RLO: ACCE Framework - Introduction

Introduction

The ACCE framework is a helpful model in order to emphasise the key components of a genetic test evaluation.

ACCE stands for:

Analytical validity
Clinical validity
Clinical utility
Ethical, legal and social implications of genetic testing

The guiding principle of the ACCE framework is that the evaluation of genetic tests should be an integrated approach including all domains.

At the core of the framework is the need to define the genetic test and the healthcare setting in which it is going to be used. Without these definitions, the evaluation will produce results of limited value.

Each component of the ACCE framework contains sub-components to be considered when evaluating a genetic test. We will not go into these sub-components in detail, but you can view them by rolling over the shaded area.