Yana Vinogradova

Contact

• workRoom 1402 Tower Building
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 846 6939
• yana.vinogradova@nottingham.ac.uk

Biography

Yana Vinogradova completed a Diploma in Applied Mathematics [MSc equivalent] at Moscow State University (MGU) and joined the Cardiology Research Centre at the Russian Academy of Medical Sciences in Moscow as a Research Fellow. After moving to the UK, she worked in the Division of Cardiology at the University of Leicester, and in the Centre for Health Service Studies (CHESS) and the Division of Health in the Community at the University of Warwick. She joined the University of Nottingham as an expert in medical statistics in 2005. Working as a Research Fellow in the Division of Primary Care of the School of Medicine, she was awarded a PhD in Medicine by published works in 2017.

Expertise Summary

Medical statistics

Epidemiology of diseases

Drug safety studies

Large primary and secondary care databases

Teaching Summary

Yana has taught short courses on how to use statistical software in Epidemiology for Masters and PhD students.

Research Summary

Yana's research primarily involves the use of mathematical models and statistical methods to improve understanding of the dynamics and incidence of diseases, and of treatment outcomes. Her work at… read more

Selected Publications

• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2020. Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases British Medical Journal. 371, m3873
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2019. Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases British Medical Journal. 364, k4810
• VINOGRADOVA, Y., COUPLAND, C., HILL, T. and HIPPISLEY-COX, J., 2018. Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care. British Medical Journal. 362, k2505
• VINOGRADOVA, Y., COUPLAND, C., BRINDLE, P. and HIPPISLEY-COX, J., 2016. Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database. British Medical Journal. 353, i3305

• View all publications

• Statistical adviser to students and staff

Current Research

Yana's research primarily involves the use of mathematical models and statistical methods to improve understanding of the dynamics and incidence of diseases, and of treatment outcomes. Her work at Nottingham has largely been in the area of drug safety, focusing in particular on two aspects. The first is adherence to prescribed medications, because failure to use medicines like statins as prescribed may compromise their effectiveness. Identifying patient characteristics associated with various patterns of non-adherence is the aim of such studies. The second is identifying those drugs where prolonged exposure may be associated with increased risks of development of a serious or life-threatening condition or with generally increased mortality. Such observational studies, based on data gathered over long periods in real treatment environments, aim to clarify 'real world' outcomes among the general population, to identify slowly-developing problems such as cancers, which do not manifest themselves in the short term, and to highlight the relative safety or otherwise of different drugs - and, where possible, of different formulations of a particular drug type.

Yana is currently working on drug safety issues associated with hormone replacement therapy (HRT), used to overcome problems associated with menopause. A paper on the associations between venous thromboembolism risk and exposure to specific HRT treatments has been published and a companion study on the risks of breast cancer associated with HRT treatments is in progress.

Past Research

Yana facilitated a variety of studies as a research statistician. These included observational and trial studies in Moscow Cardiological Research Centre and Warwick University. Since joining Nottingham University, she has also worked on risk prediction modelling (QRisk) and observational studies run by the Injury Prevention group.

Future Research

Yana has developed special skills in the handling of very large data sets and has pioneered the use of multiple databases (specifically QResearch and CPRD) to facilitate more detailed research into drug types and formulations and improve the accuracy of risk estimates. Her aim is to build on what has been achieved at Nottingham to continue to deliver independently-researched drug safety information of use to patients, doctors and regulators. She also hopes to develop national and international links with researchers having similar interests. Yana also has many years of experience of medical statistics and epidemiology in many different environments and a wide interest in clinical and medical developments, so will always be seeking other areas where she might usefully contribute.

• IYEN, B., VINOGRADOVA, Y., AKYEA, R. K., WENG, S., QURESHI, N. and KAI, J., 2022. Ethnic disparities in mortality among overweight or obese adults with newly diagnosed type 2 diabetes: a population-based cohort study Journal of Endocrinological Investigation. Published Online: 13 January 2022,
• AKYEA, R.K., VINOGRADOVA, Y., QURESHI, N., PATEL, R.S., KONTOPANTELIS, E., NTAIOS, G., ASSELBERGS, F.W., KAI, J. and WENG, S.F., 2021. Sex, age, and socioeconomic differences in non-fatal stroke incidence and subsequent major adverse outcomes. Stroke. 52(2), 396–405
• VINOGRADOVA, Y., DENING, T., HIPPISLEY-COX, J., TAYLOR, L., MOORE, M. and COUPLAND, C., 2021. Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series. 38(26 February 2021),
• IYEN, B., WENG, S., VINOGRADOVA, Y., AKYEA, R.K., QURESHI, N. and KAI, J., 2021. Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK BMC Public Health. 21(1), 576
• VINOGRADOVA, Y., DENING, T., HIPPISLEY-COX, J., TAYLOR, L., MOORE, M. and COUPLAND, C., 2021. Use of menopausal hormone therapy and risk of dementia: nested case-control studies using QResearch and CPRD databases British Medical Journal. 374, n2182
• PERSSON, M.S.M., HARMAN, K.E., VINOGRADOVA, Y., LANGAN, S.M., HIPPISLEY-COX, J., THOMAS, K.S. and GRAN, S., 2020. Incidence, prevalence and mortality of bullous pemphigoid in England 1998–2017: a population-based cohort study British Journal of Dermatology. Published Online First: 9 March 2020,
• PERSSON, M.S.M., HARMAN, K.E., VINOGRADOVA, Y., LANGAN, S.M., HIPPISLEY-COX, J., THOMAS, K.S. and GRAN, S., 2020. Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England BMJ Open. 10(7), e035934
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2020. Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases British Medical Journal. 371, m3873
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2019. Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases British Medical Journal. 364, k4810
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2018. Risk of bleeding with direct oral anticoagulants versus warfarin: cohort studies using primary care datasets. British Journal of General Practice. 68(supplement 1), bjgp18X696629
• VINOGRADOVA, Y., COUPLAND, C., HILL, T. and HIPPISLEY-COX, J., 2018. Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care. British Medical Journal. 362, k2505
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2018. Re: Use of combined oral contraceptives and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases British Medical Journal. 350, h2135
• LITTLE, I., VINOGRADOVA, Y., ORTON, E., KAI, J. and QURESHI, N., 2017. Venous thromboembolism in adults screened for sickle cell trait: a population-based cohort study with nested case–control analysis BMJ Open. 7(3), e012665
• VINOGRADOVA, Y., COUPLAND, C., BRINDLE, P. and HIPPISLEY-COX, J., 2016. Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database. British Medical Journal. 353, i3305
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2015. Use of combined oral contraceptives and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases British Medical Journal. 350, h2135
• VINOGRADOVA, Y., COUPLAND, C., BRINDLE, P. and HIPPISLEY-COX, J., 2015. Patients who discontinued statin treatment: a protocol for cohort study using primary care data BMJ Open. 5(10), e008701
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2015. Authors’ reply to Zagarella British Medical Journal. 350, h3308
• COUPLAND, C., HILL, T., BRINDLE, P., VINOGRADOVA, Y. and HIPPISLEY-COX, J., 2015. Thiazolidinedione drugs and the risk of cancer in patients with diabetes: nested case-control studies using a primary care database In: Proceedings of the 44th annual scientific meeting, Society for Academic Primary Care, Oxford University, 8-10 July 2015.
• VINOGRADOVA, Y., LEWIS, N. and HAWKEY, C., 2015. Trends in the use of non-steroidal anti-inflammatory drugs and aspirin and the use of proton pump inhibitors for gastro-duodenal protection in the UK: a cross-sectional study using the CPRD database. (Poster Presentation, Abstract number: 0123) In: Proceedings of 44nd Annual Scientific Meeting of the Society for Academic Primary Care, 8-10 July 2015.
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2014. Exposure to combined oral contraceptives and risk of venous thromboembolism: a protocol for nested case–control studies using the QResearch and the CPRD databases BMJ Open. 4(4), e004499
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2013. Exposure to bisphosphonates and risk of gastrointestinal cancers: series of nested case-control studies with QResearch and CPRD data British Medical Journal. 346(7894), f114
• LYONS, R.A., KENDRICK, D., TOWNER, E.M. L., COUPLAND, C., HAYES, M., CHRISTIE, N., SLENEY, J., JONES, S. J., KIMBERLEE, R., RODGERS, S.E., TURNER, S., BRUSSONI, M., VINOGRADOVA, Y., SARVOTHAM, T. and MACEY, S., 2013. The Advocacy for Pedestrian Safety Study: Cluster Randomised Trial Evaluating a Political Advocacy Approach to Reduce Pedestrian Injuries in Deprived Communities PLoS ONE. 8(4), e60158
• KENDRICK, D., VINOGRADOVA, Y., COUPLAND, C., MULVANEY, C.A, CHRISTIE, N., LYONS, R.A. and TOWNER, E.L., 2013. Recovery from injury: the UK Burden of Injury Multicentre Longitudinal Study Injury Prevention. 19, 370-381
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2013. Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case-control studies using two primary-care databases British Journal of Cancer. 109(3), 795-806
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2013. Bisphosphonates and gastrointestinal cancers: Authors’ reply to Abrahamsen and colleagues BMJ. 346, f1518
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2013. Exposure to bisphosphonates and risk of common non-gastrointestibnal cancers: series of nested case-control studies using QResearch and CPRD data. Primary Health Care Research and Development. 14(Supplement 1), 19
• VINOGRADOVA Y, COUPLAND C and HIPPISLEY-COX J, 2012. Exposure To Bisphosphonates And Risk Of Cancer: A Protocol For Nested Case-Control Studies Using The Qresearch Primary Care Database. BMJ Open. 2(1), e000548
• KENDRICK, D., VINOGRADOVA, Y., COUPLAND, C., CHRISTIE, N., LYONS, R.A., TOWNER, E.L. and ON BEHALF OF THE UK BURDEN OF INJURIES STUDY GROUP,, 2012. Making a successful return to work: the UK burden of injury multicentre longitudinal study: British Journal of General Practice British Journal of General Practice. 62, 76-77
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2012. Exposure to bisphosphonates and risk of gastrointestinal cancers: series of nested case-control studies using QResearch data. Primary Health Care Research and Development. 13(Supplement 1), 47
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2011. Exposure to Cyclo-oxygenase-2 Inhibitors and risk of Cancer: nested case-control studies Journal of Epidemiology and Community Health. 65(Supplement 1), A44-A45
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2011. Risk of pneumonia in patients taking statins: population-based nested case control study British Journal of General Practice. 61(592), e742-e748
• KULIKOV, Y.I., VINOGRADOVA, Y., MILES, A.W. and GIDDINS, G., 2011. Optimal configuration of the spiral linking technique for tendon repair. Journal of Hand Surgery (European Volume). 36(3), 210-214
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2011. Exposure to statins and risk of common cancers: a series of nested case-control studies BMC Cancer. 11(September), 409
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2011. Exposure to cyclooxygenase-2 inhibitors and risk of cancer: nested case–control studies British Journal of Cancer. 105(3), 452-459
• BECK, C.R., MCKENZIE, B.C., HASHIM, A.B., HARRIS, R.C., ZANUZDANA, A., AGBOADO, G., ORTON, E., BÉCHARD-EVANS, L., MORGAN, G., STEVENSON, C., WESTON, R., MUKAIGAWARA, M., ENSTONE, J., AUGUSTINE, G., BUTT, M., KIM, S., PULESTON, R., DABKE, G., HOWARD, R., O'BOYLE, J., O'BRIEN, M., AHYOW, L., DENNESS, H., FARMER, S., FIGUREROA, J., FISHER, P., GREAVES, F., HAROON M, HAROON, S., HIRD, C., ISBA, R., ISHOLA, D.A., KERAC, M., PARISH, V., ROBERTS, J., ROSSER, J., THEAKER, S., WALLACE, D., WIGGLESWORTH, N., LINGARD, L., VINOGRADOVA, Y., HORIUCHI, H., PENALVER, J. and NGUYEN-VAN-TAM, J.S., 2011. Influenza vaccination for immunocompromised patients: systematic review and meta-analysis from a public health policy perspective PLoS One. 6(12), e29249
• AVERY, A.J., RODGERS, S., CANTRILL, J., ARMSTRONG, S., BOYD, M., CRESSWELL, K., EDEN, M., ELLIOTT, R., FRANKLIN, M., HIPPISLEY-COX, J., HOWARD, R., KENDRICK, D., MORRIS, C.J., MURRAY, S.A., PRESCOTT, R.J., PUTMAN, K., SWANWICK, G., TUERSLEY, L., TURNER, T., VINOGRADOVA, Y. and SHEIKH, A., 2010. The PINCER trial: A cluster randomised trail comparing the effectiveness of a Pharmacist led IT intervention with simple feedback in reducing rates of clinically important errors in medicines management in general practices (PS024). A Report to the Department of Health Patient Safety Research Portfolio. February 2010
• VINOGRADOVA, Y., COUPLAND, C., HIPPISLEY-COX, J., WHYTE, S. and PENNY, C., 2010. Effects of severe mental illness on survival of people with diabetes British Journal of Psychiatry. 197(4), 272-277
• VINOGRADOVA, Y., LEIGHTON, M., HIPPISLEY-COX, J. and HAWKEY, C.J., 2010. Continuing Undue Risks in UK Prescribing of Non-Steroidal Anti-Inflammatory Drugs In: Proceedings of Digestive Disease Week, 1-5 May 2010; New Orleans.
• VINOGRADOVA, Y., HIPPISLEY-COX, J., AVERY, A., KENDRICK, D., RODGERS, S., ARMSTRONG, S. and EDEN, M., 2010. QResearch evaluation of PINCER Trial: Analysis of secular trends in outcome measures. Primary Health Care Research & Development. 11(Supplement 1), S44
• LEIGHTON, M., VINOGRAVADA, Y., SHONDE, A., ATHERTON, J.C., LOGAN, R.F.A., AVERY, A., KENDRICK, D., HIPPISLEY-COX, J. and HAWKEY, C.J., 2009. Diagnostic Precision of Primary Care Electronic Database for Study of Gastrointestinal Bleeding and Its Ability to Detect the Influence of Aspirin Gut. 58(Supplement 1), A139-A139
• VINOGRAVADA, Y., LEIGHTON, M., AVERY, A., LOGAN, R.F.A., KENDRICK, D., ATHERTON, J.C., HIPPISLEY-COX, A.S.J. and HAWKEY, C.J., 2009. Increased Aspirin Use and Upper Gastrointestinal Bleeding Rates in Socially Deprived Patients Gut. 58(Supplement 1), A36-A36
• VINOGRADOVA, Y., LEIGHTON, M., AVERY, A., LOGAN, R.F., KENDRICK, D., ATHERTON, J.C., SHONDE, A., HIPPISLEY-COX, J, and HAWKEY, C.J., 2009. 408 Increased Aspirin Use and Upper Gastrointestinal Bleeding Rates in Socially Deprived Patients Gastroenterology. 136(5, Supplement 1), A-69
• LEIGHTON, M., VINOGRADOVA, Y., SHONDE, A., ATHERTON, J.C., LOGAN, R.F., AVERY, A., KENDRICK, D., HIPPISLEY-COX, J. and HAWKEY, C.J., 2009. T1973 Diagnostic Precision of Primary Care Electronic Database for Study of Gastrointestinal Bleeding and Its Ability to Detect the Influence of Aspirin Gastroenterology. 136(5, Supplement 1), A-612
• VINOGRADOVA, Y., HIPPISLEY-COX, J. and COUPLAND, C., 2009. Identification of new risk factors for pneumonia: population-based case-control study British Journal of General Practice. 59(567), e329-e338
• HIPPISLEY-COX, J. and VINOGRADOVA, Y., 2009. Trends in consultation rates in General Practice 1995/1996 to 2008/2009: Analysis of the QResearch® database. Final Report to the NHS Information Centre and Department of Health Published by The NHS Information Centre for Health and Social Care, part of the Government Statistical Service, September 2009.
• HIPPISLEY-COX, J., COUPLAND, C., VINOGRADOVA, Y., ROBSON, J., MINHAS, R., SHEIKH, A. and BRINDLE, P., 2008. Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2 BMJ. 336(7659), 1475
• VINOGRADOVA, Y. and HIPPISLEY-COX, J., 2008. Patients at high risk of pneumonia: population case-control study (Oral Presentation, Abstract number: 1073) In: Proceedings of the Society for Academic Primary Care’s Annual Scientific Meeting, National University of Ireland, Galway, 9-11 July 2008.
• HIPPISLEY-COX, J., COUPLAND, C., VINOGRADOVA, Y., ROBSON, J. and BRINDLE, P., 2008. Performance of the QRISK cardiovascular risk prediction algorithm in an independent UK sample of patients from general practice: a validation study Heart. 94(1), 34-39
• HIPPISLEY-COX, J., COUPLAND, C., VINOGRADOVA, Y., ROBSON, J., MAY, M. and BRINDLE, P., 2007. Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study BMJ : British Medical Journal. 335(7611), 136-141
• VINOGRADOVA, Y., HIPPISLEY-COX, J., COUPLAND, C. and LOGAN, R.F., 2007. Risk of colorectal cancer in patients prescribed statins, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 inhibitors: nested case-control study Gastroenterology. 133(2), 393-402
• COUPLAND, CAROL, HARCOURT, SALLY, VINOGRADOVA, YANA, SMITH, GILLIAN, JOSEPH, CAROL, PRINGLE, MIKE and HIPPISLEY-COX, JULIA, 2007. Inequalities in uptake of influenza vaccine by deprivation and risk group: Time trends analysis. Vaccine. 25(42), 7363-71
• HIPPISLEY-COX , J., PARKER,C,, COUPLAND, C. and VINOGRADOVA, Y., 2007. Inequalities in the primary care of coronary heart disease patients with serious mental health problems: cross-sectional study Heart. 93, 1256-1262
• HIPPISLEY-COX, J., VINOGRADOVA, Y., COUPLAND, C. and PARKER, C., 2007. Risk of malignancy in patients with Schizophrenia or Bipolar Disorder Archives of General Psychiatry. 64(12), 1368-1376
• PARKER, C., HIPPISLEY-COX, J., COUPLAND, C. and VINOGRADOVA, Y., 2007. Rectal and postmenopausal bleeding: consultation and referral of patients with and without severe mental health problems British Journal of General Practice. 57(538), 371-376
• COUPLAND, C.A.C., HARCOURT, S., VINOGRADOVA, Y., SMITH, G., JOSEPH, C., PRINGLE. M. and HIPPISLEY-COX, J., 2007. Inequalities in uptake of influenza vaccine by deprivation and risk group: time trends analysis. Journal of Epidemiology & Community Health. 61(Supplement 1), A40
• HIPPISLEY-COX, J., VINOGRADOVA, Y., COUPLAND, C. and HEAPS, M., 2007. Time Series Analysis for 2001-2006 for Selected Clinical Indicators from the Quality and Outcomes Framework. QRESEARCH research highlights. Leeds: The Information Centre The Information Centre.
• TIRUVOIPATI, R., VINOGRADOVA, Y., FAULKNER, G., SOSNOWSKI, A.W., FIRMIN, R.K. and PEEK, G.J., 2007. Predictors of outcome in patients with congenital diaphragmatic hernia requiring extracorporeal membrane oxygenation. Journal of Pediatric Surgery. 42(8), 1345-50
• HIPPISLEY-COX, J., PARKER, C., VINOGRADOVA, Y. and COUPLAND, C., 2006. Health outcomes for patients with serious mental health problems: second report to the Disability Rights Commission; February 2006 Nottingham: University of Nottingham.
• VINOGRADOVA, Y., HIPPISLEY-COX, J., COUPLAND, C. and PARKER, C., 2006. Risk of malignancy in patients with mental health problems (Parallel 037) In: Proceedings of the Society for Academic Primary Care, 35th Annual Scientific Meeting; The contribution of research and education to patient- centred primary care.
• GRIMSHAW, G., STANTON, A., BLACKBURN, C., ANDREWS, K., GRIMSHAW, C., VINOGRADOVA, Y. and ROBERTSON, W., 2006. Patterns of smoking, quit attempts and services for a cohort of 15- to 19-year-olds Child Care Health and Development. 29(6), 457-464
• HIPPISLEY-COX, J., VINOGRADOVA, Y., COUPLAND, C. and PARKER, C., 2006. Risk of cancer in patients with mental health problems In: 35th NAPCRG Annual Meeting.
• SZCZEPURA, A, WESTMORELAND, D, VINOGRADOVA, Y, FOX, J and CLARK, M, 2006. Evaluation of molecular techniques in prediction and diagnosis of cytomegalovirus disease in immunocompromised patients. Health Technology Assessment. 10(10), 1-176
• TIRUVOIPATI,R., BALASUBRAMANIAN,S., VINOGRADOVA,Y., FAULKNER,G., SOSNOWSKI,A., FIRMIN,R. and PEEK,G., 2006. Outcome of patients with congenital diaphragmatic hernia requiring ECMO: can we predict? Critical Care. 10(Supplement 1), P27
• HIPPISLEY-COX,J., VINOGRADOVA,Y., COUPLAND,C. and PRINGLE,M., 2005. Comparison of key practice characteristics between general practices in England and Wales and general practices in the QRESEARCH data: report to the NHS Information Centre, November 2005 Nottingham: University of Nottingham.