ŠTAKA I, CADETE A, SURIKUTCHI BT, ABUZAID H, BRADSHAW TD, ALONSO MJ and MARLOW M, 2019. A novel low molecular weight nanocomposite hydrogel formulation for intra-tumoural delivery of anti-cancer drugs. International journal of pharmaceutics. 565, 151-161 AL-ANI, ALI W, ZHANG, LEI, FERREIRA, LENNY, TURYANSKA, LYUDMILA, BRADSHAW, TRACEY D and THOMAS, NEIL R, 2019. Listeria innocua Dps as a nanoplatform for bioluminescence based photodynamic therapy utilizing Gaussia princeps luciferase and zinc protoporphyrin IX. Nanomedicine : nanotechnology, biology, and medicine. 20, 102005 HOSSAN MS, CHAN ZY, COLLINS HM, SHIPTON FN, BUTLER MS, RAHMATULLAH M, LEE JB, GERSHKOVICH P, KAGAN L, KHOO TJ, WIART C and BRADSHAW TD, 2019. Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition. Cancer letters. 453, 57-73 LIU, ZHIMIN, TURYANSKA, LYUDMILA, ZAMBERLAN, FRANCESCO, PACIFICO, SALVATORE, BRADSHAW, TRACEY D, MORO, FABRIZIO, FAY, MICHAEL W, WILLIAMS, HUW and THOMAS, NEIL R, 2019. Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells. Nanotechnology. 30, 505102 A F BREEN, G WELLS, L TURYANSKA and T D BRADSHAW, 2019. Development of novel apoferritin formulations for antitumour benzothiazoles. Cancer Reports. 2, e1155 KAOUTHAR BOUZINAB, HELEN SUMMERS, JIHONG ZHANG, MALCOLM F. G. STEVENS, CHRISTOPHER J. MOODY, LYUDMILA TURYANSKA, NEIL R. THOMAS, PAVEL GERSHKOVICH, MARIANNE B. ASHFORD, EMILY VITTERSO, LISA C. D. STORER, RICHARD GRUNDY and TRACEY D. BRADSHAW, 2019. In search of effective therapies to overcome resistance to Temozolomide in brain tumours Cancer Drug Resistance. 2, GARCES, AIMIE E., AL-HAYALI, MOHAMMED, LEE, JONG BONG, LI, JIAXIN, GERSHKOVICH, PAVEL, BRADSHAW, TRACEY D. and STOCKS, MICHAEL J., 2019. Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer ACS Medicinal Chemistry Letters. acsmedchemlett.9b00378 BOUZINAB, KAOUTHAR, THOMAS, NEIL R., TURYANSKA, LYUDMILA, GERSHKOVICH, PAVEL, WESTON, NICOLA, ASHFORD, MARIANNE B. and BRADSHAW, TRACEY D., 2019. TARGETING BRAIN TUMOURS: APOFERRITIN NANOCAGE FOR DELIVERY OF NOVEL ANALOGUES OF TEMOZOLOMIDE NEURO-ONCOLOGY. 21, 4-4 JC QUILLES, FR ROCHCO, CA MONTANARI, A LEITAO, VW MIGNONE, MA ARRUDA, L TURYANSKA and TD BRADSHAW, 2019. Apoferritin-encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells. RSC Advances. 9, 36699-36706 ABID, MOHAMMED, NOUCH, RYAN, BRADSHAW, TRACEY D., LEWIS, WILLIAM and WOODWARD, SIMON, 2019. Tripodal O-N-O Bis-Phenolato Amine Titanium(IV) Complexes Show High in vitro Anti-Cancer Activity EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. 2774-2780 YANG, ZHIKUAN, WEI, DANPING, DAI, XIAOLI, STEVENS, MALCOLM F. G., BRADSHAW, TRACEY D., LUO, YING and ZHANG, JIHONG, 2019. C8-Substituted Imidazotetrazine Analogs Overcome Temozolomide Resistance by Inducing DNA Adducts and DNA Damage FRONTIERS IN ONCOLOGY. 9, ZAMBERLAN, F., TURYANSKA, L., PATANE, A., LIU, Z., WILLIAMS, H. E. L., FAY, M. W., CLARKE, P. A., IMAMURA, Y., JIN, T., BRADSHAW, T. D., THOMAS, N. R. and GRABOWSKA, A. M., 2018. Stable DHLA-PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging: Journal of Materials Chemistry B Journal of Materials Chemistry B. 6(4), 550-555 BIN BREAK, MOHAMMED KHALED, HOSSAN, MD SHAHADAT, KHOO, YIVONN, QAZZAZ, MOHANNAD EMAD, AL-HAYALI, MOHAMMED Z. K., CHOW, SEK CHUEN, WIART, CHRISTOPHE, BRADSHAW, TRACEY D., COLLINS, HILARY and KHOO, TENG-JIN, 2018. Discovery of a highly active anticancer analogue of cardamonin that acts as an inducer of caspase-dependent apoptosis and modulator of the mTOR pathway FITOTERAPIA. 125, 161-173 SANTOS, MARILIA S., NORTCLIFFE, ANDREW, LEWIS, WILLIAM, BRADSHAW, TRACEY D. and MOODY, CHRISTOPHER J., 2018. 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Self-Assembling Benzothiazole-Based Gelators: A Mechanistic Understanding of in Vitro Bioactivation and Gelation MOLECULAR PHARMACEUTICS. 15(4), 1578-1586 LEE JB, ZGAIR A, MALEC J, KIM TH, KIM MG, ALI J, QIN C, FENG W, CHIANG M, GAO X, VORONIN G, GARCES AE, LAU CL, CHAN TH, HUME A, MCINTOSH TM, SOUKARIEH F, AL-HAYALI M, CIPOLLA E, COLLINS HM, HEERY DM, SHIN BS, YOO SD, KAGAN L, STOCKS MJ, BRADSHAW TD, FISCHER PM and GERSHKOVICH P, 2018. Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system. Journal of controlled release : official journal of the Controlled Release Society. 286, 10-19 SMEDLEY, CHRISTOPHER J., STANLEY, PAUL A., QAZZAZ, MOHANNAD E., PROTA, ANDREA E., OLIERIC, NATACHA, COLLINS, HILARY, EASTMAN, HARRY, BARROW, ANDREW S., LIM, KUAN-HON, KAM, TOH-SEOK, SMITH, BRIAN J., DUIVENVOORDEN, HENDRIKA M., PARKER, BELINDA S., BRADSHAW, TRACEY D., STEINMETZ, MICHEL O. and MOSES, JOHN E., 2018. Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site SCIENTIFIC REPORTS. 8, BLESSING ONYEGEME-OKERENTA and TRACEY BRADSHAW, 2018. Anti-proliferative Activity of Ethyl Acetate Leaf Extract of Annona muricata L. on Selected Carcinoma Human Cell Lines London Journal of Research in Science: Natural and Formal. 18(4),
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YANG Z, WEI D, LIU F, LIU J, WU X, STEVENS MFG, BRADSHAW TD, LUO Y and ZHANG J, 2018. Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells. Journal of cellular biochemistry. 119(7), 5350-5358 E. BISHOP and T.D. BRADSHAW, 2018. Autophagy modulation: a prudent approach in cancer treatment? Cancer Chemotherapy and Pharmacology. 82(6), 913-922 CINI, MELCHIOR, BRADSHAW, TRACEY D. and WOODWARD, SIMON, 2017. Using titanium complexes to defeat cancer: the view from the shoulders of titans CHEMICAL SOCIETY REVIEWS. 46(4), 1040-1051 SOO, HSIEN-CHUEN, CHUNG, FELICIA FEI-LEI, LIM, KUAN-HON, YAP, VERONICA ALICIA, BRADSHAW, TRACEY D., HII, LING-WEI, TAN, SI-HOEY, SEE, SZE-JIA, TAN, YUEN-FEN, LEONG, CHEE-ONN and MAI, CHUN-WAI, 2017. Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway PLOS ONE. 12(1), CHUNG, FELICIA FEI-LEI, TAN, PERRY FAITH TZE MING, RAJA, VIJAY JOSEPH, TAN, BOON-SHING, LIM, KUAN-HON, KAM, TOH-SEOK, HII, LING-WEI, TAN, SI HOEY, SEE, SZE-JIA, TAN, YUEN-FEN, WONG, LI-ZHE, YAM, WAI KEAT, MAI, CHUN WAI, BRADSHAW, TRACEY D. and LEONG, CHEE-ONN, 2017. Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1) SCIENTIFIC REPORTS. 7, LUZZANI GA, CALLERO MA, KURUPPU AI, TRAPANI V, FLUMIAN C, TODARO L, BRADSHAW TD and LOAIZA PEREZ AI, 2017. In Vitro Antitumor Effects of AHR Ligands Aminoflavone (AFP 464) and Benzothiazole (5F 203) in Human Renal Carcinoma Cells. Journal of cellular biochemistry. 118(12), 4526-4535 SCHWEHM C, KELLAM B, GARCES AE, HILL SJ, KINDON ND, BRADSHAW TD, LI J, MACDONALD SJ, ROWEDDER JE, STODDART LA and STOCKS MJ, 2017. Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase δ (PI3Kδ) Inhibitors. Journal of medicinal chemistry. 60(4), 1534-1554 SALEH, MAYSAA M., LAUGHTON, CHARLES A., BRADSHAW, TRACEY D. and MOODY, CHRISTOPHER J., 2017. Development of a series of bis-triazoles as Gquadruplex ligands RSC ADVANCES. 7(75), 47297-47308 SALEH, MAYSAA M., LAUGHTON, CHARLES A., BRADSHAW, TRACEY D. and MOODY, CHRISTOPHER J., 2017. Development of a series of bis-triazoles as G-quadruplex ligands (vol 7, pg 47297, 2017) RSC ADVANCES. 7(77), 49056-49056 CINI, MELCHIOR, WILLIAMS, HUW, FAY, MIKE W., SEARLE, MARK S., WOODWARD, SIMON and BRADSHAW, TRACEY D., 2016. Enantiopure titanocene complexes - direct evidence for paraptosis in cancer cells METALLOMICS. 8(3), 286-297 AL-HAYALI, M., LIM, K.H., KAM, T.S. and BRADSHAW, T.D., 2016. Conopantinine, a Novel Alkaloid with Anti-cancer Properties In: 17th Annual Drug Discovery Leaders Summit 2016 & 4th Annual Discovery Chemistry & Drug Design Congress 2016, at Berlin, Germany.
QAZZAZ ME, RAJA VJ, LIM KH, KAM TS, LEE JB, GERSHKOVICH P and BRADSHAW TD, 2016. In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B. Cancer letters. 370(2), 185-97 YAP, VERONICA ALICIA, QAZZAZ, MOHANNAD E., RAJA, VIJAY J., BRADSHAW, TRACEY D., LOH, HWEI-SAN, SIM, KAE-SHIN, YONG, KIEN-THAI, LOW, YUN-YEE and LIM, KUAN-HON, 2016. Fistulopsines A and B antiproliferative septicine-type alkaloids from Ficus fistulosa PHYTOCHEMISTRY LETTERS. 15, 136-141 COUSIN, DAVID, ZHANG, JIHONG, HUMMERSONE, MARC G., MATTHEWS, CHARLES S., FRIGERIO, MARK, BRADSHAW, TRACEY D. and STEVENS, MALCOLM F. G., 2016. Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell lines MEDCHEMCOMM. 7(12), 2332-2343 SKILLING, K. J., KELLAM, B., ASHFORD, M., BRADSHAW, T. D. and MARLOW, M., 2016. Developing a self-healing supramolecular nucleoside hydrogel SOFT MATTER. 12(43), 8950-8957 HAN LC, STANLEY PA, WOOD PJ, SHARMA P, KURUPPU AI, BRADSHAW TD and MOSES JE, 2016. Horner-Wadsworth-Emmons approach to piperlongumine analogues with potent anti-cancer activity. Organic & biomolecular chemistry. 14(31), 7585-93 LIM, K.H., RAJA, V.J., BRADSHAW, T.D., LIM, S.H., LOW, Y.Y. and KAM, T.S., 2015. Ibogan, Tacaman, and Cytotoxic Bisindole Alkaloids from Tabernaemontana. Cononusine, an Iboga Alkaloid with Unusual Incorporation of a Pyrrolidone Moiety Journal of Natural Products. 78(5), 1129-1138 KURUPPU, ANCHALA I., ZHANG, LEI, COLLINS, HILARY, TURYANSKA, LYUDMILA, THOMAS, NEIL R. and BRADSHAW, TRACEY D., 2015. An Apoferritin-based Drug Delivery System for the Tyrosine Kinase Inhibitor Gefitinib ADVANCED HEALTHCARE MATERIALS. 4(18), 2816-2821 STONE, ERICA L., CITOSSI, FRANCESCA, SINGH, RAJINDER, KAUR, BALVINDER, GASKELL, MARGARET, FARMER, PETER B., MONKS, ANNE, HOSE, CURTIS, STEVENS, MALCOLM F. G., LEONG, CHEE-ONN, STOCKS, MICHAEL, KELLAM, BARRIE, MARLOW, MARIA and BRADSHAW, TRACEY D., 2015. Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery BIOORGANIC & MEDICINAL CHEMISTRY. 23(21), 6891-6899 LU, TIANGONG, LAUGHTON, CHARLES A., WANG, SHUDONG and BRADSHAW, TRACEY D., 2015. In Vitro Antitumor Mechanism of (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide Molecular Pharmacology. 87(1), 18-30 CINI, MELCHIOR, BRADSHAW, TRACEY D., WOODWARD, SIMON and LEWIS, WILLIAM, 2015. Asymmetric Pentafulvene Carbometalation-Access to Enantiopure Titanocene Dichlorides of Biological Relevance ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 54(47), 14179-14182 ZHANG, JIHONG, HUNNMERSONE, MARC, MATTHEWS, CHARLES S., STEVENS, MALCOLM F. G. and BRADSHAW, TRACEY D., 2015. N3-Substituted Temozolomide Analogs Overcome Methylguanine-DNA Methyltransferase and Mismatch Repair Precipitating Apoptotic and Autophagic Cancer Cell Death ONCOLOGY. 88(1), 28-48 RAJA, V.J., LIM, K.H., LEONG, C.O., KAM, T.S. and BRADSHAW, T.D., 2014. Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules. Investigational new drugs. 32(5), 838-50 K. J. SKILLING, A. NDUNGU, B. KELLAM, M. ASHFORD, T. D. BRADSHAW and M. MARLOW, 2014. Gelation properties of self-assembling N-acyl modified cytidine derivatives Journal of Materials Chemistry B. 2, 8412-8417 OTHMAN RT, KIMISHI I, BRADSHAW TD, STORER LCD, KORSHUNOV A, PFISTER SM, GRUNDY RG, KERR ID and COYLE B, 2014. Overcoming multiple drug resistance mechanisms in medulloblastoma. Acta neuropathologica communications. 2, 57 LAM, F., ABBAS, A. Y., SHAO, H., TEO, T., ADAMS, J., LI, P., BRADSHAW, T. D., FISCHER, P. M., WALSBY, E., PEPPER, C., CHEN, Y., DING, J. and WANG, S., 2014. Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73: Oncotarget Oncotarget. 5(17), 7691-704 WALSBY, ELISABETH, PRATT, GUY, SHAO, HAO, ABBAS, ABDULLAH Y., FISCHER, PETER M., BRADSHAW, TRACEY D., BRENNAN, PAUL, FEGAN, CHRIS, WANG, SHUDONG and PEPPER, CHRIS, 2014. A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine: Oncotarget Oncotarget. 5, 375-385 SKILLING, KATHRYN J, CITOSSI, FRANCESCA, BRADSHAW, TRACEY D, ASHFORD, MARIANNE, KELLAM, BARRIE and MARLOW, MARIA, 2014. Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications.: Soft Matter Soft Matter. 10(2), 237-256 LIM, SU-WEN, LOH, HWEI-SAN, TING, KANG-NEE, BRADSHAW, TRACEY D. and ZEENATHUL, NAZARIAH A., 2014. Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE. 14, LIM, SU-WEN, LOH, HWEI-SAN, TING, KANG NEE, BRADSHAW, TRACEY D. and ZEENATHUL, NAZARIAH A., 2014. Antiproliferation and induction of caspase-8-dependent mitochondria-mediated apoptosis by beta-tocotrienol in human lung and brain cancer cell lines BIOMEDICINE & PHARMACOTHERAPY. 68(8), 1105-1115
K. J. SKILLING, F. CITOSSI, T. D. BRADSHAW, M. ASHFORD, B. KELLAM and M. MARLOW, 2013. Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications SOFT MATTER. 10(2), 237-256 TURYANSKA, LYUDMILA, MORO, FABRIZIO, KNOTT, ANDREW N., FAY, MICHAEL W., BRADSHAW, TRACEY D. and PATANE, AMALIA, 2013. Paramagnetic, Near-Infrared Fluorescent Mn-Doped PbS Colloidal Nanocrystals PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION. 30(11), 945-949 TURYANSKA, L, BRADSHAW, TD, LI, M, BARDELANG, P, DREWE, WC, FAY, MW, MANN, S, PATANE, A and THOMAS, NR, 2012. The Differential Effect Of Apoferritin-Pbs Nanocomposites On Cell Cycle Progression In Normal And Cancerous Cells Journal Of Materials Chemistry. 22(2), 660-665 LAM, FRANKIE, BRADSHAW, TRACEY D., MAO, HUI, ROBERTS, SCOTT, PAN, YUANJIANG and WANG, SHUDONG, 2012. ZJU-6, a novel derivative of Erianin, shows potent anti-tubulin polymerisation and anti-angiogenic activities INVESTIGATIONAL NEW DRUGS. 30(5), 1899-1907 LIM, S.W., TING, K.N., BRADSHAW, T.D., ZEENATHUL N.A., WIART, C., KHOO, T.J., LIM, K.H. and LOH, H.S., 2011. Acalypha wilkesiana extracts induce apoptosis by causing single strand and double strand DNA breaks. Journal of Ethnopharmacology. 138, 616-623 TING, KN, OTHMAN, M, TELFORD, G, CLARKE, G, BRADSHAW, TD, KHOO, TJ, LOH, HS, WIART, C, PRITCHARD, D and FRY, JR, 2011. Antioxidant, Cytoprotective, Growth Inhibitory And Immunomodulatory Activities Of Extracts Of Dysoxylum Cauliflorum Hiern., A Malaysian Meliaceae. Journal Of Medicinal Plants Research. 5(24), 5867-5872
TAN BS, TIONG KH, MURUHADAS A, RANDHAWA N, CHOO HL, BRADSHAW TD, STEVENS MFG and LEONG C, 2011. CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells. Molecular cancer therapeutics. 10(10), 1982-92 CHEW, EH, NAGLE, AA, ZHANG, YC, SCARMAGNANI, S, PALANIAPPAN, P, BRADSHAW, TD, HOLMGREN, A and WESTWELL, AD, 2010. Cinnamaldehydes Inhibit Thioredoxin Reductase And Induce Nrf2: Potential Candidates For Cancer Therapy And Chemoprevention Free Radical Biology And Medicine. 48(1), 98-111 TURYANSKA, L., BRADSHAW, T.D., SHARPE, J., LI, M., MANN, S., THOMAS, N.R. and PATANÈ, A., 2009. The biocompatibility of apoferritin-encapsulated PbS quantum dots Small. 5(15), 1738-1741 BRADSHAW, T.D., STONE, E.L., TRAPANI, V., LEONG, C.-O., MATTHEWS, C.S., TE POELE, R. and STEVENS, M.F.G., 2008. Mechanisms of acquired resistance to 2-(4-amino-3-methylphenyl)benzothiazole in breast cancer cell lines Breast Cancer Research and Treatment. 110(1), 57-68 AIELLO, S., WELLS, G., STONE, E.L., KADRI, H., BAZZI, R., BELL, D.R., STEVENS, M.F.G., MATTHEWS, C.S., BRADSHAW, T.D. and WESTWELL, A.D., 2008. Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (Pmx 610, Nsc 721648) Journal of Medicinal Chemistry. 51(16), 5135-5139 ATHANASIOU, ANDRIANI, CLARKE, ANNA B, TURNER, AMY E, KUMARAN, NETHIA M, VAKILPOUR, SARA, SMITH, PAUL A, BAGIOKOU, DIMITRA, BRADSHAW, TRACEY D, WESTWELL, ANDREW D, FANG, LIN, LOBO, DILEEP N and CONSTANTIN, 2007. Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and biophysical research communications. 364(1), 131-7 MCCARROLL, ANDREW J, BRADSHAW, TRACEY D, WESTWELL, ANDREW D, MATTHEWS, CHARLES S and STEVENS, MALCOLM F G, 2007. Quinols as novel therapeutic agents. 7.1 Synthesis of antitumor 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira reactions. Journal of Medicinal Chemistry. 50(7), 1707-10 MORTIMER, CATRIONA G, WELLS, GEOFFREY, CROCHARD, JEAN-PHILIPPE, STONE, ERICA L, BRADSHAW, TRACEY D, STEVENS, MALCOLM F G and WESTWELL, ANDREW D, 2006. Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. Journal of Medicinal Chemistry. 49(1), 179-85 SHAH, M., WELLS, G., BRADSHAW, T. D., LAUGHTON, C. A., STEVENS, M. F. G. and WESTWELL, A. D., 2006. Antitubercular Properties of Substituted Hydroxycyclohexadienones LETTERS IN DRUG DESIGN AND DISCOVERY. VOL 3(NUMB 6), 419-423 LION, CEDRIC J, MATTHEWS, CHARLES S, WELLS, GEOFFREY, BRADSHAW, TRACEY D, STEVENS, MALCOLM F G and WESTWELL, ANDREW D, 2006. Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols'). Bioorganic and Medicinal Chemistry Letters. 16(19), 5005-8 BRADSHAW, T.D., MATTHEWS, C.S., COOKSON, J., CHEW, E.-H., SHAH, M., BAILEY, K., MONKS, A., HARRIS, E., WESTWELL, A.D., WELLS, G., LAUGHTON, C.A. and STEVENS, M.FG., 2005. Elucidation of thioredoxin as a molecular target for antitumor quinols Cancer Research. 65(9), 3911-3919 MUKHERJEE, A., WESTWELL, A.D., BRADSHAW, T.D., STEVENS, M.F.G., CARMICHAEL, J. and MARTIN, S.G., 2005. Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study British Journal of Cancer. 92, 350-358 BERRY, J.M., BRADSHAW, T.D., FICHTNER, I., REN, R., SCHWALBE, C.H., WELLS, G., CHEW, E.-H., STEVENS, M.F.G. and WESTWELL, A.D., 2005. Quinols as novel therapeutic agents. 2. 4-(1-arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents Journal of Medicinal Chemistry. 48(2), 639-644 BRADSHAW,T.D., MORTIMER,C.G. and WESTWELL,A.D., 2005. Update to: the aryl hydrocarbon receptor in anticancer drug discovery: friend or foe? Medicinal Chemistry Reviews - Online. 2(2), 153-161 LEONG, C.O., SUGGITT, M., SWAINE, D.J., BIBBY, M.C., STEVENS, M.F.G. and BRADSHAW, T.D., 2004. In vitro, in vivo, and in silico analyses of the antitumor activity of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazoles. Molecular Cancer Therapeutics. 3(12), 1565-1575 FICHTNER, I., MONKS, A., HOSE, C., STEVENS, M.F.G. and BRADSHAW, T.D., 2004. The experimental antitumor agents Phortress and Doxorubicin are equiactive against human-derived breast carcinoma xenograft models Breast Cancer Research and Treatment. 87(1), 97-107 BRANTLEY, E., TRAPANI, V., ALLEY, M.C., HOSE, C.D., BRADSHAW, T.D., STEVENS, M.F.G., SAUSVILLE, E.A. and STINSON, S.F., 2004. Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells Drug Metabolism and Disposition. 32(12), 1392-1401 HIORNS, L R, BRADSHAW, T D, SKELTON, L A, YU, Q, KELLAND, L R and LEYLAND-JONES, B, 2004. Variation in RNA expression and genomic DNA content acquired during cell culture. British Journal of Cancer. 90(2), 476-82 PALLIS, MONICA, BRADSHAW, TRACEY D, WESTWELL, ANDREW D, GRUNDY, MARTIN, STEVENS, MALCOLM F G and RUSSELL, NIGEL, 2003. Induction of apoptosis without redox catastrophe by thioredoxin-inhibitory compounds. Biochemical Pharmacology. 66(9), 1695-705 O'BRIEN, S.E., BROWNE, H.L., BRADSHAW, T.D., WESTWELL, A.D., STEVENS, M.F.G. and LAUGHTON, C.A., 2003. Antitumor benzothiazoles. Frontier molecular orbital analysis predicts bioactivation of 2-(4-aminophenyl)benzothiazoles to reactive intermediates by cytochrome P4501A1 Organic & Biomolecular Chemistry. 1(3), 493-497 WELLS, G., BERRY, J.M., BRADSHAW, T.D., BURGER, A.M., SEATON, A., WANG, B., WESTWELL, A.D. and STEVENS, M.F.G., 2003. 4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines Journal of Medicinal Chemistry. 46(4), 532-541 HUTCHINSON, IAN, BRADSHAW, TRACEY D, MATTHEWS, CHARLES S, STEVENS, MALCOLM F G and WESTWELL, ANDREW D, 2003. Antitumour benzothiazoles. Part 20: 3'-cyano and 3'-alkynyl-substituted 2-(4'-aminophenyl)benzothiazoles as new potent and selective analogues. Bioorganic and Medicinal Chemistry Letters. 13(3), 471-4 PALLIS, M., BRADSHAW, T.D., WESTWELL, A.D., GRUNDY, M., STEVENS, M.F. and RUSSELL, N.H., 2003. The thioredoxin inhibitor AW464 and the dithiol oxidant diamide induce apoptosis without accumulation of reactive oxygen species Leukemia. 17, P25
LEONG, C-O, GASKELL, M, MARTIN, E A, HEYDON, R T, FARMER, P B, BIBBY, M C, COOPER, P A, DOUBLE, J A, BRADSHAW, T D and STEVENS, M F G, 2003. Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo. British Journal of Cancer. 88(3), 470-7 WELLS, G., BERRY, J.M., BRADSHAW, T.D., MATTHEWS, C.S., STEVENS, M.F., WESTWELL, A.D. and VASSELIN, D., 2002. Novel lead antitumour structures from oxygenated and hydroxylated bicyclic heterocycles British Journal of Cancer. 86(1), S117
WESTWELL, A.D., WELLS, G., BERRY, J.M., BRADSHAW, T.D., BURGER, A.M., MATTHEWS, C.S. and STEVENS, M.F., 2002. Synthesis of heteroaromatic quinols, novel agents with selective activity clustered in colon and renal cell lines Proceedings of the American Association for Cancer Research. 43, 1034
STEVENS, M.F., WELLS, G., BRADSHAW, T.D., WESTWELL, A.D. and HOLBECK, S.L., 2002. The use of the COMPARE algorithm to guide mechanistic studies on novel antitumour agents Proceedings of the American Association for Cancer Research. 43, 4731
MUKHERJEE, A., MARTIN, S., BRADSHAW, T.D., WESTWELL, A.D. and CARMICHAEL, J., 2002. In vitro antitumour and antiangiogenic activity of AW 464 (NSC 706704), a novel quinol British Journal of Cancer. 86(1), S108-S109
BRADSHAW, T D, CHUA, M-S, BROWNE, H L, TRAPANI, V, SAUSVILLE, E A and STEVENS, M F G, 2002. In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. British Journal of Cancer. 86(8), 1348-54 BRADSHAW, T D, TRAPANI, V, VASSELIN, D A and WESTWELL, A D, 2002. The aryl hydrocarbon receptor in anticancer drug discovery: friend or foe? Current Pharmaceutical Design. 8(27), 2475-90 BRADSHAW, TRACEY D, BIBBY, MICHAEL C, DOUBLE, JOHN A, FICHTNER, IDUNA, COOPER, PATRICIA A, ALLEY, MICHAEL C, DONOHUE, SUSAN, STINSON, SHERMAN F, TOMASZEWJSKI, JOSEPH E, SAUSVILLE, EDWARD A and STEVENS, MALCOLM F G, 2002. Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles. Molecular Cancer Therapeutics. 1(4), 239-46
LOAIZA-PÉREZ, ANDREA I, TRAPANI, VALENTINA, HOSE, CURTIS, SINGH, SHEO S, TREPEL, JANE B, STEVENS, MALCOLM F G, BRADSHAW, TRACEY D and SAUSVILLE, EDWARD A, 2002. Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole. Molecular Pharmacology. 61(1), 13-9
BRADSHAW, T.D., BROWNE, H.L., HUTCHINSON, I., LAUGHTON, C.A., LEONG, C.O., OBRIEN, S., STEVENS, M.F., TRAPANI, V. and WESTWELL, A.D., 2001. Mechanistic studies and evaluation of clinical markers for phortress, a new agent for clinical trials British Journal of Cancer. 85, 272
HUTCHINSON, I., CHUA, M., BROWNE, H.L., TRAPANI, V., BRADSHAW, T.D., WESTWELL, A.D. and STEVENS, M.F., 2001. Antitumour benzothiazoles 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles Journal of Medicinal Chemistry. 44, 1446-1455 BRADSHAW, T.D., STEVENS, M.F. and WESTWELL, A.D., 2001. The discovery of the potent and selective antitumour agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203) and related compounds Current Medicinal Chemistry. 8, 203-210
SHI, D F, BRADSHAW, T D, CHUA, M S, WESTWELL, A D and STEVENS, M F, 2001. Antitumour benzothiazoles. Part 15: The synthesis and physico-chemical properties of 2-(4-aminophenyl)benzothiazole sulfamate salt derivatives. Bioorganic and Medicinal Chemistry Letters. 11(8), 1093-5