Contact

• workRoom C06 Biodiscovery Institute (Entrance 1)
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 8467856
• felicity.rose@nottingham.ac.uk
• https://www.nottingham.ac.uk/pharmacy/people/felicity.rose

Biography

I attained a BSc (HONS) degree in Applied Biochemistry from Liverpool John Moores University in 1993 following which I joined the Department of Gastroenterology at the University of Nottingham. I attained my PhD in 1999 under the supervision of Professor Yash Mahida. In 2000, I took the opportunity to join the Tissue Engineering Group within the School of Pharmacy and was rapidly promoted to Senior Research Fellow in 2002. In 2003, I was awarded a prestigious University of Nottingham sponsored Anne McLaren Research Fellowship, aimed at encouraging female scientists to pursue a career in academia. At the same time, I was appointed to a Lectureship in Tissue Engineering, a post which I took up in 2005. I was promoted to Associate Professor in 2007 and Reader in 2013. I took up the position of Head of the Tissue Engineering Group in 2015 and have recently been appointed as Head of the Division of Regenerative Medicine and Cellular Therapies.

In addition to my research, I am a Tissue and Cell Engineering Society (TCES) committee member (membership secretary). I am also a member of the EPSRC Peer Review College 2006 and regularly review grant applications for BBSRC, NC3Rs and including for the EU member states. In addition, I review manuscripts for publication for journals such as Biomaterials, Journal of Biomedical Materials Research, and Tissue Engineering. Communicating science to school children is a particular passion for which I won an 'Exceptional Winner' Staff Volunteering Award (2005) from the Higher Education Active Community Fund (HEACF) for establishing a departmental after-school science club for primary school children.

Expertise Summary

As part of a team of stem cell biologists and tissue engineers, I am an academic member of the Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM) based within the multidisciplinary research facilities of the Centre for Biomolecular Sciences (CBS). A biochemist by training, I now have over 15 years year experience within the field of tissue engineering. My expertise lies in scaffold fabrication primarily from synthetic polymers, in particular electrospinning, and the subsequent assessment of mammalian cell interaction with those materials. I specialise in mucosal tissue engineering having led projects on lung, gut and cornea regeneration with a particular interest in developing human in vitro models to study disease biology and for drug screening applications, with the ultimate goal of developing tissue grafts for transplantation.

Teaching Summary

Master of Pharmacy (MPharm)

B31BFI Bacterial and Fungal Infections Year 1 (module contributor)

Final Year Research Projects

PhD training courses

Mammalian Cell Culture: theory to support the practice

EPSRC Thematic CDT - bio-hybrid and bioinstructive materials for healthcare applications (PI)

Research Summary

My research focuses on the ability to control stem and differentiated cell behaviour during the tissue regeneration process to develop in vivo-like in vitro models for research and drug screening… read more

Recent Publications

• HE, YINFENG, TUCK, CHRISTOPHER J., PRINA, ELISABETTA, KILSBY, SAM, CHRISTIE, STEVEN D. R., EDMONDSON, STEPHEN, HAGUE, RICHARD J. M., ROSE, FELICITY R. A. J. and WILDMAN, RICKY D., 2017. A new photocrosslinkable polycaprolactone-based ink for three-dimensional inkjet printing JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 105(6), 1645-1657
• D KUMAR, V WORKMAN, MC O'BRIEN, JS MCLAREN, LJ WHITE, K RAGUNATH, FRAJ ROSE, J GOUGH and A SAIANI, 2017. Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures. Advanced Functional Materials.
• AMER, MAHETAB H., ROSE, FELICITY R. A. J., WHITE, LISA J. and SHAKESHEFF, KEVIN M., 2016. A Detailed Assessment of Varying Ejection Rate on Delivery Efficiency of Mesenchymal Stem Cells Using Narrow-Bore Needles STEM CELLS TRANSLATIONAL MEDICINE. 5(3), 366-378
• VAITHILINGAM, J., PRINA, E., GOODRIDGE, R. D., HAGUE, R. J. M., EDMONDSON, S., ROSE, F. R. A. J. and CHRISTIE, S. D. R., 2016. Surface chemistry of Ti6Al4V components fabricated using selective laser melting for biomedical applications: Materials Science and Engineering C Materials Science and Engineering C. 67, 294-303

• View all publications

Current Research

My research focuses on the ability to control stem and differentiated cell behaviour during the tissue regeneration process to develop in vivo-like in vitro models for research and drug screening applications, and ultimately tissues for transplantation. In particular, I have interests in epithelial tissue engineering with a focus on intestinal and corneal regeneration. In addition, I am involved in developing scaffolds that support tissue growth, by providing more efficient nutrient transport networks, and those that mimic the in vivo architecture of the native tissue. I also collaborate with optical engineers to develop sophisticated bioreactor systems that can be used for online monitoring of tissue growth.

The intestinal tissue engineering programme is currently supported with funding from the BBSRC (and in collaboration with Professors Chris Hawkey and Ilyas Mohammed, and Drs Lee Buttery, Virginie Sottile, Luisa Martinez Pomares, and Morgan Alexander, Nottingham) and is focussed on developing methods to derive and maintain intestinal progenitors for future tissue engineering programmes and the design of scaffolds to mimic the intestinal stem cell niche in vitro. This includes a collaboration with mathematical modellers (Dr Sarah Waters and Professor John King, Nottingham) to derive models of the dynamic environment of the intestinal crypts in order to recreate this in vitro. Corneal regeneration is funded by the EPSRC and MRC (in collaboration with Professors Kevin Shakesheff and Harminder Dua, and Dr Paddy Tighe, Nottingham) and involves developing a controlled release drug delivery device for wound healing and tissue engineering of the corneal stroma. Collaborations with Drs John Crowe and Steven Morgan from the Applied Optics Group (Nottingham) and Sarah Waters have focussed on developing imaging systems for monitoring tissue development within bioreactors and we are currently developing methods to include nutrient monitoring which will eventually lead to automated feedback systems.

Memberships of Committees and Professional Bodies

• Tissue and Cell Engineering Society (TCES) Committee Member.• EU COST (European Cooperation in the field of Scientific and Technical Research) Committee Member (Biomedicine and Molecular Biosciences Domain Committee).• Member, EPSRC Peer Review College.

• HE, YINFENG, TUCK, CHRISTOPHER J., PRINA, ELISABETTA, KILSBY, SAM, CHRISTIE, STEVEN D. R., EDMONDSON, STEPHEN, HAGUE, RICHARD J. M., ROSE, FELICITY R. A. J. and WILDMAN, RICKY D., 2017. A new photocrosslinkable polycaprolactone-based ink for three-dimensional inkjet printing JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 105(6), 1645-1657
• D KUMAR, V WORKMAN, MC O'BRIEN, JS MCLAREN, LJ WHITE, K RAGUNATH, FRAJ ROSE, J GOUGH and A SAIANI, 2017. Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures. Advanced Functional Materials.
• AMER, MAHETAB H., ROSE, FELICITY R. A. J., WHITE, LISA J. and SHAKESHEFF, KEVIN M., 2016. A Detailed Assessment of Varying Ejection Rate on Delivery Efficiency of Mesenchymal Stem Cells Using Narrow-Bore Needles STEM CELLS TRANSLATIONAL MEDICINE. 5(3), 366-378
• VAITHILINGAM, J., PRINA, E., GOODRIDGE, R. D., HAGUE, R. J. M., EDMONDSON, S., ROSE, F. R. A. J. and CHRISTIE, S. D. R., 2016. Surface chemistry of Ti6Al4V components fabricated using selective laser melting for biomedical applications: Materials Science and Engineering C Materials Science and Engineering C. 67, 294-303
• BRIDGE JC, AYLOTT JW, BRIGHTLING CE, GHAEMMAGHAMI AM, KNOX AJ, LEWIS MP, ROSE FR and MORRIS GE, 2015. Adapting the Electrospinning Process to Provide Three Unique Environments for a Tri-layered In Vitro Model of the Airway Wall. Journal of Visualized Experiments : JoVE. 101, e52986
• KAUR D, GOMEZ E, DOE C, BERAIR R, WOODMAN L, SAUNDERS R, HOLLINS F, ROSE FR, AMRANI Y, MAY R, KEARLEY J and HUMBLES A, 2015. IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk Allergy. 70, 556-567
• HTWE, SU SU, HARRINGTON, HELEN, KNOX, ALAN, ROSE, FELICITY, AYLOTT, JONATHAN, HAYCOCK, JOHN W. and GHAEMMAGHAMI, AMIR M., 2015. Investigating NF-kappa B signaling in lung fibroblasts in 2D and 3D culture systems RESPIRATORY RESEARCH. 16, 144
• GOTHARD, DAVID, SMITH, EMMA L., KANCZLER, JANOS M., BLACK, CAMERON R., WELLS, JULIA A., ROBERTS, CAROL A., WHITE, LISA J., QUTACHI, OMAR, PETO, HEATHER, RASHIDI, HASSAN, ROJO, LUIS, STEVENS, MOLLY M., EL HAJ, ALICIA J., ROSE, FELICITY R. A. J., SHAKESHEFF, KEVIN M. and OREFFO, RICHARD O. C., 2015. In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors PLOS ONE. 10(12),
• RAHMAN, CHERYL V., BEN-DAVID, DROR, DHILLON, AMRITPAUL, KUHN, GISELA, GOULD, TOBY W. A., MUELLER, RALPH, ROSE, FELICITY R. A. J., SHAKESHEFF, KEVIN M. and LIVNE, ERELLA, 2014. Controlled release of BMP-2 from a sintered polymer scaffold enhances bone repair in a mouse calvarial defect model JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 8(1), 59-66
• REINWALD, Y., JOHAL, R. K., GHAEMMAGHAMI, A. M., ROSE, F. R. A. J., HOWDLE, S. M. and SHAKESHEFF, K. M., 2014. Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution POLYMER. 55(1), 435-444
• HARRINGTON, HELEN, CATO, PAUL, SALAZAR, FABIAN, WILKINSON, MALCOLM, KNOX, ALAN, HAYCOCK, JOHN W., ROSE, FELICITY, AYLOTT, JON W. and GHAEMMAGHAMI, AMIR M., 2014. Immunocompetent 3D Model of Human Upper Airway for Disease Modeling and In Vitro Drug Evaluation MOLECULAR PHARMACEUTICS. 11(7), 2082-2091
• MORRIS, G. E., BRIDGE, J. C., ELTBOLI, O. M. I., KNOX, A. J., AYLOTT, J. W., BRIGHTLING, C. E., GHAEMMAGHAMI, A. M. and ROSE, F. R. A. J., 2014. Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 307(1), L38-L47
• MORRIS, G. E., BRIDGE, J. C., BRACE, L. A., KNOX, A. J., AYLOTT, J. W., BRIGHTLING, C. E., GHAEMMAGHAMI, A. M. and ROSE, F. R. A. J., 2014. A novel electrospun biphasic scaffold provides optimal three-dimensional topography for in vitro co-culture of airway epithelial and fibroblast cells BIOFABRICATION. 6(3),
• SMITH, E. L., KANCZLER, J. M., GOTHARD, D., ROBERTS, C. A., WELLS, J. A., WHITE, L. J., QUTACHI, O., SAWKINS, M. J., PETO, H., RASHIDI, H., ROJO, L., STEVENS, M. M., EL HAJ, A. J., ROSE, F. R. A. J., SHAKESHEFF, K. M. and OREFFO, R. O. C., 2014. Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model ACTA BIOMATERIALIA. 10(10), 4186-4196
• SMITH, E. L., KANCZLER, J. M., GOTHARD, D., ROBERTS, C. A., WELLS, J. A., WHITE, L. J., QUTACHI, O., SAWKINS, M. J., PETO, H., RASHIDI, H., ROJO, L., STEVENS, M. M., EL HAJ, A. J., ROSE, F. R. A. J., SHAKESHEFF, K. M. and OREFFO, R. O. C., 2014. Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model ACTA BIOMATERIALIA. 10(10), 4197-4205
• ROGERS, CATHERINE M., DEEHAN, DAVID J., KNUTH, CALLIE A., ROSE, FELICITY R. A. J., SHAKESHEFF, KEVIN M. and OLDERSHAW, RACHEL A., 2014. Biocompatibility and enhanced osteogenic differentiation of human mesenchymal stem cells in response to surface engineered poly(D,L-lactic-co-glycolic acid) microparticles JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. 102(11), 3872-3882
• ROGERS, C. M., MORRIS, G. E., GOULD, T. W., BAIL, R., TOUMPANIARI, S., HARRINGTON, H., DIXON, J. E., SHAKESHEFF, K. M., SEGAL, J. and ROSE, F. R., 2014. A novel technique for the production of electrospun scaffolds with tailored three-dimensional micro-patterns employing additive manufacturing: Biofabrication Biofabrication. 6(3), 035003
• ROSE JB, PACELLI, S, EL HAJ A, DUA HS, HOPKINSON A, WHITE LJ and ROSE FRAJ, 2014. Gelatin-Based Materials in Ocular Tissue Engineering MATERIALS. 7(4), 3106-3135
• HARRINGTON, H. C., ROSE, F. R. A. J., REINWALD, Y., BUTTERY, L. D. K., GHAEMMAGHAMI, A. M. and AYLOTT, J. W., 2013. Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: self-reporting scaffolds for application in tissue engineering ANALYTICAL METHODS. 5(1), 68-71
• RAHMAN CV, KUHN G, WHITE LJ, KIRBY GTS, VARGHESE OP, MCLAREN JS, COX HC, ROSE FRAJ, MÜLLER R, HILBORN J and SHAKESHEFF KM, 2013. PLGA/PEG-hydrogel composite scaffolds with controllable mechanical properties. Journal of biomedical materials research. Part B, Applied biomaterials. 101(4), 648-55
• SAWKINS MJ, BOWEN W, DHADDA P, MARKIDES H, SIDNEY LE, TAYLOR AJ, ROSE FRAJ, BADYLAK SF, SHAKESHEFF KM and WHITE LJ, 2013. Hydrogels derived from demineralized and decellularized bone extracellular matrix. Acta biomaterialia. (In Press.)
• WATSON NJ, JOHAL RK, GLOVER Z, REINWALD Y, WHITE LJ, GHAEMMAGHAMI AM, MORGAN SP, ROSE FRAJ, POVEY MJW and PARKER NG, 2013. Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport. Materials science & engineering. C, Materials for biological applications. 33(8), 4825-32
• HELEN HARRINGTON, FELICITY RJ ROSE, JONATHAN W AYLOTT and AMIR M. GHAEMMAGHAMI, 2013. Self-reporting Scaffolds for 3-Dimensional Cell Culture. Journal of Visualized Experiments. 81, e50608
• RAHMAN CV, SMITH SJ, MORGAN PS, LANGMACK KA, CLARKE PA, RITCHIE AA, MACARTHUR DC, ROSE FR, SHAKESHEFF KM, GRUNDY RG and RUMAN RAHMAN, 2013. Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix. PloS one. 8(10), e77435
• HUYNH, N.T., HE, D., HAYES-GILL, B.R., CROWE, J.A., WALKER, J.G., MATHER, M.L., ROSE, F.R.A.J., PARKER, N.G., POVEY, M.J.W. and MORGAN, S.P., 2012. Application of a maximum likelihood algorithm to ultrasound modulated optical tomography Journal of Biomedical Optics. 17(2), 026014
• SP MORGAN, FRAJ ROSE and SJ MATCHER, eds., 2012. Optical Techniques in Regenerative Medicine Taylor and Francis. (In Press.)
• DAVID Y S CHAU, SHERIDAN V BROWN, MELISSA MATHER, VICTORIA HUTTER, NAING L TINT, HARMINDER S DUA and FELICITY ROSE, 2012. Tissue transglutaminase (TG-2) modified amniotic membrane: a novel scaffold for biomedical applications Biomedical Materials. (In Press.)
• ROGERS CM, WOOLLEY TS, CRUWYS SC, BUTTERY LDK, ROSE FRAJ and SHAKESHEFF KM, 2012. Engineering an in-vitro model of rodent cartilage. The journal of pharmacy and pharmacology. 64(6), 821-31
• HUYNH NT, HE D, HAYES-GILL BR, CROWE JA, WALKER JG, MATHER ML, ROSE FRAJ, PARKER NG, POVEY MJW, MORGAN SP, 2011. Application of a maximum likelihood algorithm to ultrasound modulated optical tomography In: Proc. Photons plus Ultrasound: Imaging and Sensing 2011, SPIE Vol. 7899.
• LEMON, G., HOWARD, D., YANG, H., RATCHEV, S.M., SEGAL, J.I., ROSE, F.R.A.J., JENSEN, O.E., WATERS, S.L. and KING, J.R., 2011. Growth of the chorioallantoic membrane into a rapid-prototyped model pore system: experiments and mathematical model Biomechanics and Modeling in Mechanobiology. 10(4), 539-558
• LEMON, G., HOWARD, D., ROSE, F. R. A. J. and KING, J. R., 2011. Individual-based modelling of angiogenesis inside three-dimensional porous biomaterials Biosystems. VOL 103(NUMBER 3), 372-383
• NELSON, M.R., HOWARD, D., JENSEN, O.E., KING, J.R., ROSE, F.R.A.J. and WATERS, S.L., 2011. Growth-induced buckling of an epithelial layer Biomechanics and Modelling in Mechanobiology. 10, 883-900
• DEY, S., KELLAM, B., ALEXANDER, M.R., ALEXANDER, C. and ROSE, F.R.A.J., 2011. Enzyme-passage free culture of mouse embryonic stem cells on thermo-responsive polymer surfaces Journal of Materials Chemistry. 21(19), 6883-6890
• MAHLSTEDT, M.M., ANDERSON, D., SHARP, J.S., MCGILVRAY, R., MUÑOZ, M.D., BUTTERY, L.D., ALEXANDER, M.R., ROSE, F.R.A.J. and DENNING, C., 2010. Maintenance of pluripotency in human embryonic stem cells cultured on a synthetic substrate in conditioned medium Biotechnology and Bioengineering. 105(1), 130-140
• CHAU DYS, TINT NL, COLLIGHAN RJ, GRIFFIN M, DUA HS, SHAKESHEFF KM, ROSE FRAJ, 2010. The visualisation of vitreous using surface modified poly(DL-lactic-co-glycolic acid) microparticles British Journal of Ophthalmology. 94, 648-653 (In Press.)
• MAJANI, RUBY, ZELZER, MISCHA, GADEGAARD, NIKOLAJ, ROSE, FELICITY R and ALEXANDER, MORGAN R, 2010. Preparation of Caco-2 cell sheets using plasma polymerised acrylic acid as a weak boundary layer. Biomaterials. 31(26), 6764-71
• YANG, J., ROSE, F.R.A.J., GADEGAARD, N. and ALEXANDER, M.R., 2009. A high-throughput assay of cell-surface interactions using topographical and chemical gradients Advanced Materials. 21(3), 300-304
• CUMMINGS, L.J, SAWYER. N.B.E, MORGAN, S.P, ROSE, F.R.A.J and WALTERS, S.L., 2009. Tracking large solid constructs suspended in a rotating bioreactor: a combined experimental and theoretical study Biotechnology and Bioengineering. 104(6), 1224-1234
• YANG, J., ROSE, F.R.A.J, GADEGAARD, N. and ALEXANDER, M.R., 2009. Effect of Sessile Drop Volume on the Wetting Anisotropy observed on grooved surfaces Langmuir. 25 (5), 2567-2571
• FRIEBOES, H.B., EDGERTON, M.E., FRUEHAUF, J.P., ROSE, F.R.A.J., WORRALL, L.K., GATENBY, R.A., FERRARI, M. and CRISTINI, V., 2009. Prediction of drug response in breast cancer using integrative experimental/computational modeling Cancer Research. 69(10), 4484-4492
• ZELZER, M., MAJANI, R., BRADLEY, J.W., ROSE, F.R.A.J., DAVIES, M.C. and ALEXANDER, M.R., 2008. Investigation of cell-surface interactions using chemical gradients formed from plasma polymers Biomaterials. 29(2), 172-184
• HOU, Q, CHAU, DYS, PRATOOMSOOT, C, TIGHE, PJ, DUA, HS, SHAKESHEFF, KM and ROSE, FRAJ, 2008. In situ gelling hydrogels incorporating microparticles as drug delivery carriers for regenerative medicine. Journal of Pharmaceutical Sciences. 97(9), 3972-3980
• PRATOOMSOOT, C., TANIOKA, H., HORI, K., KAWASAKI, S., KINOSHITA, S., TIGHE, P.J., DUA, H., SHAKESHEFF, K.M. and ROSE, F.R.A.J., 2008. A thermoreversible hydrogel as a biosynthetic bandage for corneal wound repair Biomaterials. 29(3), 272-281
• GINTY, P.J., HOWARD, D., UPTON, C.E., BARRY, JJ.A., ROSE, R.A.J., SHAKESHEFF, K.M. and HOWDLE, S.M., 2008. A supercritical CO2 injection system for the production of polymer/mammalian cell composites Journal of Supercritical Fluids. 43, 535-541 (In Press.)
• SAWYER, N.B.E., WORRALL, L.K., CROWE, J.A., WATERS, S.L., SHAKESHEFF, K.M., ROSE, F.R.A.J. and MORGAN, S.P., 2008. In situ monitoring of 3D in vitro cell aggregation using an optical imaging system Biotechnology and Bioengineering. 100(1), 159-167
• HIDALGO-BASTIDA, L.A., BARRY, J.J.A., EVERITT, N.M., ROSE, F.R.A.J., BUTTERY, L.D., HALL, I.P., CLAYCOMB, W.C. and SHAKESHEFF, K.M., 2007. Mechanical properties of a Flexible Scaffold for Cardiac Tissue Engineering Acta Biomaterialia. 387(4), 457-462
• LEMON, G., WATERS, S.L., ROSE, F.R.A.J. and KING, J.R., 2007. Mathematical modelling of human messenchymal stem cell proliferation and differentiation inside artificial porous scaffolds Journal of Theoretical Biology. 249, 543-553
• GATENBY, R.A., SMALLBONE, K., MAINI, P., ROSE, F.R.A.J., AVERILL, J., NAGLE, R. and GILLIES, R., 2007. Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer British Journal of Cancer. 97 (5), 646-653
• GINTY, P.J., HOWARD, D., ROSE, F.R.A.J., WHITAKER, M.J., BARRY, J.J.A., TIGHE, P., MUTCH, S.R., SERHATKULU, G., OREFFO, R.O.C., HOWDLE, S.M. and SHAKESHEFF, K.M., 2006. Mammalian cell survival and processing in supercritical CO₂ Proceedings of the National Academy of Sciences of the United States of America. 103(19), 7426-7431
• SILVA, M.M.C.G., CYSTER, L.A., BARRY, J.J.A., YANG, X.B., OREFFO, R.O.C., GRANT, D.M., SCOTCHFORD, C.A., HOWDLE, S.M., SHAKESHEFF, K.M. and ROSE, F.R.A.J., 2006. The effect of anisotropic architecture on cell and tissue infiltration into tissue engineering scaffolds Biomaterials. 27(35), 5909-5917
• WATERS, S.L., CUMMINGS, L.J., SHAKESHEFF, K.M and ROSE, F.R.A.J., 2006. Tissue growth in a rotating bioreactor. Part I: mechanical stability Mathematical Medicine and Biology. 23(4), 311-337
• SUCIATI, T., HOWARD, D., BARRY, J., EVERITT, N.M., SHAKESHEFF, K.M. and ROSE, F.R., 2006. Zonal release of proteins within tissue engineering scaffolds Journal of Materials Science: Materials in Medicine. 17(11), 1049-1056
• CYSTER, L.A., GRANT, D.M., HOWDLE, S.M., ROSE, F.R.A.J., IRVINE, D.J., FREEMAN, D., SCOTCHFORD, C.A. and SHAKESHEFF, K.M., 2005. The influence of dispersant concentration on the pore morphology of hydroxyapatite ceramics for bone tissue engineering Biomaterials. 26(7), 697-702
• BARRY, J.J.A., NAZHAT, S.N., ROSE, F.R.A.J., HAINSWORTH, A.H., SCOTCHFORD, C.A. and HOWDLE, S.M., 2005. Supercritical carbon dioxide foaming of elastomer/heterocyclic methacrylate blends as scaffolds for tissue engineering Journal of Materials Chemistry. 15(46), 4881-4888
• ROSE, F.R., CYSTER, L.A., GRANT, D.M., SCOTCHFORD, C.A., HOWDLE, S.M. and SHAKESHEFF, K.M., 2004. In vitro assessment of cell penetration into porous hydroxyapatite scaffolds with a central aligned channel. Biomaterials. 25(24), 5507-14
• ROSE, F.R.A.J., HOU, Q. and OREFFO, R.O.C., 2004. Delivery systems for bone growth factors - the new players in skeletal regeneration J. Pharm. Pharmacol. 56, 415-427
• SALEM, A.K., ROSE, F.R.A.J., OREFFO, R.O.C., YANG, X., DAVIES, M.C., MITCHELL, J.R., ROBERTS, C.J., STOLNIK-TRENKIC, S., TENDLER, S.J.B., WILLIAMS, P.M. and SHAKESHEFF, K.M., 2003. Porous polymer and cell composites that self-assemble in situ Advanced Materials. 15(3), 210-213
• UNSWORTH, J. M., ROSE, F. R. A. J., WRIGHT, E., SCOTCHFORD, C. A. and SHAKESHEFF, K. M., 2003. Seeding Cells into Needled Felt Scaffolds for Tissue Engineering Applications JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. VOL 66(PART 2), 425-431
• CUNLIFFE, R.N., KAMAL, M., ROSE, F.R.A.J., JAMES, P.D. and MAHIDA, Y.R., 2002. Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa Journal of Clinical Pathology. 55(4), 298-304
• SHAKESHEFF, K.M., SILVA, M., HOWDLE, S.M., SALEM, A.K., ROSE, F.R., WHITAKER, M.J., WOOD, I., DE BANK, P., KENDALL, D.A. and KELLAM, B., 2002. Delivering protein and cell therapeutics for tissue regeneration In: International Symposium on Recent Advances in Drug Delivery Systems.
• ROSE, FELICITY R A J and OREFFO, RICHARD O C, 2002. Bone tissue engineering: hope vs hype. Biochemical and Biophysical Research Communications. 292(1), 1-7
• CUNLIFFE, R.N., ROSE, F.R.A.J., KEYTE, J., ABBERLEY, L., CHAN, W.C. and MAHIDA, Y.R., 2001. Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease Gut: Journal of the British Society of Gastroenterology. 48(2), 176-185
• ROSE, F.R., SHAKESHEFF, K.M. and QUIRK, R., 2001. Tissue Engineering - New Technologies at the Interface between Pharmaceutical and Cell Sciences
• ROSE, F.R.A.J., BAILEY, K., KEYTE, J.W., CHAN, W.C., GREENWOOD, D and MAHIDA, Y.R., 1998. Potential role of epthelial cell-derived histone H1 proteins in innate antimicrobial defence in the human gastrointestinal tract Infect. Immun.. 66, 3255
• MAHIDA, Y.R., ROSE, F.R.A.J. and CHAN, W.C., 1997. Antimicrobial peptides in the gastrointestinal tract Gut. 40, 161
• Gelatin-Based Materials in Ocular Tissue Engineering