Philip Bath

Contact

• workRoom B51 Clinical Sciences Building
  Nottingham City Hospital
  Hucknall Road
  Nottingham
  NG5 1PB
  UK
• work0115 823 1765
• fax0115 823 1767
• philip.bath@nottingham.ac.uk
• http://www.nottingham.ac.uk/research/groups/stroke/people/philip.bath

Biography

Philip Bath is Stroke Association Professor of Stroke Medicine, and Chair and Head of the Division of Clinical Neuroscience at the University of Nottingham.

Clinically, he contributes to the Nottingham University Hospitals NHS Trust Stroke Service (in-patient stroke care). As an NIHR Senior Investigator, his main research interests cover the treatment of acute stroke (blood pressure lowering), prevention of stroke recurrence and cognitive impairment (antiplatelet agentss, blood pressure and lipid lowering) and enhancement of recovery using stem cells. He uses preclinical studies, clinical trials (phase I to IV) and systematic reviews to help address these questions.

He is also part of the Multicentre Preclinical Animal Research Team.

Find out more:

• http://scholar.google.co.uk/citations?user=xV0XIyAAAAAJ&hl=en
• http://www.linkedin.com/profile/view?id=146945824
• https://www.researchgate.net/profile/Philip_Bath/
• http://www.scopus.com/authid/detail.url?authorId=24723490800

Research Summary

• Treatment of acute stroke
• Anticoagulation in acute stroke
• Nitric oxide in acute stroke
• Management of blood pressure in acute stroke
• Platelet and megakaryocyte function in stroke

Selected Publications

• ENGLAND, T.J., ABAEI, M., AUER, D.P., LOWE, J., JONES, D.R.E., SARE, G., WALKER, M. and BATH, P.M.W., 2012. Granulocyte-colony stimulating factor for mobilizing bone marrow stem cells in subacute stroke: the Stem Cell Trial Of Recovery Enhancement After Stroke 2 Randomized Controlled Trial Stroke. 43(2), 405-411
• SANDSET, E.C., BATH, P.M.W., BOYSEN, G., JATUZIS, D., KÕRV, J., LÜDERS, S., MURRAY, G.D., RICHTER, P.S., ROINE, R.O., TERÉNT, A., THIJS, V. and BERGE, E., 2011. The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo-controlled, double-blind trial Lancet. 377(9767), 741-750
• OVBIAGELE, B., DIENER, H.-C., YUSUF, S., MARTIN, R.H., COTTON, D., VINISKO, R., DONNAN, G.A. and BATH, P.M., 2011. Level of systolic blood pressure within the normal range and risk of recurrent stroke Journal of the American Medical Association. 306(19), 2137-2144
• YUSUF S., H-C., SACCO, R., COTTON, D., OUNPUU, S., LAWTON, W., PALESCH, Y., MARTIN, R., ALBERS, G.W., BATH, P., BORNSTEIN, N., CHAN, B., CHEN, S.T., DAHLOF, B., DE KEYSER, J., DONNAN, G. and EST, 2008. Randomized trial of telmisartan therapy to prevent recurrent strokes and major vascular events among 20,332 individuals with recent stroke New England Journal of Medicine.

• View all publications

• MUIR, KEITH W., BULTERS, DIEDERIK, WILLMOT, MARK, SPRIGG, NIKOLA, DIXIT, ANAND, WARD, NICK, TYRRELL, PIPPA, MAJID, ARSHAD, DUNN, LAURENCE, BATH, PHILIP, HOWELL, JULIAN, STROEMER, PAUL, POLLOCK, KENNETH and SINDEN, JOHN, 2020. Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2) JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 91(4), 396-401
• APPLETON JP, WOODHOUSE LJ, BERECZKI D, BERGE E, CHRISTENSEN HK, COLLINS R, GOMMANS J, NTAIOS G, OZTURK S, SZATMARI S, WARDLAW JM, SPRIGG N, ROTHWELL PM, BATH PM and , 2019. Effect of Glyceryl Trinitrate on Hemodynamics in Acute Stroke. Stroke. STROKEAHA118023190 (In Press.)
• WANG Y, JOHNSTON SC, BATH PM, GROTTA JC, PAN Y, AMARENCO P, WANG Y, SIMON T, KIM JS, JENG JS, LIU L, LIN Y, WONG KSL, WANG D and LI H, 2019. Acute dual antiplatelet therapy for minor ischaemic stroke or transient ischaemic attack. BMJ (Clinical research ed.). 364, l895
• BLAIR GW, APPLETON JP, FLAHERTY K, DOUBAL F, SPRIGG N, DOOLEY R, RICHARDSON C, HAMILTON I, LAW ZK, SHI Y, STRINGER MS, THRIPPLETON MJ, BOYD J, SHULER K, BATH PM and WARDLAW JM, 2019. Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial. EClinicalMedicine. 11, 34-43
• SANDSET EC, APPLETON JP, BERGE E, CHRISTENSEN H, GOMMANS J, KRISHNAN K, NTAIOS G, PHILLIPS S, POCOCK S, SPRIGG N, WOODHOUSE LJ, BATH PM and , 2019. Associations between change in blood pressure and functional outcome, early events and death: results from the Efficacy of Nitric Oxide in Stroke trial. Journal of hypertension. 37(10), 2104-2109
• APPLETON JP, WOODHOUSE LJ, BELCHER A, BERECZKI D, BERGE E, CASO V, CHANG HM, CHRISTENSEN HK, COLLINS R, GOMMANS J, LASKA AC, NTAIOS G, OZTURK S, SARE GM, SZATMARI S, WANG Y, WARDLAW JM, SPRIGG N and BATH PM, 2019. It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis. Stroke and vascular neurology. 4(1), 28-35
• ROBINSON TG, BRAY BD, PALEY L, SPRIGG N, WANG X, ARIMA H, BATH PM, BRODERICK JP, DURHAM AC, KIM JS, LAVADOS PM, LEE TH, MARTINS S, NGUYEN TH, PANDIAN JD, PARSONS MW, PONTES-NETO OM, RICCI S, SHARMA VK, WANG J, WOODWARD M, RUDD AG, CHALMERS J, S ANDERSON C and , 2019. Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous thrombolysis in England and Wales: Comparison with the Sentinel Stroke National Audit Programme registry. International journal of stroke : official journal of the International Stroke Society. 1747493019841246 (In Press.)
• BATH, PHILIP M., SCUTT, POLLY, ANDERSON, CRAIG S., ANKOLEKAR, SANDEEP, APPLETON, JASON P., BERGE, EIVIND, CALA, LESLEY, DIXON, MARK, ENGLAND, TIMOTHY J., GODOLPHIN, PETER J., HAVARD, DIANE, HAYWOOD, LEE, HEPBURN, TRISH, KRISHNAN, KAILASH, MAIR, GRANT, MONTGOMERY, ALAN A., MUIR, KEITH, PHILLIPS, STEPHEN J., POCOCK, STUART, POTTER, JOHN, PRICE, CHRIS I., RANDALL, MARC, ROBINSON, THOMPSON G., ROFFE, CHRISTINE, ROTHWELL, PETER M., SANDSET, ELSE C., SANOSSIAN, NERSES, SAVER, JEFFREY L., SHONE, ANGELA, SIRIWARDENA, A. NIROSHAN, WARDLAW, JOANNA M., WOODHOUSE, LISA J., VENABLES, GRAHAM and SPRIGG, NIKOLA, 2019. Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial LANCET. 393(10175), 1009-1020
• SASEGBON A, WATANABE M, SIMONS A, MICHOU E, VASANT DH, MAGARA J, BATH PM, ROTHWELL J, INOUE M, HAMDY S., 2019. Cerebellar repetitive transcranial magnetic stimulation restores pharyngeal brain activity and swallowing behaviour after disruption by a cortical virtual lesion. J Physiol.. 579(9), 2533-2546
• KRISHNAN K, BASSILIOUS K, ERIKSEN E, BATH PM, SPRIGG N, BRÆKKEN SK, IHLE-HANSEN H, HORN MA, SANDSET EC., 2019. Posterior circulation stroke diagnosis using HINTS in patients presenting with acute vestibular syndrome: A systematic review Eur Stroke J. 2019. 4(3), 233-239
• WARDLAW, JOANNA M. and BATH, PHILIP M., 2019. Stroke research in 2018: extended time windows, refined benefit, and lifestyle prevention targets LANCET NEUROLOGY. 18(1), 2-3
• ANDERSON, CRAIG S. and BATH, PHILIP M., 2019. Blood pressure reduction and intravenous thrombolysis reply LANCET. 394(10199), E25-E25
• ANDERSON, CRAIG S., HUANG, YINING, LINDLEY, RICHARD I., CHEN, XIAOYING, ARIMA, HISATOMI, CHEN, GUOFANG, LI, QIANG, BILLOT, LAURENT, DELCOURT, CANDICE, BATH, PHILIP M., BRODERICK, JOSEPH P., DEMCHUK, ANDREW M., DONNAN, GEOFFREY A., DURHAM, ALICE C., LAVADOS, PABLO M., LEE, TSONG-HAI, LEVI, CHRISTOPHER, MARTINS, SHEILA O., OLAVARRIA, VERONICA V., PANDIAN, JEYARAJ D., PARSONS, MARK W., PONTES-NETO, OCTAVIO M., RICCI, STEFANO, SATO, SHOICHIRO, SHARMA, VIJAY K., SILVA, FEDERICO, SONG, LILI, THANG, NGUYEN H., WARDLAW, JOANNA M., WANG, JI-GUANG, WANG, XIA, WOODWARD, MARK, CHALMERS, JOHN and ROBINSON, THOMPSON G., 2019. Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial LANCET. 393(10174), 877-888
• APPLETON, JASON P., WOODHOUSE, LISA J., BELCHER, ANDREW, BERECZKI, DANIEL, BERGE, EIVIND, CASO, VALERIA, CHANG, HUI MENG, CHRISTENSEN, HANNE K., COLLINS, RONAN, GOMMANS, JOHN, LASKA, ANN C., NTAIOS, GEORGE, OZTURK, SEREFNUR, SARE, GILLIAN M., SZATMARI, SZABOLCS, WANG, YONGJUN, WARDLAW, JOANNA M., SPRIGG, NIKOLA and BATH, PHILIP M., 2019. It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis STROKE AND VASCULAR NEUROLOGY. 4(1), 28-35
• GREVING, JACOBA P., DIENER, HANS-CHRISTOPH, REITSMA, JOHANNES B., BATH, PHILIP M., CSIBA, LASZLO, HACKE, WERNER, KAPPELLE, L. JAAP, KOUDSTAAL, PETER J., LEYS, DIDIER, MAS, JEAN-LOUIS, SACCO, RALPH L. and ALGRA, ALE, 2019. Antiplatelet Therapy After Noncardioembolic Stroke An Individual Patient Data Network Meta-Analysis STROKE. 50(7), 1812-1818
• JUSUFOVIC, MIRZA, BERGE, TRUDE ELISABETH, GUO, RUI, YOU, SHOUJIANG, DELCOURT, CANDICE, ANDERSON, CRAIG, BATH, PHILIP M., KARLSON, BJOERN W., BERGE, EIVIND and SANDSET, ELSE CHARLOTTE, 2019. Effects of Candesartan in the Acute Phase of Intracerebral Hemorrhage JOURNAL OF STROKE & CEREBROVASCULAR DISEASES. 28(8), 2262-2267
• VAN DER WORP, H. BART, MACLEOD, MALCOLM R., BATH, PHILIP M. W., BATHULA, RAJ, CHRISTENSEN, HANNE, COLAM, BRIDGET, CORDONNIER, CHARLOTTE, DEMOTES-MAINARD, JACQUES, DURAND-ZALESKI, ISABELLE, GLUUD, CHRISTIAN, JAKOBSEN, JANUS CHRISTIAN, KALLMUENZERI, BERND, KOLLMAR, RAINER, KRIEGER, DERK W., LEES, KENNEDY R., MICHALSKI, DOMINIK, MOLINA, CARLOS, MONTANER, JOAN, ROINE, RISTO O., PETERSSON, JESPER, PERRY, RICHARD, SPRIGG, NIKOLA, STAYKOV, DIMITRE, SZABO, ISTVAN, VANHOOREN, GEERT, WARDLAW, JOANNA M., WINKEL, PER, SCHWAB, STEFAN, SCHWAB, S., HOBOHM, C., SCHNEIDER, H., WARTENBERG, K., BERROUSCHOT, J., LORENZ, M., CHRISTENSEN, H. C., SPRIGG, N., BATHULA, R., FITZSIMMONS, P., PERRY, R., SAASTAMOINEN, K., CREAGH-BROWN, B. C., SWEENIE, A., LINDERT, R., RUBIERA, M., SERENAL, J., VANHOOREN, G., DESFONTAINES, P., CORDONNIER, C., SIBON, I, JATUZIS, D. and ORZI, F., 2019. Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial EUROPEAN STROKE JOURNAL. 4(3), 254-262
• STEELE CM, MUKHERJEE R, KORTELAINEN JM, PÖLÖNEN H, JEDWAB M, BRADY SL, THEIMER KB, LANGMORE S, RIQUELME LF, SWIGERT NB, BATH PM, GOLDSTEIN LB, HUGHES RL, LEIFER D, LEES KR, MERETOJA A and MUEHLEMANN N, 2019. Development of a Non-invasive Device for Swallow Screening in Patients at Risk of Oropharyngeal Dysphagia: Results from a Prospective Exploratory Study. Dysphagia. (In Press.)
• SWEENEY MD, MONTAGNE A, SAGARE AP, NATION DA, SCHNEIDER LS, CHUI HC, HARRINGTON MG, PA J, LAW M, WANG DJJ, JACOBS RE, DOUBAL FN, RAMIREZ J, BLACK SE, NEDERGAARD M, BENVENISTE H, DICHGANS M, IADECOLA C, LOVE S, BATH PM, MARKUS HS, SALMAN RA, ALLAN SM, QUINN TJ, KALARIA RN, WERRING DJ, CARARE RO, TOUYZ RM, WILLIAMS SCR, MOSKOWITZ MA, KATUSIC ZS, LUTZ SE, LAZAROV O, MINSHALL RD, REHMAN J, DAVIS TP, WELLINGTON CL, GONZÁLEZ HM, YUAN C, LOCKHART SN, HUGHES TM, CHEN CLH, SACHDEV P, O'BRIEN JT, SKOOG I, PANTONI L, GUSTAFSON DR, BIESSELS GJ, WALLIN A, SMITH EE, MOK V, WONG A, PASSMORE P, BARKOF F, MULLER M, BRETELER MMB, ROMÁN GC, HAMEL E, SESHADRI S, GOTTESMAN RF, VAN BUCHEM MA, ARVANITAKIS Z, SCHNEIDER JA, DREWES LR, HACHINSKI V, FINCH CE, TOGA AW, WARDLAW JM and ZLOKOVIC BV, 2019. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 15(1), 158-167
• PSZCZOLKOWSKI S, LAW ZK, GALLAGHER RG, MENG D, SWIENTON DJ, MORGAN PS, BATH PM, SPRIGG N and DINEEN RA, 2019. Automated segmentation of haematoma and perihaematomal oedema in MRI of acute spontaneous intracerebral haemorrhage. Computers in biology and medicine. 106, 126-139
• ALEXANDER-CURTIS M, PAULS R, CHAO J, VOLPI JJ, BATH PM and VERDOORN TA, 2019. Human tissue kallikrein in the treatment of acute ischemic stroke. Therapeutic advances in neurological disorders. 12, 1756286418821918
• ANDERSON CS, HUANG Y, LINDLEY RI, CHEN X, ARIMA H, CHEN G, LI Q, BILLOT L, DELCOURT C, BATH PM, BRODERICK JP, DEMCHUK AM, DONNAN GA, DURHAM AC, LAVADOS PM, LEE TH, LEVI C, MARTINS SO, OLAVARRIA VV, PANDIAN JD, PARSONS MW, PONTES-NETO OM, RICCI S, SATO S, SHARMA VK, SILVA F, SONG L, THANG NH, WARDLAW JM, WANG JG, WANG X, WOODWARD M, CHALMERS J, ROBINSON TG and , 2019. Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial. Lancet (London, England). (In Press.)
• BATH PM, LEE HS and EVERTON LF, 2019. Swallowing Therapy for Dysphagia in Acute and Subacute Stroke. Stroke. STROKEAHA118024299 (In Press.)
• BATH, P. M., WOODHOUSE, L. J., APPLETON, J. P., BERIDZE, M., CHRISTENSEN, H., DINEEN, R. A., DULEY, L., ENGLAND, T. J., FLAHERTY, K., HAVARD, D., HEPTINSTALL, S., JAMES, M., KRISHNAN, K., MARKUS, H. S., MONTGOMERY, A. A., POCOCK, S. J., RANDALL, M., RANTA, A., ROBINSON, T. G., SCUTT, P., VENABLES, G. S. and SPRIGG, N., 2018. Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial: Lancet Lancet. 391(10123), 850-859
• HILKENS NA, ALGRA A, KAPPELLE LJ, BATH PM, CSIBA L, ROTHWELL PM, GREVING JP and , 2018. Early time course of major bleeding on antiplatelet therapy after TIA or ischemic stroke. Neurology. 90(8), e683-e689
• BATH PM, MAY J and HEPTINSTALL S, 2018. Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders. Platelets. 29(5), 425-430
• MINHAS JS, WANG X, ARIMA H, BATH PM, BILLOT L, BRODERICK JP, DONNAN GA, KIM JS, LAVADOS PM, LEE TH, MARTINS SCO, OLAVARRÍA VV, PANDIAN JD, PONTES-NETO OM, RICCI S, SATO S, SHARMA VK, THANG NH, WANG JG, WOODWARD M, CHALMERS J, ANDERSON CS, ROBINSON TG and , 2018. Lipid-Lowering Pretreatment and Outcome Following Intravenous Thrombolysis for Acute Ischaemic Stroke: A Post Hoc Analysis of the Enhanced Control of Hypertension and Thrombolysis Stroke Study Trial. Cerebrovascular diseases (Basel, Switzerland). 45(5-6), 213-220
• SANDSET EC, SANOSSIAN N, WOODHOUSE LJ, ANDERSON C, BERGE E, LEES KR, POTTER JF, ROBINSON TG, SPRIGG N, WARDLAW JM, BATH PM and , 2018. Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomized controlled trials of vasoactive drugs in acute stroke: The Blood pressure in Acute Stroke Collaboration, stage-3. International journal of stroke : official journal of the International Stroke Society. 13(7), 759-765
• MAKIN SD, DOUBAL FN, QUINN TJ, BATH PM, DENNIS MS and WARDLAW JM, 2018. The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke. European stroke journal. 3(1), 66-73
• DZIEWAS R, STELLATO R, VAN DER TWEEL I, WALTHER E, WERNER CJ, BRAUN T, CITERIO G, JANDL M, FRIEDRICHS M, NÖTZEL K, VOSKO MR, MISTRY S, HAMDY S, MCGOWAN S, WARNECKE T, ZWITTAG P, BATH PM and , 2018. Pharyngeal electrical stimulation for early decannulation in tracheotomised patients with neurogenic dysphagia after stroke (PHAST-TRAC): a prospective, single-blinded, randomised trial. The Lancet. Neurology. 17(10), 849-859
• VENTURELLI PM, APPLETON JP, ANDERSON CS and BATH PM, 2018. Acute Treatment of Stroke (Except Thrombectomy). Current neurology and neuroscience reports. 18(11), 77
• REININK H, DE JONGE JC, BATH PM, VAN DE BEEK D, BERGE E, BORREGAARD S, CICCONE A, CSIBA L, DEMOTES J, DIPPEL DW, KÕRV J, KURKOWSKA-JASTRZEBSKA I, LEES KR, MACLEOD MR, NTAIOS G, RANDALL G, THOMALLA G and VAN DER WORP HB, 2018. PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke. Rationale and design of a randomised, open, phase III, clinical trial with blinded outcome assessment. European stroke journal. 3(3), 291-298
• BATH PM, LEE HS and EVERTON LF, 2018. Swallowing therapy for dysphagia in acute and subacute stroke. The Cochrane database of systematic reviews. 10, CD000323
• BATH PM, SCUTT P, APPLETON JP, DIXON M, WOODHOUSE LJ, WARDLAW JM and SPRIGG N, 2018. Baseline characteristics of the 1149 patients recruited into the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) randomized controlled trial. International journal of stroke : official journal of the International Stroke Society. 1747493018816451 (In Press.)
• WARDLAW JM and BATH PM, 2018. Stroke research in 2018: extended time windows, refined benefit, and lifestyle prevention targets. The Lancet. Neurology. 18(1), 2-3
• ALCOCK, JOELLE, LOWE, JAMES, ENGLAND, TIM, BATH, PHILIP and SOTTILE, VIRGINIE, 2009. Expression of Sox1, Sox2 and Sox9 is maintained in adult human cerebellar cortex. Neuroscience Letters. 450(2), 114-6