Kin-Chow Chang

Contact

• workRoom A14a Veterinary Academic Building
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6491
• svzkc@nottingham.ac.uk
• https://www.nottingham.ac.uk/vet/people/kin-chow.chang

Biography

Kin-Chow Chang qualified as a veterinary surgeon from the University of Bristol. He undertook post-graduate research training at University College London (MSc with Distinction), and at the Royal Veterinary College (RVC), University of London (PhD). He was awarded a 5-year Wellcome Trust Postdoctoral Fellowship based at the RVC after which he joined the Roslin Institute as a Principal Investigator. He subsequently took up a senior lectureship at the University of Glasgow and became a Reader. He is a Fellow of the Royal College of Veterinary Surgeons (FRCVS). He later joined the University of Nottingham in 2008 as Professor of Veterinary Molecular Medicine. His main research focus is on host innate resistance and antivirals against respiratory viruses (SARS-CoV-2, influenza and respiratory syncytial virus), with long-standing research involvement in skeletal muscle biology.

https://orcid.org/0000-0002-6602-7447

Research Summary

Mammalian host innate resistance to respiratory viruses

Coronavirus (in particular pandemic SARS-CoV-2), influenza A virus and respiratory syncytial virus are major respiratory pathogens that can inflict widespread and serious morbidity and mortality in human and animal hosts. We seek to understand the mechanisms of host innate disease resistance to such viral infections. One strategic approach we have adopted is to compare host response to virulent influenza virus infection (such as highly pathogenic avian H5N1 virus) between resistant (e.g. pig and duck) and susceptible (human and chicken) species to identify host targets for the development of antivirals to tackle active infection of different viruses.

https://orcid.org/0000-0002-6602-7447

Selected Publications

• HONGLEI SUN, HAN LI, QI TONG, QIQI HAN, JIYU LIU, HAILI YU, HAO SONG, JIANXUN QI, JIAQI LI, JIZHE YANG, RIGUO LAN, GUOJING DENG, HAOYU CHANG, YAJIN QU, JUAN PU, YIPENG SUN, YU LAN, DAYAN WANG, YI SHI, WILLIAM J. LIU, KIN-CHOW CHANG, GEORGE F. GAO and JINHUA LIU, 2023. Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets Cell. 186(19), 4074-4084
• LI, Q., JIANG, Z., REN, S., GUO, H., SONG, Z., CHEN, S., GAO, X., MENG, F., ZHU, J., LIU, L., TONG, Q., SUN, H., SUN, Y., PU, J., CHANG, K.C. and LIU, J., 2022. SRSF5-mediated alternative splicing of M gene is essential for influenza A virus replication: a host-directed target against influenza virus Advanced Science. 9(34), 2203088
• SARAH AL-BELTAGI, LEAH V. GOULDING, DANIEL K.E. CHANG, KENNETH H. MELLITS, CHRISTOPHER J. HAYES, PAVEL GERSHKOVICH, CHRISTOPHER M. COLEMAN and KIN-CHOW CHANG, 2021. Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin Virulence. 12(1), 2946-2956
• JIANG, ZHIMIN, WEI, FANHUA, ZHANG, YUYING, WANG, TONG, GAO, WEIHUA, YU, SHUFANG, SUN, HONGLEI, PU, JUAN, SUN, YIPENG, WANG, MINGYANG, TONG, QI, GAO, CHENGJIANG, CHANG, KIN-CHOW and LIU, JINHUA, 2021. IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection. Nature Microbiology. 6, 932-945

• View all publications

• HONGLEI SUN, HAN LI, QI TONG, QIQI HAN, JIYU LIU, HAILI YU, HAO SONG, JIANXUN QI, JIAQI LI, JIZHE YANG, RIGUO LAN, GUOJING DENG, HAOYU CHANG, YAJIN QU, JUAN PU, YIPENG SUN, YU LAN, DAYAN WANG, YI SHI, WILLIAM J. LIU, KIN-CHOW CHANG, GEORGE F. GAO and JINHUA LIU, 2023. Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets Cell. 186(19), 4074-4084
• WANG, C., QU, R., ZONG, Y., QIN, C., LIU, L., GAO, X., SUN, H., SUN, Y., CHANG, K.C., ZHANG, R., LIU, J. and PU, J., 2022. Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals. PLOS Pathogens. 18(7), e1010645
• SUN, HONGLEI, DENG, GUOJING, SUN, HAORAN, SONG, JINGWEI, ZHANG, WEI, LI, HAN, WEI, XIAOHUI, LI, FANGTAO, ZHANG, XIN, LIU, JIYU, PU, JUAN, SUN, YIPENG, TONG, QI, BI, YUHAI, XIE, YUFENG, QI, JIANXUN, CHANG, KIN-CHOW, GAO, GEORGE FU and LIU, JINHUA, 2022. N-linked glycosylation enhances hemagglutinin stability in avian H5N6 influenza virus to promote adaptation in mammals PNAS Nexus. pgac085
• LI, Q., JIANG, Z., REN, S., GUO, H., SONG, Z., CHEN, S., GAO, X., MENG, F., ZHU, J., LIU, L., TONG, Q., SUN, H., SUN, Y., PU, J., CHANG, K.C. and LIU, J., 2022. SRSF5-mediated alternative splicing of M gene is essential for influenza A virus replication: a host-directed target against influenza virus Advanced Science. 9(34), 2203088
• ZHANG, XUXIAO, PU, JUAN, SUN, YIPENG, YUHAI, BI, JIANG, ZHIMIN, XU, GUANLONG, ZHANG, HONGYU, CAO, JING, CHANG, KIN-CHOW, LIU, JINHUA and SUN, HONGLEI, 2021. Neurovirulence of avian influenza virus is dependent on the interaction of viral NP protein with host factor FMRP in the murine brain Journal of Virology. 95:e01272-20
• AL-BELTAGI, SARAH, PREDA, CRISTIAN ALEXANDRU, GOULDING, LEAH V., JAMES, JOE, PU, JUAN, SKINNER, PAUL, JIANG, ZHIMIN, WANG, BELINDA LEI, YANG, JIAYUN, BANYARD, ASHLEY C., MELLITS, KENNETH H., GERSHKOVICH, PAVEL, HAYES, CHRISTOPHER J., NGUYEN-VAN-TAM, JONATHAN, BROWN, IAN H., LIU, JINHUA and CHANG, KIN-CHOW, 2021. Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus Viruses. 13, 234
• HONGLEI SUN, FANGTAO LI, QINGZHI LIU, JIANYONG DU, LITAO LIU, HAORAN SUN, CHONG LI, JIYU LIU, XIN ZHANG, JIZHE YANG, YUHONG DUAN, YUHAI BI, JUAN PU, YIPENG SUN, QI TONG, YONGQIANG WANG, XIANGJUN DU, YUELONG SHU, KIN-CHOW CHANG and JINHUA LIU, 2021. Mink is a highly susceptible host species to circulating human and avian influenza viruses Emerging Microbes & Infections. 10(1), 472-480
• PU, JUAN, YIN, YANBO, LIU, JIYU, WANG, XINYU, ZHOU, YONG, WANG, ZEJIANG, SUN, YIPENG, SUN, HONGLEI, LI, FANGTAO, SONG, JINGWEI, QU, RUNKANG, GAO, WEIHUA, WANG, DONGDONG, WANG, ZHEN, YAN, SHIJIE, CHEN, MINGYUE, ZENG, JINFENG, JIANG, ZHIMIN, SUN, HAORAN, ZONG, YANAN, WANG, CHENXI, TONG, QI, BI, YUHAI, HUANG, YINHUA, DU, XIANGJUN, CHANG, KIN-CHOW and LIU, JINHUA, 2021. Reassortment with dominant chicken H9N2 influenza virus contributed to the fifth H7N9 virus human epidemic Journal of Virology. 95(11), e01578-20
• JIANG, ZHIMIN, WEI, FANHUA, ZHANG, YUYING, WANG, TONG, GAO, WEIHUA, YU, SHUFANG, SUN, HONGLEI, PU, JUAN, SUN, YIPENG, WANG, MINGYANG, TONG, QI, GAO, CHENGJIANG, CHANG, KIN-CHOW and LIU, JINHUA, 2021. IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection. Nature Microbiology. 6, 932-945
• SARAH AL-BELTAGI, LEAH V. GOULDING, DANIEL K.E. CHANG, KENNETH H. MELLITS, CHRISTOPHER J. HAYES, PAVEL GERSHKOVICH, CHRISTOPHER M. COLEMAN and KIN-CHOW CHANG, 2021. Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin Virulence. 12(1), 2946-2956
• LI, FANGTAO AND LIU, JIYU AND YANG, JIZHE AND SUN, HAORAN AND JIANG, ZHIMIN AND WANG, CHENXI AND ZHANG, XIN AND YU, YINGHUI AND ZHAO, CHUANKUO AND PU, JUAN AND SUN, YIPENG AND CHANG, KIN-CHOW AND LIU, JINHUA AND SUN, HONGLEI, 2021. H9N2 virus-derived M1 protein promotes H5N6 virus release in mammalian cells: Mechanism of avian influenza virus inter-species infection in humans PLOS Pathogens. 17(12), 1-24
• SUN, HONGLEI, XIAO, YIHONG, LIU, JIYU, WANG, DAYAN, LI, FANGTAO, WANG, CHENXI, LI, CHONG, ZHU, JUNDA, SONG, JINGWEI, SUN, HAORAN, JIANG, ZHIMIN, LIU, LITAO, ZHANG, XIN, WEI, KAI, HOU, DONGJUN, PU, JUAN, SUN, YIPENG, TONG, QI, BI, YUHAI, CHANG, KIN-CHOW, LIU, SIDANG, GAO, GEORGE F. and LIU, JINHUA, 2020. Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection Proceedings of the National Academy of Sciences USA. 117(29), 17204-17210
• GOULDING, L.V., YANG, J., JIANG, Z., ZHANG, H., LEA, D., EMES, R.D., DOTTORINI, T., PU, J., LIU, J. and CHANG, K.C., 2020. Thapsigargin at non-cytotoxic levels induces a potent host antiviral response that blocks influenza A virus replication Viruses. 12, 1093
• GAO,W., ZU,Z., SONG,J., WANG,X., WANG,C., LIU,L., TONG,O., WANG,M., SUN,H., SUN,Y., LIU,J., CHANG,K.C. and PU,J., 2019. Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells. J. Gen. Virol. 100(9), 1273-1281
• SLATER,T., ECKERLE,I. and CHANG,K.C., 2018. Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses Virol.J. 15, 68
• PU,J., SUN,H., QU,Y., WANG,C., GAO,W., ZHU,J., SUN,Y., BI,Y., CHANG,K.C., CUI,J. and LIU,J., 2017. M-gene reassortment in H9N2 influenza virus promotes early infection and replication: contribution to rising virus prevalence in chickens in China J.Virol. 91(8), e02055-16
• ZHANG,X., XU,G., WANG,C., JIANG,M., GAO,W., WANG,M., SUN,H., SUN,Y., CHANG,K.C., LIU,J. and PU,J., 2017. Enhanced pathogenicity and neurotropism of mouse-adapted H10N7 influenza virus are mediated by novel PB2 and NA mutations J.Gen.Virol. 98, 1185-1195
• KONG,W., LIU,Q., SUN,Y., WANG,Y., GAO,H., LIU,L., QIN,Z., HE,Q., SUN,H., PU,J., WANG,D., GUO,X., YANG,H., CHANG,K.C., SHU,Y. and LIU,J., 2016. Transmission and pathogenicity of novel reassortants derived from Eurasian avian-like and 2009 pandemic H1N1 influenza viruses in mice and guinea pigs Sci.Rep. 6, 27067
• SUN,H., PU,J., WEI,Y., SUN,Y., HU,J., LIU,L., XU,G., GAO,W., LI,C., ZHANG,X., HUANG,Y., CHANG,K.C., LIU,X. and LIU,J., 2016. Highly pathogenic avian influenza H5N6 viruses exhibit enhanced affinity for human type sialic acid receptor and in-contact transmission in model ferrets J.Virol. 90(14), 6235-6243
• XU,G., ZHANG,X., GAO,W., WANG,C., WANG,J., SUN,H., SUN,Y., GUO,L., ZHANG,R., CHANG,K.C., LIU,J. and PU,J., 2016. Prevailing PA mutation K356R in avian influenza H9N2 virus increases mammalian replication and pathogenicity J.Virol. 90(18), 8105-8114
• BAQUERO-PEREZ,B., KUCHIPUDI,S.V., HO,J., SEBASTIAN,S., PURANIK,A., HOWARD,W., BROOKES,S.M., BROWN,I.H. and CHANG,K.C., 2015. Chicken and duck myotubes are highly susceptible and permissive to influenza virus infection J.Virol. 89, 2494-2506
• GAO,H., SUN,Y., HU,J., QI,L., WANG,J., XIONG,X., WANG,Y., HE,Q., LIN,Y., KONG,W., SENG,L.G., SUN,H., PU,J., CHANG,K.C., LIU,X. and LIU,J., 2015. The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses Sci.Rep. 5, 8262
• MAINE,I.R., ATTERBURY,R. and CHANG,K.C., 2015. Investigation into the animal species contents of popular wet pet foods Acta Vet.Scand. 57, 7
• GAO,H., SUN,H., HU,J., QI,L., WANG,J., XIONG,X., WANG,Y., HE,Q., LIN,Y., KONG,W., SENG,L.G., PU,J., CHANG,K.C., LIU,X. and LIU,J., 2015. The 20 amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity J.Gen.Virol. 96(8), 2036-2049
• GAO,H., XU,G., SUN,Y., QI,L., WANG,J., KONG,W., SUN,H., PU,J., CHANG,K.C. and LIU,J., 2015. PA-X is a virulence factor in avian H9N2 influenza virus J.Gen.Virol. 96(9), 2587-2594
• SEBASTIAN,S., GOULDING,L., KUCHIPUDI,S.V. and CHANG,K.C., 2015. Extended 2D myotube culture recapitulates postnatal fibre type plasticity BMC Cell Biol. 16, 23
• CHANG,P., KUCHIPUDI,S.V., MELLITS,K.H., SEBASTIAN,S., JAMES,J., LIU,J., SHELTON,H. and CHANG,K.C., 2015. Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and pro-inflammatory dysregulation Sci.Rep. 5, 17999
• SUN, H., SUN, Y., PU, J., ZHANG, Y., ZHU, Q., LI, J., GU, J., CHANG, K.C. and LIU, J., 2014. Comparative virus replication and host innate response in human cells infected with 3 prevalent clades (2.3.4, 2.3.2 and 7) of highly pathogenic avian influenza H5N1 viruses J.Virol. 88(1), 725-729
• SUN, Y., XU, Q., SHEN, Y., LIU, L., WEI, K., SUN, H., PU, J., CHANG, K.C. and LIU, J., 2014. Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice J.Virol. 88(8), 4600-4604
• WEI, K., SUN, H., SUN, Z., SUN, Y., KONG, W., PU, J., MA, G., YIN, Y., YANG, Y., GUO, X., WEBSTER, R.G., CHANG, K.C. and LIU, J., 2014. Influenza A virus acquires enhanced pathogenicity and transmissibility after serial passages in swine J.Virol. 88(20), 11981-11994
• SENG, L.G., DALY, J., CHANG, K.C. and KUCHIPUDI, S.V., 2014. High basal expression of interferon-stimulated genes in human bronchial epithelial (BEAS-2B) cells contributes to influenza A virus resistance PLOS ONE. 9(10), e109023
• KUCHIPUDI, S.V., TELLABATI, M., SEBASTIAN, S., LONDT, B.Z., JANSEN, C., VERVELDE, L., BROOKES, S.M., BROWN, I.H., DUNHAM, S.P. and CHANG, K.C., 2014. Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses Vet.Res. 45, 118
• SCHARF, M., NEEF, S., FREUND, R., GEERS-KNORR, C., BRANDIS, A., KRONE, D., SCHNEIDER, H., GROOS, S., MENON, M., CHANG, K.C., KRAFT, T., MEISSNER, J., BOHELER, K., MAIER, L., GAESTEL, M. and SCHEIBE, R., 2013. MAPKAPK2/3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function Mol.Cell.Biol. 33, 2586-2602
• WEI, W., HE, H.B., ZHANG, W.Y., ZHANG, H.X., BAI, J.B., LIU, H.Z., CAO, J.H., CHANG, K.C., LI, X.Y. and ZHAO, S.H., 2013. miR-29 targets Akt3 to reduce proliferation and facilitate differentiation of myoblasts in skeletal muscle development Cell Death Dis. 4, e668
• BAQUERO-PEREZ, B., KUCHIPUDI, S.V., NELLI, R.K. and KIN-CHOW CHANG, 2012. A simplified but robust method for the isolation of avian and mammalian muscle satellite cells BMC Cell Biology. 13, 16
• NELLI, R.K., DUNHAM, S.P., KUCHIPUDI, S.V., WHITE, G.A., BAQUERO-PEREZ, B., CHANG, P., GHAEMMAGHAMI, A., BROOKES, S.M., BROWN, I.H. and CHANG, K.-C., 2012. Mammalian innate resistance to highly pathogenic avian influenza h5n1 virus infection is mediated through reduced pro-inflammation and infectious virus release Journal of Virology. 86(17), 9201-9210
• KUCHIPUDI, S.V., TELLABATI, M., NELLI, R.K., WHITE, G.A., BAQUERO-PEREZ, B., SEBASTIAN, S., SLOMKA, M.J., BROOKES, S.M., BROWN, I.H., DUNHAM, S.P. and CHANG, K.C., 2012. 18S rRNA is a reliable normalisation gene for real time PCR derived from influenza virus infected cells Virol.J. 9, 230 "Highly Accessed"
• HANKE, N., SCHEIBE, R.J., MANUKJAN, G., EWERS, D., UMEDA, P.K., CHANG, K.C., KUBIS, H.P., GROS, G. and MEISSNER, J.D., 2011. Gene regulation mediating fiber-type transformation in skeletal muscle cells is partly glucose- and ChREBP-dependent Biochimica et Biophysica Acta (BBA): Molecular Cell Research. 1813(3), 377-389
• KUCHIPUDI, S.V., DUNHAM, S.P., NELLI, R.K., WHITE, G.A., PEREZ, B.B., BROWN, I. and CHANG, K.C., 2011. Rapid death of duck cells infected with Influenza A: a mechanism for host resistance to H5N1 Immunol.Cell Biol. 90, 116-123
• MEISSNER, J.D., FREUND, R., KRONE, D., UMEDA, P.K., CHANG, K.C., GROS, G. and SCHEIBE, R.J., 2011. Extracellular signal-regulated kinase 1/2-mediated phosphorylation of p300 enhances myosin heavy chain I/ β gene expression via acetylation of nuclear factor of activated T cells c1 Nucleic Acids Research. 39(14), 5907-5925
• CHANG, K.C., MCCULLOCH, M.-L.C. and ANDERSON, T.J., 2010. Molecular and cellular characterisation of a distinct myopathy of Great Dane dogs. Vet.J. 183, 322-327
• NELLI, R.K., KUCHIPUDI, S.V., WHITE, G.A., PEREZ, B.B., DUNHAM, S.P. and CHANG, K.-C., 2010. Comparative distribution of human and avian type sialic acid influenza receptors in the pig. BMC Veterinary Research. 6(1), 4
• KUCHIPUDI, S.V., NELLI, R., WHITE G., BAIN, M., CHANG, K.C. and DUNHAM, S., 2009. Differences in influenza virus receptor in chickens and ducks: implications for interspecies transmission. J. Mol.Genetic Med. 3, 143-151
• MALLINSON, J., MEISSNER, J. and CHANG, K.C., 2009. Calcineurin signalling and the slow-oxidative skeletal muscle fibre type Int.Rev.Cell Mol.Biol. 277, 67-101
• SCHOLZ, M.E., MEISSNER, J.D., SCHEIBE, R.J., UMEDA, P.K., CHANG, K.-C., GROS, G. and KUBIS, H.-P., 2009. Different roles of H-ras for regulation of myosin heavy chain promoters in satellite cell-derived muscle cell culture during proliferation and differentiation American Journal of Physiology: Cell Physiology. 297(4), C1012-C1018
• BÜNGER, L., NAVAJAS, E.A., STEVENSON, L., LAMBE, N.R., MALTIN, C.A., SIMM, G., FISHER, A.V. and CHANG, K.C., 2009. Muscle fibre characteristics of two contrasting sheep breeds: Scottish Blackface and Texel Meat Science. 81(2), 372-381
• MEISSNER, J.D., UMEDA, P.K., CHANG, K.C., GROS, G. and SCHEIBE, R.J., 2007. Activation of the beta myosin heavy chain promoter by MEF-2D, MyoD, p300, and the calcineurin/NFATc1 pathway J.Cell.Physiol. 211, 138-148
• DA COSTA, N., EDGAR, J., OOI, P.T., SU, Y., MEISSNER, J.D. and CHANG, K.C., 2007. Calcineurin differentially regulates fast myosin heavy chain genes in oxidative muscle fibre type conversion Cell Tissue Res. 329, 515-527
• CHANG, K.C., 2007. Key signalling factors and pathways in the molecular determination of skeletal muscle phenotype Animal. 1, 681-698
• WIMMERS, K., MURANI, E., TE PAS, M.F.W., CHANG, K.C., DAVOLI, R., MERKS, J.W.M., HENNE, H., MURANIOVA, M., DA COSTA, N., HARLIZIUS, B., SCHELLANDER, K., BÖLL, I., BRAGLIA, S., DE WIT, A.A.C., CAGNAZZO, M., FONTANESI, L., PRINS, D. and PONSUKSILI, S., 2007. Associations of functional candidate genes derived from gene-expression profiles of prenatal porcine muscle tissue with meat quality and muscle deposition Anim.Genet. 38, 474-484
• MEISSNER, J.D., CHANG, K.C., KUBIS, H.-P., NEBREDA, A.R., GROS, G. and SCHEIBE, R.J., 2007. The p38alpha/beta mitogen-activated protein kinases mediate recruitment of CREB-binding protein to preserve fast MyHCIId/x gene activity in myotubes J.Biol.Chem. 282, 7265-7275
• CHANG, K.C. AND STEAR, M.J., 2006. Genetic influences on susceptibility to acquired diseases. In: STRAW, B.E, D’ALLAIRE, S, MENGELING, W.L. and TAYLOR, D.J., eds., Diseases of Swine, 9th Edition. Iowa State Press. 987-992
• OOI, P.T., DA COSTA, N., EDGAR, J. and CHANG, K.C., 2006. Porcine congenital splayleg is a condition of muscle fibre atrophy associated with elevated MAFbx and reduced P311 expression BMC Vet.Res. 2, 23
• LUJAN FELIU-PASCUAL, A., SHELTON, G.D., TARGETT, M.P., LONG, S.N., COMERFORD, E.J., MCMILLAN, C., RUSBRIDGE, C., MELLOR, D., CHANG, K.C. and ANDERSON, T.J., 2006. Inherited myopathy of Great Danes J.Small Anim.Pract. 47, 249-254
• KANELLOS, T., SYLVESTER, I.D., D’MELLO, F., HOWARD, C.R., MACKIE, A., DIXON, P.F., CHANG. K.C., RAMSTAD, A., MIDTLYNG, P.J. and RUSSELL, P.H., 2006. DNA Vaccination can protect Cyprinus Caprio against the Spring Viraemia of Carp Virus (SVCV) Vaccine. 24, 4927-4933
• DA COSTA, N. and CHANG, K.C., 2005. Molecular characterisation of the porcine skeletal myosin heavy chain cluster and a major candidate regulatory domain. Arch.Anim.Breed. 48, 32-39
• DA COSTA, N., MCGILLIVRAY, C., BAI, Q., WOOD, J.D., EVANS, G. and CHANG, K.C., 2004. Energy and protein restriction induces molecular changes in young porcine skeletal muscles J.Nutr. 134, 2191-2199
• WOOD, J.D., NUTE, G.R., RICHARDSON, R.I., WHITTINGTON, F.M., SOUTHWOOD, O., PLASTOW, G., MANSBRIDGE, R., DA COSTA, N. and CHANG, K.C., 2004. Effects of breed, diet and muscle on fat deposition and eating quality in pigs Meat Sci. 67, 651-667
• CHANG, K.C., DA COSTA, N., BLACKLEY, R., SOUTHWOOD, O., EVANS, G., PLASTOW, G., WOOD, J.D. and RICHARDSON, R.I., 2003. Relationships of myosin heavy chain fibre types to meat quality traits in traditional and modern pigs Meat Sci. 64, 93-103
• SUN, Y.M., DA COSTA, N. and CHANG, K.C., 2003. Cluster characterisation and temporal expression of porcine sarcomeric myosin heavy chain genes J. Muscle Res. Cell Motil. 24, 561-570
• DA COSTA, N., MCGILLIVRAY, C. and CHANG, K.C., 2003. Post-natal myosin heavy chain isoforms in pre-natal porcine skeletal muscles Anat.Rec.A. 273A, 731-740
• CHANG, K.C and BEUZEN, N.D. AND HALL, A.D., 2003. Identification of microsatellites in expressed muscle genes: assessment of a desmin (CT) dinucleotide repeat as a marker for meat quality Vet. J. 165, 157-163
• BAI, Q., MCGILLIVRAY, C., DA COSTA, N., DORNAN, S., EVANS, G., STEAR, M.J. and CHANG, K.C., 2003. Development of a porcine skeletal muscle cDNA microarray: analysis of differential transcript expression in phenotypically distinct muscles BMC Genomics. 4, 8
• ALZUHERRI, H. AND CHANG, K.C., 2003. Calcineurin activates NF-kappaB in skeletal muscle C2C12 cells Cell.Signal. 15, 471-478
• DA COSTA, N., BLACKLEY, R., ALZUHERRI, H. and CHANG, K.C., 2002. Quantifying the temporo-spatial expression of porcine postnatal skeletal myosin heavy chain genes J.Histochem.Cytochem. 50, 353-364
• SUN, Y.M., DA COSTA, N., BIRRELL, R., ALZUHERRI, H. and CHANG, K.C., 2001. Molecular and quantitative characterisation of the porcine embryonic myosin heavy chain gene J. Muscle Res. Cell Motil. 22, 317-327