Patrick McClure

Contact

• workRoom W/A1328 Queens Medical Centre, West Block A Floor
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 31633
• patrick.mcclure@nottingham.ac.uk
• https://scholar.google.com/citations?hl=en&user=xq18890AAAAJ&view_op=list_works&sortby=pubdate

Teaching Summary

My teaching is laboratory focused, running practical classes for 5 to 65 students across many undergraduate and postgraduate courses. These currently include BMedsci, MSc Molecular Medical… read more

Research Summary

RT-PCR detection and characterisation of human and animal viral pathogens, alongside construction of viral molecular clones and chimeras.

Recent Publications

• 2016. Flexible and rapid construction of viral chimeras applied to Hepatitis C Virus. The Journal of general virology. (In Press.)
• FERNS RB, TARR AW, HUE S, URBANOWICZ RA, MCCLURE CP, GILSON R, BALL JK, NASTOULI E, GARSON JA and PILLAY D, 2016. Hepatitis C virus quasispecies and pseudotype analysis from acute infection to chronicity in HIV-1 co-infected individuals. Virology. 492, 213-24
• URBANOWICZ RA and TARR AW, 2016. Novel functional hepatitis C virus glycoprotein isolates identified using an optimised viral pseudotype entry assay. The Journal of general virology.
• 2016. Broad neutralization of hepatitis C virus resistant variants by Civacir® hepatitis C immune globulin. Hepatology (Baltimore, Md.). (In Press.)

• View all publications

My teaching is laboratory focused, running practical classes for 5 to 65 students across many undergraduate and postgraduate courses. These currently include BMedsci, MSc Molecular Medical Microbiology, Clinical Microbiology, Microbiology & Immunology and the BBSRC Doctoral Training Programme.

The molecular biology sessions I have designed range from an introduction to basic molecular techniques such as micro-pipetting through to advanced methods such as Realtime PCR and Western Blotting - sometimes in the space of a few hours!

• 2016. Flexible and rapid construction of viral chimeras applied to Hepatitis C Virus. The Journal of general virology. (In Press.)
• FERNS RB, TARR AW, HUE S, URBANOWICZ RA, MCCLURE CP, GILSON R, BALL JK, NASTOULI E, GARSON JA and PILLAY D, 2016. Hepatitis C virus quasispecies and pseudotype analysis from acute infection to chronicity in HIV-1 co-infected individuals. Virology. 492, 213-24
• URBANOWICZ RA and TARR AW, 2016. Novel functional hepatitis C virus glycoprotein isolates identified using an optimised viral pseudotype entry assay. The Journal of general virology.
• 2016. Broad neutralization of hepatitis C virus resistant variants by Civacir® hepatitis C immune globulin. Hepatology (Baltimore, Md.). (In Press.)
• URBANOWICZ RA, MCCLURE CP, SAKUNTABHAI A, SALL AA, KOBINGER G, MÜLLER MA, HOLMES EC, REY FA, SIMON-LORIERE E and BALL JK, 2016. Human Adaptation of Ebola Virus during the West African Outbreak. Cell. 167(4), 1079-1087.e5
• TSOLERIDIS T, ONIANWA O, HORNCASTLE E, DAYMAN E, ZHU M, DANJITTRONG T, WACHTL M, BEHNKE JM, CHAPMAN S, STRONG V, DOBBS P, BALL JK, TARLINTON RE and MCCLURE CP, 2016. Discovery of Novel Alphacoronaviruses in European Rodents and Shrews. Viruses. 8(3), 84
• VERCAUTEREN K, BROWN RJP, MESALAM AA, DOERRBECKER J, BHUJU S, GEFFERS R, VAN DEN EEDE N, MCCLURE CP, TROISE F, VERHOYE L, BAUMERT T, FARHOUDI A, CORTESE R, BALL JK, LEROUX-ROELS G, PIETSCHMANN T, NICOSIA A and MEULEMAN P, 2015. Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice. Gut. (In Press.)
• URBANOWICZ, R. A., MCCLURE, C. P., BROWN, R. J., TSOLERIDIS, T., PERSSON, M. A., KREY, T., IRVING, W. L., BALL, J. K. and TARR, A. W., 2015. A Diverse Panel of Hepatitis C Virus Glycoproteins for Use in Vaccine Research Reveals Extremes of Monoclonal Antibody Neutralization Resistance: J Virol J Virol. 90(7), 3288-301
• PACIELLO R, URBANOWICZ RA, RICCIO G, SASSO E, MCCLURE CP, ZAMBRANO N, BALL JK, CORTESE R, NICOSIA A and DE LORENZO C, 2015. Novel human anti-claudin 1 mAbs inhibit hepatitis C virus infection and may synergize with anti-SRB1 mAb. The Journal of general virology. 97(1), 82-94
• HAMED MR, BROWN RJP, ZOTHNER C, URBANOWICZ RA, MASON CP, KRARUP A, MCCLURE CP, IRVING WL, BALL JK, HARRIS M, HICKLING TP and TARR AW, 2014. Recombinant human L-ficolin directly neutralizes hepatitis C virus entry. Journal of innate immunity. 6(5), 676-84
• GIRÓN-CALLEJAS A, CLARK G, IRVING WL and MCCLURE CP, 2014. In silico and in vitro interrogation of a widely used HEV RT-qPCR assay for detection of the species Orthohepevirus A. Journal of virological methods. 214C, 25-28 (In Press.)
• MEOLA A, TARR AW, ENGLAND P, MEREDITH LW, MCCLURE CP, FOUNG SKH, MCKEATING JA, BALL JK, REY FA and KREY T, 2014. Structural Flexibility of a Conserved Broadly Neutralizing Epitope in Hepatitis C Virus Glycoprotein E2. Journal of virology. (In Press.)
• IRVING WL, RUPP D, MCCLURE CP, THAN LM, TITMAN A, BALL JK, STEINMANN E, BARTENSCHLAGER R, PIETSCHMANN T and BROWN RJP, 2014. Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region. Antiviral research. 110, 52-9
• MCCLURE C, BOWMAN C, GEARY I, RYAN C, BALL J and ELEY A, 2013. HIV-1 co-receptor expression and epithelial immune cells of the cervix in asymptomatic women attending a genitourinary medicine clinic. HIV medicine. 14(2), 108-14
• SUPPIAH V, ARMSTRONG NJ, O'CONNOR KS, BERG T, WELTMAN M, ABATE ML, SPENGLER U, BASSENDINE M, DORE GJ, IRVING WL, POWELL E, NATTERMANN J, MUELLER T, RIORDAN S, STEWART GJ, GEORGE J, BOOTH DR, AHLENSTIEL G, AND THE INTERNATIONAL HEPATITIS C GENETICS CONSORTIUM (IHCGC), MICHALK M, MALIK B, MCCLURE P, SMITH S, SHERIDAN D, SNAPE E, FRAGOMELI V, NORRIS R, HOW-CHOW D, JONSSON JR, BARRIE H, STELZER-BRAID S, FLETCHER S, APPLEGATE T, GREBELY J, MATTHEWS G, BHARADWAJ M and SMEDILE A, 2013. CCR5-Δ32 genotype does not improve predictive value of IL28B polymorphisms for treatment response in chronic HCV infection. Genes and immunity. (In Press.)
• SAEED A, BALOCH K, BROWN RJP, WALLIS R, CHEN L, DEXTER L, MCCLURE CP, SHAKESHEFF K and THOMSON BJ, 2013. Mannan binding lectin-associated serine protease 1 is induced by hepatitis C virus infection and activates human hepatic stellate cells. Clinical and experimental immunology. (In Press.)
• EDWARDS V, MCCLURE CP, BROWN R, THOMSON E, IRVING WL and BALL J, 2013. Use of short-tandem repeat (STR) fingerprinting to validate sample origins in hepatitis C virus molecular epidemiology studies. The Journal of general virology. (In Press.)
• BROWN, R.J.P., KOUTSOUDAKIS, G., URBANOWICZ, R.A., MIRZA, D., GINKEL, C., RIEBESEHL, N., CALLAND, N., ALBECKA, A., PRICE, L., HUDSON, N., DESCAMPS, V., BACKX, M., MCCLURE, C.P., DUVERLIE, G., PECHEUR, E., DUBUISSON, J., PEREZ-DEL-PULGAR, S., FORNS, X., STEINMANN, E., TARR, A.W., PIETSCHMANN, T. and BALL, J.K., 2013. Analysis of serine codon conservation reveals diverse phenotypic constraints on Hepatitis C Virus glycoprotein evolution Journal of Virology. n/a(n/a), n/a
• SIMMONS, R., SHARP, C., MCCLURE, C.P., ROHRBACH, J., KOVARI, H., FRANGOU, E., SIMMONDS, P., IRVING, W., RAUCH, A., BOWNESS, P. and KLENERMAN, P., 2012. Parvovirus 4 infection and clinical outcome in high-risk populations Journal of Infectious Diseases. 205(12), 1816-1820
• MCCLURE P, 2011. Preparing Lab Novices for a 3 Month Research Project Bioscience Bulletin. 1(33), 8
• BROWN, RICHARD J P, PETERS, PAUL J, CARON, CATHERINE, GONZALEZ-PEREZ, MARIA PAZ, STONES, LEANNE, ANKGHUAMBOM, CHIAMBAH, PONDEI, KEMEBRADIKUMO, MCCLURE, C PATRICK, ALEMNJI, GEORGE, TAYLOR, STEPHEN and SHA, 2011. Intercompartmental Recombination of HIV-1 Contributes to env Intrahost Diversity and Modulates Viral Tropism and Sensitivity to Entry Inhibitors. Journal of virology. 85(12), 6024-37
• SUPPIAH, V., GAUDIERI, S., ARMSTRONG, N.J., O'CONNOR, K.S., BERG, T., WELTMAN, N., ABATE, M.L., SPENGLER, U., BASSENDINE, M., DORE, D.J., IRVING, W.L., POWELL, E., HELLARD, M., RIORDAN, S., MATTHEWS, G., SHERIDAN, D., NATTERMANN, J., SMEDILE, A., MÜLLER, T., HAMMOND, E., DUNN, D., NEGRO, F., BOCHUD, P-Y., MALLAL, S., AHLENSTIEL, G., STEWART, G.J., GEORGE, J. and BOOTH, D.R., 2011. IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European cohort: a cross-sectional study PLoS Medicine. 8(9), e1001092
• TARR, A.W., URBANOWICZ, R.A., HAMED, M.R., ALBECKA, A., MCCLURE, C.P., BROWN, R.J.P., IRVING, W.L., DUBUISSON, J. and BALL, J.K., 2011. Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: genetic subtype defines antigenic but not neutralization serotype Journal of Virology. 85(9), 4246-4257
• TARR AW, URBANOWICZ RA, HAMED MR, ALBECKA A, MCCLURE CP, BROWN RJP, IRVING WL, DUBUISSON J and BALL JK, 2011. Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: genetic subtype defines antigenic but not neutralization serotype. Journal of virology. 85(9), 4246-57
• HAMED, M.R.B., TARR, A.W., MCCLURE, C.P., BALL, J.K., HICKLING, T.P. and IRVING, W.L., 2008. Association of antibodies to hepatitis C virus glycoproteins 1 and 2 (anti-E1E2) with HCV disease Journal of Viral Hepatitis. 15(5), 339-345
• BROWN RJP, TARR AW, MCCLURE P, JUTTLA VS, TAGIURI N, IRVING WL, BALL JK., 2007. Cross-genotype characterization of genetic diversity and molecular adaptation in hepatitis C virus envelope glycoproteins. Journal of General Virology. 88, 458-469
• TARR, A.W., OWSIANKA, A.M., TIMMS, J.M., MCCLURE, C.P., BROWN, R.J.P., HICKLING, T.P., PIETSCHMANN, T., BARTENSCHLAGER, R., PATEL, A.H. and BALL, J.K., 2006. Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33. Hepatology (Baltimore, Md.). 43(3), 592-601
• MCCLURE, C.P., TIGHE, P.J., ROBINS, R.A., BANSAL, D., BOWMAN, C.A. and KINGSTON, M. BALL, J. K., 2005. HIV coreceptor and chemokine ligand gene expression in the male urethra and female cervix AIDS. 19(12), 1257-1265
• MCCLURE, P, CURRAN, R, BONEHAM, S and BALL, J K, 2000. A polymerase chain reaction method for the amplification of full-length envelope genes of HIV-1 from DNA samples containing single molecules of HIV-1 provirus. Journal of virological methods. 88(1), 73-80
• MURTAGH, G. J., DYER, P. S., MCCLURE, P. C. and CRITTENDEN, P. D., 1999. Use of randomly amplified polymorphic DNA markers as a tool to study variation in lichen-forming fungi Lichenologist. VOL 31(NUMBER 3), 257-268
• YI, C.H., TERRETT, J.A., LI, Q.Y., ELLINGTON, K., PACKHAM, E.A., ARMSTRONG-BUISSERET, L., MCCLURE, P., SLINGSBY, T. and BROOK, J.D., 1999. Identification, mapping, and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19 Genomics. 55(1), 10-20