Stam Sotiropoulos

Contact

• workRoom A39j Precision Imaging Beacon & Sir Peter Mansfield Imaging Centre
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 8231027
• fax0115 8231180
• Stamatios.Sotiropoulos@nottingham.ac.uk

Expertise Summary

Pubmed Search | Google Scholar Profile | ORCID ID | CoNI Lab

I am an Associate Professor in the Sir Peter Mansfield Imaging Centre, School of Medicine and I also hold an honorary affiliation with the University of Oxford (Centre for Functional MRI of the Brain).

I am the Head of the Computational Neuroimaging Group at the University of Nottingham. I develop computational methods for exploring brain organisation using Magnetic Resonance Imaging. Specifically, I am interested in brain connectivity and brain tissue microstrucure in health and disease. My research focuses on the biophysical modelling and inference of brain connections at different scales mostly using diffusion MRI, but I am also particularly interested in data fusion approaches for combining strengths and bridging the gaps across modalities.

The methodology we develop is made publicly available through FSL, the most widely-used software package for brain image analysis.

I also review for the top journals in the field and I am a member of the Editorial Board of NeuroImage and of Brain Multiphysics. More details on Publons.

Research Summary

Research Interests: Neuroimaging, Brain connectivity/Connectome estimation, Diffusion MRI analysis, Functional MRI analysis, Brain microstructure & Biophysical modeling, Bayesian inference,… read more

Recent Publications

• HUTTER, JANA, TOURNIER, J DONALD, PRICE, ANTHONY N, CORDERO-GRANDE, LUCILIO, HUGHES, EMER J, MALIK, SHAIHAN, STEINWEG, JOHANNES, BASTIANI, MATTEO, SOTIROPOULOS, STAMATIOS N, JBABDI, SAAD, ANDERSSON, JESPER, EDWARDS, A DAVID and HAJNAL, JOSEPH V, 2018. Time-efficient and flexible design of optimized multishell HARDI diffusion. Magnetic resonance in medicine. 79(3), 1276-1292
• ALFARO-ALMAGRO, FIDEL, JENKINSON, MARK, BANGERTER, NEAL K., ANDERSSON, JESPER L. R., GRIFFANTI, LUDOVICA, DOUAUD, GWENAELLE, SOTIROPOULOS, STAMATIOS N., JBABDI, SAAD, HERNANDEZ-FERNANDEZ, MOISES, VALLEE, EMMANUEL, VIDAURRE, DIEGO, WEBSTER, MATTHEW, MCCARTHY, PAUL, RORDEN, CHRISTOPHER, DADUCCI, ALESSANDRO, ALEXANDER, DANIEL C., ZHANG, HUI, DRAGONU, IULIUS, MATTHEWS, PAUL M., MILLER, KARLA L. and SMITH, STEPHEN M., 2018. Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank NEUROIMAGE. 166, 400-424
• MARS, ROGIER B, SOTIROPOULOS, STAMATIOS N, PASSINGHAM, RICHARD E, SALLET, JEROME, VERHAGEN, LENNART M, KHRAPITCHEV, ALEXANDRE A, SIBSON, NICOLA and JBABDI, SAAD, 2018. Whole brain comparative anatomy using connectivity blueprints. eLife. 7,
• COTTAAR, MICHIEL, BASTIANI, MATTEO, CHEN, CHARLES, DIKRANIAN, KRIKOR, VAN ESSEN, DAVID, BEHRENS, TIMOTHY E, SOTIROPOULOS, STAMATIOS N and JBABDI, SAAD, 2018. A gyral coordinate system predictive of fibre orientations. NeuroImage. 176, 417-430

• View all publications

Current Research

Research Interests: Neuroimaging, Brain connectivity/Connectome estimation, Diffusion MRI analysis, Functional MRI analysis, Brain microstructure & Biophysical modeling, Bayesian inference, Machine learning, Numerical Methods, Image processing & analysis.

See my lab's website for further details: CoNI Lab

• HUTTER, JANA, TOURNIER, J DONALD, PRICE, ANTHONY N, CORDERO-GRANDE, LUCILIO, HUGHES, EMER J, MALIK, SHAIHAN, STEINWEG, JOHANNES, BASTIANI, MATTEO, SOTIROPOULOS, STAMATIOS N, JBABDI, SAAD, ANDERSSON, JESPER, EDWARDS, A DAVID and HAJNAL, JOSEPH V, 2018. Time-efficient and flexible design of optimized multishell HARDI diffusion. Magnetic resonance in medicine. 79(3), 1276-1292
• ALFARO-ALMAGRO, FIDEL, JENKINSON, MARK, BANGERTER, NEAL K., ANDERSSON, JESPER L. R., GRIFFANTI, LUDOVICA, DOUAUD, GWENAELLE, SOTIROPOULOS, STAMATIOS N., JBABDI, SAAD, HERNANDEZ-FERNANDEZ, MOISES, VALLEE, EMMANUEL, VIDAURRE, DIEGO, WEBSTER, MATTHEW, MCCARTHY, PAUL, RORDEN, CHRISTOPHER, DADUCCI, ALESSANDRO, ALEXANDER, DANIEL C., ZHANG, HUI, DRAGONU, IULIUS, MATTHEWS, PAUL M., MILLER, KARLA L. and SMITH, STEPHEN M., 2018. Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank NEUROIMAGE. 166, 400-424
• MARS, ROGIER B, SOTIROPOULOS, STAMATIOS N, PASSINGHAM, RICHARD E, SALLET, JEROME, VERHAGEN, LENNART M, KHRAPITCHEV, ALEXANDRE A, SIBSON, NICOLA and JBABDI, SAAD, 2018. Whole brain comparative anatomy using connectivity blueprints. eLife. 7,
• COTTAAR, MICHIEL, BASTIANI, MATTEO, CHEN, CHARLES, DIKRANIAN, KRIKOR, VAN ESSEN, DAVID, BEHRENS, TIMOTHY E, SOTIROPOULOS, STAMATIOS N and JBABDI, SAAD, 2018. A gyral coordinate system predictive of fibre orientations. NeuroImage. 176, 417-430
• HADIDA, J, SOTIROPOULOS, S N, ABEYSURIYA, R G, WOOLRICH, M W and JBABDI, S, 2018. Bayesian Optimisation of Large-Scale Biophysical Networks. NeuroImage. 174, 219-236
• GARCIA-GONZALEZ D, RACE NS, VOETS NL, JENKINS DR, SOTIROPOULOS SN, ACOSTA G, CRUZ-HACES M, TANG J, SHI R and JÉRUSALEM A, 2018. Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations. Scientific reports. 8(1), 10273
• COTTAAR M, BASTIANI M, CHEN C, DIKRANIAN K, VAN ESSEN D, BEHRENS TE, SOTIROPOULOS SN and JBABDI S, 2018. A gyral coordinate system predictive of fibre orientations. NeuroImage. 176, 417-430
• HADIDA J, SOTIROPOULOS SN, ABEYSURIYA RG, WOOLRICH MW and JBABDI S, 2018. Bayesian Optimisation of Large-Scale Biophysical Networks. NeuroImage. 174, 219-236
• BASTIANI M, COTTAAR M, FITZGIBBON SP, SURI S, ALFARO-ALMAGRO F, SOTIROPOULOS SN, JBABDI S and ANDERSSON JLR, 2018. Automated quality control for within and between studies diffusion MRI data using a non-parametric framework for movement and distortion correction. NeuroImage. 184, 801-812
• MARS RB, SOTIROPOULOS SN, PASSINGHAM RE, SALLET J, VERHAGEN L, KHRAPITCHEV AA, SIBSON N and JBABDI S, 2018. Whole brain comparative anatomy using connectivity blueprints. eLife. 7,
• LERCH JP, VAN DER KOUWE AJ, RAZNAHAN A, PAUS T, JOHANSEN-BERG H, MILLER KL, SMITH SM, FISCHL B and SOTIROPOULOS SN, 2017. Studying neuroanatomy using MRI. Nature neuroscience. 20(3), 314-326
• ALEXANDER, DANIEL C, ZIKIC, DARKO, GHOSH, AUROBRATA, TANNO, RYUTARO, WOTTSCHEL, VIKTOR, ZHANG, JIAYING, KADEN, ENRICO, DYRBY, TIM B, SOTIROPOULOS, STAMATIOS N, ZHANG, HUI and CRIMINISI, ANTONIO, 2017. Image quality transfer and applications in diffusion MRI. NeuroImage. 152, 283-298
• PISHARADY, PRAMOD KUMAR, SOTIROPOULOS, STAMATIOS N, SAPIRO, GUILLERMO and LENGLET, CHRISTOPHE, 2017. A Sparse Bayesian Learning Algorithm for White Matter Parameter Estimation from Compressed Multi-shell Diffusion MRI. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. 10433, 602-610
• COLCLOUGH, GILES L., SMITH, STEPHEN M., NICHOLS, THOMAS E., WINKLER, ANDERSON M., SOTIROPOULOS, STAMATIOS N., GLASSER, MATTHEW F., VAN ESSEN, DAVID C. and WOOLRICH, MARK W., 2017. The heritability of multi-modal connectivity in human brain activity ELIFE. 6,
• AKRAM, HARITH, SOTIROPOULOS, STAMATIOS N., JBABDI, SAAD, GEORGIEV, DEJAN, MAHLKNECHT, PHILIPP, HYAM, JONATHAN, FOLTYNIE, THOMAS, LIMOUSIN, PATRICIA, DE VITA, ENRICO, JAHANSHAHI, MARJAN, HARIZ, MARWAN, ASHBURNER, JOHN, BEHRENS, TIM and ZRINZO, LUDVIC, 2017. Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson's disease NEUROIMAGE. 158, 332-345
• BASTIANI, MATTEO, COTTAAR, MICHIEL, DIKRANIAN, KRIKOR, GHOSH, AUROBRATA, ZHANG, HUI, ALEXANDER, DANIEL C., BEHRENS, TIMOTHY E., JBABDI, SAAD and SOTIROPOULOS, STAMATIOS N., 2017. Improved tractography using asymmetric fibre orientation distributions NEUROIMAGE. 158, 205-218
• PISHARADY, PRAMOD KUMAR, SOTIROPOULOS, STAMATIOS N, DUARTE-CARVAJALINO, JULIO M, SAPIRO, GUILLERMO and LENGLET, CHRISTOPHE, 2017. Estimation of white matter fiber parameters from compressed multiresolution diffusion MRI using sparse Bayesian learning. NeuroImage.
• SOTIROPOULOS, STAMATIOS N and ZALESKY, ANDREW, 2017. Building connectomes using diffusion MRI: why, how and but. NMR in biomedicine.
• MOLLINK, JEROEN, KLEINNIJENHUIS, MICHIEL, VAN WALSUM, ANNE-MARIE VAN CAPPELLEN, SOTIROPOULOS, STAMATIOS N., COTTAAR, MICHIEL, MIRFIN, CHRISTOPHER, HEINRICH, MATTIAS P., JENKINSON, MARK, PALLEBAGE-GAMARALLAGE, MENUKA, ANSORGE, OLAF, JBABDI, SAAD and MILLER, KARLA L., 2017. Evaluating fibre orientation dispersion in white matter: Comparison of diffusion MRI, histology and polarized light imaging NEUROIMAGE. 157, 561-574
• ALFARO-ALMAGRO F, JENKINSON M, BANGERTER NK, ANDERSSON JLR, GRIFFANTI L, DOUAUD G, SOTIROPOULOS SN, JBABDI S, HERNANDEZ-FERNANDEZ M, VALLEE E, VIDAURRE D, WEBSTER M, MCCARTHY P, RORDEN C, DADUCCI A, ALEXANDER DC, ZHANG H, DRAGONU I, MATTHEWS PM, MILLER KL and SMITH SM, 2017. Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank. NeuroImage. 166, 400-424
• MILLER KL, ALFARO-ALMAGRO F, BANGERTER NK, THOMAS DL, YACOUB E, XU J, BARTSCH AJ, JBABDI S, SOTIROPOULOS SN, ANDERSSON JL, GRIFFANTI L, DOUAUD G, OKELL TW, WEALE P, DRAGONU I, GARRATT S, HUDSON S, COLLINS R, JENKINSON M, MATTHEWS PM and SMITH SM, 2016. Multimodal population brain imaging in the UK Biobank prospective epidemiological study. Nature neuroscience. 19(11), 1523-1536
• GLASSER MF, SMITH SM, MARCUS DS, ANDERSSON JL, AUERBACH EJ, BEHRENS TE, COALSON TS, HARMS MP, JENKINSON M, MOELLER S, ROBINSON EC, SOTIROPOULOS SN, XU J, YACOUB E, UGURBIL K and VAN ESSEN DC, 2016. The Human Connectome Project's neuroimaging approach. Nature neuroscience. 19(9), 1175-87
• ANDERSSON JL, GRAHAM MS, ZSOLDOS E and SOTIROPOULOS SN, 2016. Incorporating outlier detection and replacement into a non-parametric framework for movement and distortion correction of diffusion MR images. NeuroImage. 141, 556-72
• DONAHUE CJ, SOTIROPOULOS SN, JBABDI S, HERNANDEZ-FERNANDEZ M, BEHRENS TE, DYRBY TB, COALSON T, KENNEDY H, KNOBLAUCH K, VAN ESSEN DC and GLASSER MF, 2016. Using Diffusion Tractography to Predict Cortical Connection Strength and Distance: A Quantitative Comparison with Tracers in the Monkey. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(25), 6758-70
• SOTIROPOULOS SN, HERNÁNDEZ-FERNÁNDEZ M, VU AT, ANDERSSON JL, MOELLER S, YACOUB E, LENGLET C, UGURBIL K, BEHRENS TE and JBABDI S, 2016. Fusion in diffusion MRI for improved fibre orientation estimation: An application to the 3T and 7T data of the Human Connectome Project. NeuroImage. 134, 396-409
• ANDERSSON JL and SOTIROPOULOS SN, 2016. An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. NeuroImage. 125, 1063-78
• CHECHLACZ M, HUMPHREYS GW, SOTIROPOULOS SN, KENNARD C and CAZZOLI D, 2015. Structural Organization of the Corpus Callosum Predicts Attentional Shifts after Continuous Theta Burst Stimulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(46), 15353-68
• JBABDI S, SOTIROPOULOS SN, HABER SN, VAN ESSEN DC and BEHRENS TE, 2015. Measuring macroscopic brain connections in vivo. Nature neuroscience. 18(11), 1546-55
• CANALES-RODRÍGUEZ EJ, DADUCCI A, SOTIROPOULOS SN, CARUYER E, AJA-FERNÁNDEZ S, RADUA J, YURRAMENDI MENDIZABAL JM, ITURRIA-MEDINA Y, MELIE-GARCÍA L, ALEMÁN-GÓMEZ Y, THIRAN JP, SARRÓ S, POMAROL-CLOTET E and SALVADOR R, 2015. Spherical Deconvolution of Multichannel Diffusion MRI Data with Non-Gaussian Noise Models and Spatial Regularization. PloS one. 10(10), e0138910
• VAN BAARSEN KM, KLEINNIJENHUIS M, JBABDI S, SOTIROPOULOS SN, GROTENHUIS JA and VAN CAPPELLEN VAN WALSUM AM, 2015. A probabilistic atlas of the cerebellar white matter. NeuroImage. 124(Pt A), 724-32
• VU AT, AUERBACH E, LENGLET C, MOELLER S, SOTIROPOULOS SN, JBABDI S, ANDERSSON J, YACOUB E and UGURBIL K, 2015. High resolution whole brain diffusion imaging at 7T for the Human Connectome Project. NeuroImage. 122, 318-31
• ANDERSSON JL and SOTIROPOULOS SN, 2015. Non-parametric representation and prediction of single- and multi-shell diffusion-weighted MRI data using Gaussian processes. NeuroImage. 122, 166-76
• KOCHUNOV P, JAHANSHAD N, MARCUS D, WINKLER A, SPROOTEN E, NICHOLS TE, WRIGHT SN, HONG LE, PATEL B, BEHRENS T, JBABDI S, ANDERSSON J, LENGLET C, YACOUB E, MOELLER S, AUERBACH E, UGURBIL K, SOTIROPOULOS SN, BROUWER RM, LANDMAN B, LEMAITRE H, DEN BRABER A, ZWIERS MP, RITCHIE S, VAN HULZEN K, ALMASY L, CURRAN J, DEZUBICARAY GI, DUGGIRALA R, FOX P, MARTIN NG, MCMAHON KL, MITCHELL B, OLVERA RL, PETERSON C, STARR J, SUSSMANN J, WARDLAW J, WRIGHT M, BOOMSMA DI, KAHN R, DE GEUS EJ, WILLIAMSON DE, HARIRI A, VAN 'T ENT D, BASTIN ME, MCINTOSH A, DEARY IJ, HULSHOFF POL HE, BLANGERO J, THOMPSON PM, GLAHN DC and VAN ESSEN DC, 2015. Heritability of fractional anisotropy in human white matter: a comparison of Human Connectome Project and ENIGMA-DTI data. NeuroImage. 111, 300-11
• HAHAMY A, SOTIROPOULOS SN, HENDERSON SLATER D, MALACH R, JOHANSEN-BERG H and MAKIN TR, 2015. Normalisation of brain connectivity through compensatory behaviour, despite congenital hand absence. eLife. 4,
• FILIPPINI N, ZSOLDOS E, HAAPAKOSKI R, SEXTON CE, MAHMOOD A, ALLAN CL, TOPIWALA A, VALKANOVA V, BRUNNER EJ, SHIPLEY MJ, AUERBACH E, MOELLER S, UĞURBIL K, XU J, YACOUB E, ANDERSSON J, BIJSTERBOSCH J, CLARE S, GRIFFANTI L, HESS AT, JENKINSON M, MILLER KL, SALIMI-KHORSHIDI G, SOTIROPOULOS SN, VOETS NL, SMITH SM, GEDDES JR, SINGH-MANOUX A, MACKAY CE, KIVIMÄKI M and EBMEIER KP, 2014. Study protocol: The Whitehall II imaging sub-study. BMC psychiatry. 14, 159
• SOTIROPOULOS SN, JBABDI S, XU J, ANDERSSON JL, MOELLER S, AUERBACH EJ, GLASSER MF, HERNANDEZ M, SAPIRO G, JENKINSON M, FEINBERG DA, YACOUB E, LENGLET C, VAN ESSEN DC, UGURBIL K, BEHRENS TE and , 2013. Advances in diffusion MRI acquisition and processing in the Human Connectome Project. NeuroImage. 80, 125-43
• UĞURBIL K, XU J, AUERBACH EJ, MOELLER S, VU AT, DUARTE-CARVAJALINO JM, LENGLET C, WU X, SCHMITTER S, VAN DE MOORTELE PF, STRUPP J, SAPIRO G, DE MARTINO F, WANG D, HAREL N, GARWOOD M, CHEN L, FEINBERG DA, SMITH SM, MILLER KL, SOTIROPOULOS SN, JBABDI S, ANDERSSON JL, BEHRENS TE, GLASSER MF, VAN ESSEN DC, YACOUB E and , 2013. Pushing spatial and temporal resolution for functional and diffusion MRI in the Human Connectome Project. NeuroImage. 80, 80-104
• GLASSER MF, SOTIROPOULOS SN, WILSON JA, COALSON TS, FISCHL B, ANDERSSON JL, XU J, JBABDI S, WEBSTER M, POLIMENI JR, VAN ESSEN DC, JENKINSON M and , 2013. The minimal preprocessing pipelines for the Human Connectome Project. NeuroImage. 80, 105-24
• HERNÁNDEZ M, GUERRERO GD, CECILIA JM, GARCÍA JM, INUGGI A, JBABDI S, BEHRENS TE and SOTIROPOULOS SN, 2013. Accelerating fibre orientation estimation from diffusion weighted magnetic resonance imaging using GPUs. PloS one. 8(4), e61892
• SOTIROPOULOS SN, MOELLER S, JBABDI S, XU J, ANDERSSON JL, AUERBACH EJ, YACOUB E, FEINBERG D, SETSOMPOP K, WALD LL, BEHRENS TE, UGURBIL K and LENGLET C, 2013. Effects of image reconstruction on fiber orientation mapping from multichannel diffusion MRI: reducing the noise floor using SENSE. Magnetic resonance in medicine. 70(6), 1682-9
• SOTIROPOULOS SN, JBABDI S, ANDERSSON JL, WOOLRICH MW, UGURBIL K and BEHRENS TE, 2013. RubiX: combining spatial resolutions for Bayesian inference of crossing fibers in diffusion MRI. IEEE transactions on medical imaging. 32(6), 969-82
• JBABDI S, SOTIROPOULOS SN and BEHRENS TE, 2013. The topographic connectome. Current opinion in neurobiology. 23(2), 207-15
• ASSAF Y, ALEXANDER DC, JONES DK, BIZZI A, BEHRENS TE, CLARK CA, COHEN Y, DYRBY TB, HUPPI PS, KNOESCHE TR, LEBIHAN D, PARKER GJ, POUPON C, , ANABY D, ANWANDER A, BAR L, BARAZANY D, BLUMENFELD-KATZIR T, DE-SANTIS S, DUCLAP D, FIGINI M, FISCHI E, GUEVARA P, HUBBARD P, HOFSTETTER S, JBABDI S, KUNZ N, LAZEYRAS F, LEBOIS A, LIPTROT MG, LUNDELL H, MANGIN JF, DOMINGUEZ DM, MOROZOV D, SCHREIBER J, SEUNARINE K, NAVA S, POUPON C, RIFFERT T, SASSON E, SCHMITT B, SHEMESH N, SOTIROPOULOS SN, TAVOR I, ZHANG HG and ZHOU FL, 2013. The CONNECT project: Combining macro- and micro-structure. NeuroImage. 80, 273-82
• JBABDI S, SOTIROPOULOS SN, SAVIO AM, GRAÑA M and BEHRENS TE, 2012. Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems. Magnetic resonance in medicine. 68(6), 1846-55
• SOTIROPOULOS SN, BEHRENS TE and JBABDI S, 2012. Ball and rackets: Inferring fiber fanning from diffusion-weighted MRI. NeuroImage. 60(2), 1412-25
• SOTIROPOULOS, STAMATIOS N, BAI, LI, MORGAN, PAUL S, CONSTANTINESCU, CRIS S and TENCH, CHRISTOPHER R, 2009. Brain tractography using Q-ball imaging and graph theory: Improved connectivities through fibre crossings via a model-based approach. NeuroImage.
• SOTIROPOULOS SN, BAI L and TENCH CR, 2009. Fuzzy anatomical connectedness of the brain using single and multiple fibre orientations estimated from diffusion MRI. Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society. 34(6), 504-13
• SOTIROPOULOS SN, BAI L, MORGAN PS, AUER DP, CONSTANTINESCU CS and TENCH CR, 2008. A regularized two-tensor model fit to low angular resolution diffusion images using basis directions. Journal of magnetic resonance imaging : JMRI. 28(1), 199-209
• SOTIROPOULOS SN and STEINMETZ PN, 2007. Assessing the direct effects of deep brain stimulation using embedded axon models. Journal of neural engineering. 4(2), 107-19
• PAPADIMITRIOU, KYPRIANOS, DOLLAS, APOSTOLOS and SOTIROPOULOS, STAMATIOS N., 2006. Low-cost real-time 2-D motion detection based on reconfigurable computing IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT. 55(6), 2234-2243
• DOLLAS A, SOTIROPOULOS S and PAPADEMETRIOU K, 2005. A 2-D motion detection model for low-cost embedded reconfigurable I/O devices. IEEE transactions on bio-medical engineering. 52(8), 1443-9