Contact

• workRoom E34e The University of Nottingham Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30190
• fax0115 82 30142
• richard.roberts@nottingham.ac.uk

Research Summary

Cardiovascular pharmacology including the study of signal transduction pathways that mediate vasoconstriction.Techniques include tissue bath experiments, SDS-PAGE electrophoresis, Western blotting,… read more

Recent Publications

• CURRY, LIAM, ALMUKHTAR, HANI, ALAHMED, JALA, ROBERTS, RICHARD and SMITH, PAUL A, 2019. Simvastatin inhibits L-type Ca2+-channel activity through impairment of mitochondrial function. Toxicological sciences : an official journal of the Society of Toxicology.
• LEE, MEI KEE, LI, XIAOJIE, YAP, ALVIN CHEE SUM, CHEUNG, PETER CHI KEUNG, TAN, CHON SENG, NG, SZU TING, ROBERTS, RICHARD, TING, KANG NEE and FUNG, SHIN YEE, 2018. Airway Relaxation Effects of Water-Soluble Sclerotial Extract From Lignosus rhinocerotis FRONTIERS IN PHARMACOLOGY. 9,
• ABDULLA AHMAD, MICHAEL RANDALL and RICHARD ROBERTS, 2017. Sex differences in the regulation of porcine coronary artery tone by perivascular adipose tissue: a role of adiponectin? British Journal of Pharmacology. (In Press.)
• AHMAD A and RANDAL MD, 2017. Sex differences in the role of phospholipase A2-dependent arachidonic acid pathway in the perivascular adipose tissue function in pigs Journal of Physiology: J Physiol. (In Press.)

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Current Research

Cardiovascular pharmacology including the study of signal transduction pathways that mediate vasoconstriction.Techniques include tissue bath experiments, SDS-PAGE electrophoresis, Western blotting, immunoprecipitation, measurement of signalling intermedia

• CURRY, LIAM, ALMUKHTAR, HANI, ALAHMED, JALA, ROBERTS, RICHARD and SMITH, PAUL A, 2019. Simvastatin inhibits L-type Ca2+-channel activity through impairment of mitochondrial function. Toxicological sciences : an official journal of the Society of Toxicology.
• LEE, MEI KEE, LI, XIAOJIE, YAP, ALVIN CHEE SUM, CHEUNG, PETER CHI KEUNG, TAN, CHON SENG, NG, SZU TING, ROBERTS, RICHARD, TING, KANG NEE and FUNG, SHIN YEE, 2018. Airway Relaxation Effects of Water-Soluble Sclerotial Extract From Lignosus rhinocerotis FRONTIERS IN PHARMACOLOGY. 9,
• ABDULLA AHMAD, MICHAEL RANDALL and RICHARD ROBERTS, 2017. Sex differences in the regulation of porcine coronary artery tone by perivascular adipose tissue: a role of adiponectin? British Journal of Pharmacology. (In Press.)
• AHMAD A and RANDAL MD, 2017. Sex differences in the role of phospholipase A2-dependent arachidonic acid pathway in the perivascular adipose tissue function in pigs Journal of Physiology: J Physiol. (In Press.)
• MATTHEY M, ROBERTS RE, SEIDINGER A, SIMON A, SCHRODER R, KUSCHAK M, ANNALA S, KONNIG GM, MULLER CE, HALL IP, KOSTENIS E and FLEISCHMANN BK, 2017. Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma Science Translation Medicine. 9(407), 2288
• ALMUKHTAR H, GARLE MJ, SMITH PA and ROBERTS RE, 2016. Effect of simvastatin on vascular tone in porcine coronary artery: Potential role of the mitochondria. Toxicology and applied pharmacology. 305, 176-185
• SHANG VC, KENDALL DA and ROBERTS RE, 2016. Δ(9)-Tetrahydrocannabinol reverses TNFα-induced increase in airway epithelial cell permeability through CB2 receptors. Biochemical pharmacology. 120, 63-71
• SHANG VCM, O'SULLIVAN SE, KENDALL DA and ROBERTS RE, 2016. The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite Pharmacological Research. 105, 152-163
• WONG PS, ROBERTS RE and RANDALL MD, 2015. Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide. Pharmacological research : the official journal of the Italian Pharmacological Society. 91, 29-35
• WONG, PUI SAN, ROBERTS, RICHARD E. and RANDALL, MICHAEL D., 2015. Sex differences in the role of transient receptor potential (TRP) channels in endothelium-dependent vasorelaxation in porcine isolated coronary arteries EUROPEAN JOURNAL OF PHARMACOLOGY. 750, 108-117
• WONG, PUI SAN, RANDALL, MICHAEL D. and ROBERTS, RICHARD E., 2015. Sex differences in the role of NADPH oxidases in endothelium-dependent vasorelaxation in porcine isolated coronary arteries VASCULAR PHARMACOLOGY. 72, 83-92
• DUNN WR, ALEXANDER SP, RALEVIC V and ROBERTS RE, 2015. Effects of hydrogen sulphide in smooth muscle. Pharmacology & therapeutics. 158, 101-13
• DUNN WR, ALEXANDER SP, RALEVIC V and ROBERTS RE, 2015. Effects of hydrogen sulphide in smooth muscle Pharmacology and Therapeutics. 158, 101-113
• ROBERTS, RICHARD E., 2015. Potential role of hydrogen sulphide from 3-mercaptopyruvate sulphurtransferase (3-MST) in epithelium-dependent relaxation of the airways NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 47, S19-S20
• WONG, PUI SAN, ROBERTS, RICHARD E. and RANDALL, MICHAEL D., 2015. Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide PHARMACOLOGICAL RESEARCH. 91, 29-35
• WONG PS, GARLE MJ, ALEXANDER SPH, RANDALL MD and ROBERTS RE, 2014. A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries. Pharmacological research : the official journal of the Italian Pharmacological Society. 90, 25-35
• WONG PS, ROBERTS RE and RANDALL MD, 2014. Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions? British journal of pharmacology. 171(11), 2751-66
• WONG, P. S., GARLE, M. J., ALEXANDER, S. P. H., RANDALL, M. D. and ROBERTS, R. E., 2014. A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries PHARMACOLOGICAL RESEARCH. 90, 25-35
• RASHID, S., HEER, J.K., GARLE, M.J., ALEXANDER, S.P.H. and ROBERTS, R.E., 2013. Hydrogen sulphide-induced relaxation of porcine peripheral bronchioles British Journal of Pharmacology. 168(8), 1902-1910
• ROBERTS RE, ALLEN S, CHANG APY, HENDERSON H, HOBSON GC, KARANIA B, MORGAN KN, PEK ASY, RAGHVANI K, SHEE CY, SHIKOTRA J, STREET E, ABBAS Z, ELLIS K, HEER JK and ALEXANDER SPH, 2013. Distinct mechanisms of relaxation to bioactive components from Chamomile species in porcine isolated blood vessels. Toxicology and applied pharmacology. (In Press.)
• UHIARA CO, ALEXANDER SPH and ROBERTS RE, 2012. Simvastatin evokes an unpredicted inhibition of β-adrenoceptor-mediated vasodilatation in porcine coronary artery. European journal of pharmacology. 690(1-3), 158-63
• ROBERTS RE, 2012. The extracellular signal-regulated kinase (ERK) pathway: A potential therapeutic target in hypertension. Journal of Experimental Pharmacology. 4, 1-7
• ROBERTS, R.E., 2012. Pre-contraction with the thromboxane-mimetic U46619 enhances P2X receptor-mediated contractions in the porcine splenic artery Purinergic Signalling. 8(2), 287-293
• LELLIOTT, A., NIKKAR-ESFAHANI, A., OFFER, J., ORCHARD, P. and ROBERTS, R.E., 2012. The role of extracellular-signal regulate kinase (ERK) in the regulation of airway tone in porcine isolated peripheral bronchioles European Journal of Pharmacology. 674(2-3), 407-414
• UHIARA, C.O., ALEXANDER, S.P.H. and ROBERTS, R.E., 2009. Effect of inhibition of extracellular signal-regulated kinase on relaxations to β-adrenoceptor agonists in porcine isolated blood vessels British Journal of Pharmacology. 158(7), 1713-1719
• BHATTACHARYA, B., WILLIAMS, R., LATIF, M.L. and ROBERTS, R.E, 2005. Role of cytosolic phospholipase A2 in the enhancement of alpha2-adrenoceptor-mediated vasoconstriction by the thromboxane-mimetic U46619 in the porcine isolated ear artery: comparison with vasopressin-enhanced responses. Biochemical Pharmacology. 70(8), 1200-1210
• ROBERTS, R.E, 2004. The role of Rho kinase and extracellular regulated kinase-mitogen-activated protein kinase in alpha2-adrenoceptor-mediated vasoconstriction in the porcine palmar lateral vein. Journal of Pharmacology and Experimental Therapeutics. 311(2), 742-747
• ROBERTS, R.E, 2003. Alpha 2 adrenoceptor-mediated vasoconstriction in porcine palmar lateral vein: role of phosphatidylinositol 3-kinase and EGF receptor transactivation. British Journal of Pharmacology. 138(1), 107-116
• BHATTACHARYA, B and ROBERTS, R E, 2003. Enhancement of alpha2-adrenoceptor-mediated vasoconstriction by the thromboxane-mimetic U46619 in the porcine isolated ear artery: role of the ERK-MAP kinase signal transduction cascade. British Journal of Pharmacology. 139(1), 156-62
• ROBERTS, R.E, 2001. Role of the extracellular signal-regulated kinase (Erk) signal transduction cascade in alpha(2) adrenoceptor-mediated vasoconstriction in porcine palmar lateral vein. British Journal of Pharmacology. 133(6), 859-866
• PEKINER, C, DENT, E W, ROBERTS, R E, MEIRI, K F and MCLEAN, W G, 1996. Altered GAP-43 immunoreactivity in regenerating sciatic nerve of diabetic rats. Diabetes. 45(2), 199-204