Needle fasciotomy versus limited fasciectomy for Dupuytren’s contractures (HAND-1)

Study title

Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers: a feasibility study which investigates the acceptability and design of a multicentre randomised controlled trial (HAND-1).
Funding reference number PB-PG-0613-31083.

Overview

The objective of the HAND-1 study was to investigate the feasibility and acceptability of conducting a randomised controlled trial (RCT) to compare the clinical and cost effectiveness of needle fasciotomy with limited fasciectomy for the treatment of Dupuytren’s contractures of fingers.

The HAND-1 study was led by Professor Tim Davis of Nottingham University Hospitals NHS Trust, and was co-ordinated from the Nottingham Clinical Trials Unit. Patients were recruited at Nottingham University Hospitals NHS Trust/Nottingham Treatment Centre, Derby NHS Foundation Trust and Wrightington, Wigan and Leigh NHS Foundation Trust.

The study was funded by the National Institute for Health Research (NIHR) Research for Patient Benefit (RfPB) stream.

Key facts

This was a feasibility randomised controlled trial at three secondary care centres.

Patients with Dupuytren’s contracture were recruited at Nottingham University Hospitals NHS Trust/Nottingham Treatment Centre, Derby NHS Foundation Trust and Wrightington, Wigan and Leigh NHS Foundation Trust.

The study has now been completed.

Publications

Final report 

Trial Protocol 

A feasibility study investigating the acceptability and design of a multicentre randomised controlled trial of needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren's contractures of the fingers (HAND-1): study protocol for a randomised controlled trial.
Harrison E, Tan W, Mills N, Karantana A, Sprange K, Duley L, Elliott D, Blazeby J, Hollingworth W, Montgomery AA, Davis T.
Trials. 2017 Aug 25;18(1):392. doi: 10.1186/s13063-017-2127-9.