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Lucy Fairclough

Professor of Immunology, Faculty of Medicine & Health Sciences

Personal Details
Teaching and Learning
Research
Publications

Contact

workRoom B105 Life Sciences Building
University Park
Nottingham
NG7 2RD
UK
work0115 82 30729
fax0115 82 30759
lucy.fairclough@nottingham.ac.uk

Teaching Summary

Research Summary

Selected Publications

N GOMEZ, V JAMES, KP ARKILL, ZA NIZAMUDEEN, D ONION and LC FAIRCLOUGH, 2023. PBMC derived extracellular vesicles in a smoking-related inflammatory disease model European Journal of Immunology.
GV HOPKINS, S COCHRANE, D ONION and LC FAIRCLOUGH, 2022. The Role of Lipids in Allergic Sensitization: A Systematic Review Front. Mol. Biosci.
N GOMEZ, V JAMES, D ONION and LC FAIRCLOUGH, 2022. Extracellular Vesicles and chronic obstructive pulmonary disease (COPD): a systematic review Respiratory Research.
F LOPES, I TIBERIO, A LEME and L FAIRCLOUGH, 2022. The importance of Th17/TReg imbalance in asthma and COPD development and progression Frontiers in Immunology.

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Professor Fairclough's teaching interests are in general Immunology. She lectures to a variety of students (UG and PGT). In addition to the lectures, Prof Fairclough welcomes both MSc and BMedSci students into her group each year to work on their research projects. These are related to Prof Fairclough's research interest. Prof Fairclough also has several PhD students working in her group examining the immune mechanisms driving allergic sensitisation and the effects of cigarette smoke/E Cigarette vape on immune cells and inflammation. She also supervsises PhD students who examine the role of extracellular vesicles in driving these immune responses.

Prof Fairclough lectures on the following modules:

LIFE3003 - Immunity and the Immune System
LIFE3007 - Introduction to Medical Microbiology
LIFE1034 - Core Skills (UG Biology)
LIFE2080 - Infection and Immunity
LIFE4002 - Molecular Aspects of Allergy
LIFE4012 - Research Methods
MEDS1006/1011 - Year 1 Medicine
MEDS 2012 - Year 2 Medicine

Current Research

Professor Fairclough's research examines the immune mechanisms driving allergic sensitisation and the effects of cigarette smoke/E Cigarette vape on immune cells and inflammation. She also has an interest in the role of extracellular vesicles in driving these immune responses. She utilises cutting-edge imaging and spectral flow cytometry, as well as multiplex technologies, to address these research questions. During the pandemic she led the immunity study in the "Asymptomatic COVID19 in Education (ACE)" cohort examining both humoral and cellular immunity after natural infection and vaccination. She is also the Academic lead for Flow Cytometry at UoN and Chairs the Midlands Innovation (MI) Flow Cytometry Group and MI Immunology Network (MIIN).

Past Research

For eight years my research interest related to understanding the mechanisms that cause allergic reactions, specifically investigating the immunomodulatory effects of the proteolytic activity of the house dust mite allergen Der p 1.

N GOMEZ, V JAMES, KP ARKILL, ZA NIZAMUDEEN, D ONION and LC FAIRCLOUGH, 2023. PBMC derived extracellular vesicles in a smoking-related inflammatory disease model European Journal of Immunology.
GV HOPKINS, S COCHRANE, D ONION and LC FAIRCLOUGH, 2022. The Role of Lipids in Allergic Sensitization: A Systematic Review Front. Mol. Biosci.
N GOMEZ, V JAMES, D ONION and LC FAIRCLOUGH, 2022. Extracellular Vesicles and chronic obstructive pulmonary disease (COPD): a systematic review Respiratory Research.
F LOPES, I TIBERIO, A LEME and L FAIRCLOUGH, 2022. The importance of Th17/TReg imbalance in asthma and COPD development and progression Frontiers in Immunology.
L GUMBER, N GOMEZ, G HOPKINS, D TUCIS, L BARTLETT, L AYLING, K VEDHARA, G STEERS, M CHAKRAVORTY, M RUTTER, H JACKSON, PJ TIGHE, A FERRARO, S POWER, M-J PRADERE, D ONION, P LANYON, F PEARCE and LC FAIRCLOUGH, 2022. Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV2 vaccination. Rheumatology.
A HAMED, I TODD, PJ TIGHE, RJ POWELL, T HARRISON and LC FAIRCLOUGH, 2021. Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements Journal of Immunological Methods.
P SANGAPHUNCHAI, I TODD and LC FAIRCLOUGH, 2020. Extracellular vesicles and asthma: A review of the literature Clin Exp Allergy.
I-L CHEN, PJ TIGHE, I TODD and L FAIRCLOUGH, 2020. Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells Arch Tox.
I TODD, RE THOMAS, BD WATT, L SUTHERLAND, A AFRIYIE-ASANTE, B DEB, B JOSEPH, PJ TIGHE, P LANYON and LC FAIRCLOUGH, 2020. Multiple pathways of type 1 interferon production in lupus: the case for amlexanox. Rheumatology.
M WILLIAMS, I TODD and LC FAIRCLOUGH, 2020. The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review Inflammation Research.
VEDHARA, K., AYLING, K., SUNGER, K., CALDWELL, D.M., HALLIDAY, V., FAIRCLOUGH, L., AVERY, A., ROBLES, L., GARIBALDI, J., WELTON, N.J. and ROYAL, S., 2019. Psychological Interventions as Vaccine Adjuvants: a systematic review. Vaccine. 37(25), 3255-3266
AYLING, K., FAIRCLOUGH, L., BUCHANAN, H., WETHERELL, M.A. and VEDHARA, K., 2019. Mood and influenza vaccination in older adults: A randomized controlled trial Health Psychology. Epub ahead of print: 5 August 2019,
BYRNE R, TODD I, TIGHE PJ and FAIRCLOUGH LC, 2019. Autoantibodies in chronic obstructive pulmonary disease: A systematic review. Immunology letters. 214, 8-15
TARBIAH N, TODD I, TIGHE PJ and FAIRCLOUGH LC, 2019. Cigarette smoking differentially affects immunoglobulin class levels in serum and saliva: An investigation and review. Basic & clinical pharmacology & toxicology. (In Press.)
NEGM OH, SINGH S, ABDULJABBAR W, HAMED MR, RADFORD P, MCDERMOTT EM, DREWE E, FAIRCLOUGH L, TODD I and TIGHE PJ, 2019. Patients with tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) are hypersensitive to Toll-like receptor 9 stimulation. Clinical and experimental immunology. 197(3), 352-360
CHEN IL, TODD I and FAIRCLOUGH LC, 2019. Immunological and pathological effects of electronic cigarettes. Basic & clinical pharmacology & toxicology. 125(3), 237-252
HOLMES J, FAIRCLOUGH LC and TODD I, 2019. Atopic dermatitis and autoimmunity: the occurrence of autoantibodies and their association with disease severity. Archives of dermatological research. 311(3), 141-162
WANG R, PSCHEID R, GHUMRA A, KAN LYL, COCHRANE S, FAIRCLOUGH L and ALCOCER MJC, 2019. Towards a surrogate system to express human lipid binding TCRs. Biotechnology letters. 41(10), 1095-1104
AYLING K, FAIRCLOUGH L, TIGHE P, TODD I, HALLIDAY V, GARIBALDI J, ROYAL S, HAMED A, BUCHANAN H and VEDHARA K, 2018. Positive Mood on the Day of Influenza Vaccination Predicts Vaccine Effectiveness: A Prospective Observational Cohort Study. Brain, behavior, and immunity. 314-23
AYLING, K., FAIRCLOUGH, L., TIGHE, P., TODD, I., HALLIDAY, V., GARIBALDI, J.M., ROYAL, S., HAMED, A., BUCHANAN, H. and VEDHARA, K., 2018. Positive mood on the day of influenza vaccination predicts vaccine effectiveness: A prospective observational cohort study. Brain, Behavior, and Immunity. 67, 314-323
SHORTALL SE, NEGM OH, FOWLER M, FAIRCLOUGH LC, TIGHE PJ, WIGMORE PM and KING MV, 2018. Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT6 receptor antagonist SB-399885 Molecular Neurobiology. 55(9), 7413-7430
AYLING, K., VEDHARA, K. and FAIRCLOUGH, L., 2018. Measuring Vaccine Responses in the Multiplex Era. In: YAN, Q., ed., Psychoneuroimmunology: Methods and Protocols Springer New York. 327-340
LIANGLIANG LIU, LEONEL MARQUES, RICARDO CORREIA, STEPHEN P. MORGAN, SEUNG-WOO LEE, PADDY TIGHE, LUCY FAIRCLOUGH and SERHIY KORPOSH, 2018. Highly sensitive label-free antibody detection using a long period fibre grating sensor Sensors and Actuators B: Chemical. 271, 24 - 32
ALKHATTABI N, TODD I, NEGM O, TIGHE PJ and FAIRCLOUGH LC, 2018. Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells. Toxicology letters. 299, 40-46
HUCKLE AW, FAIRCLOUGH LC and TODD I, 2018. Prophylactic Antibiotic Use in COPD and the Potential Anti-Inflammatory Activities of Antibiotics. Respiratory care. 63(5), 609-619
SANIKLIDOU, ARIADNE HADJIKYRIACOU, TIGHE, PATRICK J., FAIRCLOUGH, LUCY C. and TODD, IAN, 2018. IgE autoantibodies and their association with the disease activity and phenotype in bullous pemphigoid: a systematic review ARCHIVES OF DERMATOLOGICAL RESEARCH. 310(1), 11-28
TUBBY C, NEGM OH, HARRISON T, TIGHE PJ, TODD I and FAIRCLOUGH LC, 2017. Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction. The Journal of asthma : official journal of the Association for the Care of Asthma. 54(5), 456-466
AYLING K, BOWDEN T, TIGHE P, TODD I, DILNOT EM, NEGM OH, FAIRCLOUGH L and VEDHARA K, 2017. The application of protein microarray assays in psychoneuroimmunology. Brain, behavior, and immunity. 59, 62-66
TODD I, NEGM OH, REPS J, RADFORD P, FIGUEREDO G, MCDERMOTT EM, DREWE E, POWELL RJ, BAINBRIDGE S, HAMED M, CROUCH S, GARIBALDI J, ST-GALLAY S, FAIRCLOUGH LC and TIGHE PJ, 2017. A signalome screening approach in the autoinflammatory disease TNF Receptor Associated Periodic Syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing. Pharmacological Research.
SHINDI R, ALMEHAIRI A, NEGM OH, KALSHEKER N, GALE NS, SHALE DJ, HARRISON TW, BOLTON CE, JOHN M, TODD I, TIGHE PJ and FAIRCLOUGH LC, 2017. Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease. Clinical immunology (Orlando, Fla.). (In Press.)
BURR SA, WHITTLE J, FAIRCLOUGH LC, COOMBES L and TODD I, 2016. Modifying Hofstee standard setting for assessments that vary in difficulty, and to determine boundaries for different levels of achievement. BMC medical education. 16, 34
SELVARAJAH S, TODD I, TIGHE PJ, JOHN M, BOLTON CE, HARRISON T and FAIRCLOUGH LC, 2016. Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease. Mediators of inflammation. 2016, 3604842
TIGHE, P. J., RYDER, R. R., TODD, I. and FAIRCLOUGH, L. C., 2015. ELISA in the multiplex era: potentials and pitfalls: Proteomics Clin Appl Proteomics Clin Appl. 9(3-4), 406-22
GALOZZI, P., NEGM, O., GRECO, E., ALKHATTABI, N., GAVA, A., SFRISO, P., FAIRCLOUGH, L., TODD, I., TIGHE, P. and PUNZI, L., 2015. Ex vivo and in vitro production of pro-inflammatory cytokines in Blau syndrome: Reumatismo Reumatismo. 66(4), 277-84
DAFFA, N. I., TIGHE, P. J., CORNE, J. M., FAIRCLOUGH, L. C. and TODD, I., 2015. Natural and disease-specific autoantibodies in chronic obstructive pulmonary disease: Clin Exp Immunol Clin Exp Immunol. 180(1), 155-63
FAIRCLOUGH LC, STOOP AA, NEGM OH, RADFORD PM, TIGHE PJ and TODD I, 2015. Tumour necrosis factor receptor I blockade shows that TNF-dependent and TNF-independent mechanisms synergise in TNF receptor associated periodic syndrome. European journal of immunology. 45(10), 2937-44
SELVARAJAH S, NEGM OH, HAMED MR, TUBBY C, TODD I, TIGHE PJ, HARRISON T and FAIRCLOUGH LC, 2014. Development and validation of protein microarray technology for simultaneous inflammatory mediator detection in human sera. Mediators of inflammation. 2014, 820304
ALOTIBY, A. A., FAIRCLOUGH, L. C., TODD, I. and TIGHE, P. J., 2014. Generation and characterisation of transcription activator-like effector nucleases (TALENs) targeting TNFR1 genome editing IMMUNOLOGY. 143, 95-95
HALALA, R. A., TIGHE, P., TODD, I. and FAIRCLOUGH, L., 2014. Profiling of natural autoantibodies in relation to chronic obstructive pulmonary disease IMMUNOLOGY. 143, 79-79
TARBIAH, N., TIGHE, P., FAIRCLOUGH, L. and TODD, I., 2014. Comparing between smokers and non-smokers immunoglobulin levels and B-cell differentiation IMMUNOLOGY. 143, 81-81
ALBOGAMI, S., NEGM, O., ZANG, L., THOMAS, N., FAIRCLOUGH, L., TODD, I. and TIGHE, P., 2014. The inhibitory effects of recombinant PLAD wild type (WT) protein on the inflammatory signalling pathways IMMUNOLOGY. 143, 125-125
HAMED, A., TODD, I., TIGHE, P., POWELL, R. and FAIRCLOUGH, L., 2014. Development of IgE microarray assays for classification of allergic individuals IMMUNOLOGY. 143, 170-170
NEGM OH, MANNSPERGER HA, MCDERMOTT EM, DREWE E, POWELL RJ, TODD I, FAIRCLOUGH LC and TIGHE PJ, 2014. A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS). European journal of immunology. 44(7), 2096-110
TODD I, BURR S, WHITTLE J and FAIRCLOUGH L, 2014. Modifying the Hofstee method may overcome problems. Medical teacher. 36(4), 358-9
TIGHE, P., NEGM, O., TODD, I. and FAIRCLOUGH, L., 2013. Utility, reliability and reproducibility of immunoassay multiplex kits Methods. 61(1), 23-29
WANG, J., URBANOWICZ, R.A., TIGHE, P.J., TODD, I., CORNE, J.M. and FAIRCLOUGH, L.C., 2013. Differential activation of killer cells in the circulation and the lung: a study of current smoking status and chronic obstructive pulmonary disease (COPD) PLoS ONE. 8(3), e58556
TUBBY, C., HARRISON, T., TODD, I. and FAIRCLOUGH, L., 2011. Immunological basis of reversible and fixed airways disease Clinical Science. 121(7), 285-296
RICHENS, J.L., URBANOWICZ, R.A., METCALF, R., CORNE, J., O’SHEA, P. and FAIRCLOUGH, L., 2010. Quantitative validation and comparison of multiplex cytokine kits Journal of Biomolecular Screening. 15(5), 562-568
LANE, N., ROBINS, R.A. and CORNE, J. AND FAIRCLOUGH L., 2010. Regulation in Chronic Obstructive Pulmonary Disease: The Role of Regulatory T Cells and Th17 cells. Clinical Science. 119, 75-86
URBANOWICZ, R.A., LAMB, J.R., TODD, I., CORNE, J.M. and FAIRCLOUGH, L.C., 2010. Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients Respiratory Research. 11, 76
HASAN, A.A., GHAEMMAGHAMI, A.M., FAIRCLOUGH, L., ROBINS, A., SEWELL, H.F. and SHAKIB, F., 2009. Allergen-driven suppression of thiol production by human dendritic cells and the effect of thiols on T cell function Immunobiology. 214(1), 2-16
RICHENS, JOANNA L, URBANOWICZ, RICHARD A, LUNT, ELIZABETH A M, METCALF, REBECCA, CORNE, JONATHAN, FAIRCLOUGH, LUCY and O'SHEA, PAUL, 2009. Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease. Respiratory Research. 10, 29
URBANOWICZ, R.A, LAMB, J.R., TODD, I., CORNE, J.M. and FAIRCLOUGH, L.C., 2009. Altered effector function of peripheral cytotoxic cells in COPD Respiratory Research. 10(June), 53
FAIRCLOUGH, L., URBANOWICZ, R.A., CORNE, J. and LAMB, J.R., 2008. Killer cells in chronic obstructive pulmonary disease Clinical Science. 114(8), 533-541
RICHENS, J., FAIRCLOUGH, L., GHAEMMAGHAMI, A.M., MAHDAVI, J., SHAKIB, F. and SEWELL, H.F., 2007. The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets Immunobiology. 212(1), 29-38
HARRIS, J., MASON, D.E., LI, J., BURDICK, K.W., BACKES, B.J., CHEN, T., SHIPWAY, A., VAN HEEKE, G., GOUGH, L., GHAEMMAGHAMI, A., SHAKIB, F., DEBAENE, F. and WINSSINGER, N., 2004. Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays Chemistry & Biology. 11(10), 1361-1372
GOUGH, L., CAMPBELL, E., BAYLEY, D., VAN HEEKE, G. and SHAKIB, F., 2003. Proteolytic activity of the house dust mite allergen Der p 1 enhances allergenicity in a mouse inhalation model Clinical and Experimental Allergy. 33(8), 1159-1163
FURTADO, P.B., MCELVEEN, J.E., GOUGH, L., ARMOUR, K.L., CLARK, M.R., SEWELL, H.F. and SHAKIB, F., 2002. The production and characterisation of a chimaeric human IgE antibody, recognising the major mite allergen Der p 1, and its chimaeric human IgG1 anti-idiotype Molecular Pathology. 55(5), 315-324
GHAEMMAGHAMI, A.M., GOUGH, L., SEWELL, H.F. and SHAKIB, F., 2002. The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: allergen-induced Th2 bias determined at the dendritic cell level Clinical and Experimental Allergy. 32(10), 1468-1475
SHAKIB F, SCHULZ O, GOUGH L AND GHAEMMAGHAMI A.M., 2002. The role of the enzymatic activity of the house dust mite antigen Der p 1 in enhancing its allergenicity Eur. Respir. Mon. 21, 153-160
GHAEMMAGHAMI, A.M., ROBINS, A., GOUGH, L., SEWELL, H.F. and SHAKIB, F., 2001. Human T cell subset commitment determined by the intrinsic property of antigen: the proteolytic activity of the major mite allergen Der p 1 conditions T cells to produce more IL-4 and less IFN-γ European Journal of Immunology. 31(4), 1211-1216
GOUGH, L., SEWELL, H.F. and SHAKIB, F., 2001. The proteolytic activity of the major dust mite allergen Der p 1 enhances the IgE antibody response to a bystander antigen Clinical and Experimental Allergy. 31(10), 1594-1598
SHAKIB, F and GOUGH, L, 2000. The proteolytic activity of Der p 1 selectively enhances IgE synthesis: a link between allergenicity and cysteine protease activity. Clinical and Experimental Allergy. 30(6), 751-2
GOUGH, L., SCHULZ, O., SEWELL, H.F. and SHAKIB, F., 1999. The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response Journal of Experimental Medicine. VOL 190(PART 12), 1897-1902