Felicity De Cogan

Contact

• workRoom D11 Boots Science Building
  University Park
  Nottingham
  NG7 2RD
  UK
• Felicity.DeCogan@nottingham.ac.uk

Biography

I attained an MChem in Chemistry from the University of York in 2008. I then joined the University of Manchester to undertake a PhD under the supervision of Professor Julie Gough and Dr Simon Webb. I then moved to the University of Birmingham to undertake postdoctoral positions in Material Science, Drug Delivery, Ophthalmology and Translational Healthcare Technologies. I was awarded the ARVO/Genentech Fellowship in 2015, The Royal Academy of Engineering Enterprise Fellowship in 2016 and the Birmingham Fellowship in 2017. I joined the University of Nottingham in 2022 as Assistant Professor in the School of Pharmacy.

Research Summary

My research focuses on the design and translation of novel technologies from bench to bedside to solve clinical problems in 3 main areas:

1) Delivery of biological molecules. Biological therapeutics are key treatments for a number of diseases. However, the delivery of the therapeutic to the target location can be challenging. My research focuses on drug delivery and penetration enhancing systems which can translocate the target therapeutic into tissue.

2) Development of synthetic alternatives to biologicals for the treatment of disease. The manufacture of biological molecules on the scale and purity level required for treatment can be challenging. This research focuses on developing small synthetic alternatives to desired biological molecules to accelerate the pathway to the clinic.

3) Development of novel antimicrobial technologies. With the global problem of antimicrobial resistance the need for novel antimicrobial technologies is pressing. My research focuses on developing a range of antimicrobial materials from coating implantable orthopaedic materials to developing anti-viral air filters.

Recent Publications

• ROWAN WATSON, MORWENNA OLDFIELD, JACK A BRYANT, LILY RIORDAN, HARRIET J HILL, JULIE A WATTS, MORGAN R ALEXANDER, MICHAEL J COX, ZANIA STAMATAKI, DAVID J SCURR and FELICITY DE COGAN, 2022. Efcacy of antimicrobial and anti‑viral coated air flters Efficacy of antimicrobial and anti‑viral coated air filters to prevent the spread of airborne pathogens pathogens Nature Sci Rep.. 9(12), 1
• BRYANT JA, RIORDAN L, WATSON R, NIKOI ND, TRZASKA W, SLOPE L, TIBBATTS C, ALEXANDER MR, SCURR DJ, MAY RC and DE COGAN F, 2022. Stability of Cell-Penetrating Peptide anti-VEGF Formulations for the Treatment of Age-Related Macular Degeneration Global Challenges. 8(6), 5
• NIKOI ND, BERWICK M, BRYANT JA, RIORDAN L, SLOPE L, PEACOCK AFA and DE COGAN F, 2021. Stability of Cell-Penetrating Peptide anti-VEGF Formulations for the Treatment of Age-Related Macular Degeneration Current Eye Research. 46(5), 751
• SLOPE L, HILL MG, SMITH CF, TEARE P, DE COGAN F, BRITTON MM and PEACOCK AFA, 2020. Tuning Coordination chemistry through second sphere in designed metallocoiled coils Chemical Communications. 4(56), 26

• View all publications

• ROWAN WATSON, MORWENNA OLDFIELD, JACK A BRYANT, LILY RIORDAN, HARRIET J HILL, JULIE A WATTS, MORGAN R ALEXANDER, MICHAEL J COX, ZANIA STAMATAKI, DAVID J SCURR and FELICITY DE COGAN, 2022. Efcacy of antimicrobial and anti‑viral coated air flters Efficacy of antimicrobial and anti‑viral coated air filters to prevent the spread of airborne pathogens pathogens Nature Sci Rep.. 9(12), 1
• BRYANT JA, RIORDAN L, WATSON R, NIKOI ND, TRZASKA W, SLOPE L, TIBBATTS C, ALEXANDER MR, SCURR DJ, MAY RC and DE COGAN F, 2022. Stability of Cell-Penetrating Peptide anti-VEGF Formulations for the Treatment of Age-Related Macular Degeneration Global Challenges. 8(6), 5
• NIKOI ND, BERWICK M, BRYANT JA, RIORDAN L, SLOPE L, PEACOCK AFA and DE COGAN F, 2021. Stability of Cell-Penetrating Peptide anti-VEGF Formulations for the Treatment of Age-Related Macular Degeneration Current Eye Research. 46(5), 751
• SLOPE L, HILL MG, SMITH CF, TEARE P, DE COGAN F, BRITTON MM and PEACOCK AFA, 2020. Tuning Coordination chemistry through second sphere in designed metallocoiled coils Chemical Communications. 4(56), 26
• RIORDAN, LILY, SMITH, EMILY F., MILLS, STUART, HUDSON, JAMES, STAPLEY, SARAH, NIKOI, NAA-DEI, EDMONDSON, STEFAN, BLAIR, JESSICA, PEACOCK, ANNA F. A., SCURR, DAVID, FORSTER, GRAEME and DE COGAN, FELICITY, 2019. Directly bonding antimicrobial peptide mimics to steel and the real world applications of these materials MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. 102, 299-304
• CHOUHAN G, MOAKES RJA, ESMAEILI M, HILL LJ, DE COGAN F, HARWICKE J, RAUZ S, LOGAN A and GROVER LM, 2019. A self-healing hydrogel eye drop for the sustained delivery of decorin to prevent corneal scarring Biomaterials. 210, 41
• MOHAMMED S, CHOUHAN G, ANUFOROM O, COOKE M, WALSH A, MORGAN-WARREN P, JENKINS M and DE COGAN F, 2017. Thermosensitive hydrogel as an in situ gelling antimicrobial ocular dressing. 1(78), 203
• DE COGAN F, HILL LJ, LYNCH A, MORGAN-WARREN P, LECHNER J, BERWICK M, PEACOCK AFA, CHEN M, SCOTT RAH and XU H, 2017. Topical delivery of Anti-VEGF Drugs to the Ocular Posterior Segment using cell penetrating Peptides IOVS. 1(58), 5
• TOWNSEND L, WILLIAMS RL, ANUFOROM O, BERWICK M, HALSTEAD F, HUGHES E, STAMBOULIS A, OPPENHEIM B, GOUGH J, GROVER LM, SCOTT RAH, WEBBER M, PEACOCK AFA, BELLI A, LOGAN A and DE COGAN F, 2017. Antimicrobial peptide coatings for hydroxyapatite: Electrostatic and covalent attachment of antimicrobial peptides to surfaces J R Soc INterface. 14(126), 20160657
• MORGAN-WARREN P, O'NEILL J, DE COGAN F, SPIVAK I, ASHUSH H, KALINSKI H, AHMED Z, BERRY M, FEINSTEIN E, SCOTT RAH and LOGAN A, 2016. siRNA-Mediated Knockdown of the mTOR Inhibitor RTP801 Promotes Retinal Ganglion Cell Survival and Axon Elongation by Direct and Indirect Mechanisms. IOVS. 57(2), 429
• KELLY M, WILLIAMS RL, AOJULA A, O'NEILL J, TRZINSCKA Z, GROVER LM, SCOTT RAH, PEACOCK AFA, LOGAN A, STAMBOULIS A and DE COGAN F, 2015. Peptide aptamers: Novel Coatings for Orthopaedic Implants Material Science and Engineering C. 54, 83
• HILL LJ, MEAD B, BLANCH RJ, AHMED Z, DE COGAN F, MORGAN-WARREN P, MOHAMED S, LEADBEATER W, SCOTT RAH, BERRY M and LOGAN A, 2015. Decorin Reduces Intraocular Pressure and Retinal Ganglion Cell Loss in Rodents Through Fibrolysis of the Scarred Trabecular meshwork IOVS. 56(6), 3743
• DE COGAN F, BOOTH A, GOUGH J and WEBB SJ, 2011. Conversion of Magnetic Impulses into Cellular Responses by Self-assembled nanoparticle-vesicle hydrogels Angewandte Chemie International Edition. 50(51), 12290
• DE COGAN F, GOUGH J and WEBB SJ, 2011. Adhesive Interactions Between Cells and Biotinylated Phospholipid Vesicles in Alginate: Towards new Responsive Biomaterials Journal of Material Science Materials in Medicine. 22(4), 1045