Catarina Gadelha

Contact

• workRoom D100 Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 8230378
• fax0115 8230338
• Catarina.Gadelha@nottingham.ac.uk
• http://www.catarinagadelha.com

Biography

BSc in Biological Sciences (Genetics) 1997; MRes in Biological Sciences (Biophysics) 2000; and Doctorate in Biological Sciences (Molecular Cell Biology) 2005, Universidade Federal do Rio de Janeiro. Postdoctoral Researcher at University of Oxford, 2005-2009; Postdoctoral Fellow at University of Cambridge, 2010-2012. Lecturer in the School of Life Sciences, University of Nottingham, 2013.

Research Summary

My lab focuses on the structure and function of cell surface membranes in human pathogens, and how these relate to disease, evolution and development of treatment. In particular, we study the… read more

Recent Publications

• BOEHM CM, OBADO S, GADELHA C, KAUPISCH A, MANNA PT, GOULD GW, MUNSON M, CHAIT BT, ROUT MP and FIELD MC, 2017. The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis. PLoS pathogens. 13(1), e1006063
• MANNA PT, OBADO SO, BOEHM C, GADELHA C, SALI A, CHAIT BT, ROUT MP and FIELD MC, 2017. Lineage-specific proteins essential for endocytosis in trypanosomes. Journal of cell science. (In Press.)
• GADELHA, C., ZHANG, W., CHAMBERLAIN, J.W., CHAIT, B.T., WICKSTEAD, B. and FIELD, M.C., 2015. Architecture of a Host-Parasite Interface: Complex Targeting Mechanisms Revealed Through Proteomics. Mol Cell Proteomics. 14(7), 1911-1926
• MANNA PT, GADELHA C, PUTTICK AE and FIELD MC, 2015. ENTH and ANTH domain proteins participate in AP2-independent clathrin-mediated endocytosis. Journal of cell science. 128(11), 2130-42

• View all publications

Current Research

My lab focuses on the structure and function of cell surface membranes in human pathogens, and how these relate to disease, evolution and development of treatment. In particular, we study the causative agent of human African trypanosomiasis, a disease that threatens 60 million people in sub-Saharan countries. These parasites proliferate in the host bloodstream in an exclusively extracellular form by periodic switching of the parasite surface coat. Cell surface structure and composition is key to the parasite's strategy of immune evasion, survival and disease transmission. However, very little is known about the molecules that reside at this interface, in particular which ones are essential to the parasite's success. This severely hampers the development of drugs or vaccines against human African trypanosomiasis and related parasitic diseases. Work in the lab takes innovative approaches to elucidate cell membrane function, structure, molecular composition and evolution. Our work aims to unravel the mechanics of parasite success and thereby to expose avenues for therapeutic intervention.

• BOEHM CM, OBADO S, GADELHA C, KAUPISCH A, MANNA PT, GOULD GW, MUNSON M, CHAIT BT, ROUT MP and FIELD MC, 2017. The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis. PLoS pathogens. 13(1), e1006063
• MANNA PT, OBADO SO, BOEHM C, GADELHA C, SALI A, CHAIT BT, ROUT MP and FIELD MC, 2017. Lineage-specific proteins essential for endocytosis in trypanosomes. Journal of cell science. (In Press.)
• GADELHA, C., ZHANG, W., CHAMBERLAIN, J.W., CHAIT, B.T., WICKSTEAD, B. and FIELD, M.C., 2015. Architecture of a Host-Parasite Interface: Complex Targeting Mechanisms Revealed Through Proteomics. Mol Cell Proteomics. 14(7), 1911-1926
• MANNA PT, GADELHA C, PUTTICK AE and FIELD MC, 2015. ENTH and ANTH domain proteins participate in AP2-independent clathrin-mediated endocytosis. Journal of cell science. 128(11), 2130-42
• SAMSON RY, XU Y, GADELHA C, STONE TA, FAQIRI JN, LI D, QIN N, PU F, LIANG YX, SHE Q and BELL SD, 2013. Specificity and Function of Archaeal DNA Replication Initiator Proteins. Cell reports. 3, 485-496
• ADUNG'A VO, GADELHA C and FIELD MC, 2013. Proteomic analysis of clathrin interactions in trypanosomes reveals dynamic evolution of endocytosis. Traffic (Copenhagen, Denmark). 14, 440-457
• TIENGWE C, MARCELLO L, FARR H, GADELHA C, BURCHMORE R, BARRY JD, BELL SD and MCCULLOCH R, 2012. Identification of ORC1/CDC6-interacting factors in Trypanosoma brucei reveals critical features of origin recognition complex architecture. PloS one. 7(3), e32674
• GADELHA C, HOLDEN JM, ALLISON HC and FIELD MC, 2011. Specializations in a successful parasite: what makes the bloodstream-form African trypanosome so deadly? Molecular and biochemical parasitology. 179(2), 51-8
• JONES, M.D.M., FORN, I., GADELHA, C., EGAN, M.J., BASS, D., MASSANA, R. and RICHARDS, T.A., 2011. Discovery of novel intermediate forms redefines the fungal tree of life Nature. 474(7350), 200-203
• COENE, E.D., GADELHA, C., WHITE, N., MALHAS, A., THOMAS, B., SHAW, M. and VAUX, D.J., 2011. A novel role for BRCA1 in regulating breast cancer cell spreading and motility The Journal of Cell Biology. 192(3), 497-512
• LACOMBLE S, VAUGHAN S, GADELHA C, MORPHEW MK, SHAW MK, MCINTOSH JR and GULL K, 2010. Basal body movements orchestrate membrane organelle division and cell morphogenesis in Trypanosoma brucei. Journal of cell science. 123(Pt 17), 2884-91
• GADELHA, C., ROTHERY, S., MORPHEW, M., MCINTOSH, J.R., SEVERS, N.J. and GULL, K., 2009. Membrane domains and flagellar pocket boundaries are influenced by the cytoskeleton in African trypanosomes Proceedings of the National Academy of Sciences of the United States of America. 106(41), 17425-17430
• LACOMBLE, S., VAUGHAN, S., GADELHA, C., MORPHEW, M.K., SHAW, M.K., MCINTOSH, J.R. and GULL, K., 2009. Three-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomography Journal of Cell Science. 122(8), 1081-1090
• GADELHA, CATARINA, WICKSTEAD, BILL and GULL, KEITH, 2007. Flagellar and ciliary beating in trypanosome motility. Cell motility and the cytoskeleton. 64(8), 629-43
• GADELHA, CATARINA, WICKSTEAD, BILL, MCKEAN, PAUL G and GULL, KEITH, 2006. Basal body and flagellum mutants reveal a rotational constraint of the central pair microtubules in the axonemes of trypanosomes. Journal of cell science. 119(Pt 12), 2405-13
• WOOLLEY D, GADELHA C and GULL K, 2006. Evidence for a sliding-resistance at the tip of the trypanosome flagellum. Cell motility and the cytoskeleton. 63(12), 741-6
• GADELHA, CATARINA, WICKSTEAD, BILL, DE SOUZA, WANDERLEY, GULL, KEITH and CUNHA-E-SILVA, NARCISA, 2005. Cryptic paraflagellar rod in endosymbiont-containing kinetoplastid protozoa. Eukaryotic cell. 4(3), 516-25
• SANT'ANNA C, CAMPANATI L, GADELHA C, LOURENÇO D, LABATI-TERRA L, BITTENCOURT-SILVESTRE J, BENCHIMOL M, CUNHA-E-SILVA NL and DE SOUZA W, 2005. Improvement on the visualization of cytoskeletal structures of protozoan parasites using high-resolution field emission scanning electron microscopy (FESEM). Histochemistry and cell biology. 124(1), 87-95
• GADELHA C, LEBOWITZ JH, MANNING J, SEEBECK T and GULL K, 2004. Relationships between the major kinetoplastid paraflagellar rod proteins: a consolidating nomenclature. Molecular and biochemical parasitology. 136(1), 113-5
• DE MORAES NETO AHA, LANFREDI RM, GADELHA C, CUNHA-E-SILVA NL, SIMÃO RA, ACHETE C and DE SOUZA W, 2003. Further studies on the structural analysis of the cuticle of Litomosoides chagasfilhoi (Nematoda: Filarioidea). Parasitology research. 89(5), 397-406