Preclinical models of Osteoarthritis pain: from Bench to Clinic and back again
- MIA Model of OA: monosodium iodoacetate (MIA) is a glycolytic inhibitor, the injection of which leads to behavioural, histological and biochemical events that reflect human osteoarthritis pathology and joint pain. In the animal model, the symptoms manifest by biphasic pain behaviours and inflammatory phases.
- MNX Model of OA: this model involved the transection of the medial collateral ligament which is followed by a full-thickness cut through the meniscus. This procedure causes pathological processes which resemble post-traumatic human OA. The effects are produced by an existing instability and incongruity between joint surfaces.
- DMM Model of OA: The model of destabilization of the medial meniscus (DMM) is useful for studying the onset and progression of posttraumatic osteoarthritis (OA) as well as the structural and biological processes throughout the progression of the pathology. The procedure results in physiological changes that mimic clinical meniscal injury which is a factor that predisposes to OA pathology.
