Contact

• workMaternity Unit
  Nottingham City Hospital
  Hucknall Road
  Nottingham
  NG5 1PB
  UK
• Fiona.Broughton-Pipkin@nottingham.ac.uk

Biography

I am a graduate of the University of Oxford (Somerville College and the Nuffield Institute for Medical Research), and am currently Professor Emeritus of PerinatalPhysiology in the University of Nottingham. My research interests have always related to the pathophysiology of pregnancy, in both mother and fetus, with special reference to pre-eclampsia and to the role of the renin-angiotensin system in pregnancy. Pre-eclampsia is a world-wide problem, and one of the "Big Three" killers of pregnant women. Pre-eclampsia and gestational hypertension are also associated with increased risk of long-term cardiovascular and metabolic disease, and i am particularly interested in this aspect,both in relation to the underlying disease processes and also whether aspects of hypertensive pregnancy can be used as indicators of future problems.

I am a Past-President of the International Society for the Study of Hypertension in Pregnancy (recipient of the Chesley Award), the Neonatal Society and the International Society of Developmental Pharmacology.

I have on-going research commitments in relation to the FP7-funded InterPregGen project (www.interpreggen.org/), and in relation to trans-abdominal monitoring of the fetal e.c.g. during pregnancy, with Prof Barrie Hayes-Gill and Dr Pamela Loughna. I am also collaborating with the Universities of Cambridge (Professors Graham Burton, Robin Carrell FRS and Randy Read), Bern , Switzerland (Prof Markus Mohaupt) and Newcastle, New South Wales (Prof Eugenie Lumbers and Dr Kirsty Pringle).

Recent Publications

• MISTRY HD, BROUGHTON PIPKIN F and KURLAK LO, 2016. Letter Regarding: Selenium and Preeclampsia: A Systemic Review and Meta-Analysis. Biological trace element research. 171(1), 235
• DELFORCE SJ, WANG Y, VAN-AALST ME, CORBISIER DE MEAULTSART C, MORRIS BJ, BROUGHTON-PIPKIN F, ROBERTS CT, LUMBERS ER and PRINGLE KG, 2016. Effect of oxygen on the expression of renin-angiotensin system components in a human trophoblast cell line. Placenta. 37, 1-6
• KAPAYA H, BROUGHTON PIPKIN F, HAYES-GILL B and LOUGHNA PV, 2016. Circadian changes and sex-related differences in fetal heart rate parameters. Maternal health, neonatology and perinatology. 2(1), 9
• AFOLABI BB, OLADIPO OO, AKANMU AS, ABUDU OO, SOFOLA OA and BROUGHTON PIPKIN F, 2016. Volume regulatory hormones and plasma volume in pregnant women with sickle cell disorder. Journal of the renin-angiotensin-aldosterone system : JRAAS. 17(3),

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• MISTRY HD, BROUGHTON PIPKIN F and KURLAK LO, 2016. Letter Regarding: Selenium and Preeclampsia: A Systemic Review and Meta-Analysis. Biological trace element research. 171(1), 235
• DELFORCE SJ, WANG Y, VAN-AALST ME, CORBISIER DE MEAULTSART C, MORRIS BJ, BROUGHTON-PIPKIN F, ROBERTS CT, LUMBERS ER and PRINGLE KG, 2016. Effect of oxygen on the expression of renin-angiotensin system components in a human trophoblast cell line. Placenta. 37, 1-6
• KAPAYA H, BROUGHTON PIPKIN F, HAYES-GILL B and LOUGHNA PV, 2016. Circadian changes and sex-related differences in fetal heart rate parameters. Maternal health, neonatology and perinatology. 2(1), 9
• AFOLABI BB, OLADIPO OO, AKANMU AS, ABUDU OO, SOFOLA OA and BROUGHTON PIPKIN F, 2016. Volume regulatory hormones and plasma volume in pregnant women with sickle cell disorder. Journal of the renin-angiotensin-aldosterone system : JRAAS. 17(3),
• SMITH-JACKSON, K., HENTSCHKE, M. R., POLI-DE-FIGUEIREDO, C. E., PINHEIRO DA COSTA, B. E., KURLAK, L. O., PIPKIN, F. BROUGHTON, CZAJKA, A. and MISTRY, H. D., 2015. Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia PLACENTA. 36(5), 607-610
• KURLAK, L. O., WILLIAMS, P. J., BULMER, J. N., PIPKIN, F. BROUGHTON and MISTRY, H. D., 2015. Placental expression of adenosine A(2A) receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: Interactions with placental renin-angiotensin system PLACENTA. 36(5), 611-613
• BROUGHTON PIPKIN, F., MISTRY, H. D., ROY, C., DICK, B., WAUGH, J., CHIKHI, R., KURLAK, L. O. and MOHAUPT, M. G., 2015. Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year: Endocr Connect
• KURLAK LO, MISTRY HD, CINDROVA-DAVIES T, BURTON GJ and BROUGHTON PIPKIN F, 2015. Human placental renin-angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia-reoxygenation insult. The Journal of physiology. 594(5), 1327-40
• BROUGHTON PIPKIN F, MISTRY HD, ROY C, DICK B, WAUGH J, CHIKHI R, KURLAK LO and MOHAUPT MG, 2015. Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year. Endocrine connections. 4(4), 233-41
• FORHEAD AJ, JELLYMAN JK, DE BLASIO MJ, JOHNSON E, GIUSSANI DA, BROUGHTON PIPKIN F and FOWDEN AL, 2015. Maternal Dexamethasone Treatment Alters Tissue and Circulating Components of the Renin-Angiotensin System in the Pregnant Ewe and Fetus. Endocrinology. 156(8), 3038-46
• KAPAYA, HABIBA, BROUGHTON-PIPKIN, FIONA, HAYES-GILL, BARRIE and LOUGHNA, PAMELA V., 2015. Smoking in pregnancy affects the fetal heart: possible links to future cardiovascular disease JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. 28(14), 1664-1668
• KURLAK LO, WILLIAMS PJ, BULMER JN, BROUGHTON PIPKIN F and MISTRY HD, 2015. Placental expression of adenosine A(2A) receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system. Placenta. 36(5), 611-3
• SMITH-JACKSON K, HENTSCHKE MR, POLI-DE-FIGUEIREDO CE, PINHEIRO DA COSTA BE, KURLAK LO, BROUGHTON PIPKIN F, CZAJKA A and MISTRY HD, 2015. Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia. Placenta. 36(5), 607-10
• KAPAYA H, BROUGHTON-PIPKIN F, HAYES-GILL B and LOUGHNA PV, 2014. Smoking in pregnancy affects the fetal heart: possible links to future cardiovascular disease. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 28(14), 1664-8
• KURLAK, L. O., MISTRY, H. D., KAPTEIN, E., VISSER, T. J. and BROUGHTON PIPKIN, F., 2013. Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy: Placenta 34(5), 395-400
• ROBERTS A, GREEN A, LOUGHNA P and BROUGHTON-PIPKIN F, 2013. PP074. Persistent proteinuria after a pre-eclamptic pregnancy. Pregnancy hypertension. 3(2), 94
• ROBERTS A, GREEN A, LOUGHNA P and BROUGHTON PIPKIN F, 2013. PP075. Poor renal function following hypertensive pregnancy: Older mothers and smaller babies. Pregnancy hypertension. 3(2), 94-5
• STREVENS H, KURLAK L, MISTRY H, HANSEN A and BROUGHTON PIPKIN F, 2013. PP039. ETK/BMX and renin-angiotensin system (RAS) components are differentially expressed in renal tissue in both normal and preeclamptic pregnancy. Pregnancy hypertension. 3(2), 81
• KURLAK L, MISTRY H, CINDROVA-DAVIES T, VAN PATOT MT, BURTON G and BROUGHTON PIPKIN F, 2013. PP018. Does altitude affect the placental renin angiotensin system (RAS) in pre-eclampsia (PE)? Pregnancy hypertension. 3(2), 74
• HENTSCHKE M, SMITH-JACKSON K, POLI-DE-FIGUEIREDO CE, COSTA BE, KURLAK LO, BROUGHTON PIPKIN F, CZAJKA A and MISTRY HD, 2013. PP011. Placental expression of the major protein components of caveolae, eNOS and iNOS in pre-eclampsia. Pregnancy hypertension. 3(2), 71
• KURLAK LO, MISTRY HD, KAPTEIN E, VISSER TJ and BROUGHTON PIPKIN F, 2013. Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy. Placenta. 34(5), 395-400
• PIJACKA W, HUNTER MG, BROUGHTON PIPKIN F and LUCK MR, 2013. Expression of renin-angiotensin system components in the early bovine embryo. Endocrine connections. 1(1), 22-30
• GREEN A, LOUGHNA P and BROUGHTON PIPKIN F, 2012. OS102. Continuing pathology following a hypertensive pregnancy and the risk of future disease. Pregnancy hypertension. 2(3), 235
• MISTRY HD, KURLAK LO, WHITLEY GS, CARTWRIGHT JE, TRIBE RM and BROUGHTON PIPKIN F, 2012. OS081. Novel KCNQ3/KCNE5 isoform protein and mRNA expression in first trimester human placentae. Pregnancy hypertension. 2(3), 221-2
• VON DADELSZEN, P., PAYNE, B, LI, J., ANSERMINO, J.M., PIPKIN, F.B., COTE, A., DOUGLAS, M.J., GRUSLIN, A., HUTCHEON, J.A., JOSEPH, K.S., KYLE, P.M., LEE, T., LOUGHNA, P., MENZIES, J.M., MERIALDI, M., MILLMAN, A.L., MOORE, M.P., MOUTQUIN, J., OUELLET, A.B., SMITH, G.N., WALKER, J.J., WALLEY, K.R., WALTERS, B.N., WIDMER, M., LEE, S.K., RUSSELL, J.A. and MAGEE, L.A., 2011. Prediction of adverse maternal outcomes In pre-eclampsia: development and validation of the fullPIERS model Lancet. 377(9761), 219-227
• MISTRY HD, BROUGHTON PIPKIN F, REDMAN CW and POSTON L, 2011. Selenium in reproductive health. American journal of obstetrics and gynecology. 206(1), 21-30
• WILLIAMS PJ, MISTRY HD, INNES BA, BULMER JN and BROUGHTON PIPKIN F, 2010. Expression of AT1R, AT2R and AT4R and their roles in extravillous trophoblast invasion in the human. Placenta. 31(5), 448-55
• ZHOU A, CARRELL RW, MURPHY MP, WEI Z, YAN Y, STANLEY PL, STEIN PE, BROUGHTON PIPKIN F, READ RJ,