Contact

• workRoom E62 The University of Nottingham Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30185
• fax0115 82 30142
• michael.randall@nottingham.ac.uk

Research Summary

Interests

• Vascular endothelium (especially the endothelium-derived hyperpolarizing factor, EDHF).
• Vascular actions of sex hormones.
• Cardiac ischaemia.

Techniques

• Isolated perfused blood vessels.
• Wire myography.
• Langendorff preparation

Projects

• Vascular actions of cannabinoids (funded by the British Heart Foundation).
• Vascular actions of sex hormones (funded by the Thai Government).

Recent Publications

• WONG PS, ROBERTS RE and RANDALL MD, 2015. Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide. Pharmacological research : the official journal of the Italian Pharmacological Society. 91, 29-35
• WONG, PUI SAN, ROBERTS, RICHARD E. and RANDALL, MICHAEL D., 2015. Sex differences in the role of transient receptor potential (TRP) channels in endothelium-dependent vasorelaxation in porcine isolated coronary arteries EUROPEAN JOURNAL OF PHARMACOLOGY. 750, 108-117
• WONG, PUI SAN, RANDALL, MICHAEL D. and ROBERTS, RICHARD E., 2015. Sex differences in the role of NADPH oxidases in endothelium-dependent vasorelaxation in porcine isolated coronary arteries VASCULAR PHARMACOLOGY. 72, 83-92
• WHEAL AJ, CIPRIANO M, FOWLER CJ, RANDALL MD and O'SULLIVAN SE, 2014. Cannabidiol improves vasorelaxation in Zucker diabetic fatty rats through cyclooxygenase activation. The Journal of pharmacology and experimental therapeutics. 351(2), 457-66

• View all publications

Future Research

Research is centred on vascular regulation by the endothelium, with a special interest in the endothelium-derived hyperpolarizing factor (EDHF).

• WONG PS, ROBERTS RE and RANDALL MD, 2015. Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide. Pharmacological research : the official journal of the Italian Pharmacological Society. 91, 29-35
• WONG, PUI SAN, ROBERTS, RICHARD E. and RANDALL, MICHAEL D., 2015. Sex differences in the role of transient receptor potential (TRP) channels in endothelium-dependent vasorelaxation in porcine isolated coronary arteries EUROPEAN JOURNAL OF PHARMACOLOGY. 750, 108-117
• WONG, PUI SAN, RANDALL, MICHAEL D. and ROBERTS, RICHARD E., 2015. Sex differences in the role of NADPH oxidases in endothelium-dependent vasorelaxation in porcine isolated coronary arteries VASCULAR PHARMACOLOGY. 72, 83-92
• WHEAL AJ, CIPRIANO M, FOWLER CJ, RANDALL MD and O'SULLIVAN SE, 2014. Cannabidiol improves vasorelaxation in Zucker diabetic fatty rats through cyclooxygenase activation. The Journal of pharmacology and experimental therapeutics. 351(2), 457-66
• WONG PS, GARLE MJ, ALEXANDER SPH, RANDALL MD and ROBERTS RE, 2014. A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries. Pharmacological research : the official journal of the Italian Pharmacological Society. 90, 25-35
• WONG PS, ROBERTS RE and RANDALL MD, 2014. Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions? British journal of pharmacology. 171(11), 2751-66
• WHEAL, A.J., ALEXANDER, S.P.H. and RANDALL, M.D., 2012. Hydrogen peroxide as a mediator of vasorelaxation evoked by N-oleoylethanolamine and anandamide in rat small mesenteric arteries European Journal Of Pharmacology. 674(2-3), 384-390
• HOPPS, J.J., DUNN, W.R. and RANDALL, M.D., 2012. Vasorelaxation to capsaicin and its effects on calcium influx in arteries. European Journal of Pharmacology. 681, 88-93
• RANDALL, M.D., KENDALL, D.A. and ALEXANDER, S.P.H., 2012. Fast Track Pharmacology Second edition.
• HOPPS, J.J., DUNN, W.R. and RANDALL, M.D., 2012. Enhanced vasorelaxant effects of the endocannabinoid-like mediator, oleamide, in hypertension. European Journal of Pharmacology. 684, 102-107
• WHEAL, A.J., ALEXANDER, S.P.H. and RANDALL, M.D., 2010. Vasorelaxation to N-oleoylethanolamine in rat isolated arteries: mechanisms of action and modulation via cyclooxygenase activity British Journal of Pharmacology. 160(3), 701-711
• TEP-AREENAN, P., INGKANINAN, K. and RANDALL, M.D., 2010. Mechanisms of Kaempferia parviflora extract (KPE)-induced vasorelaxation in the rat aorta Asian Biomedicine. 4, 103-111
• O'SULLIVAN SE, KENDALL DA, RANDALL MD., 2009. Time-Dependent Vascular Effects of Endocannabinoids Mediated by Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma). PPAR Research. Volume 2009, 425289
• WHEAL, A.J. and RANDALL, M.D., 2009. Effects of hypertension on vasorelaxation to endocannabinoids in vitro European Journal of Pharmacology. 603(1-3), 79-85
• O'SULLIVAN, S.E., SUN, Y., BENNETT, A.J., RANDALL, M.D. and KENDALL, D.A., 2009. Time-dependent vascular actions of cannabidiol in the rat aorta European Journal of Pharmacology. 612(1-3), 61-68
• RANDALL, M.D. and NEIL, K.E., 2009. Disease Management: A guide to clinical pharmacology Second edition. Pharmaceutical Press.
• RANDALL, M.D., KENDALL, D.A. and ALEXANDER, S.P.H., 2009. Fast Track Pharmacology First edition. Pharmaceutical Press.
• HO, W-S.V., BARRETT, D.A. and RANDALL, M.D., 2008. ‘Entourage’ effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors British Journal of Pharmacology. 155(6), 837-846
• RANDALL, MICHAEL D, KENDALL, DAVID A, BENNETT, ANDREW J and O'SULLIVAN, SAOIRSE E, 2007. Rimonabant in obese patients with type 2 diabetes. Lancet. 369(9561), 555
• ALEXANDER, S P H and RANDALL, M, 2007. Cannabinoids and their actions. British Journal of Pharmacology. 152(5), 557-8
• O'SULLIVAN, S.E., RANDALL, M.D. and GARDINER, S.M, 2007. The in vitro and in vivo cardiovascular effects of Delta9-tetrahydrocannabinol in rats made hypertensive by chronic inhibition of nitric-oxide synthase. Journal of Pharmacology and Experimental Therapeutics. 321(2), 663-672
• WHEAL, A J, BENNETT, T, RANDALL, M D and GARDINER, S M, 2007. Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats. British Journal of Pharmacology. 152(5), 717-24
• WHEAL, A J, BENNETT, T, RANDALL, M D and GARDINER, S M, 2007. Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro. British Journal of Pharmacology. 150(5), 662-71
• HO, W-S V and RANDALL, M D, 2007. Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. British Journal of Pharmacology. 150(5), 641-51
• RANDALL, M D, 2007. Endocannabinoids and the haematological system. British Journal of Pharmacology. 152(5), 671-5
• WHEAL, AJ, BENNETT, T, RANDALL, MD and GARDINER, SM, 2007. Cardiovascular Effects Of Cannabinoids In Conscious Spontaneously Hypertensive Rats British Journal Of Pharmacology. 152(5), 717-724
• RANDALL, MD, KENDALL, DA, BENNETT, AJ and O'SULLIVAN, SE, 2007. Rimonabant In Obese Patients With Type 2 Diabetes
• CLARKE, ZL, MOAT, SJ, MILLER, AL, RANDALL, MD, LEWIS, MJ and LANG, D, 2006. Differential Effects Of Low And High Dose Folic Acid On Endothelial Dysfunction In A Murine Model Of Mild Hyperhomocysteinaemia European Journal Of Pharmacology. 551(1-3), 92-97
• O'SULLIVAN, SE, KENDALL, DA and RANDALL, MD, 2006. Further Characterization Of The Time-Dependent Vascular Effects Of Delta(9)-Tetrahydrocannabinol Journal Of Pharmacology And Experimental Therapeutics. 317(1), 428-438
• O'SULLIVAN, S.E., KENDALL, D.A and RANDALL, M.D, 2005. The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide. British Journal of Pharmacology. 145(4), 514-526
• O'SULLIVAN, SE, TARLING, EJ, BENNETT, AJ, KENDALL, DA and RANDALL, MD, 2005. Novel Time-Dependent Vascular Actions Of Delta(9)-Tetrahydrocannabinol Mediated By Peroxisome Proliferator-Activated Receptor Gamma Biochemical And Biophysical Research Communications. 337(3), 824-831
• RANDALL, MD, 2005. The Cardiovascular Actions Of Anandamide: More Targets?
• O'SULLIVAN, SE, KENDALL, DA and RANDALL, MD, 2005. The Effects Of Delta(9)-Tetrahydrocannabinol In Rat Mesenteric Vasculature, And Its Interactions With The Endocannabinoid Anandamide British Journal Of Pharmacology. 145(4), 514-526
• O'SULLIVAN, SE, KENDALL, DA and RANDALL, MD, 2005. Vascular Effects Of Delta(9)-Tetrahydrocannabinol (Thc), Anandamide And N-Arachidonoyldopamine (Nada) In The Rat Isolated Aorta European Journal Of Pharmacology. 507(1-3), 211-221
• O'SULLIVAN, S.E., KENDALL, D.A. and RANDALL, M.D, 2004. Heterogeneity in the mechanisms of vasorelaxation to anandamide in resistance and conduit rat mesenteric arteries. British Journal of Pharmacology. 142(3), 435-42
• O'SULLIVAN, S.E., KENDALL, D.A. and RANDALL, M.D, 2004. Characterisation of the vasorelaxant properties of the novel endocannabinoid N-arachidonoyl-dopamine (NADA). British Journal of Pharmacology. 141(5), 803-812
• RANDALL, MD, KENDALL, DA and O'SULLIVAN, S, 2004. The Complexities Of The Cardiovascular Actions Of Cannabinoids
• O'SULLIVAN, SE, KENDALL, DA and RANDALL, MD, 2004. Characterisation Of The Vasorelaxant Properties Of The Novel Endocannabinoid N-Arachidonoyl-Dopamine (Nada) British Journal Of Pharmacology. 141(5), 803-812
• TEP-AREENAN, P., KENDALL, D. A. and RANDALL, M. D., 2003. Mechanisms of vasorelaxation to testosterone in the rat aorta European Journal of Pharmacology. VOL 465(NUMBER 1-2), 125-132
• TEP-AREENAN, P., KENDALL, D. A. and RANDALL, M. D., 2003. Mechanisms of vasorelaxation to 17b-oestradiol in rat arteries European Journal of Pharmacology. VOL 476(NUMBER 1-2), 139-149
• RANDALL, M. D., 2003. A New Endothelial Target for Cannabinoids ? Molecular Pharmacology. VOL 63(PART 3), 469-470
• O'SULLIVAN, SE, KENDALL, DA and RANDALL, MD, 2003. Evidence for cannabinoid-induced contractions in the rat isolated aorta In: Meeting of the British-Pharmacological-Society. -
• KENNY, L.C., BAKER, P.N., KENDALL, D.A., RANDALL, M.D. and DUNN, W.R, 2002. Differential mechanisms of endothelium-dependent vasodilator responses in human myometrial small arteries in normal pregnancy and pre-eclampsia. Clinical Science. 103(1), 67-73
• HARRIS, D., MCCULLOCH, A.I., KENDALL, D.A. and RANDALL, M.D, 2002. Characterization of vasorelaxant responses to anandamide in the rat mesenteric arterial bed. Journal of Physiology. 539(3), 893-902
• KENNY, L.C., BAKER, P.N., KENDALL, D.A., RANDALL, M.D. and DUNN, W.R, 2002. The role of gap junctions in mediating endothelium-dependent responses to bradykinin in myometrial small arteries isolated from pregnant women British Journal of Pharmacology. 136(8), 1085-1088
• TEP-AREENAN, P., KENDALL, D.A. and RANDALL, M.D, 2002. Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels. British Journal of Pharmacology. 135(3), 735-740
• RANDALL, M. D., HARRIS, D., KENDALL, D. A. and RALEVIC, V., 2002. Cardiovascular effects of cannabinoids Pharmacology and Therapeutics. VOL 95(NUMBER 2), 191-202
• RALEVIC, VERA, KENDALL, DAVID A, RANDALL, MICHAEL D and SMART, DARREN, 2002. Cannabinoid modulation of sensory neurotransmission via cannabinoid and vanilloid receptors: roles in regulation of cardiovascular function. Life Sciences. 71(22), 2577-94