Publications in the Biomolecular Science and Medicinal Chemistry Division

Publications

Content: DUFOUR, M., YAN, C., SIEGEL, D., COLUCCI, M.A., JENNER, M., OLDHAM, N.J., GOMEZ, J., REIGAN, P., LI, Y., DE MATTEIS, C.I., ROSS, D. and MOODY, C.J., 2011. Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition ChemBioChem. 12(8), 1203-1208

Content: LIM, S.W., TING, K.N., BRADSHAW, T.D., ZEENATHUL N.A., WIART, C., KHOO, T.J., LIM, K.H. and LOH, H.S., 2011. Acalypha wilkesiana extracts induce apoptosis by causing single strand and double strand DNA breaks. Journal of Ethnopharmacology. 138, 616-623

Content: TING, KN, OTHMAN, M, TELFORD, G, CLARKE, G, BRADSHAW, TD, KHOO, TJ, LOH, HS, WIART, C, PRITCHARD, D and FRY, JR, 2011. Antioxidant, Cytoprotective, Growth Inhibitory And Immunomodulatory Activities Of Extracts Of Dysoxylum Cauliflorum Hiern., A Malaysian Meliaceae. Journal Of Medicinal Plants Research. 5(24), 5867-5872

Content: TAN BS, TIONG KH, MURUHADAS A, RANDHAWA N, CHOO HL, BRADSHAW TD, STEVENS MFG and LEONG C, 2011. CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells. Molecular cancer therapeutics. 10(10), 1982-92

Content: LUKEN, B.M., WINN, L.Y.N., EMSLEY, J., LANE, D.A. and CRAWLEY, J.T.B., 2010. Brief report The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function BLOOD -NEW YORK-. VOL 115(NUMB 23), 4910-4913

Content: EMSLEY, JONAS, MCEWAN, PAUL A and GAILANI, DAVID, 2010. Structure and function of factor XI. Blood. 115(13), 2569-77

Content: HALL, G. and EMSLEY, J., 2010. Structure of human thioredoxin exhibits a large conformational change Protein Science. 19(9), 1807-1811

Content: GINGRAS, ALEXANDRE R, BATE, NEIL, GOULT, BENJAMIN T, PATEL, BIPIN, KOPP, PETRA M, EMSLEY, JONAS, BARSUKOV, IGOR L, ROBERTS, GORDON C K and CRITCHLEY, DAVID R, 2010. Central region of talin has a unique fold that binds vinculin and actin. The Journal of biological chemistry. 285(38), 29577-87

Content: WADELIN, F., FULTON, J., MCEWAN, P.A., SPRIGGS, K.A., EMSLEY, J. and HEERY, D.M., 2010. Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia Molecular Cancer. 27(9), 226

Content: GAILANI D, SUN M, CHENG Q, MATAFONOV A, TUCKER EI, GRUBER A and EMSLEY J, 2010. Evidence Against A Protein In Plasma That Is A Product Of A Factor Xi Mrna Splice Variant Missing Exons 6 And 7. Blood. 116(7), 1185-6; author reply 1186-7

Content: RYAN, COLM M, KINDLE, KARIN B, COLLINS, HILARY M and HEERY, DAVID M, 2010. SUMOylation regulates the nuclear mobility of CREB binding protein and its association with nuclear bodies in live cells. Biochemical and biophysical research communications. 391(1), 1136-41

Content: KINDLE, K.B., COLLINS, H.M. and HEERY, D.M., 2010. MOZ-TIF2-mediated destruction of CBP/p300 is blocked by calpain inhibitor 2 Leukemia. 24(7), 1359-1361

Content: CANNELL, I.G., KONG, Y.W., JOHNSTON, S.J., CHEN, M.L., COLLINS, H.M., DOBBYN, H.C., ELIA, A., KRESS, T.R., DICKENS, M., CLEMENS, M.J., HEERY, D.M., GAESTEL, M., EILERS, M., WILLIS, A.E. and BUSHELL, M., 2010. p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication Proceedings of the National Academy of Sciences of the United States of America. 107(12), 5375-5380

Content: WANG, S., MIDGLEY, C.A., SCAËROU, F., GRABAREK, J.B., GRIFFITHS, G., JACKSON, W., KONTOPIDIS, G., MCCLUE, S.J., MCINNES, C., MEADES, C., MEZNA, M., PLATER, A., STUART, I., THOMAS, M.P., WOOD, G., CLARKE, R.G., BLAKE, D.G., ZHELEVA, D.I., LANE, D.P., JACKSON, R.C., GLOVER, D.M. and FISCHER, P.M., 2010. Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors Journal of Medicinal Chemistry. 53(11), 4367-4378

Content: WANG, S., GRIFFITHS, G., MIDGLEY, C.A., BARNETT, A.L., COOPER, M., GRABAREK, J., INGRAM, L., JACKSON, W., KONTOPIDIS, G., MCCLUE, S.J., MCINNES, C., MCLACHLAN, J., MEADES, C., MEZNA, M., STUART, I., THOMAS, M.P., ZHELEVA, D.I., LANE, D.P., JACKSON, R.C., GLOVER, D.M., BLAKE, D.G. and FISCHER, P.M., 2010. Discovery and characterization of 2-anilino-4- (thiazol-5-yl) pyrimidine transcriptional CDK inhibitors as anticancer agents Chemistry & Biology. 17(10), 1111-1121

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