JAMES, JENNA R., CURD, JOHNATHAN, ASHWORTH, JENNIFER C., ABUHANTASH, MAYS, GRUNDY, MARTIN, SEEDHOUSE, CLAIRE H., ARKILL, KENTON P., WRIGHT, AMANDA J., MERRY, CATHERINE L. R. and THOMPSON, ALEXANDER, 2023. Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 24(4),
JENKINS, HARRY H., LOPEZ, ANA A. TELLECHEA, TARANTINI, FRANCESCO SAVERIO, TOMLIN, HANNAH, SCALES, DANIELLE, LEE, I-NING, WU, SIYU, HYDE, RALPH, LIS-SLIMAK, KATARZYNA, BYARUHANGA, TIMOTHY, THOMPSON, JAMIE L., PIJUAN-GALITO, SARA, DOOLAN, LARA, KANEKO, KAZUYO, GWYNNE, PENNY, REFFIN, CAROLINE, PARK, EMILY, DEY, JAYASREE, HILL, JACK, ARENDT-TRANHOLM, ASTA, STROUD, AMY, PETRIE, MOIRA, DENNING, CHRIS, BENEST, ANDREW, V and SEEDHOUSE, CLAIRE, 2022. Performance evaluation of a non-invasive one-step multiplex RT-qPCR assay for detection of SARS-CoV-2 direct from saliva SCIENTIFIC REPORTS. 12(1),
NICHOLSON, RACHAEL, MENEZES, ANA CATARINA, AZEVEDO, ALEKSANDRA, LECKENBY, ADAM, DAVIES, SARA, SEEDHOUSE, CLAIRE, GILKES, AMANDA, KNAPPER, STEVE, TONKS, ALEX and DARLEY, RICHARD L., 2022. Protein Kinase C Epsilon Overexpression Is Associated With Poor Patient Outcomes in AML and Promotes Daunorubicin Resistance Through p-Glycoprotein-Mediated Drug Efflux FRONTIERS IN ONCOLOGY. 12,
TARANTINI, FRANCESCO SAVERIO, WU, SIYU, JENKINS, HARRY, LOPEZ, ANA TELLECHEA, TOMLIN, HANNAH, HYDE, RALPH, LIS-SLIMAK, KATARZYNA, THOMPSON, JAMIE LOUISE, PIJUAN-GALITO, SARA, SCALES, DANIELLE, KANEKO, KAZUYO, DEY, JAYASREE, PARK, EMILY, HILL, JACK, LEE, I-NING, DOOLAN, LARA, ARENDT-TRANHOLM, ASTA, DENNING, CHRIS, SEEDHOUSE, CLAIRE and BENEST, ANDREW, V, 2022. Direct RT-qPCR Assay for the Detection of SARS-CoV-2 in Saliva Samples METHODS AND PROTOCOLS. 5(2),
THOMPSON, JAMIE L., VELASCO, ANGELA DOWNIE RUIZ, CARDALL, ALICE, TARBOX, REBECCA, RICHARDSON, JAINEETA, CLARKE, GEMMA, LISTER, MICHELLE, HOWSON-WELLS, HANNAH C., FLEMING, VICKI M., KHAKH, MANJINDER, SLOAN, TIM, DUCKWORTH, NICHOLA, WALSH, SARAH, DENNING, CHRIS, MCCLURE, C. PATRICK, BENEST, ANDREW V. and SEEDHOUSE, CLAIRE H., 2021. Comparative effects of viral-transport-medium heat inactivation upon downstream SARS-CoV-2 detection in patient samples JOURNAL OF MEDICAL MICROBIOLOGY. 70(3), ALMASMOUM, HIBAH ALI, AIRHIHEN, BLESSING, SEEDHOUSE, CLAIRE and WINKLER, GERLOF SEBASTIAAN, 2021. Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma LEUKEMIA & LYMPHOMA. 62(2), 281-290
GRUNDY, MARTIN, AL-KAISI, FIRAS, CULL, JOANNA, WILLIAMS, CATHY, SMITH, DEAN and SEEDHOUSE, CLAIRE H, 2021. A same-day assay predicts apoptotic response to combined BCL-2 and MCL-1 BH3-mimetic targeting in multiple myeloma cells. EJHaem. 2(1), 40-47
ALHUTHALI, HAYAA MOEED, BRADSHAW, TRACEY D., LIM, KUAN-HON, KAM, TOH-SEOK and SEEDHOUSE, CLAIRE H., 2020. The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun BMC CANCER. 20(1), BAILEY, G. D., DOOLAN, L., BASKAR, A., SMITH, L. C. and SEEDHOUSE, C. H., 2020. Preferential transcription of the mutated allele in NPM1 mutated acute myeloid leukaemia SCIENTIFIC REPORTS. 10(1), BAILEY, GRAHAM D, QUTOB, HAITHAM M H, AKHTAR, ASMA, RUSSELL, NIGEL H and SEEDHOUSE, CLAIRE H, 2019. DNA damage corrects the aberrant cytoplasmic localisation of nucleophosmin in NPM1 mutated acute myeloid leukaemia. British journal of haematology. ALMARS, AMANY, CHONDROU, PANAGIOTA S., ONYIDO, EMENIKE K., ALMOZYAN, SHEEMA, SEEDHOUSE, CLAIRE, BABAEI-JADIDI, ROYA and NATERI, ABDOLRAHMAN S., 2019. Increased FLYWCH1 Expression is Negatively Correlated with Wnt/-catenin Target Gene Expression in Acute Myeloid Leukemia Cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 20(11), GRUNDY M, SEEDHOUSE C, JONES T, ELMI L, HALL M, GRAHAM A, RUSSELL N and PALLIS M, 2018. Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling. PloS one. 13(1), e0190682 AL-ASADI MG, BRINDLE G, CASTELLANOS M, MAY ST, MILLS KI, RUSSELL NH, SEEDHOUSE CH and PALLIS M, 2018. A molecular signature of dormancy in CD34+CD38- acute myeloid leukaemia cells. Oncotarget. 8(67), 111405-111418 GRUNDY, MARTIN, BALAKRISHNAN, SAHANA, FOX, MATTHEW, SEEDHOUSE, CLAIRE H and RUSSELL, NIGEL H, 2018. Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells. Oncotarget. 9(102), 37777-37789
YU, NING, SEEDHOUSE, CLAIRE, RUSSELL, NIGEL and PALLIS, MONICA, 2018. Quantitative assessment of the sensitivity of dormant AML cells to the BAD mimetics ABT-199 and ABT-737 LEUKEMIA & LYMPHOMA. 59(10), 2447-2453
ALI, REEM, AL-KAWAZ, ABDULBAQI, TOSS, MICHAEL S., GREEN, ANDREW R., MILIGY, ISLAM M., MESQUITA, KATIA A., SEEDHOUSE, CLAIRE, MIRZA, SAMEER, BAND, VIMLA, RAKHA, EMAD A. and MADHUSUDAN, SRINIVASAN, 2018. Targeting PARP1 in XRCC1-Deficient Sporadic Invasive Breast Cancer or Preinvasive Ductal Carcinoma In Situ Induces Synthetic Lethality and Chemoprevention CANCER RESEARCH. 78(24), 6818-6827 SHAFIEE, MOHAMAD NASIR, SEEDHOUSE, CLAIRE, MONGAN, NIGEL, CHAPMAN, CAROLINE, DEEN, SUHA, ABU, JAFARU and ATIOMO, WILLIAM, 2016. Up-regulation of genes involved in the insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link polycystic ovarian syndrome and endometrial cancer MOLECULAR AND CELLULAR ENDOCRINOLOGY. 424(C), 94-101 PALLIS, M, BURROWS, F, RYAN, J, GRUNDY, M, SEEDHOUSE, C, ABDUL-AZIZ, A, MONTERO, J and LETAI, A, 2016. Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells Oncotarget. SHAW, B. E., LEE, F., KRISHNAMURTHY, S., BYRNE, J. L., SEEDHOUSE, C., MAYOR, N. P., MALDONADO-TORRES, H., SAUDEMONT, A., MARSH, S. G. E., MADRIGAL, J. A. and RUSSELL, N. H., 2015. Caspase-8 polymorphisms result in reduced Alemtuzumab-induced T-cell apoptosis and worse survival after transplantation BONE MARROW TRANSPLANTATION. 50(2), 237-243 SHAFIEE, MOHAMAD NASIR, ABD MALIK, DAHLIA, YUNOS, RYIA ILLANI MOHD, ATIOMO, WILLIAM, OMAR, MOHD HASHIM, GHANI, NUR AZURAH ABDUL, HATTA, AHMAD ZAILANI, SEEDHOUSE, CLAIRE, CHAPMAN, CAROLINE and MOKHTAR, NORFILZA MOHD, 2015. The effect of Metformin on endometrial tumor-regulatory genes and systemic metabolic parameters in polycystic ovarian syndrome - a proof-of-concept study GYNECOLOGICAL ENDOCRINOLOGY. 31(4), 286-290 ALBARAKATI, NADA, ABDEL-FATAH, TAREK M. A., DOHERTY, RACHEL, RUSSELL, ROSLIN, AGARWAL, DEVIKA, MOSELEY, PAUL, PERRY, CHRISTINA, ARORA, ARVIND, ALSUBHI, NOUF, SEEDHOUSE, CLAIRE, RAKHA, EMAD A., GREEN, ANDREW, BALL, GRAHAM, CHAN, STEPHEN, CALDAS, CARLOS, ELLIS, IAN O. and MADHUSUDAN, SRINIVASAN, 2015. Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy MOLECULAR ONCOLOGY. 9(1), 204-217 SHAFIEE, MOHAMAD NASIR, KHAN, GULAFSHANA, ARIFFIN, RINA, ABU, JAFARU, CHAPMAN, CAROLINE, DEEN, SUHA, NUNNS, DAVID, BARRETT, DAVID A., SEEDHOUSE, CLAIRE and ATIOMO, WILLIAM, 2014. Preventing endometrial cancer risk in polycystic ovarian syndrome (PCOS) women: Could metformin help? GYNECOLOGIC ONCOLOGY. 132(1), 248-253 SEEDHOUSE, CLAIRE H., MILLS, KEN I., AHLUWALIA, SOPHIE, GRUNDY, MARTIN, SHANG, SHILI, BURNETT, ALAN K., RUSSELL, NIGEL H. and PALLIS, MONICA, 2014. Distinct poor prognostic subgroups of acute myeloid leukaemia, FLT3-ITD and P-glycoprotein-positive, have contrasting levels of FOXO1 LEUKEMIA RESEARCH. 38(1), 131-137 ABBOTTS, RACHEL, JEWELL, ROSALYN, NSENGIMANA, JEREMIE, MALONEY, DAVID J., SIMEONOV, ANTON, SEEDHOUSE, CLAIRE, ELLIOTT, FAYE, LAYE, JON, WALKER, CHRISTY, JADHAV, AJIT, GRABOWSKA, ANNA, BALL, GRAHAM, PATEL, POULAM M., NEWTON-BISHOP, JULIA, WILSON, DAVID M., III and MADHUSUDAN, SRINIVASAN, 2014. Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy ONCOTARGET. 5(10), 3273-3286 SULTANA, R., ABDEL-FATAH, T., ABBOTTS, R., HAWKES, C., ALBARAKATI, N., SEEDHOUSE, C., BALL, G., CHAN, S., RAKHA, E.A., ELLIS, I.O. and MADHUSUDAN, S., 2013. Targeting XRCC1 deficiency in breast cancer for personalized therapy Cancer Research. 73(5), 1621-1634 PALLIS M, BURROWS F, WHITTALL A, BODDY N, SEEDHOUSE C and RUSSELL N, 2013. Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells. BMC pharmacology & toxicology. 14(1), 32 (In Press.)
ABDEL-FATAH, TAREK, SULTANA, REBEKA, ABBOTTS, RACHEL, HAWKES, CLAIRE, SEEDHOUSE, CLAIRE, CHAN, STEPHEN and MADHUSUDAN, SRINIVASAN, 2013. Clinicopathological and functional significance of XRCC1 expression in ovarian cancer INTERNATIONAL JOURNAL OF CANCER. 132(12), 2778-2786 WANG, QUNWEI, FRANKS, HESTER A., LAX, STEPHANIE J., EL REFAEE, MOHAMED, MALECKA, ANNA, SHAH, SABARIA, SPENDLOVE, IAN, GOUGH, MICHAEL J., SEEDHOUSE, CLAIRE, MADHUSUDAN, SRINIVASAN, PATEL, POULAM M. and JACKSON, ANDREW M., 2013. The Ataxia Telangiectasia Mutated Kinase Pathway Regulates IL-23 Expression by Human Dendritic Cells JOURNAL OF IMMUNOLOGY. 190(7), 3246-3255 PALLIS, MONICA, BURROWS, FRANCIS, WHITTALL, ABIGAIL, BODDY, NICHOLAS, SEEDHOUSE, CLAIRE and RUSSELL, NIGEL, 2013. Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells BMC PHARMACOLOGY & TOXICOLOGY. 14, SULTANA, R., MCNEILL, D.R., ABBOTTS, R., MOHAMMED, M.Z., ZDZIENICKA, M.Z., QUTOB, H., SEEDHOUSE, C., LAUGHTON, C.A., FISCHER, P.M., PATEL, P.M., WILSON, D.M. and MADHUSUDAN, S., 2012. Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors International Journal of Cancer. 131(10), 2433-2444 JAWAD, M., SEEDHOUSE, C., MONY, U., GRUNDY, M., RUSSELL, N.H. and PALLIS, M., 2010. Analysis of factors that affect in vitro chemosensitivity of leukaemic stem and progenitor cells to gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukaemia Leukemia. 24(1), 74-80 GRUNDY, M., SEEDHOUSE, C., SHANG, S., RICHARDSON, J., RUSSELL, N. and PALLIS, M., 2010. The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells Molecular Cancer Therapeutics. 9(3), 661-672 SEEDHOUSE, C., GRUNDY, M., SHANG, S., RONAN, J., PIMBLETT, H., RUSSELL, N. and PALLIS, M., 2009. Impaired S-phase arrest in acute myeloid leukemia cells with a FLT3 internal tandem duplication treated with clofarabine Clinical Cancer Research. 15(23), 7291-7298 SEEDHOUSE, C.H., PALLIS, M., GRUNDY, M., SHANG, S. and RUSSELL, N.H., 2009. FLT3-ITD expression levels and their effect on STAT5 in AML with and without NPM mutations British Journal of Haematology. 147(5), 653-661 MONY, U., JAWAD, M., SEEDHOUSE, C., RUSSELL, N. and PALLIS, M., 2008. Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment Leukemia. 22(7), 1395-1401 SEEDHOUSE,, GRUNDY,, WHITE,, LI,, FISHER,, YAKUNINA,, MOORMAN,, HOY,, RUSSELL,, BURNETT, and PALLIS,, 2007. Sequential Influences of Leukemia-Specific and Genetic Factors on P-Glycoprotein Expression in Blasts from 817 Patients Entered into the National Cancer Research Network Acute Myeloid Leukemia 14 and 15 Trials. Clinical Cancer Research. 13(23), 7059-7066 CONNELLY-SMITH,, PATTINSON,, GRUNDY,, SHANG,, SEEDHOUSE,, RUSSELL, and PALLIS,, 2007. P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholesterol deprivation and by HMG-CoA reductase inhibitors. Experimental Hematology. SEEDHOUSE, C.H, HUNTER, H.M., LLOYD-LEWIS, B., MASSIP, A-M., PALLIS, M., CARTER, G.I., GRUNDY, M., SHANG, S. and RUSSELL, N.H., 2006. DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412 Leukemia. 20(12), 2130-2136 BRADBURY, D., CLARKE, D., SEEDHOUSE, C., CORBETT, L., STOCKS, J. and KNOX, A., 2005. Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites Journal of Biological Chemistry. 280(34), 29993-30000 FERN, L., PALLIS, M., CARTER, G.I., SEEDHOUSE, C., RUSSELL, N. and BYRNE, J., 2004. Clonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQO1 pathway; possible mechanisms leading to an increased risk of t-AML/MDS. British Journal of Haematology. 126(1), 63-71 SEEDHOUSE, C., FAULKNER, R., ASHRAF, N., DAS-GUPTA, E. and RUSSELL, N., 2004. Polymorphisms in Genes Involved in Homologous Recombination Repair Interact to Increase the Risk of Developing Acute Myeloid Leukemia Clinical Cancer Research. 10(8), 2675-2680 FAULKNER, R. D., SEEDHOUSE, C. H., DAS-GUPTA, E. P. and RUSSELL, N. H., 2004. BAT-25 and BAT-26, two mononucleotide microsatellites, are not sensitive markers of microsatellite instability in acute myeloid leukaemia British Journal of Haematology. VOL 124(NUMBER 2), 160-165 HUNTER, H. M., PALLIS, M., SEEDHOUSE, C. H., GRUNDY, M., GRAY, C. and RUSSELL, N. H., 2004. The expression of P-glycoprotein in AML cells with FLT3 internal tandem duplications is associated with reduced apoptosis in response to FLT3 inhibitors British Journal of Haematology. VOL 127(NUMBER 1), 26-33 PALLIS, M., TURZANSKI, J., GRUNDY, M., SEEDHOUSE, C. and RUSSELL, N., 2003. Resistance to spontaneous apoptosis in acute myeloid leukaemia blasts is associated with p-glycoprotein expression and function, but not with the presence of FLT3 internal tandem duplications British Journal of Haematology. VOL 120(PART 6), 1009-1016 SEEDHOUSE, C., BAINTON, R., LEWIS, M., HARDING, A., RUSSELL, N. and DAS-GUPTA, E., 2002. The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia Blood. 100(10), 3761-3766 DAS-GUPTA, E. P., SEEDHOUSE, C. H. and RUSSELL, N. H., 2001. Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia British Journal of Haematology. VOL 114(PART 2), 307-312 SEEDHOUSE, C H, MARGISON, G P, HENDRY, J H, HAJEER, A and EMBLETON, M J, 2001. Anti-8-oxo-2'-deoxyguanosine phage antibodies: isolation, characterization, and relationship to disease states. Biochemical and biophysical research communications. 280(3), 595-604 DAS-GUPTA EP, SEEDHOUSE CH and RUSSELL NH, 2000. Dna Repair Mechanisms And Acute Myeloblastic Leukemia. Hematological Oncology. 18(3), 99-110