SJ FENWICK, PR HINCKS, JP SCARTH, ME WIEDER, LL HILLYER, SW PAINE, 2017. Detection and pharmacokinetics of salmeterol in thoroughbred horses following inhaled administration Journal of Veterinary Pharmacology and Therapeutics. CHERKAOUI-RBATI, MOHAMMED H, PAINE, STUART W, LITTLEWOOD, PETER and RAUCH, CYRIL, 2017. A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions. PloS one. 12(9), e0183794
STUART W. PAINE, JANE BRIGHT, JAMES P. SCARTH, PAMELA R. BROWN, CLIVE M. PEARCE, COLETTE HANNAN, MARC MACHNIK, LYNN HILLYER., 2016. Equine pharmacokinetics of butorphanol in combination with an alpha-2 agonist sedative. Proceedings of the 20th International Conference of Racing Analysts and Veterinarians. 243-250
HILLYER, L, WIEDER, M, HINCKS, P, PEARCE, C AND PAINE, SW, 2016. Administration studies of procaine penicillin to determine a Detection Time Proceedings of the 20th International Conference of Racing Analysts and Veterinarians. 471-474.
SHIBANY KA, TÖTEMEYER S, PRATT SL and PAINE SW, 2016. Equine hepatocytes: isolation, cryopreservation, and applications to in vitro drug metabolism studies. Pharmacology research & perspectives. 4(5), e00268 ME WIEDER, SW PAINE, PR HINCKS, CM PEARCE, J SCARTH, L HILLYER, 2015. Detection and pharmacokinetics of salbutamol in thoroughbred racehorses following inhaled administration Journal of veterinary pharmacology and therapeutics. 38(1), 41-47
MICHAEL J STOCKS, LILIAN ALCARAZ, ANDREW BAILEY, ROGER BONNERT, ELAINE CADOGAN, JADEEN CHRISTIE, JOHN DIXON, STEPHEN CONNOLLY, ANTHONY COOK, STUART PAINE, 2014. Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action ACS Med Chem Lett. S W PAINE and A SALAM, 2013. Computational Study of Tautomerism and Aromaticity in
Mono- and Dithio-Substituted Tropolone International Journal of Quantum Chemistry. 113, 1245–1252
BAYARD, F.J.C., THIELEMANS, W., PRITCHARD, D.I., PAINE, S.W., YOUNG, S.S., BÄCKMAN, P., EWING, P. and BOSQUILLON, C., 2013. Polyethylene glycol-drug ester conjugates for prolonged retention of small inhaled drugs in the lung Journal of Controlled Release. 171(2), 234-240 ALCARAZ, L., BAILEY, A., CADOGAN, E., CONNOLLY, S., JEWELL, R., JORDAN, S., KINDON, N., LISTER, A., LAWSON, M., MULLEN, A., DAINTY, I., NICHOLLS, D., PAINE, S., PAIRAUDEAU, G., STOCKS, M.J., THORNE, P. and YOUNG, A., 2012. From libraries to candidate: the discovery of new ultra long-acting dibasic β2-adrenoceptor agonists Bioorganic & Medicinal Chemistry Letters. 22(1), 689-95 NICHOLLS DJ, JORDAN S, CADOGAN E, LAWSON M, AUSTIN RP, PAINE SW, GARDINER P, BONNERT R, CONNOLLY S and YOUNG A, 2012. Characteristics of azd9708, a novel, selective β(2)-adrenoceptor agonist with rapid onset and long duration of action. Pulmonary pharmacology & therapeutics. (In Press.)
WIEDER, M., GRAY, B., BROWN, P., HUDSON, S., PEARCE, C., PAINE, S. and HILLYER, L., 2012. Identification of Acepromazine and Its Metabolites in Horse Plasma and Urine by LC–MS/MS and Accurate Mass Measurement Chromatographia. 75, 635-643 GARDINER P and PAINE SW, 2011. The Impact Of Hepatic Uptake On The Pharmacokinetics Of Organic Anions. Drug Metabolism And Disposition: The Biological Fate Of Chemicals. 39(10), 1930-8 PAINE SW, MÉNOCHET K, DENTON R, MCGINNITY DF and RILEY RJ, 2011. Prediction Of Human Renal Clearance From Preclinical Species For A Diverse Set Of Drugs That Exhibit Both Active Secretion And Net Reabsorption. Drug Metabolism And Disposition: The Biological Fate Of Chemicals. 39(6), 1008-13 LUKER, T., BONNERT, R., PAINE, S.W., SCHMIDT, J., SARGENT, C., COOK, A.R., COOK, A., GARDINER, P., HILL, S., WEYMAN-JONES, C., PATEL, A., THOM, S. and THORNE, P., 2011. Zwitterionic CRTh2 antagonists. Journal of Medicinal Chemistry. 54(6), 1779-1788 LUKER, T, BONNERT, R, SCHMIDT, J, SARGENT, C, PAINE, SW, THOM, S, PAIRAUDEAU, G, PATEL, A, MOHAMMED, R, AKAM, E, DOUGALL, I, DAVIS, AM, ABBOTT, P, BROUGH, S, MILLICHIP, I and MCINALLY, T, 2011. Switching Between Agonists And Antagonists At Crth2 In A Series Of Highly Potent And Selective Biaryl Phenoxyacetic Acids Bioorganic & Medicinal Chemistry Letters. 21(12), 3616-3621 LUKER, T., BONNERT, R., BROUGH, S., COOK, A.R., DICKINSON, M.R., DOUGALL, I., LOGAN, C., MOHAMMED, R.T., PAINE, S., SANGANEE, H.J., SARGENT, C., SCHMIDT, J.A., TEAGUE, S. and THOM, S., 2011. Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists—discovery of AZD1981 Bioorganic & Medicinal Chemistry Letters. 21(21), 6288-6292 CONNOLLY, S., ALCARAZ, L., BAILEY, A., CADOGAN, E., CHRISTIE, J., COOK, A.R., FISHER, A.J., HILL, S., HUMPHRIES, A., INGALL, A.H., KANE, Z., PAINE, S., PAIRAUDEAU, G., STOCKS, M.J. and YOUNG, A., 2011. Design-driven LO: the discovery of new ultra long acting dibasic β2-adrenoceptor agonists Bioorganic & Medicinal Chemistry Letters. 21(15), 4612-4616 STOCKS, M.J., ALCARAZ, L., BAILEY, A., BONNERT, R., CADOGAN, E., CHRISTIE, J., CONNOLLY, S., COOK, A., FISHER, A., FLAHERTY, A., HILL, S., HUMPHRIES, A., INGALL, A., JORDAN, S., LAWSON, M., MULLEN, A., NICHOLLS, D., PAINE, S., PAIRAUDEAU, G., ST-GALLAY, S. and YOUNG, A., 2011. Design driven HtL: the discovery and synthesis of new high efficacy β2-agonists Bioorganic & Medicinal Chemistry Letters. 21(13), 4027-4031 POTTER T, LEWIS R, LUKER T, BONNERT R, BERNSTEIN MA, BIRKINSHAW TN, THOM S, WENLOCK M and PAINE S, 2011. In Silico Prediction Of Acyl Glucuronide Reactivity. Journal Of Computer-Aided Molecular Design. 25(11), 997-1005 ALAN YOUNG, RUPERT AUSTIN, ROGER BONNERT, ELAINE CADOGAN, STEPHEN CONNOLLY, PHILIP GARDINER, STEPHEN JORDAN, MANDY LAWSON, PETER MUTCH, DAVID NICHOLLS, STUART PAINE, GARY PAIRAUDEAU, MICHAEL STOCKS, 2011. AZD3199: A potent and selective β2-adrenergic receptor agonist with rapid onset of action European Respiratory Journal. 38(Suppl 55), 1779
D NICHOLLS, S CONNOLLY, G PAIRAUDEAU, RV BONNERT, EB CADOGAN, MJ STOCKS, SM JORDAN, S PAINE, PA YOUNG, 2011. The in vivo profile of AZD3199: a novel, fast acting b2-agonist with a long duration of action Am J Respir Crit Care Med. 183, A1586
ALAN YOUNG, ROGER BONNERT, ELAINE CADOGAN, STEPHEN CONNOLLY, PHILIP GARDINER, STEPHEN JORDAN, DAVID NICHOLLS, STUART PAINE, GARY PAIRAUDEAU, MICHAEL STOCKS, 2011. AZD3199: A fast acting β2-receptor agonist with a long duration of action European Respiratory Journal. 38(Suppl 55), 858
PAINE SW, BARTON P, BIRD J, DENTON R, MENOCHET K, SMITH A, TOMKINSON NP and CHOHAN KK, 2010. A Rapid Computational Filter For Predicting The Rate Of Human Renal Clearance. Journal Of Molecular Graphics & Modelling. 29(4), 529-37 BAYARD, F, CALANDE, T, PRITCHARD, DI, THIELEMANS, W, YOUNG, S, PAINE, S and BOSQUILLON, C, 2010. Esterase activity in the Human Bronchial Epithelial Calu-3 Cell Line Journal of Pharmacy & Pharmacology. 62, 1316-1317 CAROL SARGNET, SALLY STINSON, JERZY SCHMIDT, IAIN DOUGALL, ROGER BONNERT, STUART PAINE, MICHAEL SAUNDERS, MARTYN FOSTER., 2009. The effect of a selective CRTh2 antagonist on tobacco smoke (TS) induced airway inflammation and remodelling in the mouse In: Br J Pharmacol. 7. 003P
PAINE, S.W., PARKER, A.J., GARDINER, P., WEBBORN, P.J.H. and RILEY, R.J., 2008. Prediction of the pharmacokinetics of atorvastatin, cerivastatin and indomethacin using kinetic models applied to isolated rat hepatocytes. Drug Metabolism and Disposition. 36(7), 1365-1374 KAMALDEEP K. CHOHAN, STUART W. PAINE and NIGEL J. WATERS, 2008. Advancements in Predictive In Silico Models for ADME Current Chemical Biology. 2, 215-228
GARDINER, P and PAINE, SW, 2008. PREDICTION OF THE PHARMACOKINETICS OF ANIONIC DRUGS USING KINETIC MODELS APPLIED TO ISOLATED RAT HEPATOCYTES Drug Metabolism Reviews. 40, 146-146
GLEESON MP, DAVIS AM, CHOHAN KK, PAINE SW, BOYER S, GAVAGHAN CL, ARNBY CH, KANKKONEN C and ALBERTSON N, 2007. Generation Of In-Silico Cytochrome P450 1A2, 2C9, 2C19, 2D6, And 3A4 Inhibition Qsar Models. Journal Of Computer-Aided Molecular Design. 21(10-11), 559-73 SPRINGTHORPE B, BAILEY A, BARTON P, BIRKINSHAW TN, BONNERT RV, BROWN RC, CHAPMAN D, DIXON J, GUILE SD, HUMPHRIES RG, HUNT SF, INCE F, INGALL AH, KIRK IP, LEESON PD, LEFF P, LEWIS RJ, MARTIN BP, MCGINNITY DF, MORTIMORE MP, PAINE SW, PAIRAUDEAU G, PATEL A, RIGBY AJ, RILEY RJ, TEOBALD BJ, TOMLINSON W, WEBBORN PJH and WILLIS PA, 2007. From Atp To Azd6140: The Discovery Of An Orally Active Reversible P2y12 Receptor Antagonist For The Prevention Of Thrombosis. Bioorganic & Medicinal Chemistry Letters. 17(21), 6013-8 CHOHAN KK, PAINE SW and WATERS NJ, 2006. Quantitative Structure Activity Relationships In Drug Metabolism. Current Topics In Medicinal Chemistry. 6(15), 1569-78 GLEESON MP, WATERS NJ, PAINE SW and DAVIS AM, 2006. In Silico Human And Rat Vss Quantitative Structure-Activity Relationship Models. Journal Of Medicinal Chemistry. 49(6), 1953-63 BIRKINSHAW, TN, TEAGUE, SJ, BEECH, C, BONNERT, RV, HILL, S, PATEL, A, REAKES, S, SANGANEE, H, DOUGALL, IG, PHILLIPS, TT, SALTER, S, SCHMIDT, J, ARROWSMITH, EC, CARRILLO, JJ, BELL, FM, PAINE, SW and WEAVER, R, 2006. Discovery Of Potent Crth2 (Dp2) Receptor Antagonists Bioorganic & Medicinal Chemistry Letters. 16(16), 4287-4290 CHOHAN KK, PAINE SW, MISTRY J, BARTON P and DAVIS AM, 2005. A Rapid Computational Filter For Cytochrome P450 1A2 Inhibition Potential Of Compound Libraries. Journal Of Medicinal Chemistry. 48(16), 5154-61 BAXTER A, BROUGH S, COOPER A, FLOETTMANN E, FOSTER S, HARDING C, KETTLE J, MCINALLY T, MARTIN C, MOBBS M, NEEDHAM M, NEWHAM P, PAINE S, ST-GALLAY S, SALTER S, UNITT J and XUE Y, 2004. Hit-To-Lead Studies: The Discovery Of Potent, Orally Active, Thiophenecarboxamide Ikk-2 Inhibitors. Bioorganic & Medicinal Chemistry Letters. 14(11), 2817-22 PAINE, SW and LOGAN, C, 2003. The restricted well-stirred model revisited Drug Metabolism Reviews. 35, 60-60
ANDRAOS, J, CHIANG, Y, EUSTACE, SJ, KRESGE, AJ, PAINE, SW, POPIK, VV and SUNG, K, 1999. Solvent Isotope Effect On The Hydroxide-Ion-Catalyzed Hydration Of Ketenes In Aqueous Solution Canadian Journal Of Chemistry-Revue Canadienne De Chimie. 77(4), 459-462 CHIANG, Y, GRANT, AS, GUO, HX, KRESGE, AJ and PAINE, SW, 1997. Flash Photolytic Decarbonylation And Ring-Opening Of 2-(N-(Pentafluorophenyl)Amino)-3-Phenylcyclopropenone. Isomerization Of The Resulting Ynamine To A Ketenimine, Hydration Of The Ketenimine, And Hydrolysis Of The Enamine Produced By Ring-Opening Journal Of Organic Chemistry. 62(16), 5363-5370 CHIANG, Y, GRANT, AS, KRESGE, AJ and PAINE, SW, 1996. Flash Photolytic Generation Of Primary, Secondary, And Tertiary Ynamines In Aqueous Solution And Study Of Their Carbon-Protonation Reactions In That Medium Journal Of The American Chemical Society. 118(18), 4366-4372 CHIANG, Y, KRESGE, AJ, PAINE, SW and POPIK, VV, 1996. Reactive Species: Ynols And Ynamines Journal of Physical Organic Chemistry. 9(6), 361-370