Marie-Christine Pardon

Contact

• workRoom E65 The University of Nottingham Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30149
• fax0115 82 30142
• marie.pardon@nottingham.ac.uk

Research Summary

Stress is a normal part of life and the way we deal with it is crucial to the development of many mental diseases, ageing and most importantly age-related and neurodegenerative disorders, but the… read more

Selected Publications

• PARDON MC, YANEZ LOPEZ M, YUCHUN D, MARJAŃSKA M, PRIOR M, BRIGNELL C, PARHIZKAR S, AGOSTINI A, BAI L, AUER DP and FAAS HM, 2016. Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models. Scientific reports. 6, 19880
• GEISZLER PC, BARRON MR and PARDON MC, 2016. Impaired burrowing is the most prominent behavioral deficit of aging htau mice. Neuroscience. 329, 98-111
• DING Y, PARDON MC, AGOSTINI A, FAAS H, DUAN J, WARD WO, EASTON F, AUER D and BAI L, 2016. Novel Methods for Microglia Segmentation, Feature Extraction and Classification. IEEE/ACM transactions on computational biology and bioinformatics. (In Press.)
• EBADA ME, KENDALL DA and PARDON MC, 2016. Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice Behavioural brain research. 311, 228-238

• View all publications

Current Research

Stress is a normal part of life and the way we deal with it is crucial to the development of many mental diseases, ageing and most importantly age-related and neurodegenerative disorders, but the underlying mechanisms remain largely unknown. The focus of my research is to understand the mechanisms underlying behavioural and cognitive changes relevant to psychiatric diseases, normal aging and neurodegenerative diseases, occurring as a result of exposure to stress and/or vulnerability to stressful events, with the aim to identify novel targets for therapeutic strategies. Dr Pardon's research is highly interdisciplinary and translational, combining behavioural, pharmacological, molecular and magnetic resonance imaging (MRI) approaches to gain understanding on how stress influences aging and brain diseases using rodent models of these conditions, thereby providing a basis for clinical investigations and development of treatment strategies.

Research in Dr Pardon's group focuses on the following themes: -Identifying the stress pathways involved in the progression of Alzheimer's-like pathology that can be targeted for the development of novel treatment strategies -Understanding how the rewarding properties of the stress hormone corticosterone influence cognitive function - Modelling post-partum depression with the ultimate aim of improving our understanding of the mechanisms involved and the development of improved therapeutic strategies - Understanding how prenatal stress influences brain development and aging

• LOPEZ, MARIA YANEZ, PARDON, MARIE-CHRISTINE, BAIKER, KERSTIN, PRIOR, MALCOLM, DING YUCHUN, AGOSTINI, ALESSANDRA, BAI, LI, AUER, DOROTHEE P. and FAAS, HENRYK M., 2019. Myoinositol CEST signal in animals with increased Iba-1 levels in response to an inflammatory challenge-Preliminary findings PLOS ONE. 14(2),
• AGOSTINI, ALESSANDRA, YUCHUN, DING, LI, BAI, KENDALL, DAVID A and PARDON, MARIE-CHRISTINE, 2019. Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Brain, behavior, and immunity.
• GEISZLER PC, UGUN-KLUSEK A, LAWLER K, PARDON MC, YUCHUN D, BAI L, DAYKIN CA, AUER DP and BEDFORD L, 2018. Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons. Scientific reports. 8(1), 4833
• PARDON MC, 2018. Anti-inflammatory potential of thymosin β4 in the central nervous system: implications for progressive neurodegenerative diseases. Expert opinion on biological therapy. 18(sup1), 165-169
• OYEGBAMI O, COLLINS HM, PARDON MC, EBLING FJ, HEERY DM and MORAN PM, 2017. Abnormal clock gene expression and locomotor activity rhythms in two month-old female APPSwe/PS1dE9 mice. Current Alzheimer research. 14, 850-860
• ROSSI F, GEISZLER PC, MENG W, BARRON MR, PRIOR M, HERD-SMITH A, LORETO A, LOPEZ MY, FAAS H, PARDON MC and CONFORTI L, 2017. NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy. Behavioural brain research. 339, 140-152
• DING, YUCHUN, PARDON, MARIE CHRISTINE, AGOSTINI, ALESSANDRA, FAAS, HENRYK, DUAN, JINMING, WARD, WIL O. C., EASTON, FELICITY, AUER, DOROTHEE and BAI, LI, 2017. Novel Methods for Microglia Segmentation, Feature Extraction, and Classification IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS. 14(6), 1366-1377
• EBADA ME, KENDALL DA and PARDON MC, 2016. Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice Behavioural brain research. 311, 228-238
• PARDON MC, YANEZ LOPEZ M, YUCHUN D, MARJAŃSKA M, PRIOR M, BRIGNELL C, PARHIZKAR S, AGOSTINI A, BAI L, AUER DP and FAAS HM, 2016. Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models. Scientific reports. 6, 19880
• GEISZLER PC, BARRON MR and PARDON MC, 2016. Impaired burrowing is the most prominent behavioral deficit of aging htau mice. Neuroscience. 329, 98-111
• M. YOUNG, P. C. GEISZLER and M. PARDON, 2016. A novel role for the immunophilin FKBP52 in motor coordination. Behavioural Brain Research. 313, 97-110
• BONARDI C., PARDON M-C. and ARMSTRONG P., 2016. Deficits in object-in-place but not relative recency performance in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Implications for object recognition. Behavioural Brain Research. 313, 71-81
• DING Y, PARDON MC, AGOSTINI A, FAAS H, DUAN J, WARD WO, EASTON F, AUER D and BAI L, 2016. Novel Methods for Microglia Segmentation, Feature Extraction and Classification. IEEE/ACM transactions on computational biology and bioinformatics. (In Press.)
• BARRON M, GARTLON J, DAWSON LA, ATKINSON PJ and PARDON MC, 2016. A state of delirium: Deciphering the effect of inflammation on tau pathology in Alzheimer's disease. Experimental gerontology. (In Press.)
• AGOSTINI, ALESSANDRA, PARHIZKAR, SAMIRA, KNAPP, STACEY, EBLING, FRANCIS and PARDON, MARIE-CHRISTINE, 2015. Gender differences in appswe/ps1de9 mice model of Alzheimer's disease in response to LPS-induced immune challenge EXPERIMENTAL GERONTOLOGY. 68, 98-99
• PARDON, MARIE-CHRISTINE, 2015. Lipopolysaccharide hyporesponsiveness: protective or damaging response to the brain? ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY. 56(3), 903-913
• ROSSI, FRANCESCA, MENG, WEINA, GEISZLER, PHILIPPINE C., PRIOR, MALCOLM, HERD-SMITH, ANNA, LORETO, ANDREA, FAAS, HENRYK, LOPEZ, MARIA YANEZ, PARDON, MARIE-CHRISTINE and CONFORTI, LAURA, 2015. NAD-biosynthetic enzyme NMNAT1 reduces early behavioral abnormalities in the htau mouse model of tauopathy EXPERIMENTAL GERONTOLOGY. 68, 96-96
• MAROOF N, RAVIPATI S, PARDON MC, BARRETT DA and KENDALL DA, 2014. Reductions in Endocannabinoid Levels and Enhanced Coupling of Cannabinoid Receptors in the Striatum are Accompanied by Cognitive Impairments in the AβPPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 42, 227-45
• EBADA, MOHAMED ELSAED, LATIF, LIAQUE M., KENDALL, DAVID A. and PARDON, MARIE-CHRISTINE, 2014. Corticosterone protects against memory impairments and reduced hippocampal BDNF levels induced by a chronic low dose of ethanol in C57BL/6J mice ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY. 55(4), 1303-1316
• PARDON, M. -C., HIDAYAH, A. -A. and TRIST, A., 2014. Antidepressant treatment in a model of post-partum depression age- and gender-dependently alter offspring's CNS development INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 17, 28-29
• SCULLION, G.A., HEWITT, K.N. and PARDON, M.-C., 2013. Corticotropin-releasing factor receptor 1 activation during exposure to novelty stress protects against Alzheimer's disease-like cognitive decline in AβPP/PS1 mice Journal of Alzheimer's Disease. 34(3), 781-793
• SCULLION, G.A., KENDALL, D.A., MARSDEN, C.A., SUNTER, D. and PARDON, M.-C., 2011. Chronic treatment with the α₂-adrenoceptor antagonist fluparoxan prevents age-related deficits in spatial working memory in APP × PS1 transgenic mice without altering β-amyloid plaque load or astrocytosis Neuropharmacology. 60(2-3), 223-234
• BONARDI, C., DE PULFORD, F., JENNINGS, D. and PARDON, M.C., 2011. A detailed analysis of the early context extinction deficits seen in APPswe/PS1dE9 female mice and their relevance to pre-clinical Alzheimer’s disease Behavioural Brain Research. 222(1), 89-97
• PARDON, MARIE-CHRISTINE, 2010. Therapeutic potential of some stress mediators in early Alzheimer's disease. Experimental gerontology.
• RATTRAY, I., PITIOT, A., LOWE, J., AUER, D.P., LIMA, S.J., SCHUBERT, M.I., PRIOR, M.J.W., MARSDEN, C.A., DIAZ, F.P., KENDALL, D.A. and PARDON, M.C., 2010. Novel cage stress alters remote contextual fear extinction and regional T₂ magnetic resonance relaxation times in TASTPM mice overexpressing amyloid Journal of Alzheimer's Disease. 20(4), 1049-1068
• PARDON, M.C., SARMAD, S., RATTRAY, I., BATES, T.E., SCULLION, G.A., MARSDEN, C.A., BARRETT, D.A., LOWE, J. and KENDALL, D.A., 2009. Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels Neurobiology of Aging. 30(7), 1099-1113
• SCULLION, G.A., KENDALL, D.A., SUNTER, D., MARSDEN, C.A. and PARDON, M.-C., 2009. Central noradrenergic depletion by DSP-4 prevents stress-induced memory impairments in the object recognition task. Neuroscience. 164(2), 415-423
• RATTRAY, I, SCULLION, GA, SOULBY, A, KENDALL, DA and PARDON, MC, 2009. The Occurrence Of A Deficit In Contextual Fear Extinction In Adult Amyloid-Over-Expressing Tastpm Mice Is Independent Of The Strength Of Conditioning But Can Be Prevented By Mild Novel Cage Stress Behavioural Brain Research. 200(1), 83-90
• MISDRAHI, D, PARDON, MC, PEREZ-DIAZ, F, HANOUN, N and COHEN-SALMON, C, 2005. Prepartum Chronic Ultramild Stress Increases Corticosterone And Estradiol Levels In Gestating Mice: Implications For Postpartum Depressive Disorders Psychiatry Research. 137(1-2), 123-130
• PARDON, MC, ROBERTS, RE, MARSDEN, CA, BIANCHI, M, LATIF, ML, DUXON, MS and KENDALL, DA, 2005. Social Threat And Novel Cage Stress-Induced Sustained Extracellular-Regulated Kinase1/2 (Erk112) Phosphorylation But Differential Modulation Of Brain-Derived Neurotrophic Factor (Bdnf) Expression In The Hippocampus Of Nmri Mice Neuroscience. 132(3), 561-574
• NEGRONI, J, VENAULT, P, PARDON, MC, PEREZ-DIAZ, F, CHAPOUTHIER, G and COHEN-SALMON, C, 2004. Chronic Ultra-Mild Stress Improves Locomotor Performance Of B6d2f1 Mice In A Motor Risk Situation Behavioural Brain Research. 155(2), 265-273
• PARDON, MC, KENDALL, DA, PEREZ-DIAZ, F, DUXON, MS and MARSDEN, CA, 2004. Repeated Sensory Contact With Aggressive Mice Rapidly Leads To An Anticipatory Increase In Core Body Temperature And Physical Activity That Precedes The Onset Of Aversive Responding European Journal Of Neuroscience. 20(4), 1033-1050
• PARDON, MC, HANOUN, N, PEREZ-DIAZ, F, JOUBERT, C, LAUNAY, JM, CHRISTEN, Y, HAMON, M and COHEN-SALMON, C, 2004. Long-Term Treatment With The Antioxidant Drug Egb 761 At Senescence Restored Some Neurobehavioral Effects Of Chronic Ultramild Stress Exposure Seen In Young Mice Neurobiology Of Aging. 25(8), 1067-1083
• BENMANSOUR, S, ALTAMIRANO, AV, JONES, DJ, SANCHEZ, TA, GOULD, GG, PARDON, MC, MORILAK, DA and FRAZER, A, 2004. Regulation Of The Norepinephrine Transporter By Chronic Administration, Of Antidepressants Biological Psychiatry. 55(3), 313-316
• GOULD, GG, PARDON, MC, MORILAK, DA and FRAZER, A, 2003. Regulatory Effects Of Reboxetine Treatment Alone, Or Following Paroxetine Treatment, On Brain Noradrenergic And Serotonergic Systems Neuropsychopharmacology. 28(9), 1633-1641
• PARDON, MC, MA, S and MORILAK, DA, 2003. Chronic Cold Stress Sensitizes Brain Noradrenergic Reactivity And Noradrenergic Facilitation Of The Hpa Stress Response In Wistar Kyoto Rats Brain Research. 971(1), 55-65
• PARDON, MC, GOULD, GG, GARCIA, A, PHILLIPS, L, COOK, MC, MILLER, SA, MASON, PA and MORILAK, DA, 2002. Stress Reactivity Of The Brain Noradrenergic System In Three Rat Strains Differing In Their Neuroendocrine And Behavioral Responses To Stress: Implications For Susceptibility To Stress-Related Neuropsychiatric Disorders Neuroscience. 115(1), 229-242
• PARDON, MC, PEREZ-DIAZ, F, JOUBERT, C and COHEN-SALMON, C, 2000. Age-Dependent Effects Of A Chronic Ultramild Stress Procedure On Open-Field Behaviour In B6d2f1 Female Mice Physiology & Behavior. 70(1-2), 7-13
• PARDON, MC, GERARDIN, P, JOUBERT, C, PEREZ-DIAZ, F and COHEN-SALMON, C, 2000. Influence Of Prepartum Chronic Ultramild Stress On Maternal Pup Care Behavior In Mice Biological Psychiatry. 47(10), 858-863
• PARDON, MC, PEREZ-DIAZ, F, JOUBERT, C and COHEN-SALMON, C, 2000. Influence Of A Chronic Ultramild Stress Procedure On Decision-Making In Mice Journal Of Psychiatry & Neuroscience. 25(2), 167-177
• PARDON, MC, JOUBERT, C, PEREZ-DIAZ, F, CHRISTEN, Y, LAUNAY, JM and COHEN-SALMON, C, 2000. In Vivo Regulation Of Cerebral Monoamine Oxidase Activity In Senescent Controls And Chronically Stressed Mice By Long-Term Treatment With Ginkgo Biloba Extract (Egb 761) Mechanisms Of Ageing And Development. 113(3), 157-168
• LANFUMEY, L, PARDON, MC, LAARIS, N, JOUBERT, C, HANOUN, N, HAMON, M and COHEN-SALMON, C, 1999. 5-Ht1a Autoreceptor Desensitization By Chronic Ultramild Stress In Mice Neuroreport. 10(16), 3369-3374
• COHEN-SALMON, C, VENAULT, P, MARTIN, B, RAFFALLI-SEBILLE, MJ, BARKATS, M, CLOSTRE, F, PARDON, MC, CHRISTEN, Y and CHAPOUTHIER, G, 1997. Effects Of Ginkgo Biloba Extract (Egb 761) On Learning And Possible Actions On Aging Journal Of Physiology-Paris. 91(6), 291-300