David Humes

Contact

• workQMC West Block
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 823 1153
• fax0115 823 1160
• david.humes@nottingham.ac.uk

Research Summary

I am currently using linked CPRD and HES data to study the epidemiology of venous thromboembolism following general surgical procedures and the epidemiology of complicated diverticular disease. I am… read more

Selected Publications

• CHOWDHURY, A. H., HUMES, D. J., PRITCHARD, S. E., MARCIANI, L., GOWLAND, P. A., SIMPSON, J. and LOBO, D. N., 2011. The effects of morphine-neostigmine and secretin provocation on pancreaticobiliary morphology in healthy subjects: a randomized, double-blind crossover study using serial MRCP. World Journal of Surgery. 35(9), 2102-2109
• SMITH, J K, MARCIANI, L, HUMES, D J, FRANCIS, S T, GOWLAND, P and SPILLER, R C, 2016. Anticipation of thermal pain in diverticular disease. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 28(6), 900-13
• ABDUL SULTAN A, WEST J, BAN L, HUMES D, TATA LJ, FLEMING KM, NELSON-PIERCY C and CARD T, 2016. Adverse Pregnancy Outcomes Among Women with Inflammatory Bowel Disease: A Population-Based Study from England. Inflammatory bowel diseases. 22(7), 1621-30
• HUMES DJ, AHMED I and LOBO DN, 2010. The Pedicle Effect And Direct Coupling: Delayed Thermal Injuries To The Bile Duct After Laparoscopic Cholecystectomy. Archives Of Surgery (Chicago, Ill. : 1960). 145(1), 96-8

• View all publications

Current Research

I am currently using linked CPRD and HES data to study the epidemiology of venous thromboembolism following general surgical procedures and the epidemiology of complicated diverticular disease. I am also supervising an NIHR Doctoral Fellowship awarded to Miss Elizabeth Elsey using ISCP data from UK surgical training to define evidence based standards.

Past Research

I completed my PhD on symptom aetiology in diverticular disease and the epidemiology of perforated diverticular disease. Since completion of my PhD my post doctoral work has focused on the epidemiology of complicated diverticular disease, venous thromboembolism following surgery, appendicitis and inflammatory bowel disease.

Future Research

I plan to use routinely collected health care data to study the epidemiology of various surgical conditions.

• MCGRANE JM, HUMES DJ, ACHESON AG, MINEAR F, WHEELER JMD and WALTER CJ, 2017. Significance of Anemia in Outcomes After Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer. Clinical colorectal cancer. (In Press.)
• BANERJEA A, VOLL J, CHOWDHURY A, SIDDIKA A, THOMSON S, BRIGGS R, HUMES DJ and , 2017. Straight-to-test colonoscopy for two-week wait referrals improves time to diagnosis of colorectal cancer and is feasible in a high-volume unit. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. (In Press.)
• DAVID J HUMES, ALEX J WALKER, BEVERLEY HUNT, ALYSHAH ABDUL SULTAN, JONAS LUDVIGSSON and JOE WEST, 2016. Risk of symptomatic venous thromboembolism following emergency appendicectomy in adults British Journal of Surgery. 103(4), 443-450
• SMITH, J K, MARCIANI, L, HUMES, D J, FRANCIS, S T, GOWLAND, P and SPILLER, R C, 2016. Anticipation of thermal pain in diverticular disease. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 28(6), 900-13
• ABDUL SULTAN A, WEST J, BAN L, HUMES D, TATA LJ, FLEMING KM, NELSON-PIERCY C and CARD T, 2016. Adverse Pregnancy Outcomes Among Women with Inflammatory Bowel Disease: A Population-Based Study from England. Inflammatory bowel diseases. 22(7), 1621-30
• 2016. Contemporary Review of Risk-Stratified Management in Acute Uncomplicated and Complicated Diverticulitis. World journal of surgery. (In Press.)
• HUMES D and SPILLER RC, 2016. Colonic diverticular disease: medical treatments for acute diverticulitis. BMJ clinical evidence. 2016,
• SMITH JK, MARCIANI L, HUMES DJ, FRANCIS ST, GOWLAND P and SPILLER RC, 2016. Anticipation of thermal pain in diverticular disease. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 28(6), 900-13
• HUMES DJ, LUDVIGSSON JF and JARVHOLM B, 2016. Smoking and the Risk of Hospitalization for Symptomatic Diverticular Disease: A Population-Based Cohort Study from Sweden. Diseases of the colon and rectum. 59(2), 110-4
• HUMES DJ, WALKER AJ, HUNT BJ, SULTAN AA, LUDVIGSSON JF and WEST J, 2016. Risk of symptomatic venous thromboembolism following emergency appendicectomy in adults. The British journal of surgery. 103(4), 443-50
• ELSEY EJ, GRIFFITHS G, HUMES DJ and WEST J, 2016. Meta-analysis of operative experiences of general surgery trainees during training. The British journal of surgery. 104(1), 22-33
• SØREIDE K, BOERMEESTER MA, HUMES DJ and VELMAHOS GC, 2016. Acute colonic diverticulitis: modern understanding of pathomechanisms, risk factors, disease burden and severity. Scandinavian journal of gastroenterology. 51(12), 1416-1422
• HUMES DJ, NORDENSKJÖLD A, WALKER AJ, WEST J and LUDVIGSSON JF, 2015. Risk of venous thromboembolism in children after general surgery. Journal of pediatric surgery. (In Press.)
• SULTAN, A.A., WEST, J., STEPHANSSON, O., GRAINGE, M.J., TATA, L.J., FLEMING, K.M., HUMES, D., LUDVIGSSON, J.F., 2015. Defining venous thromboembolism and measuring its incidence using Swedish health registries: A nationwide pregnancy cohort study BMJ Open. 5(11),
• GEMMILL EH, HUMES DJ and CATTON JA, 2015. Systematic review of enhanced recovery after gastro-oesophageal cancer surgery. Annals of the Royal College of Surgeons of England. 97(3), 173-9
• ABDUL SULTAN A, WEST J, STEPHANSSON O, GRAINGE MJ, TATA LJ, FLEMING KM, HUMES D and LUDVIGSSON JF, 2015. Defining venous thromboembolism and measuring its incidence using Swedish health registries: a nationwide pregnancy cohort study. BMJ open. 5(11), e008864
• HUMES DJ, WALKER AJ, BLACKWELL J, HUNT BJ and WEST J, 2015. Variation in the risk of venous thromboembolism following colectomy. The British journal of surgery. 102(13), 1629-38
• BAN L, TATA LJ, HUMES DJ, FIASCHI L and CARD T, 2015. Decreased fertility rates in 9639 women diagnosed with inflammatory bowel disease: a United Kingdom population-based cohort study. Alimentary pharmacology & therapeutics. 42(7), 855-66
• HUMES, D. J. and SPILLER, R. C., 2014. Review article: the pathogenesis and management of acute colonic diverticulitis ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 39(4), 359-370
• ZINGONE F, SULTAN AA, HUMES DJ and WEST J, 2014. Risk of Acute Appendicitis in and Around Pregnancy: A Population-Based Cohort Study From England. Annals of surgery. 261(2), 332-337
• WALKER AJ, WEST J, CARD TR, HUMES DJ and GRAINGE MJ, 2014. Variation in the risk of venous thromboembolism in people with colorectal cancer: a population-based cohort study from England. Journal of thrombosis and haemostasis : JTH. 12(5), 641-9
• TANG, J., HUMES, D. J., GEMMIL, E., WELCH, N. T., PARSONS, S. L. and CATTON, J. A., 2013. Reduction in length of stay for patients undergoing oesophageal and gastric resections with implementation of enhanced recovery packages ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND. 95(5), 323-328
• HUMES, D. J., RADCLIFFE, R. S., CAMM, C. and WEST, J., 2013. Population-based study of presentation and adverse outcomes after femoral hernia surgery BRITISH JOURNAL OF SURGERY. 100(13), 1827-1832
• AL-KHYATT W, THOMAS JD, HUMES DJ and LOBO DN, 2013. Intestinal ischemia following laparoscopic surgery: a case series. Journal of medical case reports. 7, 25
• HUMES, D.J., SIMPSON, J., SMITH, J., SUTTON, P., ZAITOUN, A., BUSH, D., BENNETT, A., SCHOLEFIELD, J.H. and SPILLER, R.C., 2012. Visceral hypersensitivity in symptomatic diverticular disease and the role of neuropeptides and low grade inflammation Neurogastroenterology & Motility. 24(4), e163
• HUMES DJ, 2012. Diagnosing and managing acute diverticulitis. The Practitioner. 256(1753), 21-3, 2-3
• HUMES DJ, 2012. Changing epidemiology: does it increase our understanding? Digestive diseases (Basel, Switzerland). 30(1), 6-11
• HUMES, D.J., FLEMING, K.M., SPILLER, R.C. and WEST, J., 2011. Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study Gut. 60(2), 219-224
• HUMES, DAVID J and WEST, JOE, 2011. Diet and risk of diverticular disease. BMJ (Clinical research ed.). 343, d4115
• HUMES, D.J. and WEST, J., 2011. Role of acute diverticulitis in the development of complicated colonic diverticular disease and 1-year mortality after diagnosis in the UK: population-based cohort study Gut. 61(1), 95-100
• SMITH, J. K., HUMES, D. J., HEAD, K. E., BUSH, D., WHITE, T. P., STEVENSON, C. M., BROOKES, M. J., MARCIANI, L., SPILLER, R .C., GOWLAND, P. A. and FRANCIS, S. T., 2011. fMRI and MEG analysis of visceral pain in healthy volunteers. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
• CHOWDHURY, A. H., HUMES, D. J., PRITCHARD, S. E., MARCIANI, L., GOWLAND, P. A., SIMPSON, J. and LOBO, D. N., 2011. The effects of morphine-neostigmine and secretin provocation on pancreaticobiliary morphology in healthy subjects: a randomized, double-blind crossover study using serial MRCP. World Journal of Surgery. 35(9), 2102-2109
• SMITH J, HUMES DJ and SPILLER RC, 2011. Should We Treat Uncomplicated Symptomatic Diverticular Disease With Fibre? Bmj (Clinical Research Ed.). 342, d2951
• HUMES D, SMITH JK and SPILLER RC, 2011. Colonic Diverticular Disease. American Family Physician. 84(10), 1163-4
• HUMES D, SMITH JK and SPILLER RC, 2011. Colonic Diverticular Disease. Clinical Evidence. 2011,
• SPILLER RC, HUMES DJ, CAMPBELL E, HASTINGS M, NEAL KR, DUKES GE and WHORWELL PJ, 2010. The Patient Health Questionnaire 12 Somatic Symptom Scale As A Predictor Of Symptom Severity And Consulting Behaviour In Patients With Irritable Bowel Syndrome And Symptomatic Diverticular Disease. Alimentary Pharmacology & Therapeutics. 32(6), 811-20
• HUMES DJ, AHMED I and LOBO DN, 2010. The Pedicle Effect And Direct Coupling: Delayed Thermal Injuries To The Bile Duct After Laparoscopic Cholecystectomy. Archives Of Surgery (Chicago, Ill. : 1960). 145(1), 96-8
• VARADHAN KK, HUMES DJ, NEAL KR and LOBO DN, 2010. Antibiotic Therapy Versus Appendectomy For Acute Appendicitis: A Meta-Analysis. World Journal Of Surgery. 34(2), 199-209
• HUMES, D.J., SOLAYMANI-DODARAN, M., FLEMING, K.M., SIMPSON, J., SPILLER, R.C. and WEST, J., 2009. A population-based study of perforated diverticular disease incidence and associated mortality Gastroenterology. 136(4), 1198-1205
• SIMPSON J, SUNDER F, HUMES DJ, JENKINS D, SCHOLEFIELD JH, SPILLER RC, 2009. Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship to symptoms Neurogastroenterol Motility. 21(8), 847-858
• MACAFEE DAL, HUMES DJ, BOULIOTIS G, BECKINGHAM IJ, WHYNES DK and LOBO DN, 2009. Prospective randomized trial using cost-utility analysis of early versus delayed laparoscopic cholecystectomy for acute gallbladder disease. The British journal of surgery. 96(9), 1031-40
• SUTTON PA, HUMES DJ, PURCELL G, SMITH JK, WHITING F, WRIGHT T, MORGAN L and LOBO DN, 2009. The role of routine assays of serum amylase and lipase for the diagnosis of acute abdominal pain. Annals of the Royal College of Surgeons of England. 91(5), 381-4
• SIMPSON J, SUNDER F, HUMES DJ, JENKINS D, WAKELIN D, SCHOLEFIELD JH, SPILLER RC, 2008. Prolonged elevation of galanin and tachykinin expression in mucosal and myenteric enteric nerves in trinitrobenzene suophonic acid colitis Neurogastroenterol Motility. 20(4), 392-406
• HUMES, D.J., SIMPSON, J., NEAL, K.R., SCHOLEFIELD, J.H. and SPILLER, R.C., 2008. Psychological and colonic factors in painful diverticulosis British Journal of Surgery. 95(2), 195-198
• SIMPSON J, HUMES DJ, O'ROURKE EJ, JAMES PD and ACHESON AG, 2008. Rigler On The Roof. Rigler's Sign. Gut. 57(6), 798, 836
• HUMES D, SIMPSON J and SPILLER RC, 2007. Colonic Diverticular Disease. Clinical Evidence. 2007,
• HUMES D, SPEAKE WJ and SIMPSON J, 2007. Appendicitis. Clinical Evidence. 2007,
• HUMES, D.J. and SIMPSON, J., 2006. Acute appendicitis BMJ. 333(7567), 530-534
• HUMES, DAVID and LOBO, DILEEP N, 2005. Removal of a rectal foreign body by using a Foley catheter passed through a rigid sigmoidoscope. Gastrointestinal Endoscopy. 62(4), 610
• HUMES D, JÄHNICH H, REHM A and COMPSON JP, 2004. The Osteology Of The Trapezium. Journal Of Hand Surgery (Edinburgh, Scotland). 29(1), 42-5