Publications in the Biomolecular Science and Medicinal Chemistry Division

Publications

Content: WANG, S., MIDGLEY, C.A., SCAËROU, F., GRABAREK, J.B., GRIFFITHS, G., JACKSON, W., KONTOPIDIS, G., MCCLUE, S.J., MCINNES, C., MEADES, C., MEZNA, M., PLATER, A., STUART, I., THOMAS, M.P., WOOD, G., CLARKE, R.G., BLAKE, D.G., ZHELEVA, D.I., LANE, D.P., JACKSON, R.C., GLOVER, D.M. and FISCHER, P.M., 2010. Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors Journal of Medicinal Chemistry. 53(11), 4367-4378

Content: WANG, S., GRIFFITHS, G., MIDGLEY, C.A., BARNETT, A.L., COOPER, M., GRABAREK, J., INGRAM, L., JACKSON, W., KONTOPIDIS, G., MCCLUE, S.J., MCINNES, C., MCLACHLAN, J., MEADES, C., MEZNA, M., STUART, I., THOMAS, M.P., ZHELEVA, D.I., LANE, D.P., JACKSON, R.C., GLOVER, D.M., BLAKE, D.G. and FISCHER, P.M., 2010. Discovery and characterization of 2-anilino-4- (thiazol-5-yl) pyrimidine transcriptional CDK inhibitors as anticancer agents Chemistry & Biology. 17(10), 1111-1121

Content: MCINTYRE, N.A., MCINNES, C., GRIFFITHS, G., BARNETT, A.L., KONTOPIDIS, G., SLAWIN, A.M.Z., JACKSON, W., THOMAS, M., ZHELEVA, D.I., WANG, S., BLAKE, D.G., WESTWOOD, N.J. and FISCHER, P.M., 2010. Design, synthesis and evaluation of 2-methyl- and 2-amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin-dependent kinase inhibitors Journal of Medicinal Chemistry. 53(5), 2136-2145

Content: LI, C., REDDY, T.R.K., FISCHER, P.M. and DEKKER, L.V., 2010. A Cy5-labelled S100A10 tracer used to identify inhibitors of the protein interaction with Annexin A2 ASSAY and Drug Development Technologies. 8(1), 85-95

Content: SHAO, D., SEGAL, A.W. and DEKKER, L.V., 2010. Subcellular localisation of the _p40_phox component of NADPH oxidase involves direct interactions between the Phox homology domain and F-actin International Journal of Biochemistry and Cell Biology. 42(10), 1736-1743

Content: REDDY, T.R.K., LI, C., GUO, X., FISCHER, P.M. and DEKKER, L.V., 2010. Structure-based design, synthesis, and SAR exploration of pyrrole-2-one analogues as inhibitors of the annexin A2-S100A10 protein interaction: potential anti-angiogenesis therapeutics. Journal of Pharmacy and Pharmacology. 62(10), 1373-1374

Content: WINKLER, G.S., 2010. The mammalian anti-proliferative BTG/Tob protein family. Journal of cellular physiology. 222(1), 66-72

Content: BOAKES DE, CODLING, EA, THORN, GJ and STEINKE, M, 2010. Analysis and modelling of swimming behaviour in Oxyrrhis marina Journal of Plankton Research. 33(4), 641-649

Content: CODLING, EA, BEARON, RN and THORN, GJ, 2010. Diffusion about the mean drift location in a biased random walk. Ecology. 91(10), 3106-13

Content: THORN GJ and BEARON RN, 2010. Transport of spherical hyrotactic organisms in general three-dimensional flow Fields Physics of Fluids. 22, 041902

Content: ASHRAF, S., MAPP, P. I. and WALSH, D. A., 2010. Angiogenesis and the persistence of inflammation in a rat model of proliferative synovitis Arthritis Rheum. 62(7), 1890-8

Content: ZHANG, JIHONG, STEVENS, MALCOLM F G, LAUGHTON, CHARLES A, MADHUSUDAN, SRINIVASAN and BRADSHAW, TRACEY D, 2010. Acquired resistance to temozolomide in glioma cell lines: molecular mechanisms and potential translational applications. Oncology. 78(2), 103-14

Content: ROY, JULIE and LAUGHTON, CHARLES A, 2010. Long-timescale molecular-dynamics simulations of the major urinary protein provide atomistic interpretations of the unusual thermodynamics of ligand binding. Biophysical journal. 99(1), 218-26

Content: WANG, HAO and LAUGHTON, CHARLES A, 2010. Molecular modelling methods to quantitate drug-DNA interactions. Methods in molecular biology (Clifton, N.J.). 613, 119-31

Content: LAVERY, R., ZAKRZEWSKA, K., BEVERIDGE, D., BISHOP, T.C., CASE, D.A., CHEATHAM, T., DIXIT, S., JAYARAM, B., LANKAS, F., LAUGHTON, C., MADDOCKS, J.H., MICHON, A., OSMAN, R., OROZCO, M., PEREZ, A., SINGH, T., SPACKOVA, N. and SPONER, J., 2010. A systematic molecular dynamics study of nearest-neighbor effects on base pair and base pair step conformations and fluctuations in B-DNA Nucleic Acids Research. 38(1), 299-313

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