Ravinder Anand-Ivell

Contact

• workRoom B11 North Laboratories
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6298
• Ravinder.Anand-ivell@nottingham.ac.uk

Biography

Ravinder is researching the hormone systems which govern fertility and reproductive health in men and women, as well as in domestic and other species, and is particularly interested in how early life experience, including lifestyle and nutrition, can dictate the health of an individual later in life and during ageing. Ravinder is also engaged in the development of a number of novel assay systems supporting both human and veterinary clinical science. Besides reproduction, Ravinder is interested in developing and understanding novel cell-based models for evaluating other tissues, including kidney and adrenal functions. She brings with her a long international experience of research, teaching and supervision from Europe, Asia, and Australia.

At various undergraduate and postgraduate levels, Ravinder teaches modules on Reproduction, Endocrine Systems, and Antibody Biotechnology. She is a firm believer in using research to inform her teaching. Ravinder supervises researchers at all levels (UG, PG, postdoc, senior scientist and internship candidates).

Expertise Summary

Research Keywords

• Health across the lifespan
• Reproductive physiology and fertility
• Cells and Hormones
• Lifestyle, nutrition, and healthy ageing
• Environmental endocrine disruption

Expertise

• Endocrinology and physiology of male and female reproduction in humans and domestic species, looking at foetal development, as well as puberty and adult function, including ageing.
• Cell culture and molecular analysis of primary and secondary cell systems from human and domestic species, with emphasis on both male and female reproductive physiology and their regulation.
• Cell signalling, particularly studying the role of novel G-protein-coupled receptors in reproductive cells and other tissues.
• Sperm biology.
• Development of novel immunoassays for the measurement of hormones and signalling molecules in a variety of different matrices, mostly employing a time-resolved fluorescence immunoassay (TRFIA) platform.

Teaching Summary

I teach in the following UG and PG modules

Introductory Physiology (BIOS1001)

Reproductive Physiology (BIOS2011) (convenor)

Endocrinology Control Systems (BIOS2028) (convenor)

Reproduction and Fertility (D236Z5)

Academic Development and Employability skills (D21BP1)

Antibody Biotechnology (BIOS4004)

Research Summary

The role of the neohormones relaxin and INSL3, and their G-protein-coupled receptors, in male and female physiology. In the male this relates to foetal development, puberty, and healthy ageing; in… read more

Selected Publications

• DAI Y, IVELL R, LIU X, JANOWSKI D and ANAND-IVELL R, 2017. Relaxin-Family Peptide Receptors 1 and 2 Are Fully Functional in the Bovine. Frontiers in physiology. 8, 359
• TOFT, GUNNAR, JONSSON, BO A. G., BONDE, JENS PETER, NORGAARD-PEDERSEN, BENT, HOUGAARD, DAVID M., COHEN, ARIEH, LINDH, CHRISTIAN H., IVELL, RICHARD, ANAND-IVELL, RAVINDER and LINDHARD, MORTEN S., 2016. Perfluorooctane Sulfonate Concentrations in Amniotic Fluid, Biomarkers of Fetal Leydig Cell Function, and Cryptorchidism and Hypospadias in Danish Boys (1980-1996) ENVIRONMENTAL HEALTH PERSPECTIVES. 124(1), 151-156
• IVELL, RICHARD, DAI, YANZHENZI, MANN, NAVDEEP and ANAND-IVELL, RAVINDER, 2014. Non-classical mechanisms of steroid sensing in the ovary: Lessons from the bovine oxytocin model MOLECULAR AND CELLULAR ENDOCRINOLOGY. 382(1), 466-471
• GLYNN DJ, HENG K, RUSSELL DL, SHARKEY DJ, ROBERTSON SA, ANAND-IVELL R and IVELL R, 2017. Male Seminal Relaxin Contributes to Induction of the Post-mating Cytokine Response in the Female Mouse Uterus. Frontiers in physiology. 8, 422

• View all publications

Current Research

• The role of the neohormones relaxin and INSL3, and their G-protein-coupled receptors, in male and female physiology. In the male this relates to foetal development, puberty, and healthy ageing; in the female to fertility and miscarriage, as well as to ovarian dysfunction.
• The role of foetal gender on maternal physiology.
• Mechanisms of action of environmental endocrine disrupting chemicals, such as phthalates and xenoestrogens, in influencing the reproductive phenotype.
• Non-classical actions of steroid hormones on reproductive cells and tissues.
• Development of a new cell-based kidney model for evaluating excretion.

• DAI Y, IVELL R, LIU X, JANOWSKI D and ANAND-IVELL R, 2017. Relaxin-Family Peptide Receptors 1 and 2 Are Fully Functional in the Bovine. Frontiers in physiology. 8, 359
• GLYNN DJ, HENG K, RUSSELL DL, SHARKEY DJ, ROBERTSON SA, ANAND-IVELL R and IVELL R, 2017. Male Seminal Relaxin Contributes to Induction of the Post-mating Cytokine Response in the Female Mouse Uterus. Frontiers in physiology. 8, 422
• TOFT, GUNNAR, JONSSON, BO A. G., BONDE, JENS PETER, NORGAARD-PEDERSEN, BENT, HOUGAARD, DAVID M., COHEN, ARIEH, LINDH, CHRISTIAN H., IVELL, RICHARD, ANAND-IVELL, RAVINDER and LINDHARD, MORTEN S., 2016. Perfluorooctane Sulfonate Concentrations in Amniotic Fluid, Biomarkers of Fetal Leydig Cell Function, and Cryptorchidism and Hypospadias in Danish Boys (1980-1996) ENVIRONMENTAL HEALTH PERSPECTIVES. 124(1), 151-156
• VERNUNFT, ANDREAS, IVELL, RICHARD, HENG, KEE and ANAND-IVELL, RAVINDER, 2016. The Male Fetal Biomarker INSL3 Reveals Substantial Hormone Exchange between Fetuses in Early Pig Gestation PLOS ONE. 11(3),
• IVELL R, AGOULNIK AI and ANAND-IVELL R, 2016. Relaxin-like peptides in male reproduction - a human perspective. British journal of pharmacology. 174(10), 990-1001
• VERNUNFT A, IVELL R, HENG K and ANAND-IVELL R, 2016. Correction: The Male Fetal Biomarker INSL3 Reveals Substantial Hormone Exchange between Fetuses in Early Pig Gestation. PloS one. 11(6), e0157954
• HAGEN, CASPER P., MIERITZ, MIKKEL G., NIELSEN, JOHN E., ANAND-IVELL, RAVINDER, IVELL, RICHARD and JUUL, ANDERS, 2015. Longitudinal assessment of circulating insulin-like peptide 3 levels in healthy peripubertal girls FERTILITY AND STERILITY. 103(3), 780-U502
• JENSEN, MORTEN SONDERGAARD, ANAND-IVELL, RAVINDER, NORGAARD-PEDERSEN, BENT, JONSSON, BO A. G., BONDE, JENS PETER, HOUGAARD, DAVID M., COHEN, ARIEH, LINDH, CHRISTIAN H., IVELL, RICHARD and TOFT, GUNNAR, 2015. Amniotic Fluid Phthalate Levels and Male Fetal Gonad Function EPIDEMIOLOGY. 26(1), 91-99
• BARTHOLD, JULIA S., ROBBINS, ALAN, WANG, YANPING, PUGARELLI, JOAN, MATESON, ABIGAIL, ANAND-IVELL, RAVINDER, IVELL, RICHARD, MCCAHAN, SUZANNE M. and AKINS, ROBERT E., JR., 2014. Cryptorchidism in the Orl Rat Is Associated with Muscle Patterning Defects in the Fetal Gubernaculum and Altered Hormonal Signaling BIOLOGY OF REPRODUCTION. 91(2),
• JOHANSEN, MARIE LINDHARDT, ANAND-IVELL, RAVINDER, MOURITSEN, ANNETTE, HAGEN, CASPER P., MIERITZ, MIKKEL G., SOEBORG, TUE, JOHANNSEN, TRINE HOLM, MAIN, KATHARINA M., ANDERSSON, ANNA-MARIA, IVELL, RICHARD and JUUL, ANDERS, 2014. Serum levels of insulin-like factor 3, anti-Mullerian hormone, inhibin B, and testosterone during pubertal transition in healthy boys: a longitudinal pilot study REPRODUCTION. 147(4), 529-535
• IVELL, RICHARD, DAI, YANZHENZI, MANN, NAVDEEP and ANAND-IVELL, RAVINDER, 2014. Non-classical mechanisms of steroid sensing in the ovary: Lessons from the bovine oxytocin model MOLECULAR AND CELLULAR ENDOCRINOLOGY. 382(1), 466-471
• IVELL, RICHARD, HENG, KEE and ANAND-IVELL, RAVINDER, 2014. Insulin-Like Factor 3 and the HPG Axis in the Male. Frontiers in endocrinology. 5, 6
• BARTHOLD, JULIA S, BARTHOLD, JULIA S, ROBBINS, ALAN, WANG, YANPING, PUGARELLI, JOAN, MATESON, ABIGAIL, ANAND-IVELL, RAVINDER, IVELL, RICHARD, MCCAHAN, SUZANNE M and AKINS , ROBERT E, JR, 2014. GSE57924: Cryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling Gene Expression Omnibus.
• BAY K, ANAND-IVELL R, 2014. Human testicular insulin-like factor 3 and endocrine disrupters.
• ANAND-IVELL R and IVELL R, 2013. Regulation of the reproductive cycle and early pregnancy by relaxin family peptides. Molecular and cellular endocrinology. 382(1), 472-9
• ANAND-IVELL R and IVELL R, 2013. Insulin-like factor 3 as a monitor of endocrine disruption. Reproduction (Cambridge, England). 147(4), R87-95
• IVELL R, HENG K, NICHOLSON H and ANAND-IVELL R, 2013. Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring. Asian journal of andrology. 15(2), 261-8
• ANAND-IVELL R, DAI Y and IVELL R, 2013. Neohormones as biomarkers of reproductive health. Fertility and sterility. 99(4), 1153-60
• GLISTER C, SATCHELL L, BATHGATE RA, WADE JD, DAI Y, IVELL R, ANAND-IVELL R, RODGERS RJ and KNIGHT PG, 2013. Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proceedings of the National Academy of Sciences of the United States of America. 110(15), E1426-35
• SATCHELL L, GLISTER C, BLEACH EC, GLENCROSS RG, BICKNELL AB, DAI Y, ANAND-IVELL R, IVELL R and KNIGHT PG, 2013. Ovarian expression of insulin-like peptide 3 (INSL3) and its receptor (RXFP2) during development of bovine antral follicles and corpora lutea and measurement of circulating INSL3 levels during synchronized estrous cycles. Endocrinology. 154(5), 1897-906
• IVELL R, WADE JD and ANAND-IVELL R, 2013. INSL3 as a biomarker of Leydig cell functionality. Biology of reproduction. 88(6), 147
• ANAND-IVELL R, TREMELLEN K, DAI Y, HENG K, YOSHIDA M, KNIGHT PG, HALE GE and IVELL R, 2013. Circulating insulin-like factor 3 (INSL3) in healthy and infertile women. Human reproduction (Oxford, England). 28(11), 3093-102
• HUNTER D, ANAND-IVELL R, DANNER S and IVELL R, 2012. Models of in vitro spermatogenesis. Spermatogenesis. 2(1), 32-43
• JENSEN MS, NØRGAARD-PEDERSEN B, TOFT G, HOUGAARD DM, BONDE JP, COHEN A, THULSTRUP AM, IVELL R, ANAND-IVELL R, LINDH CH and JÖNSSON BA, 2012. Phthalates and perfluorooctanesulfonic acid in human amniotic fluid: temporal trends and timing of amniocentesis in pregnancy. Environmental health perspectives. 120(6), 897-903
• HENG K, ANAND-IVELL R, TEERDS K and IVELL R, 2011. The endocrine disruptors dibutyl phthalate (DBP) and diethylstilbestrol (DES) influence Leydig cell regeneration following ethane dimethane sulphonate treatment of adult male rats. International journal of andrology. 35(3), 353-63
• ANAND-IVELL R and IVELL R, 2011. The special systems biology of the sperm. The Biochemical journal. 436(3), e3-5
• ANAND-IVELL R, HIENDLEDER S, VIÑOLES C, MARTIN GB, FITZSIMMONS C, EURICH A, HAFEN B and IVELL R, 2011. INSL3 in the ruminant: a powerful indicator of gender- and genetic-specific feto-maternal dialogue. PloS one. 6(5), e19821
• IVELL R and ANAND-IVELL R, 2011. Biological role and clinical significance of insulin-like peptide 3. Current opinion in endocrinology, diabetes, and obesity. 18(3), 210-6
• IVELL R, KOTULA-BALAK M, GLYNN D, HENG K and ANAND-IVELL R, 2010. Relaxin family peptides in the male reproductive system--a critical appraisal. Molecular human reproduction. 17(2), 71-84
• ANAND-IVELL R, HENG K, HAFEN B, SETCHELL B and IVELL R, 2009. Dynamics of INSL3 peptide expression in the rodent testis. Biology of reproduction. 81(3), 480-7
• IVELL R and ANAND-IVELL R, 2009. Biology of insulin-like factor 3 in human reproduction. Human reproduction update. 15(4), 463-76
• ATLANTIS E, MARTIN SA, HAREN MT, O'LOUGHLIN PD, TAYLOR AW, ANAND-IVELL R, IVELL R, WITTERT GA and , 2009. Demographic, physical and lifestyle factors associated with androgen status: the Florey Adelaide Male Ageing Study (FAMAS). Clinical endocrinology. 71(2), 261-72
• RIJNTJES E, SWARTS HJ, ANAND-IVELL R and TEERDS KJ, 2008. Prenatal induced chronic dietary hypothyroidism delays but does not block adult-type Leydig cell development. American journal of physiology. Endocrinology and metabolism. 296(2), E305-14
• HENG K, IVELL R, WAGAARACHCHI P and ANAND-IVELL R, 2008. Relaxin signalling in primary cultures of human myometrial cells. Molecular human reproduction. 14(10), 603-11
• ANAND-IVELL R, IVELL R, DRISCOLL D and MANSON J, 2008. Insulin-like factor 3 levels in amniotic fluid of human male fetuses. Human reproduction (Oxford, England). 23(5), 1180-6
• IVELL R, HENG K and ANAND-IVELL R, 2007. Diverse signalling mechanisms used by relaxin in natural cells and tissues: the evolution of a "neohormone". Advances in experimental medicine and biology. 612, 26-33
• ANAND-IVELL R, HENG K, BARTSCH O and IVELL R, 2007. Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway. Molecular and cellular endocrinology. 272(1-2), 1-13
• ANAND-IVELL R, WOHLGEMUTH J, HAREN MT, HOPE PJ, HATZINIKOLAS G, WITTERT G and IVELL R, 2006. Peripheral INSL3 concentrations decline with age in a large population of Australian men. International journal of andrology. 29(6), 618-26
• ANAND-IVELL RJ, RELAN V, BALVERS M, COIFFEC-DORVAL I, FRITSCH M, BATHGATE RA and IVELL R, 2006. Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis. Biology of reproduction. 74(5), 945-53
• SADEGHIAN H, ANAND-IVELL R, BALVERS M, RELAN V and IVELL R, 2005. Constitutive regulation of the Insl3 gene in rat Leydig cells. Molecular and cellular endocrinology. 241(1-2), 10-20
• IVELL R, HARTUNG S and ANAND-IVELL R, 2005. Insulin-like factor 3: where are we now? Annals of the New York Academy of Sciences. 1041, 486-96
• IVELL R, ANAND-IVELL R and BARTSCH O, 2005. Relaxin signaling from natural receptors. Annals of the New York Academy of Sciences. 1041, 280-7
• IVELL R, BALVERS M, ANAND RJ, PAUST HJ, MCKINNELL C and SHARPE R, 2003. Differentiation-dependent expression of 17beta-hydroxysteroid dehydrogenase, type 10, in the rodent testis: effect of aging in Leydig cells. Endocrinology. 144(7), 3130-7
• ANAND RJ, PAUST HJ, ALTENPOHL K and MUKHOPADHYAY AK, 2003. Regulation of vascular endothelial growth factor production by Leydig cells in vitro: the role of protein kinase A and mitogen-activated protein kinase cascade. Biology of reproduction. 68(5), 1663-73
• ANAND RJ, KANWAR U and SANYAL SN, 1996. Ca(2+)-transport across brush border and basal surfaces of human term [correction of terms] placenta. Indian journal of experimental biology. 34(8), 786-93
• ANAND RJ, KANWAR U and SANYAL SN, 1996. Isolation and characterization of the basal cell membranes of the human term placenta. Indian journal of biochemistry & biophysics. 33(4), 298-307
• ANAND RJ, KANWAR U and SANYAL SN, 1996. Transport of glycine in the brush border and basal cell membrane vesicles of the human term placenta. Biochemistry and molecular biology international. 38(1), 21-30
• ANAND RJ, KANWAR U and SANYAL SN, 1996. Placental membrane transport: leucine transport across the brush border and basal cell membrane surfaces. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. 196(1), 29-43
• ANAND RJ, KANWAR U and SANYAL SN, 1994. Calcium channel antagonist verapamil modulates human spermatozoal functions. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. 194(3), 165-78
• KANWAR U, ANAND RJ and SANYAL SN, 1993. The effect of nifedipine, a calcium channel blocker, on human spermatozoal functions. Contraception. 48(5), 453-70
• In: Endocrinology of the Fetal Testis