Respiratory Medicine
We have a breadth of respiratory research within the School of Medicine in terms of conditions, research skills and opportunities.
Respiratory Research is part of the Translational Medical Sciences (TMS) academic unit with sites at City Hospital campus, Nottingham, (clinical translational, epidemiology and CTIMPs), the Biodiscovery Institute, University Park (basic science) and Queens Medical Centre (clinical translational and CTIMPS). The respiratory theme of the NIHR Nottingham Biomedical Research Centre (BRC) facilitates a lot of the respiratory research.
We can provide training across basic science, mechanistic, clinical translational, clinical trials, complex interventions and epidemiology), with university clinical academic PIs focusing on airways disease (COPD and asthma), rare diseases (including LAM), parenchymal lung disease (including LAM and ILD), lung cancer, acute and chronic infection, cystic fibrosis, global health, lung health linked to premature birth and multimorbidity.
For clinical academics, clinical training is usually delivered at Nottingham University Hospitals Trust, Sherwood Forest Hospitals Trust (Mansfield) and the Royal Derby Hospital. There are strengths in asthma, COPD, lung cancer, infection, cystic fibrosis and bronchiectasis, interstitial lung disease (ILD)including hosting the national lymphangioleiomatosis (LAM) Centre, pleural disease, ventilation and thromboembolic disease. There are opportunities to train within critical care and respiratory support centres.
There are active links with colleagues within Epidemiology, respiratory paediatrics, Sir Peter Mansfield Imaging Centre, David Greenfield Human Physiology Unit, digital health and bioinformatics.
We have a strong track record of training in respiratory clinical academia – at foundation level as well as Academic Clinical Fellows, Clinical Research Fellows and Clinical Lecturers. Many have gone on to become research leads and senior clinical academics.
Academic Clinical Lecturers
Ireti Adejumo
"I am a clinical academic trainee in Respiratory Medicine, having completed my PhD in digital health in asthma. I have ongoing interests in the role of social determinants of asthma health and in digital health. I am undertaking pilot work to inform a Fellowship application assessing the roles of socioeconomic status and race/ethnicity on UK asthma outcomes.
"I am also involved in the European Respiratory Society CONNECT Clinical Research Collaboration, a network seeking to inform the implementation of digital health in Respiratory care at a regional level."
For more information about Ireti's research, please see Ireti's ORCiD page.
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Ireti Adejumo
Amanda Goodwin
Amanda obtained her medicine degree from the University of Liverpool in 2010, then pursued clinical academic training in the East Midlands. She obtained her PhD in 2021 as part of an MRC Clinical Research Training Fellowship and is continuing this work funded by Asthma + Lung UK and The Academy of Medical Sciences.
Her laboratory research focuses on the molecular mechanisms of lung development and repair, specifically related to extracellular matrix biology and mechanical signalling, which has implications for drug development in chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), and bronchopulmonary dysplasia (BPD).
She is also co-lead of a national clinical research project aiming to understanding acute exacerbations of ILD, which may ultimately lead to the identification of prognostic markers and interventional clinical trials in this poorly understood area.
For more information about Amanda's research, please see Amanda's ORCiD page.
Amanda Goodwin
Frances Grudzinska
Frances is an academic clinical lecturer in Respiratory Medicine. Frances was awarded a PhD investigating factors influencing outcomes for older adults with community acquired pneumonia.
Frances’ research interest is community-acquired pneumonia. Her research spans the immunological deficits seen in pneumonia, understanding patient priorities and outcome measures through to establishing who is at risk of adverse outcome following CAP.
For more information about Frances's research, please see Frances's ORCiD page.
Ayushman Gupta
"I am an ST6 Respiratory registrar currently working as a clinical lecturer in Nottingham since August 2024. My previous research experience includes a PhD in assessing multi-organ physiological sequelae of severe COVID-19 in the long-term. I utilised novel functional MRI techniques during simultaneous supine exercise, in order to understand mechanisms of persistent fatigue.
"My current research interests include experimental medicine focusing on COPD and recovery from acute respiratory illnesses with applied functional MR imaging. For my clinical lectureship, I aim to build on my PhD work and incorporate the in-bore exercise protocol with other imaging modalities, to stress the body and assess changes in physiology in different organs and clinical states.
"At present I am conducting feasibility of the exercise protocol with functional lung MRI in healthy volunteers to assess regional changes in ventilation. I aim to use this as proof of principal to study regional ventilatory response to exercise in patients with stable COPD to better understand mechanisms of exertional dyspnoea. I hope this will form the basis for application to an advanced fellowship whereby exercise induced ventilatory changes can be assessed following specific interventions, e.g. lung volume reduction, to further improve clinical effectiveness. "
For more information about Ayushman's research, please see Ayushman's ORCiD page.
Frances Grudzinska
Ayushman Gupta
Find out more
More information about Respiratory Research at the University of Nottingham
More information about the NIHR Nottingham Biomedical Research Centre and the respiratory theme
For more information about Professor Charlotte Bolton and to contact her for queries about ACF and CL research opportunities, please visit her staff profile on the School of Medicine website.