School of Pharmacy

Publications in the Biomolecular Science and Medicinal Chemistry Division

Publications

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PAPAGRIGORIOU, E., GINGRAS, A.R., BARSUKOV, I.L., BATE, N., FILLINGHAM, I.J., PATEL, B., FRANK, R., ZIEGLER, W.H., ROBERTS, G.C.K., CRITCHLEY, D.R. and EMSLEY, J., 2004. Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle EMBO Journal. 23(15), 2942-2951

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EMSLEY, JONAS, KNIGHT, C GRAHAM, FARNDALE, RICHARD W and BARNES, MICHAEL J, 2004. Structure of the integrin alpha2beta1-binding collagen peptide. Journal of Molecular Biology. 335(4), 1019-28

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BAGLIA, F. A., SHRIMPTON, C. N., EMSLEY, J., KITAGAWA, K., RUGGERI, Z. M., LOPEZ, J. A. and WALSH, P. N., 2004. Factor XI Interacts with the Leucine-rich Repeats of Glycoprotein Ibalpha on the Activated Platelet Journal of Biological Chemistry. VOL 279(NUMB 47), 49323-49329

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MATSUDA, S., HARRIES, J.C., VISKADURAKI, M., TROKE, P.J.F., KINDLE, K.B., RYAN, C. and HEERY, D.M., 2004. A conserved α-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBP Journal of Biological Chemistry. 279(14), 14055-14064

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BELLODI, C., KINDLE, K., BERNASSOLA, F., DINSDALE, D., MELINO, G., COSSARIZZA, A., HEERY, D. and SALOMONI, P., 2004. Mutant PML Proteins Form Novel Cytoplasmic Bodies. (Poster # 764-III) BLOOD -NEW YORK-. VOL 104(NUMB 11), 3494

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WANG, S., MEADES, C., WOOD, G., OSNOWSKI, A., ANDERSON, S., YUILL, R., THOMAS, M., MEZNA, M., JACKSON, W., MIDGLEY, C., GRIFFITHS, G., FLEMING, I., GREEN, S., MCNAE, I., WU, S.Y., MCINNES, C., ZHELEVA, D., WALKINSHAW, M.D. and FISCHER, P.M., 2004. 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity Journal of Medicinal Chemistry. 47(7), 1662-1675

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MCINNES, C., WANG, S., ANDERSON, S., O'BOYLE, J., JACKSON, W., KONTOPIDIS, G., MEADES, C., MEZNA, M., THOMAS, M., WOOD, G., LANE, D.P. and FISCHER, P.M., 2004. Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors Chemistry & Biology. 11(4), 525-534

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WANG, S., WOOD, G., MEADES, C., GRIFFITHS, G., MIDGLEY, C., MCNAE, I., MCINNES, C., ANDERSON, S., JACKSON, W., MEZNA, M., YUILL, R., WALKINSHAW, M. and FISCHER, P.M., 2004. Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors Bioorganic and Medicinal Chemistry Letters. VOL 14(NUMBER 16), 4237-4240

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FISCHER, P.M., 2004. The design of drug candidate molecules as selective inhibitors of therapeutically relevant protein kinases. Current Medicinal Chemistry. 11(12), 1563-1583

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FISCHER, P.M., 2004. The Use of CDK Inhibitors in Oncology: A Pharmaceutical Perspective Cell Cycle. VOL 3(ISSU 6), 742-746

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FISCHER, P.M., GLOVER, D.M. and LANE, D.P., 2004. Targeting the cell cycle Drug Discovery Today. VOL 1(NUMBER 4), 417-423

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FISCHER, P.M. and LANE, D.P., 2004. Small-molecule inhibitors of the p53 suppressor HDM2: have protein-protein interactions come of age as drug targets? Trends in Pharmacological Sciences. 25(7), 343-346

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POONDRA, R.R., FISCHER, P.M. and TURNER, N.J., 2004. Efficient Palladium-Catalyzed Cross-Coupling of beta-Chloroalkylidene/arylidene Malonates Using Microwave Chemistry Journal of Organic Chemistry. VOL 69(NUMB 20), 6920-6922

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RAYNAUD, F.I., FISCHER, P.M., NUTLEY, B.P., GODDARD, P.M., LANE, D.P. and WORKMAN, P., 2004. Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis. Molecular Cancer Therapeutics. 3(3), 353-362

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ANDREWS, M.J.I., MCINNES, C., KONTOPIDIS, G., INNES, L., COWAN, A., PLATER, A. and FISCHER, P.M., 2004. Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes. Organic and Biomolecular Chemistry. 2(19), 2735-2741
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