Graham Sheridan

Contact

• workThe Queen's Medical Centre
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 82 30957
• Graham.Sheridan@nottingham.ac.uk

Research Summary

My research group works at the interface of neuropharmacology and bioengineering. We are interested in glial cell mechanosensitivity and how changes in the mechanical properties of brain tissue may… read more

Selected Publications

• COLIN-YORK H, JAVANMARDI Y, BARBIERI L, LI D, KOROBCHEVSKAYA K, GUO Y, HALL C, TAYLOR A, KHUON S, SHERIDAN GK, CHEW TL, LI D, MOEENDARBARY E and FRITZSCHE M, 2019. Spatiotemporally Super-Resolved Volumetric Traction Force Microscopy. Nano letters. (In Press.)
• MAMPAY M and SHERIDAN GK, 2019. REST: An epigenetic regulator of neuronal stress responses in the young and ageing brain. Frontiers in neuroendocrinology. 53, 100744
• VELASCO-ESTEVEZ M, MAMPAY M, BOUTIN H, CHANEY A, WARN P, SHARP A, BURGESS E, MOEENDARBARY E, DEV KK and SHERIDAN GK, 2018. Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes. Frontiers in aging neuroscience. 10, 332
• O'SULLIVAN SA, O'SULLIVAN C, HEALY LM, DEV KK and SHERIDAN GK, 2018. Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia. Journal of neurochemistry. 144(6), 736-747

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Current Research

My research group works at the interface of neuropharmacology and bioengineering. We are interested in glial cell mechanosensitivity and how changes in the mechanical properties of brain tissue may contribute to glial cell reactivity.

We aim to identify novel drug targets for currently incurable conditions of the brain and spinal cord, such as Alzheimer's disease, multiple sclerosis and cancer-related cognitive impairment.

In particular, we study how ageing and neuroinflammation can disrupt the biochemistry and mechanobiology of astrocytes, microglia, and myelin-forming oligodendrocytes. Our goal is to better understand how glial pathologies impact synaptic plasticity in key areas of the brain involved in learning and memory formation.

• ESTEKI, MOHAMMAD HADI, MALANDRINO, ANDREA, ALEMRAJABI, ALI AKBAR, SHERIDAN, GRAHAM K., CHARRAS, GUILLAUME and MOEENDARBARY, EMAD, 2021. Poroelastic osmoregulation of living cell volume ISCIENCE. 24(12),
• MAMPAY, MYRTHE, FLINT, MELANIE S. and SHERIDAN, GRAHAM K., 2021. Tumour brain: Pretreatment cognitive and affective disorders caused by peripheral cancers BRITISH JOURNAL OF PHARMACOLOGY. 178(19), 3977-3996
• LIZARRAGA-VALDERRAMA, LORENA R. and SHERIDAN, GRAHAM K., 2021. Extracellular vesicles and intercellular communication in the central nervous system FEBS LETTERS. 595(10), 1391-1410
• MAMPAY, MYRTHE, VELASCO-ESTEVEZ, MARIA, ROLLE, SARA O., CHANEY, AISLING M., BOUTIN, HERVE, DEV, KUMLESH K., MOEENDARBARY, EMAD and SHERIDAN, GRAHAM K., 2021. Spatiotemporal immunolocalisation of REST in the brain of healthy ageing and Alzheimer's disease rats FEBS OPEN BIO. 11(1), 146-163
• HALL, CHLOE M., MOEENDARBARY, EMAD and SHERIDAN, GRAHAM K., 2021. Mechanobiology of the brain in ageing and Alzheimer's disease EUROPEAN JOURNAL OF NEUROSCIENCE. 53(12), 3851-3878
• ESTEKI, MOHAMMAD HADI, ALEMRAJABI, ALI AKBAR, HALL, CHLOE M, SHERIDAN, GRAHAM K, AZADI, MOJTABA and MOEENDARBARY, EMAD, 2020. A new framework for characterization of poroelastic materials using indentation. Acta biomaterialia. 102, 138-148
• VELASCO-ESTEVEZ, MARIA, GADALLA, KAMAL K E, LINAN-BARBA, NURIA, COBB, STUART, DEV, KUMLESH K and SHERIDAN, GRAHAM K, 2019. Inhibition of Piezo1 attenuates demyelination in the central nervous system. Glia.
• VELASCO-ESTEVEZ M, ROLLE SO, MAMPAY M, DEV KK and SHERIDAN GK, 2019. Piezo1 regulates calcium oscillations and cytokine release from astrocytes. Glia. (In Press.)
• MAMPAY M and SHERIDAN GK, 2019. REST: An epigenetic regulator of neuronal stress responses in the young and ageing brain. Frontiers in neuroendocrinology. 53, 100744
• COLIN-YORK H, JAVANMARDI Y, BARBIERI L, LI D, KOROBCHEVSKAYA K, GUO Y, HALL C, TAYLOR A, KHUON S, SHERIDAN GK, CHEW TL, LI D, MOEENDARBARY E and FRITZSCHE M, 2019. Spatiotemporally Super-Resolved Volumetric Traction Force Microscopy. Nano letters. (In Press.)
• O'SULLIVAN SA, O'SULLIVAN C, HEALY LM, DEV KK and SHERIDAN GK, 2018. Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia. Journal of neurochemistry. 144(6), 736-747
• VELASCO-ESTEVEZ M, MAMPAY M, BOUTIN H, CHANEY A, WARN P, SHARP A, BURGESS E, MOEENDARBARY E, DEV KK and SHERIDAN GK, 2018. Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes. Frontiers in aging neuroscience. 10, 332
• MOEENDARBARY E, WEBER IP, SHERIDAN GK, KOSER DE, SOLEMAN S, HAENZI B, BRADBURY EJ, FAWCETT J and FRANZE K, 2017. The soft mechanical signature of glial scars in the central nervous system. Nature communications. 8, 14787
• VELASCO M, O'SULLIVAN C and SHERIDAN GK, 2016. Lysophosphatidic acid receptors (LPARs): Potential targets for the treatment of neuropathic pain. Neuropharmacology. 113(Pt B), 608-617
• KOSER DE, THOMPSON AJ, FOSTER SK, DWIVEDY A, PILLAI EK, SHERIDAN GK, SVOBODA H, VIANA M, COSTA LD, GUCK J, HOLT CE and FRANZE K, 2016. Mechanosensing is critical for axon growth in the developing brain. Nature neuroscience. 19(12), 1592-1598
• SHERIDAN GK and DEV KK, 2014. Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations. Scientific reports. 4, 5051
• SHERIDAN GK, MOEENDARBARY E, PICKERING M, O'CONNOR JJ and MURPHY KJ, 2014. Theta-burst stimulation of hippocampal slices induces network-level calcium oscillations and activates analogous gene transcription to spatial learning. PloS one. 9(6), e100546
• SHERIDAN GK, WDOWICZ A, PICKERING M, WATTERS O, HALLEY P, O'SULLIVAN NC, MOONEY C, O'CONNELL DJ, O'CONNOR JJ and MURPHY KJ, 2014. CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity. Frontiers in cellular neuroscience. 8, 233
• HEALY LM, SHERIDAN GK, PRITCHARD AJ, RUTKOWSKA A, MULLERSHAUSEN F and DEV KK, 2013. Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes. British journal of pharmacology. 169(5), 1114-29
• SHERIDAN GK and MURPHY KJ, 2013. Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage. Open biology. 3(12), 130181
• SHERIDAN GK and DEV KK, 2011. S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures. Glia. 60(3), 382-92
• MCKEE AG, LOSCHER JS, O'SULLIVAN NC, CHADDERTON N, PALFI A, BATTI L, SHERIDAN GK, O'SHEA S, MORAN M, MCCABE O, FERNÁNDEZ AB, PANGALOS MN, O'CONNOR JJ, REGAN CM, O'CONNOR WT, HUMPHRIES P, FARRAR GJ and MURPHY KJ, 2009. AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity. Journal of neurochemistry. 112(4), 991-1004
• O'SULLIVAN NC, MCGETTIGAN PA, SHERIDAN GK, PICKERING M, CONBOY L, O'CONNOR JJ, MOYNAGH PN, HIGGINS DG, REGAN CM and MURPHY KJ, 2007. Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning. Journal of neurochemistry. 101(4), 1085-98
• SHERIDAN GK, PICKERING M, TWOMEY C, MOYNAGH PN, O'CONNOR JJ and MURPHY KJ, 2007. NF-kappaB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations. Learning & memory (Cold Spring Harbor, N.Y.). 14(8), 525-32