan 26;166(1-2):93-5. doi: 10.1016/j.autneu.2011.09.006. Epub 2011 Oct 19. PMID: 22014539 [PubMed - indexed for MEDLINE]

DNMTs are required for delayed genome instability caused by radiation. Armstrong CA, Jones GD, Anderson R, Iyer P, Narayanan D, Sandhu J, Singh R, Talbot CJ, Tufarelli C. Epigenetics. 2012 Aug;7(8):892-902.

Overcoming drug resistance and treating advanced prostate cancer. Semenas J, Allegrucci C, Boorjian SA, Mongan NP, Persson JL. Curr Drug Targets. 2012 Sep 1;13(10):1308-23. PMID: 22746994

The androgen receptor and stem cell pathways in prostate and bladder cancers (review). Marcinkiewicz K, Scotland KB, Boorjian SA, Nilsson EM, Persson JL, Abrahamsson PA, Allegrucci C, Hughes IA, Gudas LJ, Mongan NP. Int J Oncol. 2012 Jan;40(1):5-12. doi: 10.3892/ijo.2011.1212. Epub 2011 Sep 28. Review. PMID:21956088

Loss of INI1 Protein Expression Defines a Subgroup of Aggressive Central Nervous System Primitive Neuroectodermal Tumors. Miller S, Ward JH, Rogers HA, Lowe J, Grundy RG. Brain Pathol. 2012 Jun 1.

Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis. Picard D, Miller S, Hawkins CE, Bouffet E, Rogers HA, Chan TS, Kim SK, Ra YS, Fangusaro J, Korshunov A, Toledano H, Nakamura H, Hayden JT, Chan J, Lafay-Cousin L, Hu P, Fan X, Muraszko KM, Pomeroy SL, Lau CC, Ng HK, Jones C, Van Meter T, Clifford SC, Eberhart C, Gajjar A, Pfister SM, Grundy RG, Huang A. Lancet. Oncol. 2012 Jun 8.

Objective assessment of blood and lymphatic vessel invasion and association with macrophage infiltration in cutaneous melanoma. SJ Storr, S Safuan, A Mitra, F Elliott, C Walker, MJ Vasko, B Ho, M Cook, RAA Mohammed, P Patel, IO Ellis, JA Newton-Bishop, SG. Martin. Modern Pathology 25(4):493-504. 2012.

Base excision repair, the redox environment and therapeutic implications. SJ Storr, CM. Woolston, SG. Martin. Current Molecular Pharmacology 5(1):88-101. 2012.

Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer. SJ Storr, S Safuan, CM. Woolston, T Abdel-Fatah, S Deen, SY. Chan, SG. Martin (2012). Journal of Cellular and Molecular Medicine 16(10):2422-8.

The prognostic and predictive power of redox protein expression for anthracycline based chemotherapy response in locally advanced breast cancer. CM Woolston, SJ Storr, L Zhang, A Al-Attar; M Shehata; IO Ellis, SY Chan; SG Martin. Modern Pathology. 2012;25(8):1106-16.

Calpain system protein expression in basal-like and triple-negative invasive breast cancer. SJ. Storr, K Lee, CM. Woolston, S Safuan, AR. Green, RD Macmillan, A Benhasouna, T Parr, IO. Ellis, SG. Martin (2012). Annals of Oncology; 23(9):2289-96.

The Expression of Angiogenic Chemokines in Ovarian Clear Cell Carcinoma. L Quattrocchi, M Sisson, SG Martin, L Durrant, S Deen (2012). Journal of Obstetrics and Gynaecology Research 39(1):297-304.

Coexpression of CA9 and VEGF in epithelial ovarian carcinoma and relationship to survival. E Williams, R.Moss, S Martin, I Spendlove, L Durrant, S Deen (2012). Virchows Archiv 461(1):33-9.

A comparative study of adhesion of melanoma and breast cancer cells to blood and lymphatic endothelium. S Safuan, SJ.Storr, PM.Patel, SG.Martin (2012). Lymphatic Research and Biology 10(4):173-81.

Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla. SJ Storr, AM Zaitoun, A Arora, LG Durrant, DN Lobo, S Madhusudan and SG Martin (2012). BMC Cancer 12:511-520.

Redox environment, free radical and oxidative DNA damage. S Storr, C Woolston, Y Zhang, S Martin (2012). Antioxid Redox Signal. 2012 Dec 18 [Epub ahead of print] PMID:23249296.

Loss of Dicer expression is associated with breast cancer progression and recurrence. Khoshnaw SM, Rakha EA, Abdel-Fatah TM, Nolan CC, Hodi Z, Macmillan DR, Ellis IO, Green AR. Breast Cancer Res Treat. 2012 Jul 21. [Epub ahead of print]

Comparison of the PharmDx Immunohistochemical System With Standard Methods for Assessing Estrogen and Progesterone Receptors in Invasive Carcinoma of the Breast. Gill MS, Paish EC, Ronan J, Green AR, Ellis IO, Lee AH. Appl Immunohistochem Mol Morphol. 2012 Jul 19. [Epub ahead of print]

Innovating information-delivery for potential clinical trials participants. What do patients want from multi-media resources? Shneerson C, Windle R, Cox K. Patient Educ Couns. 2012 Jul 19. [Epub ahead of print]

Development and validation of a high throughput system for discovery of antigens for autoantibody detection. Macdonald IK, Allen J, Murray A, Parsy-Kowalska CB, Healey GF, Chapman CJ, Sewell HF, Robertson JF. PLoS One. 2012;7(7):e40759. Epub 2012 Jul 18.

Using rule-based machine learning for candidate disease gene prioritization and sample classification of cancer gene expression data. Glaab E, Bacardit J, Garibaldi JM, Krasnogor N. PLoS One. 2012;7(7):e39932. Epub 2012 Jul 11.

Effects of allogeneic red blood cell transfusions on clinical outcomes in patients undergoing colorectal cancer surgery: a systematic review and meta-analysis. Acheson AG, Brookes MJ, Spahn DR. Ann Surg. 2012 Aug;256(2):235-44.

Radiotherapy as sole adjuvant treatment for older patients with low-risk breast cancer. Walker GA, Kaidar-Person O, Kuten A, Morgan DA. Breast. 2012 Jul 2. [Epub ahead of print]

Primary cutaneous B cell lymphoma in Nottinghamshire UK-prognosis of sub-types defined in the WHO-EORTC classification. Bessell EM, Humber CE, O'Connor S, English JS, Perkins W, Dickinson PD, Patel AN. Br J Dermatol. 2012 Jul 3.

Adjuvant Therapy in Stage I Carcinoma of the Breast: The Influence of Multigene Analyses and Molecular Phenotyping. Schwartz GF, Bartelink H, Burstein HJ, Cady B, Cataliotti L, Fentiman IS, Holland R, Hughes KS, Masood S, McCormick B, Palazzo JA, Pressman PI, Reis-Filho J, Pusztai L, Rutgers EJ, Seidman AD, Solin LJ, Sparano JA. Breast J. 2012 Jul;18(4):303-311.

Low-Estrogen Receptor-Positive Breast Cancer: The Impact of Tissue Sampling, Choice of Antibody, and Molecular Subtyping. Rakha EA, Lee AH, Roberts J, Villena Salinas NM, Hodi Z, Ellis IO, Reis-Filho JS. J Clin Oncol. 2012 Jul 2.

New anticancer immunotherapies. Franks HA, Wang Q, Patel PM. Anticancer Res. 2012 Jul;32(7):2439-53.

C-Terminal Tensin-Like Gene Functions as an Oncogene and Promotes Cell Motility in Pancreatic Cancer. Al-Ghamdi S, Cachat J, Albasri A, Ahmed M, Jackson D, Zaitoun A, Guppy N, Otto WR, Alison MR, Kindle KB, Ilyas M. Pancreas. 2012 Jun 28. [Epub ahead of print]

Measurement Methods and Algorithms for the Management of Solid Nodules. Nair A, Baldwin DR, Field JK, Hansell DM, Devaraj A. J Thorac Imaging. 2012 Jun 12. [Epub ahead of print]

Salvage radiotherapy after high intensity focused ultrasound for prostate cancer. Dickinson P, Sundar S. BMJ Case Rep. 2012 Jun 8.

Spirolactone, a possible selective androgen receptor modulator, should be used with caution in patients with metastatic carcinoma of the prostate. Sundar S, Dickinson PD. BMJ Case Rep. 2012 Feb 25;2012.

Effect of colon cancer and surgical resection on skeletal muscle mitochondrial enzyme activity in colon cancer patients: a pilot study. Phillips BE, Smith K, Liptrot S, Atherton PJ, Varadhan K, Rennie MJ, Larvin M, Lund JN, Williams JP. J Cachexia Sarcopenia Muscle. 2012 May 31

Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study. Hippisley-Cox J, Coupland C. BMJ. 2012 May 22;344:e3427.

Statistical methods for survival analysis in oesophageal cancer. Rao VP. Eur J Cardiothorac Surg. 2012

Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy. Fareed KR, Soomro IN, Hameed K, Arora A, Lobo DN, Parsons SL, Madhusudan S. World J Gastroenterol. 2012 Apr 28;18(16):1915-20

Encapsulated papillary carcinoma of the breast: a study of invasion associated markers. Rakha EA, Tun M, Junainah E, Ellis IO, Green A. J Clin Pathol. 2012 May 3.

Fatty acid binding protein 7 expression and its sub-cellular localization in breast cancer. Alshareeda AT, Rakha EA, Nolan CC, Ellis IO, Green AR. Breast Cancer Res Treat. 2012 Jul;134(2):519-29.

New insights regarding the regulation of chemotaxis by nucleotides, adenosine, and their receptors. Corriden R, Insel PA. Purinergic Signal. 2012 Sep;8(3):587-98.

MicroRNAs: Relevant Tools for a Colorectal Surgeon? Peacock O, Lee AC, Larvin M, Tufarelli C, Lund JN. World J Surg. 2012 Aug;36(8):1881-92

Identifying patients with suspected pancreatic cancer in primary care: derivation and validation of an algorithm. Hippisley-Cox J, Coupland C. Br J Gen Pract. 2012 Jan;62(594):e38-45.

EarlyCDT®-Lung test: improved clinical utility through additional autoantibody assays. Chapman CJ, Healey GF, Murray A, Boyle P, Robertson C, Peek LJ, Allen J, Thorpe AJ, Hamilton-Fairley G, Parsy-Kowalska CB, Macdonald IK, Jewell W, Maddison P, Robertson JF. Tumour Biol. 2012 Apr 11.

Inter-observer variability in the histological assessment of colorectal polyps detected through the NHS Bowel Cancer Screening Programme. Foss FA, Milkins S, McGregor AH. Histopathology. 2012 Jul;61(1):47-52.

The prognostic and predictive power of redox protein expression for anthracycline-based chemotherapy response in locally advanced breast cancer. Woolston CM, Zhang L, Storr SJ, Al-Attar A, Shehata M, Ellis IO, Chan SY, Martin SG. Mod Pathol. 2012 Apr 6

The addition of the farnesyl transferase inhibitor, tipifarnib, to low dose cytarabine does not improve outcome for older patients with AML. Burnett AK, Russell NH, Culligan D, Cavanagh J, Kell J, Wheatley K, Virchis A, Hills RK, Milligan D; on behalf of the AML Working Group of the UK National Cancer Research Institute. Br J Haematol. 2012 May 29.

Role of HCT-comorbidity index, age and disease status at transplantation in predicting survival and non-relapse mortality in patients with myelodysplasia and leukemia undergoing reduced-intensity-conditioning hemopoeitic progenitor cell transplantation. Bokhari SW, Watson L, Nagra S, Cook M, Byrne JL, Craddock C, Russell NH. Bone Marrow Transplant. 2012 Apr;47(4):528-34.

The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis. Morgan GJ, Gregory WM, Davies FE, Bell SE, Szubert AJ, Brown JM, Coy NN, Cook G, Russell NH, Rudin C, Roddie H, Drayson MT, Owen RG, Ross FM, Jackson GH, Child JA; National Cancer Research Institute Haematological Oncology Clinical Studies Group. Blood. 2012 Jan 5;119(1):7-15.

Haematopoietic stem cell transplantation (HSCT) in severe autoimmune diseases: analysis of UK outcomes from the British Society of Blood and Marrow Transplantation (BSBMT) data registry 1997-2009. Snowden JA, Pearce RM, Lee J, Kirkland K, Gilleece M, Veys P, Clark RE, Kazmi M, Abinun M, Jackson GH, Mackinnon S, Russell NH, Cook G; BSBMT Clinical Trials Committee. Br J Haematol. 2012 Jun;157(6):742-6.

Neutral risk of lung cancer in adults with celiac disease - nationwide cohort study. Ludvigsson JF, West J, Hubbard R, Card T. Lung Cancer. 2012 Sep 26. pii: S0169-5002(12)00527-2. doi: 10.1016/j.lungcan.2012.09.003. [Epub ahead of print] PubMed PMID: 23021207.

The long-term risk of malignancy following a diagnosis of coeliac disease or dermatitis herpetiformis: a cohort study. Grainge MJ, West J, Solaymani-Dodaran M, Card TR, Logan RF. Aliment Pharmacol Ther. 2012 Mar;35(6):730-9. doi: 10.1111/j.1365-2036.2012.04998.x. Epub 2012 Jan 30. PubMed PMID: 22288441.

Aspirin and other non-steroidal anti-inflammatory drug use and colorectal cancer survival: a cohort study. Walker AJ, Grainge MJ, Card TR. Br J Cancer. 2012 Sep 25.

Risk of venous thromboembolism in patients with cancer: a systematic review and meta-analysis. Horsted F, West J, Grainge MJ. PLoS Med. 2012 Jul;9(7):e1001275.

Keeping an open mind: highlights and controversies of the breast cancer stem cell theory. Shah M, Allegrucci C. Breast Cancer:Targets and Therapy 2012,4;155-166.

The Androgen Receptor And Stem Cell Pathways In Prostate And Bladder Cancers. Marcinkiewicz K, Scotland KB, Boorjian SA, Nilsson EM, Persson JL, Abrahamsson PA, Allegrucci C, Hughes IA, Gudas LJ, Mongan NP. International Journal Of Oncology 2012,40(1);5-12.

Overcoming drug resistance and treating advanced prostate cancer. Semenas J, Allegrucci C, Boorjian SA, Mongan NP, Persson JL. Current drug targets 2012,13(10);1308-2.

Early Diagnosis and Screening in Lung Cancer. Cancer Science and Therapy 2012.

Measurement Methods and Algorithms for the Management of Solid Nodules. Nair A, Deveraj A, Baldwin DR, Field JK, Hansell DM. 2012. Journal of Thoracic Imaging 27(4):230-9.

The (US) National Lung Cancer Screening trial: intensifying the debate about the introduction of screening for lung cancer. Baldwin DR. 2012. J R Coll Physicians Edinb. 42:131-2.

Lung Cancer: Investigation and Staging. 2012. Medicine 40:194-201.

NICE Quality Standard for Lung Cancer. Baldwin DR. 2012. Guidelines in Practice 15:50-59.

What determines patient preferences for treating low risk basal cell carcinoma when comparing surgery vs imiquimod? A discrete choice experiment survey from the SINS trial. Tinelli M, Ozolins M, Bath-Hextall F, Williams HC. 2012. BMC Dermatology 12:19.

Progression from First Symptom To Diagnosis In Childhood Brain Tumours. Wilne S, Collier J, Kennedy C, Jenkins A, Grout J, Mackie S, Koller K, Grundy R and Walker D. 2012. European Journal of Pediatrics. 171(1),87-93.

A dynamic 3D brain cancer model recapitulates neoplastic phenotypes and molecular signatures with decreased sensitivity to histone deacetylase inhibition. Smith SJ, Wilson M, Ward JH, Rahman CV, Peet AC, Macarthur DC, Rose FRAJ, Grundy RG, Rahman R. 2012. PLoS One; 7(12).

Adjuvant chemotherapy for brain tumours delivered via a novel intra-cavity mouldable polymer matrix. Rahman CV, Smith SJ, PS Morgan, Langmack KA, Macarthur DC, Rose FR, Shakesheff KM, Grundy RG, Rahman R. Manuscript accepted in Cancer Letters pending minor revision (2012).

Accurate classification of childhood brain tumours by in vivo(1)H MRS - A multi-centre study. Vicente J, Fuster-Garcia E, Tortajada S, García-Gómez JM, Davies N, Natarajan K, Wilson M, Grundy RG, Wesseling P, Monleón D, Celda B, Robles M, Peet AC. 2012. Eur J Cancer.

Magnetic resonance spectroscopy metabolite profiles predict survival in paediatric brain tumours. Wilson M, Cummins CL, Macpherson L, Sun Y, Natarajan K, Grundy RG, Arvanitis TN, Kauppinen RA, Peet AC. 2012. Eur J Cancer.

CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma. Smith SJ, Tilly H, Ward JH, Macarthur DC, Lowe J, Coyle B, Grundy RG. 2012. Acta Neuropathol, 124(1):99-110.

WNT/catenin pathway activation in Myc immortalized cerebellar progenitor cells inhibits neuronal differentiation and generates tumors resembling medulloblastoma. Rogers HA, Sousa S, Salto C, Arenas E, Coyle B, and Grundy RG. 2012. British Journal of Cancer 107(7):1144-52.

Supratentorial and spinal ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death. Rogers HA, Kilday JP, Mayne C, Ward J, Adamowicz-Brice M, Schwalbe E, Clifford SC, Coyle B, Grundy RG. 2012. Acta Neuropathol 123(5):711-25.

International Association for the Study of Lung Cancer Computed Tomography Screening Workshop 2011 Report. Field JK, Smith RA, Aberle DR, Oudkerk M, Baldwin DR et al. 2012. Journal of Thoracic Oncology 7(1):10-19.

What is the most effective follow-up model for lung cancer patients? A systematic review. Schmidt-Hansen, Baldwin DR, Hasler E. 2012. Journal of Thoracic Oncology 7:821-824.

Early Diagnosis and Screening in Lung cancer. Baldwin DR, Hubbard RB. 2012. Cancer Science and Therapy s7.

Measurement Methods and Algorithms for the Management of Solid Nodules. Nair A, Deveraj A, Baldwin DR, Field JK, Hansell DM. 2012. Journal of Thoracic Imaging 27(4):230-9.

The (US) National Lung Cancer Screening trial: intensifying the debate about the introduction of screening for lung cancer. Baldwin DR. 2012. J R Coll Physicians Edinb 42:131-2.

Lung Cancer: Investigation and Staging. Baldwin DR. 2012. Medicine 40:194-201.

Supportive Care in Respiratory Disease 2nd Ed. Ahmedzai SH, Baldwin DR, Currow DC. 2012. Oxford University Press. ISBN 978-0-19-959176-3.

Comparison of liver parenchymal ablation and tissue necrosis in a cadaveric bovine model using the Harmonic Scalpel, the LigaSure, the Cavitron Ultrasonic Surgical Aspirator and the Aquamantys devices. Hammond JS, Muirhead W, Zaitoun AM, Cameron IC, Lobo DN. HPB (Oxford). 2012 Dec;14(12):828-32.

Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS(®)) Society recommendations. Gustafsson UO, Scott MJ, Schwenk W, Demartines N, Roulin D, Francis N, McNaught CE, Macfie J, Liberman AS, Soop M, Hill A, Kennedy RH, Lobo DN, Fearon K, Ljungqvist O. Clin Nutr. 2012 Dec;31(6):783-800.

Guidelines for perioperative care for pancreaticoduodenectomy: Enhanced Recovery After Surgery (ERAS(®)) Society recommendations. Lassen K, Coolsen MM, Slim K, Carli F, de Aguilar-Nascimento JE, Schäfer M, Parks RW, Fearon KC, Lobo DN, Demartines N, Braga M, Ljungqvist O, Dejong CH; on behalf of the ERAS(®) Society, the European Society for Clinical Nutrition and Metabolism and the International Association for Surgical Metabolism and Nutrition. Clin Nutr. 2012 Dec;31(6):817-830.

Guidelines for perioperative care in elective rectal/pelvic surgery: Enhanced Recovery After Surgery (ERAS(®)) Society recommendations. Nygren J, Thacker J, Carli F, Fearon KC, Norderval S, Lobo DN, Ljungqvist O, Soop M, Ramirez J. Clin Nutr. 2012 Dec;31(6):801-16.

Are DNA Repair Factors Promising Biomarkers for Personalized Therapy in Gastric Cancer? Abdel-Fatah T, Arora A, Gorguc I, Abbotts R, Beebeejaun S, Storr S, Mohan V, Hawkes C, Soomro I, Lobo DN, Parsons SL, Madhusudan S. Antioxid Redox Signal. 2012 Oct 19.

A meta-analysis of the effect of combinations of immune modulating nutrients on outcome in patients undergoing major open gastrointestinal surgery. Marimuthu K, Varadhan KK, Ljungqvist O, Lobo DN. Ann Surg. 2012 Jun;255(6):1060-8.

Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla. Storr SJ, Zaitoun AM, Arora A, Durrant LG, Lobo DN, Madhusudan S, Martin SG. BMC Cancer. 2012 Nov 9;12:511

Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms. Tan, Thomas C.J., Rahman, Ruman, Jaber Hijazi, Farah, Felix, Daniel A., Chen, Chen, Louis, Edward J. and A. Aziz Aboobaker. 2012. PNAS 109:4209-4214

Embryonic NANOG Activity Defines Colorectal Cancer Stem Cells and Modulates through AP1- and TCF-dependent Mechanisms. Ibrahim, E. E., Babaei-Jadidi, R., Saadeddin, A., Spencer-Dene, B., Hossaini, S., Abuzinadah, M., Li, N., Fadhil, W., Ilyas, M., Bonnet, D. and Nateri, A. S. (2012), STEM CELLS, 30: 2076–2087.

The practice of continuous deep sedation until death in Belgium, the Netherlands and the United Kingdom: A comparative study. Anquinet, L., Rietjens, J.A., Seale, C., Seymour, J., Deliens, L., van der Heide A. (2012) Journal of Pain and Symptom Management. 44(1):33-43

Looking back, looking forward: the evolution of palliative and end of life care in England. Seymour, J.E. (2012) Mortality, 7(1).

The experiences of relatives with the practice of palliative sedation: A systematic review. Bruinsma, S.M., Rietjens, J.A., Seymour, J.E., Anquinet, L., van der Heide, A. (2012) Journal of Pain and Symptom Management.

Liminality as a framework for understanding the experience of cancer survivorship: a literature review. Blows, E., Bird, L., Seymour, J., Cox, J. (2012) Journal of Advanced Nursing.

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