Rebecca Trueman

Contact

• workRoom C10a Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work(0115 82) 30077
• Rebecca.Trueman@nottingham.ac.uk

Teaching Summary

I teach on the Neuroscience degree (BSc and MSci), and deliver sessions on the Medical degree. For a number of years, I led the large first-year module Fundamentals of Neuroscience. From Oct 2023, I… read more

Research Summary

I have a background in biological sciences, with a focus on neuroscience, and have been working on phenotyping rodent models of disease for over 20 years. My current focus is on models of myotonic… read more

Selected Publications

• 2016. Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: Tests for long-term assessment. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. (In Press.)
• STEVENTON JJ, TRUEMAN RC, MA D, YHNELL E, BAYRAM-WESTON Z, MODAT M, CARDOSO J, OURSELIN S, LYTHGOE M, STEWART A, ROSSER AE and JONES DK, 2016. Longitudinal in vivo MRI in a Huntington's disease mouse model: Global atrophy in the absence of white matter microstructural damage. Scientific reports. 6, 32423
• STEVENTON JJ, TRUEMAN RC, ROSSER AE and JONES DK, 2015. Robust MR-based approaches to quantifying white matter structure and structure/function alterations in Huntington's disease. Journal of neuroscience methods. 265, 2-12
• STEVENTON JJ, HARRISON DJ, TRUEMAN RC, ROSSER AE, JONES DK and BROOKS SP, 2015. In Vivo MRI Evidence that Neuropathology is Attenuated by Cognitive Enrichment in the Yac128 Huntington's Disease Mouse Model. Journal of Huntington's disease. 4(2), 149-60

• View all publications

I teach on the Neuroscience degree (BSc and MSci), and deliver sessions on the Medical degree. For a number of years, I led the large first-year module Fundamentals of Neuroscience. From Oct 2023, I will be running a new module on Experimental design and practical Neuroscience, aligning my research skills with my teaching interests, as well as a new 4th-year module on Current research in Neuroscience. I act as Deputy Degree Director for Neuroscience, and chair of the Learning Curriculum Forum for Neuroscience. I also Chair the inclusive curriculum working group for Life Sciences and have sat on the Faculty working group on the same subject. From this, we have developed the faculty inclusive curriculum toolkit.

Current Research

I have a background in biological sciences, with a focus on neuroscience, and have been working on phenotyping rodent models of disease for over 20 years. My current focus is on models of myotonic dystrophy, and I have a growing interest in CDK12 and CDK13 knock-out and mutation models. Over my career, I have worked with transgenic mouse models and surgical models of Huntington's disease, stroke and myotonic dystrophy. I have a keen interest in improving the standards of preclinical research, and as such set up and co-organised the inaugural UK Preclinical Stroke Symposium for 10 years. I am also a member of the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) working group on animal models of stroke which published the IMPROVE guidelines for rodent stroke studies. With my expertise in in vivo studies I have managed, as Co-investigator, the in vivo aspects of large collaborative grants from the MRC (DPFS, £2.4 million) and Wellcome Trust (Seeding drug discovery, £3 million), as well as managing PI grants.

• HALL, GERARD R., BOEHM-STURM, PHILIPP, DIRNAGL, ULRICH, FINKE, CARSTEN, FODDIS, MARCO, HARMS, CHRISTOPH, KOCH, STEFAN PAUL, KUCHLING, JOSEPH, MADAN, CHRISTOPHER R., MUELLER, SUSANNE, SASSI, CELESTE, SOTIROPOULOS, STAMATIOS N., TRUEMAN, REBECCA C., WALLIS, MARCUS D., YILDIRIM, FERAH and FARR, TRACY D., 2022. Long-Term Connectome Analysis Reveals Reshaping of Visual, Spatial Networks in a Model With Vascular Dementia Features STROKE. 53(5), 1735-1745
• ELVERS, KAREN T., LIPKA-LLOYD, MAGDALENA, TRUEMAN, REBECCA C., BAX, BENJAMIN D. and MEHELLOU, YOUCEF, 2022. Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains** CHEMBIOCHEM. 23(1),
• SORBY-ADAMS, ANNABEL J., LEAROYD, ANNASTAZIA E., BATH, PHILIP M., BURROWS, FIONA, FARR, TRACY D., LEONARD, ANNA, V, SCHIESSL, INGO, ALLAN, STUART M., TURNER, RENEE J. and TRUEMAN, REBECCA C., 2021. Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 41(12), 3248-3259
• WALLIS, MARCUS D. and TRUEMAN, REBECCA C., 2021. Immunohistochemical Detection of Modified Cytosine Bases in Rodent Brain DNA MODIFICATIONS. 2198, 183-191
• MCFALL, AISLING, HIETAMIES, TUULI M., BERNARD, ASHTON, AIMABLE, MARGAUX, ALLAN, STUART M., BATH, PHILIP M., BREZZO, GAIA, CARARE, ROXANA O., CARSWELL, HILARY, V, CLARKSON, ANDREW N., CURRIE, GILLIAN, FARR, TRACY D., FOWLER, JILL H., GOOD, MARK, HAINSWORTH, ATTICUS H., HALL, CATHERINE, HORSBURGH, KAREN, KALARIA, RAJESH, KEHOE, PATRICK, LAWRENCE, CATHERINE, MACLEOD, MALCOLM, MCCOLL, BARRY W., MCNEILLY, ALISON, MILLER, ALYSON A., MINERS, SCOTT, MOK, VINCENT, O'SULLIVAN, MICHAEL, PLATT, BETTINA, SENA, EMILY S., SHARP, MATTHEW, STRANGEWARD, PATRICK, SZYMKOWIAK, STEFAN, TOUYZ, RHIAN M., TRUEMAN, REBECCA C., WHITE, CLAIRE, MCCABE, CHRIS, WORK, LORRAINE M. and QUINN, TERENCE J., 2020. UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM.
• KETLEY, AMI, WOJCIECHOWSKA, MARZENA, GHIDELLI-DISSE, SONJA, BAMBOROUGH, PAUL, GHOSH, TUSHAR K., MORATO, MARTA LOPEZ, SEDEHIZADEH, SAAM, MALIK, NAVEED ALTAF, TANG, ZHENZHI, POWALOWSKA, PAULINA, TANNER, MATTHEW, BILLETER-CLARK, RUDOLF, TRUEMAN, REBECCA C., GEISZLER, PHILIPPINE C., AGOSTINI, ALESSANDRA, OTHMAN, OTHMAN, BOSCHE, MARKUS, BANTSCHEFF, MARCUS, RUDIGER, MARTIN, MOSSAKOWSKA, DANUTA E., DREWRY, DAVID H., ZUERCHER, WILLIAM J., THORNTON, CHARLES A., DREWES, GERARD, UINGS, IAIN, HAYES, CHRISTOPHER J. and BROOK, J. DAVID, 2020. CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model SCIENCE TRANSLATIONAL MEDICINE. 12(541),
• SIMANAVICIUTE, UGNE, AHMED, JEWEL, BROWN, RICHARD E., CONNOR-ROBSON, NATALIE, FARR, TRACY D., FERTAN, EMRE, GAMBLES, NIKKI, GARLAND, HUW, MORTON, A. JENNIFER, STAIGER, JOCHEN F., SKILLINGS, ELIZABETH A., TRUEMAN, REBECCA C., WADE-MARTINS, RICHARD, WOOD, NIGEL I., WONG, AIMEE A. and GRANT, ROBYN A., 2020. Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits JOURNAL OF NEUROSCIENCE METHODS. 331,
• HORSBURGH K, WARDLAW JM, VAN AGTMAEL T, ALLAN SM, ASHFORD MLJ, BATH PM, BROWN R, BERWICK J, CADER MZ, CARARE RO, DAVIS JB, DUNCOMBE J, FARR TD, FOWLER JH, GOENSE J, GRANATA A, HALL CN, HAINSWORTH AH, HARVEY A, HAWKES CA, JOUTEL A, KALARIA RN, KEHOE PG, LAWRENCE CB, LOCKHART A, LOVE S, MACLEOD MR, MACRAE IM, MARKUS HS, MCCABE C, MCCOLL BW, MEAKIN PJ, MILLER A, NEDERGAARD M, O'SULLIVAN M, QUINN TJ, RAJANI R, SAKSIDA LM, SMITH C, SMITH KJ, TOUYZ RM, TRUEMAN RC, WANG T, WILLIAMS A, WILLIAMS SCR and WORK LM, 2018. Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical science (London, England : 1979). 132(8), 851-868
• AHMED J, DWYER DM, FARR TD, HARRISON DJ, DUNNETT SB and TRUEMAN RC, 2017. Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke. Journal of cerebral blood flow and metabolism. 37(3), 755-761
• BOEHM-STURM P, FÜCHTEMEIER M, FODDIS M, MUELLER S, TRUEMAN RC, ZILLE M, RINNENTHAL JL, KYPRAIOS T, SHAW L, DIRNAGL U and FARR TD, 2017. Neuroimaging Biomarkers Predict Brain Structural Connectivity Change in a Mouse Model of Vascular Cognitive Impairment. Stroke. 48(2), 468-475
• PERCIE DU SERT N, ALFIERI A, ALLAN SM, CARSWELL HV, DEUCHAR GA, FARR TD, FLECKNELL P, GALLAGHER L, GIBSON CL, HALEY MJ, MACLEOD MR, MCCOLL BW, MCCABE C, MORANCHO A, MOON LD, O'NEILL MJ, PÉREZ DE PUIG I, PLANAS A, RAGAN CI, ROSELL A, ROY LA, RYDER KO, SIMATS A, SENA ES, SUTHERLAND BA, TRICKLEBANK MD, TRUEMAN RC, WHITFIELD L, WONG R and MACRAE IM, 2017. The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments). Journal of cerebral blood flow and metabolism. 37(11), 3488-3517
• LEAROYD AE, WOODHOUSE L, SHAW L, SPRIGG N, BERECZKI D, BERGE E, CASO V, CHRISTENSEN H, COLLINS R, CZLONKOWSKA A, EL ETRIBI A, FARR TD, GOMMANS J, LASKA AC, NTAIOS G, OZTURK S, POCOCK SJ, PRASAD K, WARDLAW JM, FONE KC, BATH PM, TRUEMAN RC and , 2017. Infections Up to 76 Days After Stroke Increase Disability and Death. Translational stroke research. 8(6), 541-548
• BALKAYA MG, TRUEMAN RC, BOLTZE J, CORBETT D and JOLKKONEN J, 2017. Behavioral outcome measures to improve experimental stroke research. Behavioural brain research. (In Press.)
• TRUEMAN, REBECCA C., DIAZ, CLARIS, FARR, TRACY D., HARRISON, DAVID J., FULLER, ANNA, TOKARCZUK, PAWEL F., STEWART, ANDREW J., PAISEY, STEPHEN J. and DUNNETT, STEPHEN B., 2017. Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: Tests for long-term assessment JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 37(4), 1349-1361
• STEVENTON JJ, TRUEMAN RC, MA D, YHNELL E, BAYRAM-WESTON Z, MODAT M, CARDOSO J, OURSELIN S, LYTHGOE M, STEWART A, ROSSER AE and JONES DK, 2016. Longitudinal in vivo MRI in a Huntington's disease mouse model: Global atrophy in the absence of white matter microstructural damage. Scientific reports. 6, 32423
• TURYANSKA, LYUDMILA, MORO, FABRIZIO, PATANE, AMALIA, BARR, JAMES, KOCKENBERGER, WALTER, TAYLOR, ALEXANDER, FAAS, HENRYK M., FOWLER, MAXINE, WIGMORE, PETER, TRUEMAN, REBECCA C., WILLIAMS, HUW E. L. and THOMAS, NEIL R., 2016. Developing Mn-doped lead sulfide quantum dots for MRI labels J. Mater. Chem. B. 4, 6797-6802
• MANISKAS ME, ROBERTS JM, TRUEMAN R, LEAROYD AE, GORMAN A, FRASER JF and BIX GJ, 2016. Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke. Journal of neurointerventional surgery. (In Press.)
• STEVENTON, JESSICA J., TRUEMAN, REBECCA C., ROSSER, ANNE E. and JONES, DEREK K., 2016. Robust MR-based approaches to quantifying white matter structure and structure/function alterations in Huntington's disease JOURNAL OF NEUROSCIENCE METHODS. 265, 2-12
• STEVENTON JJ, HARRISON DJ, TRUEMAN RC, ROSSER AE, JONES DK and BROOKS SP, 2015. In Vivo MRI Evidence that Neuropathology is Attenuated by Cognitive Enrichment in the Yac128 Huntington's Disease Mouse Model. Journal of Huntington's disease. 4(2), 149-60
• TRUEMAN RC, DUNNETT SB, JONES L and BROOKS SP, 2012. Five choice serial reaction time performance in the HdhQ92 mouse model of Huntington's disease. Brain research bulletin. 88(2-3), 163-70
• TRUEMAN RC, DUNNETT SB and BROOKS SP, 2012. Operant-based instrumental learning for analysis of genetically modified models of Huntington's disease. Brain research bulletin. 88(2-3), 261-75
• TRUEMAN, R.C., JONES, L., DUNNETT, S.B. and BROOKS, S.P., 2012. Early onset deficits on the delayed alternation task in the Hdh(Q92) knock-in mouse model of Huntington's disease Brain Research Bulletin. 88(2-3), 156-162
• TRUEMAN RC, KLEIN A, LINDGREN HS, LELOS MJ and DUNNETT SB, 2012. Repair of the CNS Using Endogenous and Transplanted Neural Stem Cells. Current topics in behavioral neurosciences. (In Press.)
• BROOKS SP, TRUEMAN RC and DUNNETT SB, 2012. Assessment of Motor Coordination and Balance in Mice Using the Rotarod, Elevated Bridge, and Footprint Tests. Current protocols in mouse biology. 2(1), 37-53
• FARR, T D and TRUEMAN, R. C., 2011. Functional Assessment of Subcortical Ischemia. In: LANE, E.L. and DUNNETT, S.B., eds., Animal Models of Movement Disorders 1. 62. Humana Press. 91-114
• TRUEMAN RC, HARRISON DJ, DWYER DM, DUNNETT SB, HOEHN M and FARR TD, 2011. A Critical Re-Examination of the Intraluminal Filament MCAO Model: Impact of External Carotid Artery Transection. Translational stroke research. 2(4), 651-61
• MADETE, JK, KLEIN, A, FULLER, A, TRUEMAN, RC, ROSSER, AE, DUNNETT, SB and HOLT, CA, 2010. Challenges Facing Quantification Of Rat Locomotion Along Beams Of Varying Widths Proceedings Of The Institution Of Mechanical Engineers Part H-Journal Of Engineering In Medicine. 224(H11), 1257-1265
• DOEBROESSY, MATE D., BROOKS, SIMON, TRUEMAN, REBECCA, BRASTED, PETER J. and DUNNETT, STEPHEN B., 2009. Operant Analysis of Fronto-striatal Function in Rodents METHODS OF BEHAVIOR ANALYSIS IN NEUROSCIENCE, SECOND EDITION. 215-246
• TRUEMAN RC, BROOKS SP, JONES L and DUNNETT SB, 2009. Rule learning, visuospatial function and motor performance in the Hdh(Q92) knock-in mouse model of Huntington's disease. Behavioural brain research. 203(2), 215-22
• TRUEMAN RC, BROOKS SP, JONES L and DUNNETT SB, 2008. Time course of choice reaction time deficits in the Hdh(Q92) knock-in mouse model of Huntington's disease in the operant serial implicit learning task (SILT). Behavioural brain research. 189(2), 317-24
• TRUEMAN, RC, BROOKS, SP, JONES, L and DUNNETT, SB, 2007. The Operant Serial Implicit Learning Task Reveals Early Onset Motor Learning Deficits In The Hdh(Q92) Knock-In Mouse Model Of Huntington's Disease European Journal Of Neuroscience. 25(2), 551-558
• BROOKS SP, TRUEMAN RC and DUNNETT SB, 2007. Striatal Lesions In The Mouse Disrupt Acquisition And Retention, But Not Implicit Learning, In The Silt Procedural Motor Learning Task. Brain Research. 1185, 179-88
• BROOKS SP, BETTERIDGE H, TRUEMAN RC, JONES L and DUNNETT SB, 2006. Selective Extra-Dimensional Set Shifting Deficit In A Knock-In Mouse Model Of Huntington's Disease. Brain Research Bulletin. 69(4), 452-7
• TRUEMAN, RC, BROOKS, SP and DUNNETT, SB, 2005. Implicit Learning In A Serial Choice Visual Discrimination Task In The Operant 9-Hole Box By Intact And Striatal Lesioned Mice Behavioural Brain Research. 159(2), 313-322