Alessandro Maria Carabelli

Contact

• workRoom C28 Boots Science Building
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 951 5151
• Ale.Carabelli@nottingham.ac.uk

Biography

As an NRF fellow, I am currently focusing on controlling the foreign body response related to macro-devices used for cellular therapeutic delivery in diabetes treatment. This research, a collaborative effort between MIT and the University of Nottingham, represents a cutting-edge frontier in biomedical engineering. I'm excited to contribute my expertise to this innovative field.

Prior to this, I worked as a consultant in the life sciences sector, advising on a range of projects spanning clinical research and biotechnology. This role further honed my skills in applying scientific innovation to real-world challenges. My previous research experience includes a significant stint at the University of Cambridge, where I joined in 2020. There, I contributed to virology research, focusing notably on SARS-CoV-2 evolution and the impact of mutations on viral fitness and immune escape. My work led to the identification of the British Alpha variant.

Before Cambridge, I completed my PhD at the University of Nottingham (2015-2019) under the guidance of Professors Paul Williams, Morgan Alexander, and Andrew Hook. My doctoral research focused on discovering acrylate polymers resistant to bacterial attachment and uncovering the biological mechanisms driving these interactions. These experiences at Nottingham and Cambridge have deepened my passion for research that has a meaningful impact on society.

Expertise Summary

Cell therapies for type I diabetes, novel biomaterial development, characterize immune responses to bio-materials, in vivo testing various diabetes models, complex hydrogel manufacture and system design

Recent Publications

• CARABELLI, A. M., PEACOCK, T. P., THORNE, L. G., HARVEY, W. T., HUGHES, J., COVID- GENOMICS UK CONSORTIUM, PEACOCK, S. J., BARCLAY, W. S., DE SILVA, T. I., TOWERS, G. J. and ROBERTSON, D. L., 2023. SARS-CoV-2 variant biology: immune escape, transmission and fitness: Nat Rev Microbiol Nat Rev Microbiol. 21(3), 162-177
• COX, M., PEACOCK, T. P., HARVEY, W. T., HUGHES, J., WRIGHT, D. W., COVID- GENOMICS UK CONSORTIUM, WILLETT, B. J., THOMSON, E., GUPTA, R. K., PEACOCK, S. J., ROBERTSON, D. L. and CARABELLI, A. M., 2023. SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies: Nat Rev Microbiol Nat Rev Microbiol. 21(2), 112-124
• DUBERN, J. F., HOOK, A. L., CARABELLI, A. M., CHANG, C. Y., LEWIS-LLOYD, C. A., LUCKETT, J. C., BURROUGHS, L., DUNDAS, A. A., HUMES, D. J., IRVINE, D. J., ALEXANDER, M. R. and WILLIAMS, P., 2023. Discovery of a polymer resistant to bacterial biofilm, swarming, and encrustation: Sci Adv Sci Adv. 9(4), eadd7474
• KOTOWSKA, A. M., ZHANG, J., CARABELLI, A., WATTS, J., AYLOTT, J. W., GILMORE, I. S., WILLIAMS, P., SCURR, D. J. and ALEXANDER, M. R., 2023. Toward Comprehensive Analysis of the 3D Chemistry of Pseudomonas aeruginosa Biofilms: Anal Chem Anal Chem. 95(49), 18287-18294

• View all publications

• CARABELLI, A. M., PEACOCK, T. P., THORNE, L. G., HARVEY, W. T., HUGHES, J., COVID- GENOMICS UK CONSORTIUM, PEACOCK, S. J., BARCLAY, W. S., DE SILVA, T. I., TOWERS, G. J. and ROBERTSON, D. L., 2023. SARS-CoV-2 variant biology: immune escape, transmission and fitness: Nat Rev Microbiol Nat Rev Microbiol. 21(3), 162-177
• COX, M., PEACOCK, T. P., HARVEY, W. T., HUGHES, J., WRIGHT, D. W., COVID- GENOMICS UK CONSORTIUM, WILLETT, B. J., THOMSON, E., GUPTA, R. K., PEACOCK, S. J., ROBERTSON, D. L. and CARABELLI, A. M., 2023. SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies: Nat Rev Microbiol Nat Rev Microbiol. 21(2), 112-124
• DUBERN, J. F., HOOK, A. L., CARABELLI, A. M., CHANG, C. Y., LEWIS-LLOYD, C. A., LUCKETT, J. C., BURROUGHS, L., DUNDAS, A. A., HUMES, D. J., IRVINE, D. J., ALEXANDER, M. R. and WILLIAMS, P., 2023. Discovery of a polymer resistant to bacterial biofilm, swarming, and encrustation: Sci Adv Sci Adv. 9(4), eadd7474
• KOTOWSKA, A. M., ZHANG, J., CARABELLI, A., WATTS, J., AYLOTT, J. W., GILMORE, I. S., WILLIAMS, P., SCURR, D. J. and ALEXANDER, M. R., 2023. Toward Comprehensive Analysis of the 3D Chemistry of Pseudomonas aeruginosa Biofilms: Anal Chem Anal Chem. 95(49), 18287-18294
• DUBERN, J. F., ROMERO, M., MAI-PROCHNOW, A., MESSINA, M., TRAMPARI, E., GIJZEL, H. N., CHAN, K. G., CARABELLI, A. M., BARRAUD, N., LAZENBY, J., CHEN, Y., ROBERTSON, S., MALONE, J. G., WILLIAMS, P., HEEB, S. and CAMARA, M., 2022. ToxR is a c-di-GMP binding protein that modulates surface-associated behaviour in Pseudomonas aeruginosa: NPJ Biofilms Microbiomes NPJ Biofilms Microbiomes. 8(1), 64
• HILL, V., DU PLESSIS, L., PEACOCK, T. P., AGGARWAL, D., COLQUHOUN, R., CARABELLI, A. M., ELLABY, N., GALLAGHER, E., GROVES, N., JACKSON, B., MCCRONE, J. T., O'TOOLE, A., PRICE, A., SANDERSON, T., SCHER, E., SOUTHGATE, J., VOLZ, E., BARCLAY, W. S., BARRETT, J. C., CHAND, M., CONNOR, T., GOODFELLOW, I., GUPTA, R. K., HARRISON, E. M., LOMAN, N., MYERS, R., ROBERTSON, D. L., PYBUS, O. G. and RAMBAUT, A., 2022. The origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 in the UK: Virus Evol Virus Evol. 8(2), veac080
• WRIGHT, D. W., HARVEY, W. T., HUGHES, J., COX, M., PEACOCK, T. P., COLQUHOUN, R., JACKSON, B., ORTON, R., NIELSEN, M., HSU, N. S., COVID- GENOMICS UK CONSORTIUM, HARRISON, E. M., DE SILVA, T. I., RAMBAUT, A., PEACOCK, S. J., ROBERTSON, D. L. and CARABELLI, A. M., 2022. Tracking SARS-CoV-2 mutations and variants through the COG-UK-Mutation Explorer: Virus Evol Virus Evol. 8(1), veac023
• ROMERO, M., CARABELLI, A., R. SWIFT M and I. SMITH M, 2022. Fluid dynamics and cell-bound Psl polysaccharide allows microplastic capture, aggregation and subsequent sedimentation by Pseudomonas aeruginosa in water: Environ Microbiol Environ Microbiol. 24(3), 1560-1572
• HARVEY, W. T., CARABELLI, A. M., JACKSON, B., GUPTA, R. K., THOMSON, E. C., HARRISON, E. M., LUDDEN, C., REEVE, R., RAMBAUT, A., COVID- GENOMICS UK CONSORTIUM, PEACOCK, S. J. and ROBERTSON, D. L., 2021. SARS-CoV-2 variants, spike mutations and immune escape: Nat Rev Microbiol Nat Rev Microbiol. 19(7), 409-424
• MENG, B., KEMP, S. A., PAPA, G., DATIR, R., FERREIRA, IATM, MARELLI, S., HARVEY, W. T., LYTRAS, S., MOHAMED, A., GALLO, G., THAKUR, N., COLLIER, D. A., MLCOCHOVA, P., COVID- GENOMICS UK CONSORTIUM, DUNCAN, L. M., CARABELLI, A. M., KENYON, J. C., LEVER, A. M., DE MARCO, A., SALIBA, C., CULAP, K., CAMERONI, E., MATHESON, N. J., PICCOLI, L., CORTI, D., JAMES, L. C., ROBERTSON, D. L., BAILEY, D. and GUPTA, R. K., 2021. Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7: Cell Rep Cell Rep. 35(13), 109292
• CARABELLI, A. M., ISGRO, M., SANNI, O., FIGUEREDO, G. P., WINKLER, D. A., BURROUGHS, L., BLOK, A. J., DUBERN, J. F., PAPPALARDO, F., HOOK, A. L., WILLIAMS, P. and ALEXANDER, M. R., 2020. Single-Cell Tracking on Polymer Microarrays Reveals the Impact of Surface Chemistry on Pseudomonas aeruginosa Twitching Speed and Biofilm Development: ACS Appl Bio Mater ACS Appl Bio Mater. 3(12), 8471-8480
• HOOK, A. L., FLEWELLEN, J. L., DUBERN, J. F., CARABELLI, A. M., ZAID, I. M., BERRY, R. M., WILDMAN, R. D., RUSSELL, N., WILLIAMS, P. and ALEXANDER, M. R., 2019. Simultaneous Tracking of Pseudomonas aeruginosa Motility in Liquid and at the Solid-Liquid Interface Reveals Differential Roles for the Flagellar Stators: mSystems mSystems. 4(5),
• WAIT, R., BEGUM, S., BRAMBILLA, D., CARABELLI, A. M., CONSERVA, F., ROCCO GUERINI, A., EBERINI, I., BALLERIO, R., GEMEINER, M., MILLER, I. and GIANAZZA, E., 2005. Redox options in two-dimensional electrophoresis: Amino Acids Amino Acids. 28(3), 239-72