Roman Syunyaev

Contact

• workRoom Room C53 Mathematical Sciences
  University Park
  Nottingham
  NG7 2RD
  UK
• Roman.Syunyaev@nottingham.ac.uk

Research Summary

I am currently working with Gary Mirams group on developing and refining the models of cardiac cells and ionic channels. We use mathematical simulations and model optimization to process patch-clamp… read more

Recent Publications

• ABRASHEVA, VERONIKA O, KOVALENKO, SANDAARA G, SLOTVITSKY, MIHAIL, ROMANOVA, SERAFIMA А, AITOVA, ALERIA A, FROLOVA, SHEIDA, TSVELAYA, VALERIA and SYUNYAEV, ROMAN A, 2024. Human sodium current voltage-dependence at physiological temperature measured by coupling a patch-clamp experiment to a mathematical model The Journal of Physiology. 602(4), 633-661
• DEVIATIIAROV, RUSLAN M, GAMS, ANNA, KULAKOVSKIY, IVAN V, BUYAN, ANDREY, MESHCHERYAKOV, GEORGY, SYUNYAEV, ROMAN, SINGH, RAMESH, SHAH, PALAK, TATARINOVA, TATIANA V, GUSEV, OLEG and OTHERS, 2023. An atlas of transcribed human cardiac promoters and enhancers reveals an important role of regulatory elements in heart failure Nature Cardiovascular Research. 2(1), 58-75
• PIKUNOV, ANDREY V, SYUNYAEV, ROMAN A, ALI, RHEEDA, PRAKOSA, ADITYO, BOYLE, PATRICK M, STECKMEISTER, VANESSA, KUTSCHKA, INGO, RYTKIN, ERIC, VOIGT, NIELS, TRAYANOVA, NATALIA and OTHERS, 2023. The role of structural vs cellular remodeling in arrhythmogenesis: personalized computer models of atrial fibrillation bioRxiv. 2023-05
• RYBASHLYKOV, DMITRY, BRENNAN, JACLYN, LIN, ZEXU, EFIMOV, IGOR R and SYUNYAEV, ROMAN, 2022. Open-source low-cost cardiac optical mapping system Plos one. 17(3), e0259174

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Current Research

I am currently working with Gary Mirams group on developing and refining the models of cardiac cells and ionic channels. We use mathematical simulations and model optimization to process patch-clamp data recorded in HEK-293, CHO and iPSC-CM cells. In particular we are currently focused on:

• Using model optimization and experimental artifact models to develop cell-specific models.

• Developing and testing Markov-chain IKr models for cardiac drug-testing applications.

Past Research

My past research was focused on cardiac electrophysiology simulations and process the experimental data underlying the multi-scale models, model parametrization and uncertainty quantification.

In particular I was working on

• Ventricular/atrial cardiomyocyte model personalization using functional and molecular data. We have developed genetic-algorithm based technique that allowed us to estimate ionic channel conductivities using action potential dependence on pacing frequency as input data. This technique could be used to calibrate the model in order to predict action potential waveform using the mRNA expression measurements.

• Ionic channels models. We were working on patch-clamp data recorded in iPSC-derived cardiomyocytes, in particular, we have used the parameter optimization approach to account for voltage-clamp experimental artifacts. This unconventional technique turns out to be very important, for instance, in the case of the fast sodium current, since there is often a large systematic error in the apparent voltage-dependence parameters of the I_Na.

• Atrial fibrillation (AF) simulations. The development of AF is associated with remodeling both on the single-cell level (expression profile changes) and the tissue level (fibrosis). One of the projects addressing the problem was the development of pathology-specific cardiac tissue models that included chronic AF, paroxysmal AF and sinus rhythm patients. We have also devised a novel computationally effective algorithm to locate the reentrant drivers via backtracking the conduction velocity field.

• I have participated in the development of new experimental optical mapping techniques including low-cost panoramic and multiparametric optical mapping.

• Sino-atrial node (SAN) simulations. As a native heart rhythm generator, SAN is particularly interesting due to its complex heterogeneous structure that implies synchronization between the SAN cells and robust SAN-atria interface via the conducting pathways. A number of my past projects were focused on the simulations of normal and pathological propagation in the SAN and surrounding atrial tissue both in animal and human models.

• ABRASHEVA, VERONIKA O, KOVALENKO, SANDAARA G, SLOTVITSKY, MIHAIL, ROMANOVA, SERAFIMA А, AITOVA, ALERIA A, FROLOVA, SHEIDA, TSVELAYA, VALERIA and SYUNYAEV, ROMAN A, 2024. Human sodium current voltage-dependence at physiological temperature measured by coupling a patch-clamp experiment to a mathematical model The Journal of Physiology. 602(4), 633-661
• DEVIATIIAROV, RUSLAN M, GAMS, ANNA, KULAKOVSKIY, IVAN V, BUYAN, ANDREY, MESHCHERYAKOV, GEORGY, SYUNYAEV, ROMAN, SINGH, RAMESH, SHAH, PALAK, TATARINOVA, TATIANA V, GUSEV, OLEG and OTHERS, 2023. An atlas of transcribed human cardiac promoters and enhancers reveals an important role of regulatory elements in heart failure Nature Cardiovascular Research. 2(1), 58-75
• PIKUNOV, ANDREY V, SYUNYAEV, ROMAN A, ALI, RHEEDA, PRAKOSA, ADITYO, BOYLE, PATRICK M, STECKMEISTER, VANESSA, KUTSCHKA, INGO, RYTKIN, ERIC, VOIGT, NIELS, TRAYANOVA, NATALIA and OTHERS, 2023. The role of structural vs cellular remodeling in arrhythmogenesis: personalized computer models of atrial fibrillation bioRxiv. 2023-05
• RYBASHLYKOV, DMITRY, BRENNAN, JACLYN, LIN, ZEXU, EFIMOV, IGOR R and SYUNYAEV, ROMAN, 2022. Open-source low-cost cardiac optical mapping system Plos one. 17(3), e0259174
• PIKUNOV, ANDREY V, SYUNYAEV, ROMAN A, STECKMEISTER, VANESSA, KUTSCHKA, INGO, VOIGT, NIELS and EFIMOV, IGOR R, 2021. Personalization of mathematical models of human atrial action potential In: Smart Modelling For Engineering Systems: Proceedings of the International Conference on Computational Methods in Continuum Mechanics (CMCM 2021), Volume 1. 223-236
• SMIRNOV, DMITRII, PIKUNOV, ANDREY, SYUNYAEV, ROMAN, DEVIATIIAROV, RUSLAN, GUSEV, OLEG, ARAS, KEDAR, GAMS, ANNA, KOPPEL, AARON and EFIMOV, IGOR R, 2020. Genetic algorithm-based personalized models of human cardiac action potential PloS one. 15(5), e0231695
• GAMILOV, TIMUR, KOPYLOV, PHILIPP, SEROVA, MARIA, SYUNYAEV, ROMAN, PIKUNOV, ANDREY, BELOVA, SOFYA, LIANG, FUYOU, ALASTRUEY, JORDI and SIMAKOV, SERGEY, 2020. Computational analysis of coronary blood flow: The role of asynchronous pacing and arrhythmias Mathematics. 8(8), 1205
• CATHEY, BRIANNA, OBAID, SOFIAN, ZOLOTAREV, ALEXANDER M, PRYAMONOSOV, ROMAN A, SYUNYAEV, ROMAN A, GEORGE, SHARON A and EFIMOV, IGOR R, 2019. Open-source multiparametric optocardiography Scientific reports. 9(1), 721
• ZYANTEREKOV, DA, SYUNYAEV, RA, KHARCHE, SR, ATKINSON, A, DOBRZYNSKI, H, MCINTYRE, CW and EFIMOV, IR, 2019. Is insulating border necessary for human sinoatrial node spontaneous activity In: CompBioMed Conference (Multiscale Modelling).
• KARPAEV, ALEXEY A, SYUNYAEV, ROMAN A and ALIEV, RUBIN R, 2018. Effects of fibroblast-myocyte coupling on the sinoatrial node activity: A computational study International journal for numerical methods in biomedical engineering. 34(5), e2966
• GLOSCHAT, CHRISTOPHER, ARAS, KEDAR, GUPTA, SHUBHAM, FAYE, N ROKHAYA, ZHANG, HANYU, SYUNYAEV, ROMAN A, PRYAMONOSOV, ROMAN A, ROGERS, JACK, KAY, MATTHEW W and EFIMOV, IGOR R, 2018. RHYTHM: an open source imaging toolkit for cardiac panoramic optical mapping Scientific reports. 8(1), 2921
• SYUNYAEV, ROMAN A and ALIEV, RUBIN R, 2017. Computer simulations of reentrant activity in the rabbit sinoatrial node International journal for numerical methods in biomedical engineering. 33(2), e02792
• KHOKHLOVA, AD, SYUNYAEV, RA, RYVKIN, AM, SHMARKO, DV, GONOTKOV, MA, LEBEDEVA, EA, GOLOVKO, VA, MOSKVIN, AS, SOLOVYOVA, OE and ALIEV, RR, 2016. The effects of intracellular calcium dynamics on the electrical activity of the cells of the sinoatrial node Biophysics. 61, 893-900
• TOLSTOKOROV, A. S., SYUNYAEV, R.A. and ALIEV, R. R., 2015. Simulation of the Fibroblast Effect on Electrical Activity of Sinoatrial Node Cells Biophysics. 60(2), 322-329
• SYUNYAEV, RA and ALIEV, RR, 2012. Action potential propagation and phase dynamics in the sinoatrial node Russian Journal of Numerical Analysis and Mathematical Modelling. 27(5), 493-506
• SYUNYAEV, RA and ALIEV, RR, 2012. Computer simulation of microreentry in the sinoatrial node Biophysics. 57, 676-680
• SYUNYAEV, RA and ALIEV, RR, 2011. Computer simulation of 3D electrical activity in the sinoatrial node Russ. J. Numer. Anal. Math. Modelling. 26(6), 575-587
• SYUNYAEV, RA and ALIEV, RR, 2010. Computer simulations of pacemaker shift in the sinoatrial node Biophysics. 55(6), 1025-1029
• SYUNYAEV, RA and ALIEV, RR, 2009. Modeling of the influence of gap-junction coupling on synchronization of central and peripheral sinoatrial node cells Biophysics. 54(1), 58-60