Contact

• workRoom C06 Biodiscovery Institute
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 84 66863
• Michael.Stocks@nottingham.ac.uk

Biography

I am a synthetic medicinal chemist with a PhD in organic chemistry under the supervision of Professor Philip Kocienski (University of Southampton 1991). I have over 20 years' experience in Medicinal Chemistry in the pharmaceutical industry through my career at Fisons, Astra and then AstraZeneca. I have worked in most areas of medicinal chemistry concentrating recent efforts on GPCR-based drug discovery projects most recently delivering AstraZeneca's beta-2 and muscarinic M3 inhalation projects into clinical development. I was appointed as project leader for designing and delivering chemical libraries (both targeted and diversity based) to enhance the AstraZeneca compound collection, a program that lasted for 4 years. During this time I worked with contract research organisations in China, Russia and India and recruited 2 industrial post-doctoral fellows to discover both new multi-component reactions delivering drug-like molecules as well as exploring the synthesis of new 3-dimesional scaffolds for use in medicinal chemistry. I have been co-author and inventor on over 50 publications and patent applications and recently co-authored a new "primer" book in medicinal chemistry: Stocks, Alcaraz and Griffen: On medicinal Chemistry.

In April 2012, I made the transition into academia and was appointed as Associate Professor in Medicinal Chemistry in the Division of Medicinal Chemistry and Structural Biology.

Research Summary

My research interests are focused on early stage drug discovery designing and synthesising new chemical scaffolds to interact with biological targets generating both high-quality tool compounds and… read more

Selected Publications

• GROSSMAN, SCOTT, SOUKARIEH, FADI, RICHARDSON, WILLIAM, LIU, RUILING, MASHABI, ALAA, EMSLEY, JONAS, WILLIAMS, PAUL, CAMARA, MIGUEL and STOCKS, MICHAEL J, 2020. Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR. European Journal of Medicinal Chemistry. 208, 112778
• SOU, T., SOUKARIEH, F., WILLIAMS, P., STOCKS, M.J., C'AMARA, M. and BERGSTR'OM, C.A.S., 2020. Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions ACS Omega.
• SOUKARIEH, FADI, LIU, RUILING, ROMERO, MANUEL, ROBERSTON, SHAUN N, RICHARDSON, WILLIAM, LUCANTO, SIMONE, OTON, EDUARD VICO, QUDUS, NAIM RUHUL, MASHABI, ALAA, GROSSMAN, SCOTT, ALI, SADIQUR, SOU, TOM'AS, KUKAVICA-IBRULJ, IRENA, LEVESQUE, ROGER C, BERGSTR'OM, CHRISTEL A S, HALLIDAY, NIGEL, MISTRY, SHAILESH N, EMSLEY, JONAS, HEEB, STEPHAN, WILLIAMS, PAUL, C'AMARA, MIGUEL and STOCKS, MICHAEL J, 2020. Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa Frontiers in Chemistry. 8, 204

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Current Research

My research interests are focused on early stage drug discovery designing and synthesising new chemical scaffolds to interact with biological targets generating both high-quality tool compounds and lead-like compounds to probe biological targets and provide the starting points for successful drug discovery programs.

• Utilising synthetic and physical chemistry to address and overcome drug discovery issues such as; hit and lead optimisation, absorption, metabolism and compound selectivity.
• Conformational analysis and structure-based drug design.
• Fragment based drug design - designing and optimising high-quality fragments and libraries.
• Combining synergistic pharmacology's within a single small molecule.

Expertise areas:

Drug Discovery, Design, Medicinal Chemistry, Lead Optimisation & Identification, Multi-parameter Optimization, Inhalation and Oral delivery, Fragment & Structure Based Drug Design, ADME , Synthetic Chemistry.

• GROSSMAN, SCOTT, SOUKARIEH, FADI, RICHARDSON, WILLIAM, LIU, RUILING, MASHABI, ALAA, EMSLEY, JONAS, WILLIAMS, PAUL, CAMARA, MIGUEL and STOCKS, MICHAEL J, 2020. Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR. European Journal of Medicinal Chemistry. 208, 112778
• SOU, T., SOUKARIEH, F., WILLIAMS, P., STOCKS, M.J., C'AMARA, M. and BERGSTR'OM, C.A.S., 2020. Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions ACS Omega.
• SOUKARIEH, FADI, LIU, RUILING, ROMERO, MANUEL, ROBERSTON, SHAUN N, RICHARDSON, WILLIAM, LUCANTO, SIMONE, OTON, EDUARD VICO, QUDUS, NAIM RUHUL, MASHABI, ALAA, GROSSMAN, SCOTT, ALI, SADIQUR, SOU, TOM'AS, KUKAVICA-IBRULJ, IRENA, LEVESQUE, ROGER C, BERGSTR'OM, CHRISTEL A S, HALLIDAY, NIGEL, MISTRY, SHAILESH N, EMSLEY, JONAS, HEEB, STEPHAN, WILLIAMS, PAUL, C'AMARA, MIGUEL and STOCKS, MICHAEL J, 2020. Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa Frontiers in Chemistry. 8, 204
• ADLERE, ILZE, CASPAR, BIRGIT, ARIMONT, MARTA, DEKKERS, SEBASTIAN, VISSER, KIRSTEN, STUIJT, JEFFREY, DE GRAAF, CHRIS, STOCKS, MICHAEL, KELLAM, BARRIE, BRIDDON, STEPHEN, WIJTMANS, MAIKEL, DE ESCH, IWAN, HILL, STEPHEN and LEURS, ROB, 2019. Modulators of CXCR4 and CXCR7/ACKR3 function Molecular Pharmacology. mol.119.117663
• BOSQUILLON, C, PANDUGA, V and STOCKS, M J, 2019. Understanding the mechanisms controlling inhaled drug retention in the lungs using human bronchial epithelial cell layers In: BRITISH JOURNAL OF PHARMACOLOGY. 3009
• FENN, SAMUEL, DUBERN, JEAN-FREDERIC, STOCKS, MICHAEL, ELMSLEY, JONAS and CAMARA, MIGUEL, 2019. Identification of a nitrite reductase in Pseudomonas aeruginosa as a potential antimicrobial target Access Microbiology. 1(1A), 635
• SOUKARIEH, F., OTON, E.V., DUBERN, J.-F., GOMES, J., HALLIDAY, N., DE PILAR CRESPO, M., RAMÍREZ-PRADA, J., INSUASTY, B., ABONIA, R., QUIROGA, J., HEEB, S., WILLIAMS, P., STOCKS, M.J. and CÁMARA, M., 2018. In silico and in vitro-guided identification of inhibitors of alkylquinolone-dependent quorum sensing in pseudomonas aeruginosa: Molecules Molecules. 23,
• CITOSSI, FRANCESCA, SMITH, THOMAS, LEE, JONG BONG, SEGAL, JOEL, GERSHKOVICH, PAVEL, STOCKS, MICHAEL JOHN, BRADSHAW, TRACEY D, KELLAM, BARRIE and MARLOW, MARIA, 2018. Self-assembling benzothiazole-based gelators: a mechanistic understanding of in vitro bioactivation and gelation: Molecular Pharmaceutics Molecular Pharmaceutics. acs.molpharmaceut.7b01106
• SKILLING, KATHRYN J., STOCKS, MICHAEL J., KELLAM, BARRIE, ASHFORD, MARIANNE, BRADSHAW, TRACEY, BURROUGHS, LAURENCE and MARLOW, MARIA, 2018. Nucleoside Based Self-Assembling Drugs for Localized Drug Delivery ChemMedChem.
• CONROY, SEAN, KINDON, NICHOLAS D., GLENN, JACQUELINE, STODDART, LEIGH A., LEWIS, RICHARD JAMES, HILL, STEPHEN J., KELLAM, BARRIE and STOCKS, MICHAEL JOHN, 2018. Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y 2 Receptor Based on AR-C118925 Journal of Medicinal Chemistry. 61(7), 3089-3113
• SOU, TOMAS, KUKAVICA-IBRULJ, IRENA, SOUKARIEH, FADI, HALLIDAY, NIGEL, LEVESQUE, ROGER C, WILLIAMS, PAUL, STOCKS, MICHAEL, CAMARA, MIGUEL, FRIBERG, LENA E and BERGSTROM, CHRISTEL A S, 2018. Model-based drug development in pulmonary delivery: Pharmacokinetic analysis of novel drug candidates for treatment of Pseudomonas aeruginosa lung infection. Journal of pharmaceutical sciences.
• SOUKARIEH, FADI, WILLIAMS, PAUL, STOCKS, MICHAEL JOHN and CAMARA, MIGUEL., 2018. Pseudomonas aeruginosa Quorum Sensing Systems as Drug Discovery Targets: Current Position and Future Perspectives. Journal of Medicinal Chemistry. Ahead of Print
• LEE, JONG BONG, ZGAIR, ATHEER, MALEC, JED, KIM, TAE HWAN, KIM, MIN GI, ALI, JOSEPH, QIN, CHAOLONG, FENG, WANSHAN, CHIANG, MANTING, GAO, XIZHE, VORONIN, GREGORY, GARCES, AIMIE E, LAU, CHUN LONG, CHAN, TING-HOI, HUME, AMY, MCINTOSH, TECASHANELL M, SOUKARIEH, FADI, AL-HAYALI, MOHAMMED, CIPOLLA, ELENA, COLLINS, HILARY M, HEERY, DAVID M, SHIN, BEOM SOO, YOO, SUN DONG, KAGAN, LEONID, STOCKS, MICHAEL J, BRADSHAW, TRACEY D, FISCHER, PETER M and GERSHKOVICH, PAVEL., 2018. Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system. Journal of Controlled Release. 286, 10-19
• GARCES, AIMIE E and STOCKS, MICHAEL J, 2018. Class 1 PI3K Clinical Candidates and Recent Inhibitor Design Strategies: A Medicinal Chemistry Perspective. Journal of Medicinal Chemistry. Ahead of Print
• SCHWEHM, CAROLIN, KELLAM, BARRIE, GARCES, AIMIE E., HILL, STEPHEN J., KINDON, NICHOLAS D., BRADSHAW, TRACEY D., LI, JIN, MACDONALD, SIMON J. F., ROWEDDER, JAMES E., STODDART, LEIGH A. and STOCKS, MICHAEL J., 2017. Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C–C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase $delta$ (PI3K$delta$) Inhib Journal of Medicinal Chemistry. acs.jmedchem.6b01801
• PANDUGA V, STOCKS MJ and BOSQUILLON C, 2017. Ipratropium is 'luminally recycled' by an inter-play between apical uptake and efflux transporters in Calu-3 bronchial epithelial cell layers. International journal of pharmaceutics. (In Press.)
• KINDON, NICHOLAS, ANDREWS, GLEN, BAXTER, ANDREW, CHESHIRE, DAVID, HEMSLEY, PAUL, JOHNSON, TIMOTHY, LIU, YU-ZHEN, MCGINNITY, DERMOT, MCHALE, MARK, METE, ANTONIO, REUBERSON, JAMES, ROBERTS, BRYAN, STEELE, JOHN, TEOBALD, BARRY, UNITT, JOHN, VAUGHAN, DEBORAH, WALTERS, IAIN and STOCKS, MICHAEL J., 2017. Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists ACS Medicinal Chemistry Letters. acsmedchemlett.7b00315
• KINDON N, DAVIS A, DOUGALL I, DIXON J, JOHNSON T, WALTERS I, THOM S, MCKECHNIE K, MEGHANI P and STOCKS MJ, 2017. From UTP to AR-C118925, the discovery of a potent non nucleotide antagonist of the P2Y2 receptor. Bioorganic & medicinal chemistry letters. 27(21), 4849-4853
• MICHAEL J. STOCKS, SEAN CONROY and BARRIE KELLAM, 2016. Drug-like antagonists of P2Y receptors - from lead identification to drug development Journal of Medicinal Chemistry.
• MARLOW, MARIA, AL-AMEEDEE, MOHAMMED, SMITH, THOMAS, WHEELER, SIMON and STOCKS, MICHAEL J., 2015. Linifanib - a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator CHEMICAL COMMUNICATIONS. 51(29), 6384-6387
• SCHWEHM, CAROLIN, LI, JIN, SONG, HONGMEI, HU, XIAO, KELLAM, BARRIE and STOCKS, MICHAEL J., 2015. Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold: ACS Medicinal Chemistry Letters ACS Medicinal Chemistry Letters. 6, 324-328
• STOCKS, MICHAEL, 2015. Structure-Based Design of Drugs and Other Bioactive Molecules . Edited by Arun K. Ghosh and Sandra Gemma: ChemMedChem ChemMedChem. 10, 926-928
• STONE, ERICA L., CITOSSI, FRANCESCA, SINGH, RAJINDER, KAUR, BALVINDER, GASKELL, MARGARET, FARMER, PETER B., MONKS, ANNE, HOSE, CURTIS, STEVENS, MALCOLM F.G., LEONG, CHEE-ONN, STOCKS, MICHAEL, KELLAM, BARRIE, MARLOW, MARIA and BRADSHAW, TRACEY D., 2015. Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery: Bioorganic & Medicinal Chemistry Bioorganic & Medicinal Chemistry. 23, 6891-6899
• MARLOW, MARIA, AL-AMEEDEE, MOHAMMED, SMITH, THOMAS, WHEELER, SIMON and STOCKS, MICHAEL J., 2015. Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator: Chem. Commun. Chem. Commun.. 51, 6384-6387
• MICHAEL J STOCKS, LILIAN ALCARAZ, ANDREW BAILEY, ROGER BONNERT, ELAINE CADOGAN, JADEEN CHRISTIE, JOHN DIXON, STEPHEN CONNOLLY, ANTHONY COOK, STUART PAINE, 2014. Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action ACS Med Chem Lett.
• BRIOCHE, JULIEN, COURANT, THIBAUT, ALCARAZ, LILIAN, STOCKS, MICHAEL, FURBER, MARK, ZHU, JIEPING and MASSON, GÉRALDINE, 2014. Chiral Phosphoric Acid-Catalyzed Enantioselective Three- Component Aza-Diels-Alder Reactions of Aminopyrroles and Aminopyrazoles: Advanced Synthesis & Catalysis Advanced Synthesis & Catalysis. 356, 1719-1724
• SCHWEHM, CAROLIN, LEWIS, WILLIAM, BLAKE, ALEXANDER J., KELLAM, BARRIE and STOCKS, MICHAEL J., 2014. Preparation and structural analysis of (±)- cis -ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)- trans -ethyl 2-oxooctahydro-1 H -pyrrolo[3,2- c ]pyridine-5-carboxylate: Acta Crystallographica Section C Structural Chemistry Acta Crystallographica Section C Structural Chemistry. 70, 1161-1168
• STOCKS, MICHAEL J, ALCARAZ, LILIAN, BAILEY, ANDREW, BONNERT, ROGER, CADOGAN, ELAINE, CHRISTIE, JADEEN, DIXON, JOHN, CONNOLLY, STEPHEN, COOK, ANTHONY, FISHER, ADRIAN, FLAHERTY, ALICE, HUMPHRIES, ALEXANDER, INGALL, ANTHONY, JORDAN, STEPHEN, LAWSON, MANDY, MULLEN, ALEX, NICHOLLS, DAVID, PAINE, STUART, PAIRAUDEAU, GARRY and YOUNG, ALAN, 2014. Discovery of AZD3199, An Inhaled Ultralong Acting β 2 Receptor Agonist with Rapid Onset of Action: ACS Med. Chem. Lett. ACS Med. Chem. Lett.. 5, 416-421
• ALCARAZ, L., BAILEY, A., CADOGAN, E., CONNOLLY, S., JEWELL, R., JORDAN, S., KINDON, N., LISTER, A., LAWSON, M., MULLEN, A., DAINTY, I., NICHOLLS, D., PAINE, S., PAIRAUDEAU, G., STOCKS, M.J., THORNE, P. and YOUNG, A., 2012. From libraries to candidate: the discovery of new ultra long-acting dibasic β2-adrenoceptor agonists Bioorganic & Medicinal Chemistry Letters. 22(1), 689-95
• SU Y, BOUMA MJ, ALCARAZ L, STOCKS M, FURBER M, MASSON G and ZHU J, 2012. Organocatalytic enantioselective one-pot four-component ugi-type multicomponent reaction for the synthesis of epoxy-tetrahydropyrrolo[3,4-b]pyridin-5-ones. Chemistry (weinheim an der bergstrasse, germany). 18(40), 12624-7
• CONNOLLY, S., ALCARAZ, L., BAILEY, A., CADOGAN, E., CHRISTIE, J., COOK, A.R., FISHER, A.J., HILL, S., HUMPHRIES, A., INGALL, A.H., KANE, Z., PAINE, S., PAIRAUDEAU, G., STOCKS, M.J. and YOUNG, A., 2011. Design-driven LO: the discovery of new ultra long acting dibasic β₂-adrenoceptor agonists Bioorganic & Medicinal Chemistry Letters. 21(15), 4612-4616
• STOCKS, M.J., ALCARAZ, L., BAILEY, A., BONNERT, R., CADOGAN, E., CHRISTIE, J., CONNOLLY, S., COOK, A., FISHER, A., FLAHERTY, A., HILL, S., HUMPHRIES, A., INGALL, A., JORDAN, S., LAWSON, M., MULLEN, A., NICHOLLS, D., PAINE, S., PAIRAUDEAU, G., ST-GALLAY, S. and YOUNG, A., 2011. Design driven HtL: the discovery and synthesis of new high efficacy β₂-agonists Bioorganic & Medicinal Chemistry Letters. 21(13), 4027-4031
• EDMAN, K, FURBER, M, HEMSLEY, P, JOHANSSON, C, PAIRAUDEAU, G, PETERSEN, J, STOCKS, M, TERVO, A, WARD, A, WELLS, E and WISSLER, L, 2011. The discovery of mmp7 inhibitors exploiting a novel selectivity trigger Chemmedchem. 6(5), 769-773
• ROBERTS, B, LIPTROT, D, LUKER, T, STOCKS, MJ, BARBER, C, WEBB, N, DODS, R and MARTIN, B, 2011. Molybdenum-mediated synthesis of quinazolin-4(3h)-ones via cyclocarbonylation using microwave irradiation Tetrahedron Letters. 52(29), 3793-3796
• ROBERTS, BRYAN, LIPTROT, DAVID, LUKER, TIM, STOCKS, MICHAEL J, BARBER, CATHERINE, WEBB, NICOLA, DODS, ROBERT and MARTIN, BARRIE, 2011. ChemInform Abstract: Molybdenum-Mediated Synthesis of Quinazolin-4(3H)-ones via Cyclocarbonylation Using Microwave Irradiation: ChemInform ChemInform. 42, no-no
• ROBERTS B, LIPTROT D, ALCARAZ L, LUKER T and STOCKS MJ, 2010. Molybdenum-mediated carbonylation of aryl halides with nucleophiles using microwave irradiation. Organic letters. 12(19), 4280-3
• STOCKS, MJ, ALCARAZ, L, BAILEY, A, BOWERS, K, DONALD, D, EDWARDS, H, HUNT, F, KINDON, N, PAIRAUDEAU, G, THEAKER, J and WARNER, DJ, 2010. The discovery of new spirocyclic muscarinic m-3 antagonists Bioorganic & Medicinal Chemistry Letters. 20(24), 7458-7461
• JOHNSON, TIM, CHESHIRE, DAVID R, STOCKS, MICHAEL J and THURSTON, VICKY T, 2010. ChemInform Abstract: A Carbonyl Ylide Approach to Substituted Furans: ChemInform ChemInform. 32, no-no
• STOCKS MJ, WILDEN GRH, PAIRAUDEAU G, PERRY MWD, STEELE J and STONEHOUSE JP, 2009. A practical method for targeted library design balancing lead-like properties with diversity. Chemmedchem. 4(5), 800-8
• SMITH, NM, GREAVES, MJ, JEWELL, R, PERRY, MWD, STOCKS, MJ and STONEHOUSE, JP, 2009. One-pot, three-component copper-catalysed 'click' triazole synthesis utilising the inexpensive, shelf-stable diazotransfer reagent imidazole-1-sulfonyl azide hydrochloride Synlett. 1391-1394
• GUILE, SD, ALCARAZ, L, BIRKINSHAW, TN, BOWERS, KC, EBDEN, MR, FURBER, M and STOCKS, MJ, 2009. Antagonists of the p2x(7) receptor. From lead identification to drug development Journal of Medicinal Chemistry. 52, 3123-3141
• STONEHOUSE, JP, CHEKMAREV, DS, IVANOVA, NV, LANG, S, PAIRAUDEAU, G, SMITH, N, STOCKS, MJ, SVIRIDOV, SI and UTKINA, LM, 2008. One-pot four-component reaction for the generation of pyrazoles and pyrimidines Synlett. 100-104
• HAMZA, D, STOCKS, MJ, DECOR, A, PAIRAUDEAU, G and STONEHOUSE, JP, 2007. Synthesis of novel 2,6-diazaspiro[3.3]heptanes Synlett. 2584-2586
• STOCKS, MJ, HAMZA, D, PAIRAUDEAU, G, STONEHOUSE, JP and THORNE, PV, 2007. Concise synthesis of novel 2,6-diazaspiro [3.3] heptan-1-ones and their conversion into 2,6-diazaspiro[3.3]heptanes Synlett. 2587-2589
• BOURQUE, E, KOCIENSKI, PJ, STOCKS, M and YUEN, J, 2005. Synthesis of the c14-c28 fragment of tetronasin Synthesis-Stuttgart. 3219-3224
• STOCKS, MJ, BARBER, S, FORD, R, LEROUX, F, ST-GALLAY, S, TEAGUE, S and XUE, YF, 2005. Structure-driven htl: Design and synthesis of novel aminoindazole inhibitors of c-jun n-terminal kinase activity Bioorganic & Medicinal Chemistry Letters. 15(14), 3459-3462
• STOCKS, MJ, CHESHIRE, DR and REYNOLDS, R, 2004. Efficient and regiospecific one-pot synthesis of substituted 1,2,4-triazoles Organic Letters. 6(17), 2969-2971
• JOHNSON, TIM, CHESHIRE, DAVID R, STOCKS, MICHAEL J and THURSTON, VICKY T, 2001. A Carbonyl Ylide Approach to Substituted Furans: Synlett Synlett. 0646-0648
• JAROWICKI, K, KOCIENSKI, P, NORRIS, S, OSHEA, M and STOCKS, M, 1995. Synthesis of the c16-c23 effector domain of fk-506 via copper-catalyzed metalate rearrangement of an alpha-alkoxyalkenylcuprate Synthesis-Stuttgart. 195-198
• TEAGUE, SJ, COOPER, ME and STOCKS, MJ, 1995. Synthesis of fk506-cyclosporine hybrid macrocycles Bioorganic & Medicinal Chemistry Letters. 5(20), 2341-2346
• STOCKS, MJ, HARRISON, RP and TEAGUE, SJ, 1995. Macrocyclic ring closures employing the intramolecular heck reaction Tetrahedron Letters. 36(36), 6555-6558
• JAROWICKI, KRZYSZTOF, KOCIENSKI, PHILIP, NORRIS, SIMON, O’SHEA, MICHAEL and STOCKS, MICHAEL, 1995. Synthesis of the C16-C23 Effector Domain of FK-506 via Copper-Catalysed Metallate Rearrangement of an α-Alkoxyalkenylcuprate: Synthesis Synthesis. 1995, 195-198
• STOCKS, MJ, BIRKINSHAW, TN and TEAGUE, SJ, 1994. The contribution to binding of the pyranoside substituents in the excised binding domain of fk-506 Bioorganic & Medicinal Chemistry Letters. 4(12), 1457-1460
• CAFFREY, MV, CLADINGBOEL, DE, COOPER, ME, DONALD, DK, FURBER, M, HARDERN, DN, HARRISON, RP, STOCKS, MJ and TEAGUE, SJ, 1994. Synthesis and evaluation of dual domain macrocyclic fkbp12 ligands Bioorganic & Medicinal Chemistry Letters. 4(21), 2507-2510
• TEAGUE, SJ and STOCKS, MJ, 1993. The affinity of the excised binding domain of fk-506 for the immunophilin fkbp12 Bioorganic & Medicinal Chemistry Letters. 3(10), 1947-1950
• BARTHOLOMEW, D and STOCKS, MJ, 1991. Intramolecular cyclization-n-dealkylation of azetidine-3-acetic acids Tetrahedron Letters. 32(36), 4799-4800
• BARTHOLOMEW, D and STOCKS, MJ, 1991. A novel rearrangement reaction conversion of 3-(chloromethyl)azetidin-2-ones to azetidine-3-carboxylic acid-esters Tetrahedron Letters. 32(36), 4795-4798
• KOCIENSKI, P, STOCKS, M, DONALD, D and PERRY, M, 1990. A synthesis of the c24-c34 segment of fk-506
• STOCKS, M, KOCIENSKI, P and DONALD, DK, 1990. A synthesis of the c16-c23 segment of fk-506 Tetrahedron Letters. 31(11), 1637-1640
• KOCIEŃSKI, PHILIP, STOCKS, MICHAEL, DONALD, DAVID and PERRY, MATHEW, 1990. A Synthesis of the C24-C34 Segment of FK 506: Synlett Synlett. 1990, 38-39
• KOCIENSKI, PHILIP, STOCKS, MICHAEL and DONALD, DAVID K, 1990. Recent Progress in Research on the Immunosuppressant FK-506
• KOCIENSKI, P, STOCKS, M, DONALD, D, COOPER, M and MANNERS, A, 1988. A synthesis of the c(1)-c(15) segment of tsukubaenolide (fk 506) Tetrahedron Letters. 29(35), 4481-4484