Contact

• workBiodiscovery Institute
  University Park
  Nottingham
  NG7 2RD
  UK
• Jacqueline.Shields@nottingham.ac.uk

Biography

Jacqui studied for a Bachelor's degree in Pathology and Microbiology at the University of Bristol completing a PhD in the area of tumour microcirculation and lymphatic vessels in the lab of Professor Dave Bates at Bristol. This is really where her interest in the tumour microenvironment began. In 2005, she moved to Lausanne, Switzerland and the laboratory of Professor Melody Swartz, at the Institute of Bioengineering, EPFL for her post-doctoral training to further specialize in lymphatic functionality, and how this could relate to tumour progression.

In Mid 2011, she was appointed as a Group Leader at the Medical Research Council Cancer Unit, University of Cambridge, where she started a new research programme and gained tenure in 2019. In April 2022, she moved to King's College London and her lab is continuing a programme of research to advance understanding of how the tumour stroma operates to help a tumour develop and evolve. Jacqui was appointed Professor in Cancer Immunology at the University of Nottingham in January 2024. Her group are especially interested in the mechanisms by which these non-cancerous cells are able to shut off the immune responses to avoid our defenses, and how they may use this information to improve therapy responses.

Expertise Summary

The Stromal Immunology Lab focuses on detangling the mechanisms by which stromal cells such as fibroblasts and endothelial cells modulate immunity, with the ultimate aim of developing new therapeutic approaches

One of our focuses is understanding how these stromal populations regulate immune suppressive networks within the tumour microenvironment, revealing the mechanisms by which effective immune responses are lost to instead promote disease. To do this, we consider the intimate relationship between the tumour and connected lymph node niches utilizing GEMMs, proteomic and genomic approaches, and functional assays.

Recent Publications

• NOWICKI-OSUCH, K., ZHUANG, L., CHEUNG, T. S., BLACK, E. L., MASQUE-SOLER, N., DEVONSHIRE, G., REDMOND, A. M., FREEMAN, A., DI PIETRO, M., PILONIS, N., JANUSZEWICZ, W., O'DONOVAN, M., TAVARE, S., SHIELDS, J. D. and FITZGERALD, R. C., 2023. Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia: Cancer Discov Cancer Discov. 13(6), 1346-1363
• MAZZAGLIA, C., SHENG, Y., RODRIGUES, L. N., LEI, I. M., SHIELDS, J. D. and HUANG, Y. Y. S., 2023. Deployable extrusion bioprinting of compartmental tumoroids with cancer associated fibroblasts for immune cell interactions: Biofabrication Biofabrication. 15(2),
• RIEDEL, A., HELAL, M., PEDRO, L., SWIETLIK, J. J., SHORTHOUSE, D., SCHMITZ, W., HAAS, L., YOUNG, T., DA COSTA, A. S. H., DAVIDSON, S., BHANDARE, P., WOLF, E., HALL, B. A., FREZZA, C., OSKARSSON, T. and SHIELDS, J. D., 2022. Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma: Cancer Immunol Res Cancer Immunol Res. 10(4), 482-497
• MUNIR, H., JONES, J. O., JANOWITZ, T., HOFFMANN, M., EULER, M., MARTINS, C. P., WELSH, S. J. and SHIELDS, J. D., 2021. Stromal-driven and Amyloid beta-dependent induction of neutrophil extracellular traps modulates tumor growth: Nat Commun Nat Commun. 12(1), 683

• View all publications

• NOWICKI-OSUCH, K., ZHUANG, L., CHEUNG, T. S., BLACK, E. L., MASQUE-SOLER, N., DEVONSHIRE, G., REDMOND, A. M., FREEMAN, A., DI PIETRO, M., PILONIS, N., JANUSZEWICZ, W., O'DONOVAN, M., TAVARE, S., SHIELDS, J. D. and FITZGERALD, R. C., 2023. Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia: Cancer Discov Cancer Discov. 13(6), 1346-1363
• MAZZAGLIA, C., SHENG, Y., RODRIGUES, L. N., LEI, I. M., SHIELDS, J. D. and HUANG, Y. Y. S., 2023. Deployable extrusion bioprinting of compartmental tumoroids with cancer associated fibroblasts for immune cell interactions: Biofabrication Biofabrication. 15(2),
• RIEDEL, A., HELAL, M., PEDRO, L., SWIETLIK, J. J., SHORTHOUSE, D., SCHMITZ, W., HAAS, L., YOUNG, T., DA COSTA, A. S. H., DAVIDSON, S., BHANDARE, P., WOLF, E., HALL, B. A., FREZZA, C., OSKARSSON, T. and SHIELDS, J. D., 2022. Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma: Cancer Immunol Res Cancer Immunol Res. 10(4), 482-497
• MUNIR, H., JONES, J. O., JANOWITZ, T., HOFFMANN, M., EULER, M., MARTINS, C. P., WELSH, S. J. and SHIELDS, J. D., 2021. Stromal-driven and Amyloid beta-dependent induction of neutrophil extracellular traps modulates tumor growth: Nat Commun Nat Commun. 12(1), 683
• JONES, J. O., MOODY, W. M. and SHIELDS, J. D., 2021. Microenvironmental modulation of the developing tumour: an immune-stromal dialogue: Mol Oncol Mol Oncol. 15(10), 2600-2633
• SCHUIJS, M. J., PNG, S., RICHARD, A. C., TSYBEN, A., HAMM, G., STOCKIS, J., GARCIA, C., PINAUD, S., NICHOLLS, A., ROS, X. R., SU, J., ELDRIDGE, M. D., RIEDEL, A., SERRAO, E. M., RODEWALD, H. R., MACK, M., SHIELDS, J. D., COHEN, E. S., MCKENZIE, A. N. J., GOODWIN, R. J. A., BRINDLE, K. M., MARIONI, J. C. and HALIM, T. Y. F., 2020. ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung: Nat Immunol Nat Immunol. 21(9), 998-1009
• MUNIR, H., MAZZAGLIA, C. and SHIELDS, J. D., 2020. Stromal regulation of tumor-associated lymphatics: Adv Drug Deliv Rev Adv Drug Deliv Rev. 161-162, 75-89
• MAHATA, B., PRAMANIK, J., VAN DER WEYDEN, L., POLANSKI, K., KAR, G., RIEDEL, A., CHEN, X., FONSECA, N. A., KUNDU, K., CAMPOS, L. S., RYDER, E., DUDDY, G., WALCZAK, I., OKKENHAUG, K., ADAMS, D. J., SHIELDS, J. D. and TEICHMANN, S. A., 2020. Tumors induce de novo steroid biosynthesis in T cells to evade immunity: Nat Commun Nat Commun. 11(1), 3588
• DAVIDSON, S., EFREMOVA, M., RIEDEL, A., MAHATA, B., PRAMANIK, J., HUUHTANEN, J., KAR, G., VENTO-TORMO, R., HAGAI, T., CHEN, X., HANIFFA, M. A., SHIELDS, J. D. and TEICHMANN, S. A., 2020. Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth: Cell Rep Cell Rep. 31(7), 107628
• PEDRO, L., HARMER, Q., MAYES, E. and SHIELDS, J. D., 2019. Impact of Locally Administered Carboxydextran-Coated Super-Paramagnetic Iron Nanoparticles on Cellular Immune Function: Small Small. 15(20), e1900224
• SHORTHOUSE, D., RIEDEL, A., KERR, E., PEDRO, L., BIHARY, D., SAMARAJIWA, S., MARTINS, C. P., SHIELDS, J. and HALL, B. A., 2018. Exploring the role of stromal osmoregulation in cancer and disease using executable modelling: Nat Commun Nat Commun. 9(1), 3011
• MULIADITAN, T., CARON, J., OKESOLA, M., OPZOOMER, J. W., KOSTI, P., GEORGOULI, M., GORDON, P., LALL, S., KUZEVA, D. M., PEDRO, L., SHIELDS, J. D., GILLETT, C. E., DIEBOLD, S. S., SANZ-MORENO, V., NG, T., HOSTE, E. and ARNOLD, J. N., 2018. Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis: Nat Commun Nat Commun. 9(1), 2951
• LAKINS, M. A., GHORANI, E., MUNIR, H., MARTINS, C. P. and SHIELDS, J. D., 2018. Cancer-associated fibroblasts induce antigen-specific deletion of CD8 (+) T Cells to protect tumour cells: Nat Commun Nat Commun. 9(1), 948
• RIEDEL, A., SHORTHOUSE, D., HAAS, L., HALL, B. A. and SHIELDS, J., 2016. Tumor-induced stromal reprogramming drives lymph node transformation: Nat Immunol Nat Immunol. 17(9), 1118-27
• SHIELDS, J. D., KOURTIS, I. C., TOMEI, A. A., ROBERTS, J. M. and SWARTZ, M. A., 2010. Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21: Science Science. 328(5979), 749-52
• MITEVA, D. O., RUTKOWSKI, J. M., DIXON, J. B., KILARSKI, W., SHIELDS, J. D. and SWARTZ, M. A., 2010. Transmural flow modulates cell and fluid transport functions of lymphatic endothelium: Circ Res Circ Res. 106(5), 920-31