Staff listing for the Biomolecular Science and Medicinal Chemistry Division
Ingrid Dreveny
Associate Professor, Faculty of Science
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Biography
I received my training as a chemist at the University of Graz. As a Masters student at the University Louis Pasteur, Strasbourg, I studied the folding and structure of synthetic peptides. This work sparked my interest and fascination for protein structure from which I pursued a Ph.D. in protein crystallography under the supervision of Christoph Kratky, working on the structure and mechanism of an unusual flavoprotein that has wide-ranging applications in industrial biocatalysis.
During my postdoctoral years at Imperial College London in the laboratory of Paul Freemont and Xiaodong Zhang I uncovered how the multi-functional molecular machine, the AAA ATPase p97, that has been associated with neurodegenerative diseases and cancer, recognizes adaptor proteins. After a brief period as research fellow in the School of Pharmacy, University of Nottingham, I was appointed lecturer in protein crystallography.
Research Summary
I am interested in how macromolecular structure determines function and can help explain cellular events. My main area of expertise is macromolecular X-ray crystallography, which I combine with other… read more
Current Research
I am interested in how macromolecular structure determines function and can help explain cellular events. My main area of expertise is macromolecular X-ray crystallography, which I combine with other biophysical and biochemical techniques. My research is aimed at:
- Establishing protein structure - function relationships
- Characterising protein-protein and protein-ligand interactions
- Uncovering the molecular basis of human diseases
Current research topics include:
- Structure and function of proteases in the ubiquitin pathway
- Molecular mechanism of enzymes in posttranslational modification pathways
- Protein complexes in ciliary trafficking
- Enzymes for pharmaceutical applications
For further details please visit the Structural Biology group website.
Memberships of Committees & Professional Bodies
Biochemical Society; British Crystallographic Association