Adam Dundas

Contact

• workRoom B32 Coates Building
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 8466391
• Adam.Dundas1@nottingham.ac.uk

Biography

2023 - Current - Assistant Professor in Chemical and Environmental Engineering

2017 - 2023 - Research Fellow, Chemical and Environmental Engineering, University of Nottingham

2014-2017 - PhD, School of Pharmacy, University of Nottingham

2010-2014 - Msci, School of Physics, University of Nottingham

Expertise Summary

I have developed an expertise in discovering and manufacturing novel biomaterials for healthcare applications. I have discovered biomaterials that prevent biofilm formation and promote wound healing. Much work has been done on translating coating materials into 3D biomaterials using droplet microfluidics. This has resulted in microparticles capable of promoting wound healing in a diabetic mouse model. My aim is to develop novel biomaterials that integrate materials and cells to form engineered living materials capable of treating autoimmune diseases.

Selected Publications

• DUNDAS, ADAM A., SANNI, OLUTOBA, DUBERN, JEAN-FREDERIC, DIMITRAKIS, GEORGIOS, HOOK, ANDREW L., IRVINE, DEREK J., WILLIAMS, PAUL and ALEXANDER, MORGAN R., 2019. Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation ADVANCED MATERIALS. 31(49),
• LATIF, A., FISHER, L. E., DUNDAS, A. A., CUZZUCOLI CRUCITTI, V., IMIR, Z., LAWLER, K., PAPPALARDO, F., MUIR, B. W., WILDMAN, R., IRVINE, D. J., ALEXANDER, M. R. and GHAEMMAGHAMI, A. M., 2022. Microparticles Decorated with Cell-Instructive Surface Chemistries Actively Promote Wound Healing: Advanced Materials Advanced Materials.
• DUNDAS, ADAM A., CRUCITTI, VALENTINA CUZZUCOLI, HAAS, SIMON, DUBERN, JEAN-FREDERIC, LATIF, ARSALAN, ROMERO, MANUEL, SANNI, OLUTOBA, GHAEMMAGHAMI, AMIR M., WILLIAMS, PAUL, ALEXANDER, MORGAN R., WILDMAN, RICKY and IRVINE, DEREK J., 2020. Achieving Microparticles with Cell-Instructive Surface Chemistry by Using Tunable Co-Polymer Surfactants ADVANCED FUNCTIONAL MATERIALS.
• DUNDAS, ADAM A., HOOK, ANDREW L., ALEXANDER, MORGAN R., KINGMAN, SAMUEL W., DIMITRAKIS, GEORGIOS and IRVINE, DEREK J., 2019. Methodology for the synthesis of methacrylate monomers using designed single mode microwave applicators REACTION CHEMISTRY & ENGINEERING. 4(8), 1472-1476

• View all publications

Past Research

Throughout my research career I have developed polymeric biomaterials for anti-biofilm and pro-wound healing applications using a variety of different manufacturing techniques. During my PhD I used in silico models to design polymers capable of preventing biofilm formation. I also have extensive experience in the synthesis of monomers and polymers using both microwave and conventional heating methods. Using a high throughput materials discovery platform called polymer microarrays, predicted materials were shown to prevent biofilm formation and outperform previously identified hit materials. These polymers were then used as a coating material on urinary catheters as a method to prevent catheter associated urinary tract infections. Samples were typically characterised using NMR, FTIR, Bright field microscopy, ToF-SIMS and confocal microscopy.

During my post-doctoral position, I developed an expertise in processing polymeric materials using droplet microfluidics. I used droplet microfluidics with functional surfactants to produce polymer microparticles capable of preventing biofilm formation but also for promoting wound healing in in vitro and in vivo models. This involved optimising flow conditions and surfactant concentrations to produce monodisperse particles with a functional surface. I predominantly used SEM and ToF-SIMS for the material characterisation of manufactured microparticles.

My final post-doctoral position involved synthesising oligomer materials to act as adjuvants for vaccine manufacture. This involved the scale-up of lauryl and butyl methacrylate oligomers from the 5 ml to the 3 L scale. Samples were typically characterised using NMR and GPC.

• DUBERN, J. F., HOOK, A. L., CARABELLI, A. M., CHANG, C. Y., LEWIS-LLOYD, C. A., LUCKETT, J. C., BURROUGHS, L., DUNDAS, A. A., HUMES, D. J., IRVINE, D. J., ALEXANDER, M. R. and WILLIAMS, P., 2023. Discovery of a polymer resistant to bacterial biofilm, swarming, and encrustation: Science advances Science advances. 9(4), eadd7474
• WANG, K., NI, M., DUNDAS, A. A., DIMITRAKIS, G. and IRVINE, D. J., 2023. Ring opening polymerisation of ɛ-caprolactone with novel microwave magnetic heating and cyto-compatible catalyst: Frontiers in Bioengineering and Biotechnology Frontiers in Bioengineering and Biotechnology. 11,
• CRUCITTI, VALENTINA CUZZUCOLI, ILCHEV, ALEKSANDAR, MOORE, JONATHAN C., FOWLER, HARRIET R., DUBERN, JEAN-FREDERIC, SANNI, OLUTOBA, XUE, XUAN, HUSBAND, BETHANY K., DUNDAS, ADAM A., SMITH, SEAN, WILDMAN, JONI L., TARESCO, VINCENZO, WILLIAMS, PAUL, ALEXANDER, MORGAN R., HOWDLE, STEVEN M., WILDMAN, RICKY D., STOCKMAN, ROBERT A. and IRVINE, DEREK J., 2023. Predictive Molecular Design and Structure-Property Validation of Novel Terpene-Based, Sustainably Sourced Bacterial Biofilm-Resistant Materials BIOMACROMOLECULES.
• CORDULA HEGE, AMY STIMPSON, JOSEPH SEFTON, JAMES SUMMERS, HELENA HENKE, ADAM A DUNDAS, TONY PHAN, ROBERT KINSEY, JEFFREY A. GUDERIAN, SANDRA J. SIVANANTHAN, RAODOH MOHAMATH, WILLIAM R. LYKINS, GABI RAMER-DENISOFF, SUSAN LIN, CHRISTOPHER B. FOX and DEREK J. IRVINE, 2023. Screening of Oligomeric (Meth)acrylate Vaccine Adjuvants Synthesized via Catalytic Chain Transfer Polymerization Polymers. 15(18), 3831
• LATIF, A., FISHER, L. E., DUNDAS, A. A., CUZZUCOLI CRUCITTI, V., IMIR, Z., LAWLER, K., PAPPALARDO, F., MUIR, B. W., WILDMAN, R., IRVINE, D. J., ALEXANDER, M. R. and GHAEMMAGHAMI, A. M., 2022. Microparticles Decorated with Cell-Instructive Surface Chemistries Actively Promote Wound Healing: Advanced Materials Advanced Materials.
• HENSHAW, C. A., DUNDAS, A. A., CUZZUCOLI CRUCITTI, V., ALEXANDER, M. R., WILDMAN, R., ROSE, F. R. A. J., IRVINE, D. J. and WILLIAMS, P. M., 2021. Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants: Molecules (Basel, Switzerland) Molecules (Basel, Switzerland). 26(11),
• VALENTINA CUZZUCOLI CRUCITTI, LEONARDO CONTREAS, VINCENZO TARESCO, SHAUN C HOWARD, ADAM A DUNDAS, MARION J LIMO, TAKASI NISISAKO, PHILIP M WILLIAMS, PAUL WILLIAMS, MORGAN R ALEXANDER, RICKY D WILDMAN, BENJAMIN W MUIR and DEREK J IRVINE, 2021. Generation and Characterization of a Library of Novel Biologically Active Functional Surfactants (Surfmers) Using Combined High-Throughput Methods ACS Applied Materials & Interfaces, 2021..
• DUNDAS, A. A., KERN, S., CUZZUCOLI CRUCITTI, V., SCURR, D. J., WILDMAN, R., IRVINE, D. J. and ALEXANDER, M. R., 2021. A new particle mounting method for surface analysis: Surface and Interface Analysis Surface and Interface Analysis.
• DUNDAS, ADAM A., CRUCITTI, VALENTINA CUZZUCOLI, HAAS, SIMON, DUBERN, JEAN-FREDERIC, LATIF, ARSALAN, ROMERO, MANUEL, SANNI, OLUTOBA, GHAEMMAGHAMI, AMIR M., WILLIAMS, PAUL, ALEXANDER, MORGAN R., WILDMAN, RICKY and IRVINE, DEREK J., 2020. Achieving Microparticles with Cell-Instructive Surface Chemistry by Using Tunable Co-Polymer Surfactants ADVANCED FUNCTIONAL MATERIALS.
• DUNDAS, ADAM A., HOOK, ANDREW L., ALEXANDER, MORGAN R., KINGMAN, SAMUEL W., DIMITRAKIS, GEORGIOS and IRVINE, DEREK J., 2019. Methodology for the synthesis of methacrylate monomers using designed single mode microwave applicators REACTION CHEMISTRY & ENGINEERING. 4(8), 1472-1476
• DUNDAS, ADAM A., SANNI, OLUTOBA, DUBERN, JEAN-FREDERIC, DIMITRAKIS, GEORGIOS, HOOK, ANDREW L., IRVINE, DEREK J., WILLIAMS, PAUL and ALEXANDER, MORGAN R., 2019. Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation ADVANCED MATERIALS. 31(49),
• MIKULSKIS, PAULIUS, HOOK, ANDREW, DUNDAS, ADAM A., IRVINE, DEREK, SANNI, OLUTOBA, ANDERSON, DANIEL, LANGER, ROBERT, ALEXANDER, MORGAN R., WILLIAMS, PAUL and WINKLER, DAVID A., 2018. Prediction of Broad-Spectrum Pathogen Attachment to Coating Materials for Biomedical Devices ACS APPLIED MATERIALS & INTERFACES. 10(1), 139-149