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Robin Spiller

Professor of Gastroenterology, Faculty of Medicine & Health Sciences

Personal Details
Research
Publications

Contact

workRoom WE1415 QMC West Block E Floor
Queen's Medical Centre
Nottingham
NG7 2UH
UK
work07824328319
fax0115 823 1409
robin.spiller@nottingham.ac.uk
http://www.nddcbru.org.uk/

Biography

Educated at Cambridge University and University College Hospital London

SHO posts at Hammersmith, London Chest and Queens Square and West Middlesex. 1975-78 Registrar at Charing Cross,West and Central Middlesex 1978-1984.

MRC Travelling Fellowship to Mayo Clinic 1984-5

Senior Registrar Central Middlesex 1985-1988 Appointed Consultant Physician University Hospital Nottingham

!998 Reader and Honorary Consultant Physician University of Nottingham

2000 onwards Professor of Gastroenterology

2010 -2014 Lead Director of the Nottingham Digestive Diseases Centre Biomedical Research Unit

2010 Elected Senior NIHR Investigator

Editor of Gut an international journal of Gastroenterology and Hepatology from 2003 -2009.

Expertise Summary

My main interest is in the pathophysiology of functional GI diseases, particularly focusing on the role of infection and inflammation and alterations in serotonin metabolism in the irritable bowel syndrome. I have twice edited the British Society of Gastroenterology ( BSG )Guidelines for the management of IBS and am a member of the Board of the Rome Foundation, an international group which produced the Rome III criteria for the classification of the functional GI diseases.

I was the founding Chairman of the Neurogastroenterology and Motility Section of the British Society of Gastroenterology (BSG)

I was a member of MRC EME Board 2010-2014 and National Institute for Health Research Senior Investigator. I am the author/co-author of more than 335 scientific reviews and original publications.

Research Summary

Special interest in functional GI diseases, motility disorders.

Research interests include pathology of post-infectious irritable bowel syndrome, neuropathology following gut inflammation .I also have an interest in the application of MRI to study GI pathophysiology

Techniques

Inflammation and irritable bowel syndrome and genetic basis of IBS
Clinical trials and functional bowel disease projects
Intestinal motility assessment using MRI
Projects

MRI of colonic physiology in constipation
Effect of laxatives assessed by MRI
Colonic motor patterns using both High Resolution manometry and MRI
Impact of fibre on colonic fermentation
Effect of FODMAPs on colonic physiology

Selected Publications

FOLEY, S., GARSED, K., SINGH, G., DUROUDIER, N.P., SWAN, C., HALL, I.P., ZAITOUN, A., BENNETT, A., MARSDEN, C., HOLMES, G., WALLS, A. and SPILLER, R.C., 2011. Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation Gastroenterology. 140(5), 1434-1443.e1
HUMES, D.J., SOLAYMANI-DODARAN, M., FLEMING, K.M., SIMPSON, J., SPILLER, R.C. and WEST, J., 2009. A population-based study of perforated diverticular disease incidence and associated mortality Gastroenterology. 136(4), 1198-1205
MARCIANI, L., COX, E.F., HOAD, C.L., PRITCHARD, S., TOTMAN, J.J., FOLEY, S., MISTRY, A., EVANS, S., GOWLAND, P.A. and SPILLER, R.C., 2010. Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome Gastroenterology. 138(2), 469-477
TOOTH, D., GARSED, K., SINGH, G., MARCIANI, L., LAM, C., FORDHAM, I., FIELDS, A., BANWAIT, R., LINGAYA, M., LAYFIELD, R., HASTINGS, M., WHORWELL, P. and SPILLER, R., 2013. Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea:origin and effect of gut transit Gut. n/a(n/a), n/a

View all publications

Past Research

Pathophysiology of functional GI diseases

Original description of postinfectious irritable bowel syndrome, particularly focusing on the role of inflammation and alterations in serotonin metabolism in the irritable bowel syndrome.

Development of MRI for studying gastric processing of complex meals

Future Research

MRI assessment of effect of gelling agents on colonic function and changes in gut microbiota

Effect of ondansetron in IBS-D

Assessment of pathophysiology of Cystic Fibrosis using MRI

GUNN, D., TOPAN, R., BARNARD, L., FRIED, R., HOLLOWAY, I., BRINDLE, R., CORSETTI, M., SCOTT, M., FARMER, A., KAPUR, K., SANDERS, D., EUGENICOS, M., TRUDGILL, N., WHORWELL, P., MCLAUGHLIN, J., AKBAR, A., HOUGHTON, L., DINNING, P. G., AZIZ, Q., FORD, A. C., FARRIN, A. J. and SPILLER, R., 2023. Randomised, placebo-controlled trial and meta-analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The TRITON trial: Aliment Pharmacol Ther Aliment Pharmacol Ther. 57(11), 1258-1271
ALSHAMMARI, M. T., ALYAMI, A. S., WILKINSON-SMITH, V., SPILLER, R. C., GOWLAND, P., MARCIANI, L., MORAN, G. W. and HOAD, C. L., 2023. MRI tagging of colonic chyme mixing in healthy subjects: Inter-observer variability and reliability of the measurement with time: Neurogastroenterol Motil Neurogastroenterol Motil. e14610
JALANKA, J., GUNN, D., SINGH, G., KRISHNASAMY, S., LINGAYA, M., CRISPIE, F., FINNEGAN, L., COTTER, P., JAMES, L., NOWAK, A., MAJOR, G. and SPILLER, R. C., 2022. Postinfective bowel dysfunction following Campylobacter enteritis is characterised by reduced microbiota diversity and impaired microbiota recovery: Gut Gut.
FRITZ, N., BERENS, S., DONG, Y., MARTINEZ, C., SCHMITTECKERT, S., HOUGHTON, L. A., GOEBEL-STENGEL, M., WAHL, V., KABISCH, M., GOTZE, D., D'AMATO, M., ZHENG, T., ROTH, R., MONNIKES, H., TESARZ, J., ENGEL, F., GAUSS, A., RAITHEL, M., ANDRESEN, V., KELLER, J., FRIELING, T., PEHL, C., STEIN-THORINGER, C., CLARKE, G., KENNEDY, P. J., CRYAN, J. F., DINAN, T. G., QUIGLEY, E. M. M., SPILLER, R., BELTRAN, C., MADRID, A. M., TORRES, V., MAYER, E. A., SAYUK, G., GAZOULI, M., KARAMANOLIS, G., BUSTAMANTE, M., ESTIVIL, X., RABIONET, R., HOFFMANN, P., NOTHEN, M. M., HEILMANN-HEIMBACH, S., SCHMIDT, B., FRANKE, A., LIEB, W., HERZOG, W., BOECKXSTAENS, G., WOUTERS, M. M., SIMREN, M., RAPPOLD, G. A., VICARIO, M., SANTOS, J., SCHAEFERT, R., LORENZO-BERMEJO, J. and NIESLER, B., 2022. The serotonin receptor 3E variant is a risk factor for female IBS-D: J Mol Med (Berl) J Mol Med (Berl).
DELLSCHAFT, N. S., NG, C., HOAD, C., MARCIANI, L., SPILLER, R., STEWART, I., MENYS, A., BARR, H., GOWLAND, P. A., MAJOR, G. and SMYTH, A. R., 2022. Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls: J Cyst Fibros J Cyst Fibros. 21(3), 502-505
DELLSCHAFT, N., HOAD, C., MARCIANI, L., GOWLAND, P. and SPILLER, R., 2022. Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies: Aliment Pharmacol Ther Aliment Pharmacol Ther. 55(3), 327-338
BERENS, S., DONG, Y., FRITZ, N., WALSTAB, J., D'AMATO, M., ZHENG, T., WAHL, V., BOEKSTEGERS, F., BERMEJO, J. L., MARTINEZ, C., SCHMITTECKERT, S., CLEVERS, E., ENGEL, F., GAUSS, A., HERZOG, W., SPILLER, R., GOEBEL-STENGEL, M., MONNIKES, H., ANDRESEN, V., THOMAS, F., KELLER, J., PEHL, C., STEIN-THORINGER, C., CLARKE, G., DINAN, T. G., QUIGLEY, E. M., SAYUK, G., SIMREN, M., TESARZ, J., RAPPOLD, G., VAN OUDENHOVE, L., SCHAEFERT, R. and NIESLER, B., 2022. Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study: World J Gastroenterol World J Gastroenterol. 28(21), 2334-2349
SPILLER, ROBIN C and JALANKA, JONNA, 2021. Brachyspira and IBS with diarrhoea: a Helicobacter pylori moment?: Gut Gut. 70(6), 1008-1009
SPILLER, R., 2021. Impact of Diet on Symptoms of the Irritable Bowel Syndrome: Nutrients Nutrients. 13(2),
SHARIF, HAYFA, HOAD, CAROLINE L., ABREHART, NICHOLA, GOWLAND, PENNY A., SPILLER, ROBIN C., KIRKHAM, SIAN, LOGANATHAN, SABARINATHAN, PAPADOPOULOS, MICHALIS, BENNINGA, MARC A., DEVADASON, DAVID and MARCIANI, LUCA, 2021. Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI: Diagnostics Diagnostics. 11(6), 974
MOHR, S., FRITZ, N., HAMMER, C., MARTINEZ, C., BERENS, S., SCHMITTECKERT, S., WAHL, V., SCHMIDT, M., HOUGHTON, L. A., GOEBEL-STENGEL, M., KABISCH, M., GOTZE, D., MILOVAC, I., D'AMATO, M., ZHENG, T., ROTH, R., MONNIKES, H., ENGEL, F., GAUSS, A., TESARZ, J., RAITHEL, M., ANDRESEN, V., FRIELING, T., KELLER, J., PEHL, C., STEIN-THORINGER, C., CLARKE, G., KENNEDY, P. J., CRYAN, J. F., DINAN, T. G., QUIGLEY, E. M. M., SPILLER, R., BELTRAN, C., MADRID, A. M., TORRES, V., PEREZ DE ARCE, E., HERZOG, W., MAYER, E. A., SAYUK, G., GAZOULI, M., KARAMANOLIS, G., KAPUR-POJSKIC, L., BUSTAMANTE, M., RABIONET, R., ESTIVIL, X., FRANKE, A., LIEB, W., BOECKXSTAENS, G., WOUTERS, M. M., SIMREN, M., RAPPOLD, G. A., VICARIO, M., SANTOS, J., SCHAEFERT, R., LORENZO-BERMEJO, J. and NIESLER, B., 2021. The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome: J Cell Mol Med J Cell Mol Med.
JALANKA, J., LAM, C., BENNETT, A., HARTIKAINEN, A., CRISPIE, F., FINNEGAN, L. A., COTTER, P. D. and SPILLER, R., 2021. Colonic Gene Expression and Fecal Microbiota in Diarrhea-predominant Irritable Bowel Syndrome: Increased Toll-like Receptor 4 but Minimal Inflammation and no Response to Mesalazine: J Neurogastroenterol Motil J Neurogastroenterol Motil. 27(2), 279-291
GUNN, D., ABBAS, Z., HARRIS, H. C., MAJOR, G., HOAD, C., GOWLAND, P., MARCIANI, L., GILL, S. K., WARREN, F. J., ROSSI, M., REMES-TROCHE, J. M., WHELAN, K. and SPILLER, R. C., 2021. Psyllium reduces inulin-induced colonic gas production in IBS: MRI and in vitro fermentation studies: Gut Gut.
EIJSBOUTS, C., ZHENG, T., KENNEDY, N. A., BONFIGLIO, F., ANDERSON, C. A., MOUTSIANAS, L., HOLLIDAY, J., SHI, J., SHRINGARPURE, S., ANDME RESEARCH, TEAM, VODA, A. I., BELLYGENES, INITIATIVE, FARRUGIA, G., FRANKE, A., HUBENTHAL, M., ABECASIS, G., ZAWISTOWSKI, M., SKOGHOLT, A. H., NESS-JENSEN, E., HVEEM, K., ESKO, T., TEDER-LAVING, M., ZHERNAKOVA, A., CAMILLERI, M., BOECKXSTAENS, G., WHORWELL, P. J., SPILLER, R., MCVEAN, G., D'AMATO, M., JOSTINS, L. and PARKES, M., 2021. Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders: Nat Genet Nat Genet. 53(11), 1543-1552
CORSETTI, M., BROWN, S., CHIARIONI, G., DIMIDI, E., DUDDING, T., EMMANUEL, A., FOX, M., FORD, A. C., GIORDANO, P., GROSSI, U., HENDERSON, M., KNOWLES, C. H., O'CONNELL, P. R., QUIGLEY, E. M. M., SIMREN, M., SPILLER, R., WHELAN, K., WHITEHEAD, W. E., WILLIAMS, A. B. and SCOTT, S. M., 2021. Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment: Neurogastroenterol Motil Neurogastroenterol Motil. e14070
CIBERT-GOTON, V., LAM, C., LINGAYA, M., FALCONE, Y., WOOD, J. N., BULMER, D. C. and SPILLER, R., 2021. Pain Severity Correlates With Biopsy-Mediated Colonic Afferent Activation But Not Psychological Scores in Patients With IBS-D: Clin Transl Gastroenterol Clinical and translational gastroenterology. 12(2), e00313
SPILLER, R. and HOAD, C., 2020. Enhancing our understanding of small bowel function using modern imaging techniques: Neurogastroenterol Motil Neurogastroenterol Motil. 32(1), e13616
SHARIF, H., ABREHART, N., HOAD, C. L., MURRAY, K., PERKINS, A. C., SMITH, M., GOWLAND, P. A., SPILLER, R. C., HARRIS, R., KIRKHAM, S., LOGANATHAN, S., PAPADOPOULOS, M., FROST, K., DEVADASON, D., MARCIANI, L. and YOUNG PERSONS ADVISORY, GROUP, 2020. Feasibility Study of a New Magnetic Resonance Imaging Mini-capsule Device to Measure Whole Gut Transit Time in Paediatric Constipation: J Pediatr Gastroenterol Nutr J Pediatr Gastroenterol Nutr. 71(5), 604-611
KRISHNASAMY, S., LOMER, M. C. E., MARCIANI, L., HOAD, C. L., PRITCHARD, S. E., PAUL, J., GOWLAND, P. A. and SPILLER, R. C., 2020. Processing Apples to Puree or Juice Speeds Gastric Emptying and Reduces Postprandial Intestinal Volumes and Satiety in Healthy Adults: J Nutr J Nutr. 150(11), 2890-2899
KHALAF, A., HOAD, C. L., MENYS, A., NOWAK, A., RADFORD, S., TAYLOR, S. A., LATIEF, K., LINGAYA, M., FALCONE, Y., SINGH, G., SPILLER, R. C., GOWLAND, P. A., MARCIANI, L. and MORAN, G. W., 2020. Gastrointestinal peptides and small-bowel hypomotility are possible causes for fasting and postprandial symptoms in active Crohn's disease: Am J Clin Nutr Am J Clin Nutr. 111(1), 131-140
KHALAF, A., HOAD, C. L., BLACKSHAW, E., ALYAMI, J., SPILLER, R. C., GOWLAND, P. A., VINAYAKA-MOORTHY, V., PERKINS, A. C., MORAN, G. W. and MARCIANI, L., 2020. Simultaneous Measurement of Gastric Emptying of a Soup Test Meal Using MRI and Gamma Scintigraphy: Diagnostics (Basel) Diagnostics (Basel). 10(3),
HEISSAM, K., ABREHART, N., HOAD, C. L., WRIGHT, J., MENYS, A., MURRAY, K., GLOVER, P. M., HEBBARD, G., GOWLAND, P. A., BAKER, J., HASLER, W. L., SPILLER, R. C., CORSETTI, M., BRASSEUR, J. G., HENS, B., SHEDDEN, K., DICKENS, J., MUDIE, D. M., AMIDON, G. E., AMIDON, G. L. and MARCIANI, L., 2020. Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants: PLoS One PLoS One. 15(11), e0241441
GUNN, D., MURTHY, R., MAJOR, G., WILKINSON-SMITH, V., HOAD, C., MARCIANI, L., REMES-TROCHE, J., GILL, S., ROSSI, M., HARRIS, H., AHN-JARVIS, J., WARREN, F., WHELAN, K. and SPILLER, R., 2020. Contrasting effects of viscous and particulate fibers on colonic fermentation in vitro and in vivo, and their impact on intestinal water studied by MRI in a randomized trial: Am. J Clin Nutr Am. J Clin Nutr.
BALKHY, H.H., PATEL, B.B., SPILLER, R. and AVELLA-PATINO, D., 2019. Robotic-Assisted Total Pericardiectomy for Acute Relapsing Pericarditis: A Case Report: Innovations. (Phila) Innovations. (Phila). 14(5), 468-472
WILKINSON-SMITH, V., DELLSCHAFT, N., ANSELL, J., HOAD, C., MARCIANI, L., GOWLAND, P. and SPILLER, R., 2019. Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers: Aliment. Pharmacol Ther Aliment. Pharmacol Ther. 49(6), 759-768
SPILLER, R. and MARCIANI, L., 2019. Intraluminal Impact of Food: New Insights from MRI: Nutrients Nutrients. 11(5),
MURRAY, K.A., HOAD, C.L., GARRATT, J., KAVIANI, M., MARCIANI, L., SMITH, J.K., SIEGMUND, B., GOWLAND, P.A., HUMES, D.J. and SPILLER, R.C., 2019. A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis: PLoS. ONE PLoS. ONE. 14(5), e0216528
MENYS, A., HOAD, C., SPILLER, R., SCOTT, S.M., ATKINSON, D., MARCIANI, L. and TAYLOR, S.A., 2019. Spatio-temporal motility MRI analysis of the stomach and colon: Neurogastroenterol. Motil Neurogastroenterol. Motil. 31(5), e13557
LAM, C., SANDERS, D.S., LANYON, P., GARSED, K., FOLEY, S., PRITCHARD, S., MARCIANI, L., HOAD, C.L., COSTIGAN, C., GOWLAND, P. and SPILLER, R., 2019. Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging: United. European. Gastroenterol. J United. European. Gastroenterol. J. 7(10), 1353-1360
KHALAF, A., NOWAK, A., MENYS, A., MARCIANI, L., TAYLOR, S.A., SPILLER, R.C., GOWLAND, P.A., MORAN, G.W. and HOAD, C.L., 2019. Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: Beyond the breath-hold: Neurogastroenterol. Motil Neurogastroenterol. Motil. 31(1), e13466
JALANKA, J., MAJOR, G., MURRAY, K., SINGH, G., NOWAK, A., KURTZ, C., SILOS-SANTIAGO, I., JOHNSTON, J.M., DE VOS, W.M. and SPILLER, R., 2019. The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls: Int J. Mol. Sci Int J. Mol. Sci. 20(2),
GUNN, D., GARSED, K., LAM, C., SINGH, G., LINGAYA, M., WAHL, V., NIESLER, B., HENRY, A., HALL, I.P., WHORWELL, P. and SPILLER, R., 2019. Abnormalities of mucosal serotonin metabolism and 5-HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron: Aliment Pharmacol Ther Aliment Pharmacol Ther. 50(5), 538-546
GUNN, D., GARSED, K., LAM, C., SINGH, G., LINGAYA, M., WAHL, V., NIESLER, B., HENRY, A., HALL, I., WHORWELL, P. and SPILLER, R., 2019. Editorial: understanding differences in patient response to ondansetron in irritable bowel syndrome with diarrhoea-are we any closer? Authors' reply: Aliment. Pharmacol Ther Aliment. Pharmacol Ther. 50(7), 826-827
ALYAMI, J., WHITEHOUSE, E., YAKUBOV, G.E., PRITCHARD, S.E., HOAD, C.L., BLACKSHAW, E., HEISSAM, K., CORDON, S.M., BLIGH, H.F.J., SPILLER, R.C., MACDONALD, I.A., AITHAL, G.P., GOWLAND, P.A., TAYLOR, M.A. and MARCIANI, L., 2019. Glycaemic, gastrointestinal, hormonal and appetitive responses to pearl millet or oats porridge breakfasts: a randomised, crossover trial in healthy humans: Br. J Nutr Br. J Nutr. 122(10), 1142-1154
ALYAMI, J., LADD, N., PRITCHARD, S.E., HOAD, C.L., SULTAN, A.A., SPILLER, R.C., GOWLAND, P.A., MACDONALD, I.A., AITHAL, G.P., MARCIANI, L. and TAYLOR, M.A., 2019. Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: A MRI pilot study in healthy humans: Food Res Int Food Res Int. 118, 49-57
CORSETTI, M., COSTA, M., BASSOTTI, G., BHARUCHA, A.E., BORRELLI, O., DINNING, P., DI, LORENZO C., HUIZINGA, J.D., JIMENEZ, M., RAO, S., SPILLER, R., SPENCER, N.J., LENTLE, R., PANNEMANS, J., THYS, A., BENNINGA, M. and TACK, J., 2019. First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques: Nat. Rev. Gastroenterol. Hepatol Nat. Rev. Gastroenterol. Hepatol. 16(9), 559-579
GUNN, D., FRIED, R., LALANI, R., FARRIN, A., HOLLOWAY, I., MORRIS, T., OLIVIER, C., KEARNS, R., CORSETTI, M., SCOTT, M., FARMER, A., EMMANUEL, A., WHORWELL, P., YIANNAKOU, Y., SANDERS, D., MCLAUGHLIN, J., KAPUR, K., EUGENICOS, M., AKBAR, A., TRUDGILL, N., HOUGHTON, L., DINNING, P.G., FORD, A.C., AZIZ, Q. and SPILLER, R., 2019. Treatment of irritable bowel syndrome with diarrhoea using titrated ondansetron (TRITON): study protocol for a randomised controlled trial: Trials Trials. 20(1), 517
WILKINSON-SMITH, V.C., MAJOR, G., ASHLEIGH, L., MURRAY, K., HOAD, C.L., MARCIANI, L., GOWLAND, P.A. and SPILLER, R.C., 2018. Insights Into the Different Effects of Food on Intestinal Secretion Using Magnetic Resonance Imaging: JPEN J. Parenter. Enteral Nutr JPEN J. Parenter. Enteral Nutr. 42(8), 1342-1348
CARD, T., ENCK, P., BARBARA, G., BOECKXSTAENS, G.E., SANTOS, J., AZPIROZ, F., MEARIN, F., AZIZ, Q., MARSHALL, J. and SPILLER, R., 2018. Post-infectious IBS: Defining its clinical features and prognosis using an internet-based survey: United. European. Gastroenterol. J United. European. Gastroenterol. J. 6(8), 1245-1253
KHALAF, A., HOAD, C.L., MENYS, A., NOWAK, A., TAYLOR, S.A., PAPARO, S., LINGAYA, M., FALCONE, Y., SINGH, G., SPILLER, R.C., GOWLAND, P.A., MARCIANI, L. and MORAN, G.W., 2018. MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans: Neurogastroenterol. Motil Neurogastroenterol. Motil. 30(1),
SPILLER, R.C., 2018. Hidden Dangers of Antibiotic Use: Increased Gut Permeability Mediated by Increased Pancreatic Proteases Reaching the Colon: Cell Mol. Gastroenterol. Hepatol Cell Mol. Gastroenterol. Hepatol. 6(3), 347-348
SLOAN, T.J., JALANKA, J., MAJOR, G.A.D., KRISHNASAMY, S., PRITCHARD, S., ABDELRAZIG, S., KORPELA, K., SINGH, G., MULVENNA, C., HOAD, C.L., MARCIANI, L., BARRETT, D.A., LOMER, M.C.E., DE VOS, W.M., GOWLAND, P.A. and SPILLER, R.C., 2018. A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects: PLoS. ONE PLoS. ONE. 13(7), e0201410
PITIOT, A., SMITH, J.K., HUMES, D.J., GARRATT, J., FRANCIS, S.T., GOWLAND, P.A., SPILLER, R.C. and MARCIANI, L., 2018. Cortical differences in diverticular disease and correlation with symptom reports: Neurogastroenterol. Motil Neurogastroenterol. Motil.
MAJOR, G., MURRAY, K., SINGH, G., NOWAK, A., HOAD, C.L., MARCIANI, L., SILOS-SANTIAGO, A., KURTZ, C.B., JOHNSTON, J.M., GOWLAND, P. and SPILLER, R., 2018. Demonstration of differences in colonic volumes, transit, chyme consistency, and response to psyllium between healthy and constipated subjects using magnetic resonance imaging: Neurogastroenterol. Motil Neurogastroenterol. Motil. 30(9), e13400
SPILLER, R., 2018. Inhibiting glucose absorption to treat constipation: Lancet Gastroenterol. Hepatol Lancet Gastroenterol. Hepatol.
SPILLER, R., 2018. Significance of Postinfectious Irritable Bowel Syndrome?: Gastroenterology Gastroenterology.
PRITCHARD, S E, PAUL, J, MAJOR, G, MARCIANI, L, GOWLAND, P A, SPILLER, R C and HOAD, C L, 2017. Assessment of motion of colonic contents in the human colon using MRI tagging. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
LAM, CHING, CHADDOCK, GEMMA, LAUREA, LUCA MARCIANI, COSTIGAN, CAROLYN, COX, ELEANOR, HOAD, CAROLINE, PRITCHARD, SUSAN, GOWLAND, PENNY and SPILLER, ROBIN, 2017. Distinct Abnormalities of Small Bowel and Regional Colonic Volumes in Subtypes of Irritable Bowel Syndrome Revealed by MRI AMERICAN JOURNAL OF GASTROENTEROLOGY. 112(2), 346-355
MAJOR, GILES, PRITCHARD, SUE, MURRAY, KATHRYN, ALAPPADAN, JAN PAUL, HOAD, CAROLINE L., MARCIANI, LUCA, GOWLAND, PENNY and SPILLER, ROBIN, 2017. Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome GASTROENTEROLOGY. 152(1), 124-+
KRUIS, W., KARDALINOS, V., EISENBACH, T., LUKAS, M., VICH, T., BUNGANIC, I., POKROTNIEKS, J., DEROVA, J., KONDRACKIENE, J., SAFADI, R., TUCULANU, D., TULASSAY, Z., BANAI, J., CURTIN, A., DOROFEYEV, A. E., ZAKKO, S. F., FERREIRA, N., BJORCK, S., ALONSO, M. M. DIEZ, MAKELA, J., TALLEY, N. J., DILGER, K., GREINWALD, R., MOHRBACHER, R. and SPILLER, R., 2017. Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 46(3), 282-291
SPILLER, ROBIN, PELERIN, FANNY, DECHERF, AMELIE CAYZEELE, MAUDET, CORINNE, HOUSEZ, BEATRICE, CAZAUBIEL, MURIELLE and JUESTEN, PETER, 2017. Randomized double blind placebo-controlled trial of Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: improvement in abdominal pain and bloating in those with predominant constipation (vol 4, pg 353, 2016) UNITED EUROPEAN GASTROENTEROLOGY JOURNAL. 5(2), 304-304
SPILLER, ROBIN, 2017. How do FODMAPs work? JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 32, 36-39
LAM, C., TAN, W., LEIGHTON, M., HASTINGS, M., LINGAYA, M., FALCONE, Y., ZHOU, X., XU, L., WHORWELL, P., WALLS, A. F., ZAITOUN, A., MONTGOMERY, A. and SPILLER, R., 2016. A mechanistic multicentre, parallel group, randomised placebo-controlled trial of mesalazine for the treatment of IBS with diarrhoea (IBS-D): Gut Gut. 65(1), 91-9
QUIGLEY, E. M. and SPILLER, R. C., 2016. Constipation and the Microbiome: Lumen Versus Mucosa!: Gastroenterology Gastroenterology. 150(2), 300-3
HUMES, D. and SPILLER, R. C., 2016. Colonic diverticular disease: medical treatments for acute diverticulitis: BMJ Clin Evid BMJ Clin Evid. 2016,
MURRAY, K. A., LAM, C., REHMAN, S., MARCIANI, L., COSTIGAN, C., HOAD, C. L., LINGAYA, M. R., BANWAIT, R., BAWDEN, S. J., GOWLAND, P. A. and SPILLER, R. C., 2016. Corticotropin-releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomized controlled trial: American Journal of Clinical Nutrition American Journal of Clinical Nutrition. 103(5), 1318-1326
LAM, C., CHADDOCK, G., MARCIANI, L., COSTIGAN, C., PAUL, J., COX, E., HOAD, C., MENYS, A., PRITCHARD, S., GARSED, K., TAYLOR, S., ATKINSON, D., GOWLAND, P. and SPILLER, R., 2016. Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation: Neurogastroenterol Motil Neurogastroenterol Motil. 28(6), 861-70
HOAD, C. L., MENYS, A., GARSED, K., MARCIANI, L., HAMY, V., MURRAY, K., COSTIGAN, C., ATKINSON, D., MAJOR, G., SPILLER, R. C., TAYLOR, S. A. and GOWLAND, P. A., 2016. Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI: Neurogastroenterology and Motility Neurogastroenterology and Motility. 28(3), 327-335
COLETTA, M., GATES, F. K., MARCIANI, L., SHIWANI, H., MAJOR, G., HOAD, C. L., CHADDOCK, G., GOWLAND, P. A. and SPILLER, R. C., 2016. Effect of bread gluten content on gastrointestinal function: a crossover MRI study on healthy humans: British Journal of Nutrition British Journal of Nutrition. 115(1), 55-61
SPILLER, R. C., 2015. Changing views on diverticular disease: impact of aging, obesity, diet, and microbiota: Neurogastroenterology and Motility Neurogastroenterology and Motility. 27(3), 305-312
RAJILIC-STOJANOVIC, M., JONKERS, D. M., SALONEN, A., HANEVIK, K., RAES, J., JALANKA, J., DE VOS, W. M., MANICHANH, C., GOLIC, N., ENCK, P., PHILIPPOU, E., IRAQI, F. A., CLARKE, G., SPILLER, R. C. and PENDERS, J., 2015. Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?: American Journal of Gastroenterology American Journal of Gastroenterology. 110(2), 278-287
PRITCHARD, S. E., GARSED, K. C., HOAD, C. L., LINGAYA, M., BANWAIT, R., THONGBORISUTE, W., ROBERTS, E., COSTIGAN, C., MARCIANI, L., GOWLAND, P. A. and SPILLER, R. C., 2015. Effect of experimental stress on the small bowel and colon in healthy humans: Neurogastroenterology and Motility Neurogastroenterology and Motility. 27(4), 542-549
MURRAY, K., PLACIDI, E., SCHURING, E. A. H., HOAD, C. L., KOPPENOL, W., ARNAUDOV, L. N., BLOM, W. A. M., PRITCHARD, S. E., STOYANOV, S. D., GOWLAND, P. A., SPILLER, R. C., PETERS, H. P. F. and MARCIANI, L., 2015. Aerated drinks increase gastric volume and reduce appetite as assessed by MRI: a randomized, balanced, crossover trial: American Journal of Clinical Nutrition American Journal of Clinical Nutrition. 101(2), 270-278
ALYAMI, J., SPILLER, R. C. and MARCIANI, L., 2015. Magnetic resonance imaging to evaluate gastrointestinal function: Neurogastroenterology and Motility Neurogastroenterology and Motility. 27(12), 1687-1692
CZOGALLA, B., SCHMITTECKERT, S., HOUGHTON, L. A., SAYUK, G. S., CAMILLERI, M., OLIVO-DIAZ, A., SPILLER, R., WOUTERS, M. M., BOECKXSTAENS, G., BERMEJO, J. L. and NIESLER, B., 2015. A meta-analysis of immunogenetic Case-Control Association Studies in irritable bowel syndrome: Neurogastroenterol Motil Neurogastroenterol Motil. 27(5), 717-27
HOAD, C. L., PARKER, H., HUDDERS, N., COSTIGAN, C., COX, E. F., PERKINS, A. C., BLACKSHAW, P. E., MARCIANI, L., SPILLER, R. C., FOX, M. R. and GOWLAND, P. A., 2015. Measurement of gastric meal and secretion volumes using magnetic resonance imaging: Physics in Medicine and Biology Physics in Medicine and Biology. 60(3), 1367-1383
JALANKA, J., SALONEN, A., SALOJARVI, J., RITARI, J., IMMONEN, O., MARCIANI, L., GOWLAND, P., HOAD, C., GARSED, K., LAM, C., PALVA, A., SPILLER, R. C. and DE VOS, W. M., 2015. Effects of bowel cleansing on the intestinal microbiota: Gut Gut. 64(10), 1562-1568
MARCIANI, L., COX, E. F., PRITCHARD, S. E., MAJOR, G., HOAD, C. L., MELLOWS, M., HUSSEIN, M. O., COSTIGAN, C., FOX, M., GOWLAND, P. A. and SPILLER, R. C., 2015. Additive effects of gastric volumes and macronutrient composition on the sensation of postprandial fullness in humans: European Journal of Clinical Nutrition European Journal of Clinical Nutrition. 69(3), 380-384
CHADDOCK, G., LAM, C., HOAD, C. L., COSTIGAN, C., COX, E. F., PLACIDI, E., THEXTON, I., WRIGHT, J., BLACKSHAW, P. E., PERKINS, A. C., MARCIANI, L., GOWLAND, P. A. and SPILLER, R. C., 2014. Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects: Neurogastroenterology and Motility Neurogastroenterology and Motility. 26(2), 205-214
BAWDEN, S. J., STEPHENSON, M. C., CIAMPI, E., HUNTER, K., MARCIANI, L., SPILLER, R. C., AITHAL, G. P., MORRIS, P. G., MACDONALD, I. A. and GOWLAND, P. A., 2014. A low calorie morning meal prevents the decline of hepatic glycogen stores: a pilot in vivo C-13 magnetic resonance study: Food & Function Food & Function. 5(9), 2237-2242
GARSED, K., CHERNOVA, J., HASTINGS, M., LAM, C., MARCIANI, L., SINGH, G., HENRY, A., HALL, I., WHORWELL, P. and SPILLER, R., 2014. A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea: Gut Gut. 63(10), 1617-25
SPILLER, R., 2014. Editorial: abnormal permeability and altered mucosal serotonin metabolism in the irritable bowel syndrome - is there a link?: Aliment Pharmacol Ther Aliment Pharmacol Ther. 40(9), 1116-8
SCHILLER, L. R., PARDI, D. S., SPILLER, R., SEMRAD, C. E., SURAWICZ, C. M., GIANNELLA, R. A., KREJS, G. J., FARTHING, M. J. and SELLIN, J. H., 2014. Gastro 2013 APDW/WCOG Shanghai working party report: chronic diarrhea: definition, classification, diagnosis: J Gastroenterol Hepatol J Gastroenterol Hepatol. 29(1), 6-25
PRITCHARD, S. E., MARCIANI, L., GARSED, K. C., HOAD, C. L., THONGBORISUTE, W., ROBERTS, E., GOWLAND, P. A. and SPILLER, R. C., 2014. Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea-predominant irritable bowel syndrome measured using serial MRI: Neurogastroenterology and Motility Neurogastroenterology and Motility. 26(1), 124-130
MURRAY, K., WILKINSON-SMITH, V., HOAD, C., COSTIGAN, C., COX, E., LAM, C., MARCIANI, L., GOWLAND, P. and SPILLER, R. C., 2014. Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI: American Journal of Gastroenterology American Journal of Gastroenterology. 109(1), 110-119
MUDIE, D. M., MURRAY, K., HOAD, C. L., PRITCHARD, S. E., GARNETT, M. C., AMIDON, G. L., GOWLAND, P. A., SPILLER, R. C., AMIDON, G. E. and MARCIANI, L., 2014. Quantification of Gastrointestinal Liquid Volumes and Distribution Following a 240 mL Dose of Water in the Fasted State: Molecular Pharmaceutics Molecular Pharmaceutics. 11(9), 3039-3047
MARCIANI, L., GARSED, K. C., HOAD, C. L., FIELDS, A., FORDHAM, I., PRITCHARD, S. E., PLACIDI, E., MURRAY, K., CHADDOCK, G., COSTIGAN, C., LAM, C., JALANKA-TUOVINEN, J., DE VOS, W. M., GOWLAND, P. A. and SPILLER, R. C., 2014. Stimulation of colonic motility by oral PEG electrolyte bowel preparation assessed by MRI: comparison of split vs single dose: Neurogastroenterology and Motility Neurogastroenterology and Motility. 26(10), 1426-1436
MAJOR, G. and SPILLER, R., 2014. Irritable bowel syndrome, inflammatory bowel disease and the microbiome: Curr Opin Endocrinol Diabetes Obes Curr Opin Endocrinol Diabetes Obes. 21(1), 15-21
JALANKA-TUOVINEN, J., SALOJARVI, J., SALONEN, A., IMMONEN, O., GARSED, K., KELLY, F. M., ZAITOUN, A., PALVA, A., SPILLER, R. C. and DE VOS, W. M., 2014. Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome: Gut Gut. 63(11), 1737-1745
TOOTH, D., GARSED, K., SINGH, G., MARCIANI, L., LAM, C., FORDHAM, I., FIELDS, A., BANWAIT, R., LINGAYA, M., LAYFIELD, R., HASTINGS, M., WHORWELL, P. and SPILLER, R., 2013. Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea:origin and effect of gut transit Gut. n/a(n/a), n/a
JALANKA-TUOVINEN J, SALOJÄRVI J, SALONEN A, IMMONEN O, GARSED K, KELLY FM, ZAITOUN A, PALVA A, SPILLER RC and DE VOS WM, 2013. Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome. Gut. 63(11), 1737-45
GARSED, K., CHERNOVA, J., HASTINGS, M., LAM, C., MARCIANI, L., SINGH, G., HENRY, A., HALL, I., WHORWELL, P. and SPILLER, R., 2013. A randomised trial of Ondansetron for the treatment of irritable bowel syndrome with diarrhoea Gut. n/a(n/a), n/a
MURRAY, K., WILKINSON-SMITH, V., HOAD, C., COSTIGAN, C., COX, E., LAM, C., MARCIANI, L., GOWLAND, P. and SPILLER, R.C., 2013. Differential effects of FODMAPs (Fermentable Oligo-, Di-, Mono-saccharides And Polyols) on small and large intestinal contents in healthy subjects shown by MRI American Journal of Gastroenterology. n/a(n/a), n/a
SWAN, C., DUROUDIER, N.P., CAMPBELL, E., ZAITOUN, A., HASTINGS, M., DUKES, G.E., COX, J., KELLY, F.M., WILDE, J., LENNON, M.G., NEAL, K.R., WHORWELL, P.J., HALL, I.P. and SPILLER, R.C., 2013. Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα Gut. 62(7), 985-994
PLACIDI E, MARCIANI L, HOAD CL, NAPOLITANO A, GARSED KC, PRITCHARD SE, COX EF, COSTIGAN C, SPILLER RC and GOWLAND PA, 2012. The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea. Alimentary pharmacology & therapeutics. 36(1), 64-73
HUMES, D.J., SIMPSON, J., SMITH, J., SUTTON, P., ZAITOUN, A., BUSH, D., BENNETT, A., SCHOLEFIELD, J.H. and SPILLER, R.C., 2012. Visceral hypersensitivity in symptomatic diverticular disease and the role of neuropeptides and low grade inflammation Neurogastroenterology & Motility. 24(4), e163
SMITH, J., HUMES, D. J. and SPILLER, R. C., 2011. Should we treat uncomplicated symptomatic diverticular disease with fibre?: BMJ 342, d2951
SMITH, J. K., HUMES, D. J., HEAD, K. E., BUSH, D., WHITE, T. P., STEVENSON, C. M., BROOKES, M. J., MARCIANI, L., SPILLER, R. C., GOWLAND, P. A. and FRANCIS, S. T., 2011. fMRI and MEG analysis of visceral pain in healthy volunteers: Neurogastroenterol Motil 23(7), 648-e260
HUMES, D. J., FLEMING, K. M., SPILLER, R. C. and WEST, J., 2011. Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study: Gut 60(2), 219-24
ELDEGHAIDY, S., MARCIANI, L., MCGLONE, F., HOLLOWOOD, T., HORT, J., HEAD, K., TAYLOR, A. J., BUSCH, J., SPILLER, R. C., GOWLAND, P. A. and FRANCIS, S. T., 2011. The cortical response to the oral perception of fat emulsions and the effect of taster status: J Neurophysiol 105(5), 2572-81
SPILLER, R. and LAM, C., 2011. The shifting interface between IBS and IBD: Curr Opin Pharmacol 11(6), 586-92
FOLEY, S., GARSED, K., SINGH, G., DUROUDIER, N.P., SWAN, C., HALL, I.P., ZAITOUN, A., BENNETT, A., MARSDEN, C., HOLMES, G., WALLS, A. and SPILLER, R.C., 2011. Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation Gastroenterology. 140(5), 1434-1443.e1
SPILLER, R. C., 2011. Irritable bowel syndrome: gender, infection, lifestyle or what else?: Dig Dis 29(2), 215-21
SPILLER, R. C., 2011. Targeting the 5-HT(3) receptor in the treatment of irritable bowel syndrome: Curr Opin Pharmacol 11(1), 68-74
SPILLER, R. C., 2011. Potential biomarkers: Gastroenterol Clin North Am 40(1), 121-39
MARCIANI, L., WRIGHT, J., FOLEY, S., HOAD, C. L., TOTMAN, J. J., BUSH, D., HARTLEY, C., ARMSTRONG, A., MANBY, P., BLACKSHAW, E., PERKINS, A. C., GOWLAND, P. A. and SPILLER, R. C., 2010. Effects of a 5-HT(3) antagonist, ondansetron, on fasting and postprandial small bowel water content assessed by magnetic resonance imaging: Aliment Pharmacol Ther 32(5), 655-63
PARKMAN, H. P., CAMILLERI, M., FARRUGIA, G., MCCALLUM, R. W., BHARUCHA, A. E., MAYER, E. A., TACK, J. F., SPILLER, R., HOROWITZ, M., VINIK, A. I., GALLIGAN, J. J., PASRICHA, P. J., KUO, B., SZARKA, L. A., MARCIANI, L., JONES, K., PARRISH, C. R., SANDRONI, P., ABELL, T., ORDOG, T., HASLER, W., KOCH, K. L., SANDERS, K., NORTON, N. J. and HAMILTON, F., 2010. Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting: Neurogastroenterol Motil 22(2), 113-33
DROSSMAN, D. A., CORAZZIARI, E., DELVAUX, M., SPILLER, R., TALLEY, N. J. and THOMPSON, W. G., 2010. [Appendix B: Rome III diagnostic criteria for functional gastrointestinal disorders.]: Rev Gastroenterol Mex 75(4), 511-516
DIZDAR, V., SPILLER, R., SINGH, G., HANEVIK, K., GILJA, O. H., EL-SALHY, M. and HAUSKEN, T., 2010. Relative importance of abnormalities of CCK and 5-HT (serotonin) in Giardia-induced post-infectious irritable bowel syndrome and functional dyspepsia: Aliment Pharmacol Ther 31(8), 883-91
AWAD, S., STEPHENSON, M. C., PLACIDI, E., MARCIANI, L., CONSTANTIN-TEODOSIU, D., GOWLAND, P. A., SPILLER, R. C., FEARON, K. C., MORRIS, P. G., MACDONALD, I. A. and LOBO, D. N., 2010. The effects of fasting and refeeding with a 'metabolic preconditioning' drink on substrate reserves and mononuclear cell mitochondrial function: Clin Nutr 29(4), 538-44
MARCIANI, L., COX, E.F., HOAD, C.L., PRITCHARD, S., TOTMAN, J.J., FOLEY, S., MISTRY, A., EVANS, S., GOWLAND, P.A. and SPILLER, R.C., 2010. Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome Gastroenterology. 138(2), 469-477
SPILLER, R., 2010. New insights into bloating and abdominal distension: is it all outlet obstruction?: Am J Gastroenterol 105(4), 888-9
SPILLER, R., 2010. Postinfectious functional dyspepsia and postinfectious irritable bowel syndrome: different symptoms but similar risk factors: Gastroenterology 138(5), 1660-3
SPILLER, R., CAMILLERI, M. and LONGSTRETH, G. F., 2010. Do the symptom-based, Rome criteria of irritable bowel syndrome lead to better diagnosis and treatment outcomes?: Clin Gastroenterol Hepatol 8(2), 125-9; discussion 129-36
SPILLER, R. C. and GRANT THOMPSON, W., 2010. [Intestinal Disorders.]: Rev Gastroenterol Mex 75(4), 484-496
SPILLER, R. C., HUMES, D. J., CAMPBELL, E., HASTINGS, M., NEAL, K. R., DUKES, G. E. and WHORWELL, P. J., 2010. The Patient Health Questionnaire 12 Somatic Symptom scale as a predictor of symptom severity and consulting behaviour in patients with irritable bowel syndrome and symptomatic diverticular disease: Aliment Pharmacol Ther 32(6), 811-20
SPILLER, R. C. and THOMPSON, W. G., 2010. Bowel disorders: Am J Gastroenterol 105(4), 775-85
TRAVIS, S. P., SPILLER, R. C., HOLZER, P. and COLOMBEL, J. F., 2009. IBD and IBS: novel mechanisms and future practice. Preface: Dig Dis 27 Suppl 1, 1-2
SIMPSON, J., SUNDLER, F., HUMES, D. J., JENKINS, D., SCHOLEFIELD, J. H. and SPILLER, R. C., 2009. Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship to symptoms: Neurogastroenterol Motil 21(8), 847-e58
MARCIANI, L., FAULKS, R., WICKHAM, M. S., BUSH, D., PICK, B., WRIGHT, J., COX, E. F., FILLERY-TRAVIS, A., GOWLAND, P. A. and SPILLER, R. C., 2009. Effect of intragastric acid stability of fat emulsions on gastric emptying, plasma lipid profile and postprandial satiety: Br J Nutr 101(6), 919-28
LOBO, D. N., HENDRY, P. O., RODRIGUES, G., MARCIANI, L., TOTMAN, J. J., WRIGHT, J. W., PRESTON, T., GOWLAND, P., SPILLER, R. C. and FEARON, K. C., 2009. Gastric emptying of three liquid oral preoperative metabolic preconditioning regimens measured by magnetic resonance imaging in healthy adult volunteers: a randomised double-blind, crossover study: Clin Nutr 28(6), 636-41
HUMES, D.J., SOLAYMANI-DODARAN, M., FLEMING, K.M., SIMPSON, J., SPILLER, R.C. and WEST, J., 2009. A population-based study of perforated diverticular disease incidence and associated mortality Gastroenterology. 136(4), 1198-1205
SPILLER, R. and GARSED, K., 2009. Infection, inflammation, and the irritable bowel syndrome: Dig Liver Dis 41(12), 844-9
SPILLER, R. and GARSED, K., 2009. Postinfectious irritable bowel syndrome: Gastroenterology 136(6), 1979-88
SPILLER, R. C., 2009. Overlap between irritable bowel syndrome and inflammatory bowel disease: Dig Dis 27 Suppl 1, 48-54
TOTMAN, J. J., MARCIANI, L., FOLEY, S., CAMPBELL, E., HOAD, C. L., MACDONALD, I. A., SPILLER, R. C. and GOWLAND, P. A., 2009. Characterization of the time course of the superior mesenteric, abdominal aorta, internal carotid and vertebral arteries blood flow response to the oral glucose challenge test using magnetic resonance imaging: Physiol Meas 30(10), 1117-36
WATERMEYER, G., EPSTEIN, D., HLATSHWAYO, S., GEORGE, D., LOCKETZ, M., OMAR, H. and SPILLER, R., 2008. Dysphagia and a skin rash: Gut 57(5), 672, 713
SIMPSON, J., SUNDLER, F., HUMES, D. J., JENKINS, D., WAKELIN, D., SCHOLEFIELD, J. H. and SPILLER, R. C., 2008. Prolonged elevation of galanin and tachykinin expression in mucosal and myenteric enteric nerves in trinitrobenzene sulphonic acid colitis: Neurogastroenterol Motil 20(4), 392-406
PERKINS, A. C., BLACKSHAW, P. E., HAY, P. D., LAWES, S. C., ATHERTON, C. T., DANSEREAU, R. J., WAGNER, L. K., SCHNELL, D. J. and SPILLER, R. C., 2008. Esophageal transit and in vivo disintegration of branded risedronate sodium tablets and two generic formulations of alendronic acid tablets: a single-center, single-blind, six-period crossover study in healthy female subjects: Clin Ther 30(5), 834-44
KEATING, C., BEYAK, M., FOLEY, S., SINGH, G., MARSDEN, C., SPILLER, R. and GRUNDY, D., 2008. Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction: role of altered serotonin metabolism Journal of Physiology. 586(18), 4517-4530
HUMES, D.J., SIMPSON, J., NEAL, K.R., SCHOLEFIELD, J.H. and SPILLER, R.C., 2008. Psychological and colonic factors in painful diverticulosis British Journal of Surgery. 95(2), 195-198
BELTINGER, J., DEL BUONO, J., SKELLY, M. M., THORNLEY, J., SPILLER, R. C., STACK, W. A. and HAWKEY, C. J., 2008. Disruption of colonic barrier function and induction of mediator release by strains of Campylobacter jejuni that invade epithelial cells: World J Gastroenterol 14(48), 7345-52
SPILLER, R., 2008. Irritable bowel syndrome--the new inflammatory bowel disease?: Clin Med 8(4), 417-9
SPILLER, R., 2008. Serotonin and GI clinical disorders: Neuropharmacology 55(6), 1072-80
SPILLER, R., 2008. Serotonergic agents and the irritable bowel syndrome: what goes wrong?: Curr Opin Pharmacol 8(6), 709-14
SPILLER, R., 2008. Review article: probiotics and prebiotics in irritable bowel syndrome: Aliment Pharmacol Ther 28(4), 385-96
SPILLER, R. C., MEYERS, N. L. and HICKLING, R. I., 2008. Identification of patients with non-d, non-C irritable bowel syndrome and treatment with renzapride: an exploratory, multicenter, randomized, double-blind, placebo-controlled clinical trial: Dig Dis Sci 53(12), 3191-200
SPILLER, R., 2007. Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5-HT signalling and metabolism in human disease: Neurogastroenterol Motil 19 Suppl 2, 25-31
SPILLER, R., 2007. Gut in 2007: Gut 56(12), 1645
SPILLER, R., 2007. Chronic diarrhoea: Gut 56(12), 1756-7
SPILLER, R., 2007. Serotonin, inflammation, and IBS: fitting the jigsaw together?: J Pediatr Gastroenterol Nutr 45 Suppl 2, S115-9
MARCIANI, L., WICKHAM, M., SINGH, G., BUSH, D., PICK, B., COX, E., FILLERY-TRAVIS, A., FAULKS, R., MARSDEN, C., GOWLAND, P. A. and SPILLER, R. C., 2007. Enhancement of intragastric acid stability of a fat emulsion meal delays gastric emptying and increases cholecystokinin release and gallbladder contraction: Am J Physiol Gastrointest Liver Physiol 292(6), G1607-13
HUMES, D., SIMPSON, J. and SPILLER, R. C., 2007. Colonic diverticular disease: Clin Evid (Online) 2007,
HOAD, C. L., MARCIANI, L., FOLEY, S., TOTMAN, J. J., WRIGHT, J., BUSH, D., COX, E. F., CAMPBELL, E., SPILLER, R. C. and GOWLAND, P. A., 2007. Non-invasive quantification of small bowel water content by MRI: a validation study: Phys Med Biol 52(23), 6909-22
AZPIROZ, F., BOUIN, M., CAMILLERI, M., MAYER, E. A., POITRAS, P., SERRA, J. and SPILLER, R. C., 2007. Mechanisms of hypersensitivity in IBS and functional disorders: Neurogastroenterol Motil 19(1 Suppl), 62-88
SPILLER, R., AZIZ, Q., CREED, F., EMMANUEL, A., HOUGHTON, L., HUNGIN, P., JONES, R., KUMAR, D., RUBIN, G., TRUDGILL, N. and WHORWELL, P., 2007. Guidelines on the irritable bowel syndrome: mechanisms and practical management: Gut 56(12), 1770-98
SPILLER, R. and BENNETT, A., 2007. Searching for the answer to irritable bowel syndrome in the colonic mucosa: SERTainty and unSERTainty: Gastroenterology 132(1), 437-41
SPILLER, R., 2007. Clinical update: irritable bowel syndrome: Lancet 369(9573), 1586-8
SPILLER, R. C., 2007. Is IBS caused by infectious diarrhea?: Nat Clin Pract Gastroenterol Hepatol 4(12), 642-3
SPILLER, R. C., 2007. Irritable bowel syndrome: bacteria and inflammation--clinical relevance now: Curr Treat Options Gastroenterol 10(4), 312-21
SPILLER, R. C., 2007. Role of infection in irritable bowel syndrome: J Gastroenterol 42 Suppl 17, 41-7
SPILLER, R., 2006. Role of motility in chronic diarrhoea: Neurogastroenterol Motil 18(12), 1045-55
SPILLER, R., 2006. How inflammation changes neuromuscular function and its relevance to symptoms in diverticular disease: J Clin Gastroenterol 40 Suppl 3, S117-20
PERKINS, A. C., FRIER, M., BLACKSHAW, P. E., SPILLER, R. C., FAIRBAIRN, K. J., DANSEREAU, R. J., KINGHORN, T., SAN, P. and HOSKING, D., 2006. Esophageal transit of the weekly film-coated risedronate (Actonel) placebo tablet in subjects with Kyphosis: Int J Pharm 311(1-2), 20-5
MARCIANI, L., WICKHAM, M. S., BUSH, D., FAULKS, R., WRIGHT, J., FILLERY-TRAVIS, A. J., SPILLER, R. C. and GOWLAND, P. A., 2006. Magnetic resonance imaging of the behaviour of oil-in-water emulsions in the gastric lumen of man: Br J Nutr 95(2), 331-9
MARCIANI, L., PFEIFFER, J. C., HORT, J., HEAD, K., BUSH, D., TAYLOR, A. J., SPILLER, R. C., FRANCIS, S. and GOWLAND, P. A., 2006. Improved methods for fMRI studies of combined taste and aroma stimuli: J Neurosci Methods 158(2), 186-94
LONGSTRETH, G. F., THOMPSON, W. G., CHEY, W. D., HOUGHTON, L. A., MEARIN, F. and SPILLER, R. C., 2006. Functional bowel disorders: Gastroenterology 130(5), 1480-91
DUNLOP, S. P., HEBDEN, J., CAMPBELL, E., NAESDAL, J., OLBE, L., PERKINS, A. C. and SPILLER, R. C., 2006. Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes: Am J Gastroenterol 101(6), 1288-94
COLEMAN, N. S., FOLEY, S., DUNLOP, S. P., WHEATCROFT, J., BLACKSHAW, E., PERKINS, A. C., SINGH, G., MARSDEN, C. A., HOLMES, G. K. and SPILLER, R. C., 2006. Abnormalities of serotonin metabolism and their relation to symptoms in untreated celiac disease: Clin Gastroenterol Hepatol 4(7), 874-81
SPILLER, R. and CAMPBELL, E., 2006. Post-infectious irritable bowel syndrome: Curr Opin Gastroenterol 22(1), 13-7
SPILLER, R., HARTLEB, M., NOWAK, A., BLASZCZYNSKA, M., LAMPE, P. and KAJOR, M., 2006. Hypervascular pancreatic mass: Gut 55(1), 122, 140
SPILLER, R., 2005. How Gut handles your manuscript: Gut 54(12), 1667
SPILLER, R., 2005. Probiotics: an ideal anti-inflammatory treatment for IBS?: Gastroenterology 128(3), 783-5
WHEATCROFT, J., WAKELIN, D., SMITH, A., MAHONEY, C. R., MAWE, G. and SPILLER, R., 2005. Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction: Neurogastroenterol Motil 17(6), 863-70
WICKS, D., WRIGHT, J., RAYMENT, P. and SPILLER, R., 2005. Impact of bitter taste on gastric motility: Eur J Gastroenterol Hepatol 17(9), 961-5
SIMPSON, J. and SPILLER, R., 2005. Colonic diverticular disease: Clin Evid 543-50
MODLIN, I. M., ADLER, G., ALEXANDER, K., ARNOLD, R., BRENNER, D. A., CORAZZIARI, E., FLOCH, M. H., LAPORTE, R. E., PETERSON, W. L., QUIGLEY, E. M., SHAPIRO, M. D., SPECHLER, S. J., SPILLER, R. C., TYTGAT, G. N. and WIEGERS, W., 2005. Information assimilation and distribution challenges and goals for real and virtual journals: J Clin Gastroenterol 39(3), 181-8
MARCIANI, L., COLEMAN, N. S., DUNLOP, S. P., SINGH, G., MARSDEN, C. A., HOLMES, G. K., SPILLER, R. C. and GOWLAND, P. A., 2005. Gallbladder contraction, gastric emptying and antral motility: single visit assessment of upper GI function in untreated celiac disease using echo-planar MRI: J Magn Reson Imaging 22(5), 634-8
MARCIANI, L., BUSH, D., WRIGHT, P., WICKHAM, M., PICK, B., WRIGHT, J., FAULKS, R., FILLERY-TRAVIS, A., SPILLER, R. C. and GOWLAND, P. A., 2005. Monitoring of gallbladder and gastric coordination by EPI: J Magn Reson Imaging 21(1), 82-5
DUNLOP, S. P., COLEMAN, N. S., BLACKSHAW, E., PERKINS, A. C., SINGH, G., MARSDEN, C. A. and SPILLER, R. C., 2005. Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome: Clin Gastroenterol Hepatol 3(4), 349-57
SPILLER, R. C., 2005. Potential future therapies for irritable bowel syndrome: will disease modifying therapy as opposed to symptomatic control become a reality?: Gastroenterol Clin North Am 34(2), 337-54
SPILLER, R., 2004. Can paroxetine improve well-being in patients with irritable bowel syndrome who do not respond to a high-fiber diet?: Nat Clin Pract Gastroenterol Hepatol 1(1), 14-5
SIMPSON, J. and SPILLER, R., 2004. Colonic diverticular disease: Clin Evid 599-609
PELLEGRINI, M., URSO, R., GIORGI, G., CERRETANI, D., SPILLER, R. C. and SHERWOOD, P., 2004. Influence of antisecretory drugs on Helicobacter pylori eradication rates: Gut 53(11), 1720; author reply 1720
DUNLOP, S. P., JENKINS, D. and SPILLER, R. C., 2004. Age-related decline in rectal mucosal lymphocytes and mast cells: Eur J Gastroenterol Hepatol 16(10), 1011-5
CONSEDINE, N. S., MAGAI, C., SPILLER, R., NEUGUT, A. I. and CONWAY, F., 2004. Breast cancer knowledge and beliefs in subpopulations of African American and Caribbean women: Am J Health Behav 28(3), 260-71
HOAD, C. L., RAYMENT, P., SPILLER, R. C., MARCIANI, L., ALONSO BDE, C., TRAYNOR, C., MELA, D. J., PETERS, H. P. and GOWLAND, P. A., 2004. In vivo imaging of intragastric gelation and its effect on satiety in humans: J Nutr 134(9), 2293-300
SPILLER, R. C., 2004. Irritable bowel syndrome: Br Med Bull 72, 15-29
SPILLER, R. C., 2004. Inflammation as a basis for functional GI disorders: Best Pract Res Clin Gastroenterol 18(4), 641-61
SPILLER, R. C., 2004. Infection, immune function, and functional gut disorders: Clin Gastroenterol Hepatol 2(6), 445-55
SPILLER, R. C., 2004. Progress report: Gut 53(3), 317
SPILLER, R., 2003. A change at the tiller: Gut 52(7), 917
SIMPSON, J. and SPILLER, R., 2003. Colonic diverticular disease: Clin Evid 478-87
SIMPSON, J., SCHOLEFIELD, J. H. and SPILLER, R. C., 2003. Origin of symptoms in diverticular disease: Br J Surg 90(8), 899-908
SIMPSON, J., LOBO, D. N., SPILLER, R. C. and SCHOLEFIELD, J. H., 2003. Diverticular abscess of the appendix: report of a case and review of the literature: Dis Colon Rectum 46(6), 832-4
SIMPSON, J., NEAL, K. R., SCHOLEFIELD, J. H. and SPILLER, R. C., 2003. Patterns of pain in diverticular disease and the influence of acute diverticulitis: Eur J Gastroenterol Hepatol 15(9), 1005-10
NAKAMURA, M., SPILLER, R. C., BARRETT, D. A., WIBAWA, J. I., KUMAGAI, N., TSUCHIMOTO, K. and TANAKA, T., 2003. Gastric juice, gastric tissue and blood antibiotic concentrations following omeprazole, amoxicillin and clarithromycin triple therapy: Helicobacter 8(4), 294-9
DUNLOP, S. P., JENKINS, D. and SPILLER, R. C., 2003. Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndrome: Am J Gastroenterol 98(7), 1578-83
DUNLOP, S. P., JENKINS, D., NEAL, K. R. and SPILLER, R. C., 2003. Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS: Gastroenterology 125(6), 1651-9
DUNLOP, S. P., JENKINS, D., NEAL, K. R., NAESDAL, J., BORGAONKER, M., COLLINS, S. M. and SPILLER, R. C., 2003. Randomized, double-blind, placebo-controlled trial of prednisolone in post-infectious irritable bowel syndrome: Aliment Pharmacol Ther 18(1), 77-84
CORAZZIARI, E., BYTZER, P., DELVAUX, M., HOLTMANN, G., MALAGELADA, J. R., MORRIS, J., MULLER-LISSNER, S., SPILLER, R. C., TACK, J. and WHORWELL, P. J., 2003. Clinical trial guidelines for pharmacological treatment of irritable bowel syndrome: Aliment Pharmacol Ther 18(6), 569-80
COLEMAN, N. S., MARCIANI, L., BLACKSHAW, E., WRIGHT, J., PARKER, M., YANO, T., YAMAZAKI, S., CHAN, P. Q., WILDE, K., GOWLAND, P. A., PERKINS, A. C. and SPILLER, R. C., 2003. Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans: Aliment Pharmacol Ther 18(10), 1039-48
SPILLER, R. C., 2003. Mechanisms of postoperative intestinal motor dysfunction: Curr Opin Gastroenterol 19(2), 103-5
SPILLER, R. C., 2003. Treatment of Irritable Bowel Syndrome: Curr Treat Options Gastroenterol 6(4), 329-337
SPILLER, R. C., 2003. Infection as a cause of irritable bowel syndrome: Hosp Med 64(5), 270-4
SPILLER, R. C., 2003. Postinfectious irritable bowel syndrome: Gastroenterology 124(6), 1662-71
SPILLER, R. C., 2003. Estimating the importance of infection in IBS: Am J Gastroenterol 98(2), 238-41
SPILLER, R., 2002. Serotonergic modulating drugs for functional gastrointestinal diseases: Br J Clin Pharmacol 54(1), 11-20
SPILLER, R., 2002. Pharmacotherapy: non-serotonergic mechanisms: Gut 51 Suppl 1, i87-90
SIMPSON, J. and SPILLER, R., 2002. Colonic diverticular disease: Clin Evid 436-44
SIMPSON, J., SCHOLEFIELD, J. H. and SPILLER, R. C., 2002. Pathogenesis of colonic diverticula: Br J Surg 89(5), 546-54
SHERWOOD, P. V., WIBAWA, J. I., ATHERTON, J. C., JORDAN, N., JENKINS, D., BARRETT, D. A., SHAW, P. N. and SPILLER, R. C., 2002. Impact of acid secretion, gastritis, and mucus thickness on gastric transfer of antibiotics in rats: Gut 51(4), 490-5
NEAL, K. R., BARKER, L. and SPILLER, R. C., 2002. Prognosis in post-infective irritable bowel syndrome: a six year follow up study: Gut 51(3), 410-3
MARCIANI, L., LITTLE, S. L., SNEE, J., COLEMAN, N. S., TYLER, D. J., SYKES, J., JOLLIFFE, I. G., DETTMAR, P. W., SPILLER, R. C. and GOWLAND, P. A., 2002. Echo-planar magnetic resonance imaging of Gaviscon alginate rafts in-vivo: J Pharm Pharmacol 54(10), 1351-6
HEBDEN, J. M., BLACKSHAW, E., D'AMATO, M., PERKINS, A. C. and SPILLER, R. C., 2002. Abnormalities of GI transit in bloated irritable bowel syndrome: effect of bran on transit and symptoms: Am J Gastroenterol 97(9), 2315-20
COLEMAN, N. and SPILLER, R., 2002. No cause for alarm in IBS: Practitioner 246(1638), 557
SPILLER, R. C., 2002. Neuropathology of IBS?: Gastroenterology 123(6), 2144-7
SPILLER, R. C., 2002. Role of nerves in enteric infection: Gut 51(6), 759-62
TALLEY, N. J. and SPILLER, R., 2002. Irritable bowel syndrome: a little understood organic bowel disease?: Lancet 360(9332), 555-64
THORNLEY, J. P., JENKINS, D., NEAL, K., WRIGHT, T., BROUGH, J. and SPILLER, R. C., 2001. Relationship of Campylobacter toxigenicity in vitro to the development of postinfectious irritable bowel syndrome: J Infect Dis 184(5), 606-9
PERKINS, A. C., WILSON, C. G., FRIER, M., BLACKSHAW, P. E., JUAN, D., DANSEREAU, R. J., HATHAWAY, S., LI, Z., LONG, P. and SPILLER, R. C., 2001. Oesophageal transit, disintegration and gastric emptying of a film-coated risedronate placebo tablet in gastro-oesophageal reflux disease and normal control subjects: Aliment Pharmacol Ther 15(1), 115-21
PERKINS, A. C., WILSON, C. G., FRIER, M., BLACKSHAW, P. E., DANSEREAU, R. J., VINCENT, R. M., WENDEROTH, D., HATHAWAY, S., LI, Z. and SPILLER, R. C., 2001. The use of scintigraphy to demonstrate the rapid esophageal transit of the oval film-coated placebo risedronate tablet compared to a round uncoated placebo tablet when administered with minimal volumes of water: Int J Pharm 222(2), 295-303
MARCIANI, L., YOUNG, P., WRIGHT, J., MOORE, R., COLEMAN, N., GOWLAND, P. A. and SPILLER, R. C., 2001. Antral motility measurements by magnetic resonance imaging: Neurogastroenterol Motil 13(5), 511-8
MARCIANI, L., RAMANATHAN, C., TYLER, D. J., YOUNG, P., MANOJ, P., WICKHAM, M., FILLERY-TRAVIS, A., SPILLER, R. C. and GOWLAND, P. A., 2001. Fat emulsification measured using NMR transverse relaxation: J Magn Reson 153(1), 1-6
MARCIANI, L., GOWLAND, P. A., SPILLER, R. C., MANOJ, P., MOORE, R. J., YOUNG, P. and FILLERY-TRAVIS, A. J., 2001. Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI: Am J Physiol Gastrointest Liver Physiol 280(6), G1227-33
MARCIANI, L., GOWLAND, P. A., FILLERY-TRAVIS, A., MANOJ, P., WRIGHT, J., SMITH, A., YOUNG, P., MOORE, R. and SPILLER, R. C., 2001. Assessment of antral grinding of a model solid meal with echo-planar imaging: Am J Physiol Gastrointest Liver Physiol 280(5), G844-9
DUNLOP, S. P. and SPILLER, R. C., 2001. Nutritional issues in irritable bowel syndrome: Curr Opin Clin Nutr Metab Care 4(6), 537-40
AUSTIN, A. S. and SPILLER, R. C., 2001. Inflammatory bowel disease, azathioprine and skin cancer: case report and literature review: Eur J Gastroenterol Hepatol 13(2), 193-4
SPILLER, R. C., 2001. ABC of the upper gastrointestinal tract: Anorexia, nausea, vomiting, and pain: BMJ 323(7325), 1354-7
SPILLER, R. C., 2001. Effects of serotonin on intestinal secretion and motility: Curr Opin Gastroenterol 17(2), 99-103
SHERWOOD, P. and SPILLER, R., 2000. Could the duration of anti-Helicobacter pylori treatment be shorter?: Dig Liver Dis 32(4), 281-4
MARCIANI, L., YOUNG, P., WRIGHT, J., MOORE, R. J., EVANS, D. F., SPILLER, R. C. and GOWLAND, P. A., 2000. Echoplanar imaging in GI clinical practice: assessment of gastric emptying and antral motility in four patients: J Magn Reson Imaging 12(2), 343-6
MARCIANI, L., GOWLAND, P. A., SPILLER, R. C., MANOJ, P., MOORE, R. J., YOUNG, P., AL-SAHAB, S., BUSH, D., WRIGHT, J. and FILLERY-TRAVIS, A. J., 2000. Gastric response to increased meal viscosity assessed by echo-planar magnetic resonance imaging in humans: J Nutr 130(1), 122-7
JONES, J., BOORMAN, J., CANN, P., FORBES, A., GOMBORONE, J., HEATON, K., HUNGIN, P., KUMAR, D., LIBBY, G., SPILLER, R., READ, N., SILK, D. and WHORWELL, P., 2000. British Society of Gastroenterology guidelines for the management of the irritable bowel syndrome: Gut 47 Suppl 2, ii1-19
HEBDEN, J. M., BLACKSHAW, P. E., PERKINS, A. C., WILSON, C. G. and SPILLER, R. C., 2000. Limited exposure of the healthy distal colon to orally-dosed formulation is further exaggerated in active left-sided ulcerative colitis: Aliment Pharmacol Ther 14(2), 155-61
SPILLER, R. C., 2000. Haute cuisine and the colon: Gut 46(2), 150-1
SPILLER, R. C., JENKINS, D., THORNLEY, J. P., HEBDEN, J. M., WRIGHT, T., SKINNER, M. and NEAL, K. R., 2000. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome: Gut 47(6), 804-11
ZANTEN, S. J., BRADETTE, M., FARLEY, A., LEDDIN, D., LIND, T., UNGE, P., BAYERDORFFER, E., SPILLER, R. C., O'MORAIN, C., SIPPONEN, P., WRANGSTADH, M., ZEIJLON, L. and SINCLAIR, P., 1999. The DU-MACH study: eradication of Helicobacter pylori and ulcer healing in patients with acute duodenal ulcer using omeprazole based triple therapy: Aliment Pharmacol Ther 13(3), 289-95
PERKINS, A. C., WILSON, C. G., FRIER, M., VINCENT, R. M., BLACKSHAW, P. E., DANSEREAU, R. J., JUHLIN, K. D., BEKKER, P. J. and SPILLER, R. C., 1999. Esophageal transit of risedronate cellulose-coated tablet and gelatin capsule formulations: Int J Pharm 186(2), 169-75
MEGRAUD, F., LEHN, N., LIND, T., BAYERDORFFER, E., O'MORAIN, C., SPILLER, R., UNGE, P., VAN ZANTEN, S. V., WRANGSTADH, M. and BURMAN, C. F., 1999. Antimicrobial susceptibility testing of Helicobacter pylori in a large multicenter trial: the MACH 2 study: Antimicrob Agents Chemother 43(11), 2747-52
MALFERTHEINER, P., BAYERDORFFER, E., DIETE, U., GIL, J., LIND, T., MISIUNA, P., O'MORAIN, C., SIPPONEN, P., SPILLER, R. C., STASIEWICZ, J., TREICHEL, H., UJSZASZY, L., UNGE, P., ZANTEN, S. J. and ZEIJLON, L., 1999. The GU-MACH study: the effect of 1-week omeprazole triple therapy on Helicobacter pylori infection in patients with gastric ulcer: Aliment Pharmacol Ther 13(6), 703-12
LIND, T., MEGRAUD, F., UNGE, P., BAYERDORFFER, E., O'MORAIN, C., SPILLER, R., VELDHUYZEN VAN ZANTEN, S., BARDHAN, K. D., HELLBLOM, M., WRANGSTADH, M., ZEIJLON, L. and CEDERBERG, C., 1999. The MACH2 study: role of omeprazole in eradication of Helicobacter pylori with 1-week triple therapies: Gastroenterology 116(2), 248-53
HEBDEN, J. M., GILCHRIST, P. J., PERKINS, A. C., WILSON, C. G. and SPILLER, R. C., 1999. Stool water content and colonic drug absorption: contrasting effects of lactulose and codeine: Pharm Res 16(8), 1254-9
HEBDEN, J. M., GILCHRIST, P. J., BLACKSHAW, E., FRIER, M. E., PERKINS, A. C., WILSON, C. G. and SPILLER, R. C., 1999. Night-time quiescence and morning activation in the human colon: effect on transit of dispersed and large single unit formulations: Eur J Gastroenterol Hepatol 11(12), 1379-85
GODDARD, A. F., LOGAN, R. P., LAWES, S. and SPILLER, R. C., 1999. Randomized controlled comparison of nitroimidazoles for the eradication of Helicobacter pylori and relief of ulcer-associated and non-ulcer dyspepsia: Aliment Pharmacol Ther 13(5), 637-42
HEBDEN, J. M., WILSON, C. G., SPILLER, R. C., GILCHRIST, P. J., BLACKSHAW, E., FRIER, M. E. and PERKINS, A. C., 1999. Regional differences in quinine absorption from the undisturbed human colon assessed using a timed release delivery system: Pharm Res 16(7), 1087-92
BOULBY, P., MOORE, R., GOWLAND, P. and SPILLER, R. C., 1999. Fat delays emptying but increases forward and backward antral flow as assessed by flow-sensitive magnetic resonance imaging: Neurogastroenterol Motil 11(1), 27-36
BAYERDORFFER, E., LIND, T., DITE, P., BARDHAN, K. D., O'MORAIN, C., DELCHIER, J. C., SPILLER, R., VELDHUYZEN VAN ZANTEN, S., SIPPONEN, P., MEGRAUD, F. and ZEIJLON, L., 1999. Omeprazole, amoxycillin and metronidazole for the cure of Helicobacter pylori infection: Eur J Gastroenterol Hepatol 11 Suppl 2, S19-22; discussion S23-4
SPILLER, R. C., 1999. Impact of dietary fiber on absorption from the small intestine: Curr Opin Gastroenterol 15(2), 100-2
SPILLER, R. C., 1999. Problems and challenges in the design of irritable bowel syndrome clinical trials: experience from published trials: Am J Med 107(5A), 91S-97S
SPILLER, R. C., 1999. Disturbances in large bowel motility: Baillieres Best Pract Res Clin Gastroenterol 13(3), 397-413
SPILLER, R. C., 1999. Is there any difference in Helicobacter pylori eradication rates in patients with active peptic ulcer, inactive peptic ulcer and functional dyspepsia?: Eur J Gastroenterol Hepatol 11 Suppl 2, S25-8; discussion S43-5
SPILLER, R. C., 1999. Upper gut dysmotility in slow-transit constipation: is it evidence for a pan-enteric neurological deficit in severe slow transit constipation?: Eur J Gastroenterol Hepatol 11(7), 693-6
WASHINGTON, N., HARRIS, M., MUSSELLWHITE, A. and SPILLER, R. C., 1998. Moderation of lactulose-induced diarrhea by psyllium: effects on motility and fermentation: Am J Clin Nutr 67(2), 317-21
WASHINGTON, N., RIDLEY, P., THOMAS, C., SPILLER, R. C., WATTS, P. J. and WILSON, C. G., 1998. Mebeverine decreases mass movements and stool frequency in lactulose-induced diarrhoea: Aliment Pharmacol Ther 12(6), 583-8
MCINTYRE, A. S., AYRES, R., ATHERTON, J., SPILLER, R. C. and COCKEL, R., 1998. Dissecting intramural haematoma of the oesophagus: QJM 91(10), 701-5
MARCIANI, L., MANOJ, P., HILLS, B. P., MOORE, R. J., YOUNG, P., FILLERY-TRAVIS, A., SPILLER, R. C. and GOWLAND, P. A., 1998. Echo-planar imaging relaxometry to measure the viscosity of a model meal: J Magn Reson 135(1), 82-6
HEBDEN, J. M., BLACKSHAW, P. E., PERKINS, A. C., D'AMATO, M. and SPILLER, R. C., 1998. Small bowel transit of a bran meal residue in humans: sieving of solids from liquids and response to feeding: Gut 42(5), 685-9
GODDARD, A. F., ERAH, P. O., BARRETT, D. A., SHAW, P. N. and SPILLER, R. C., 1998. The effect of protein binding and lipophilicity of penicillins on their in-vitro flux across gastric mucosa: J Antimicrob Chemother 41(2), 231-6
SPILLER, R. C., 1998. How can we improve on the efficacy of Helicobacter pylori treatment?: Ital J Gastroenterol Hepatol 30(4), 351-4
SPILLER, R., 1997. Investigation and management of gastrointestinal motility disease: J R Coll Physicians Lond 31(6), 607-13
MCINTYRE, A., VINCENT, R. M., PERKINS, A. C. and SPILLER, R. C., 1997. Effect of bran, ispaghula, and inert plastic particles on gastric emptying and small bowel transit in humans: the role of physical factors: Gut 40(2), 223-7
NEAL, K. R., HEBDEN, J. and SPILLER, R., 1997. Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome: postal survey of patients: BMJ 314(7083), 779-82
JESSA, M. J., GODDARD, A. F., BARRETT, D. A., SHAW, P. N. and SPILLER, R. C., 1997. The effect of omeprazole on the pharmacokinetics of metronidazole and hydroxymetronidazole in human plasma, saliva and gastric juice: Br J Clin Pharmacol 44(3), 245-53
GODDARD, A. F. and SPILLER, R. C., 1997. In vitro assessment of gastric mucosal transfer of anti-Helicobacter therapeutic agents: Antimicrob Agents Chemother 41(6), 1246-9
GODDARD, A. F., LOGAN, R. P., ATHERTON, J. C., JENKINS, D. and SPILLER, R. C., 1997. Healing of duodenal ulcer after eradication of Helicobacter heilmannii: Lancet 349(9068), 1815-6
ERAH, P. O., GODDARD, A. F., BARRETT, D. A., SHAW, P. N. and SPILLER, R. C., 1997. The stability of amoxycillin, clarithromycin and metronidazole in gastric juice: relevance to the treatment of Helicobacter pylori infection: J Antimicrob Chemother 39(1), 5-12
DUGGAN, A. E., ATHERTON, J. C., COCKAYNE, A., BALSITIS, M., EVISON, S., HALE, T., HAWKEY, C. J. and SPILLER, R. C., 1997. Clarification of the link between polyunsaturated fatty acids and Helicobacter pylori-associated duodenal ulcer disease: a dietary intervention study: Br J Nutr 78(4), 515-22
BOULBY, P., GOWLAND, P., ADAMS, V. and SPILLER, R. C., 1997. Use of echo planar imaging to demonstrate the effect of posture on the intragastric distribution and emptying of an oil/water meal: Neurogastroenterol Motil 9(1), 41-7
LIND, T., VELDHUYZEN VAN ZANTEN, S., UNGE, P., SPILLER, R., BAYERDORFFER, E., O'MORAIN, C., BARDHAN, K. D., BRADETTE, M., CHIBA, N., WRANGSTADH, M., CEDERBERG, C. and IDSTROM, J. P., 1996. Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH I Study: Helicobacter 1(3), 138-44
JESSA, M. J., BARRETT, D. A., SHAW, P. N. and SPILLER, R. C., 1996. Rapid and selective high-performance liquid chromatographic method for the determination of metronidazole and its active metabolite in human plasma, saliva and gastric juice: J Chromatogr B Biomed Appl 677(2), 374-9
GODDARD, A. F. and SPILLER, R. C., 1996. The effect of omeprazole on gastric juice viscosity, pH and bacterial counts: Aliment Pharmacol Ther 10(1), 105-9
GODDARD, A. F. and SPILLER, R. C., 1996. Helicobacter pylori eradication in clinical practice: one-week low-dose triple therapy is preferable to classical bismuth based triple therapy: Aliment Pharmacol Ther 10(6), 1009-13
GODDARD, A. F., JESSA, M. J., BARRETT, D. A., SHAW, P. N., IDSTROM, J. P., CEDERBERG, C. and SPILLER, R. C., 1996. Effect of omeprazole on the distribution of metronidazole, amoxicillin, and clarithromycin in human gastric juice: Gastroenterology 111(2), 358-67
GARDNER, N., HARESIGN, W., SPILLER, R., FARRAJ, N., WISEMAN, J., NORBURY, H. and ILLUM, L., 1996. Development and validation of a pig model for colon-specific drug delivery: J Pharm Pharmacol 48(7), 689-93
ATHERTON, J. C., CULLEN, D. J., KIRK, G. E., HAWKEY, C. J. and SPILLER, R. C., 1996. Enhanced eradication of Helicobacter pylori by pre- versus post-prandial amoxycillin suspension with omeprazole: implications for antibiotic delivery: Aliment Pharmacol Ther 10(4), 631-5
SPILLER, R. C., 1996. Cholesterol, fibre, and bile acids: Lancet 347(8999), 415-6
VAUTIER, G. and SPILLER, R. C., 1995. Safety of complementary medicines should be monitored: BMJ 311(7005), 633
VINCENT, R., ROBERTS, A., FRIER, M., PERKINS, A. C., MACDONALD, I. A. and SPILLER, R. C., 1995. Effect of bran particle size on gastric emptying and small bowel transit in humans: a scintigraphic study: Gut 37(2), 216-9
THOMPSON, L. and SPILLER, R. C., 1995. Impact of polyunsaturated fatty acids on human colonic bacterial metabolism: an in vitro and in vivo study: Br J Nutr 74(5), 733-41
DE FRANCO, D. J., SPILLER, R. E., JR. and VON FRAUNHOFER, J. A., 1995. Frictional resistances using Teflon-coated ligatures with various bracket-archwire combinations: Angle Orthod 65(1), 63-72; discussion 73-4
CHARNLEY, R. M., BANERJEE, A. K., WHITAKER, S. C., SPILLER, R. C. and DORAN, J., 1995. Peritoneal seeding of pancreatic cancer following transperitoneal biliary procedures: Br J Surg 82(3), 393
ATHERTON, J. C., WASHINGTON, N., BLACKSHAW, P. E., GREAVES, J. L., PERKINS, A. C., HAWKEY, C. J. and SPILLER, R. C., 1995. Effect of a test meal on the intragastric distribution of urea in the 13C-urea breath test for Helicobacter pylori: Gut 36(3), 337-40
ATHERTON, J. C., COCKAYNE, A., BALSITIS, M., KIRK, G. E., HAWKEY, C. J. and SPILLER, R. C., 1995. Detection of the intragastric sites at which Helicobacter pylori evades treatment with amoxycillin and cimetidine: Gut 36(5), 670-4
ADKIN, D. A., GOWLAND, P., SPILLER, R. C., FREEMAN, A., HYKIN, J., ISSA, B., HUCKLE, P. D. and WILDING, I. R., 1995. Echo-planar magnetic resonance imaging to assess water volume in the distal small bowel: Pharm Res 12(8), 1134-9
PERKINS, A. C., WILSON, C. G., BLACKSHAW, P. E., VINCENT, R. M., DANSEREAU, R. J., JUHLIN, K. D., BEKKER, P. J. and SPILLER, R. C., 1994. Impaired oesophageal transit of capsule versus tablet formulations in the elderly: Gut 35(10), 1363-7
CHARNLEY, R. M., SPILLER, R. C. and DORAN, J., 1994. Surgery for pancreatic cancer: BMJ 308(6945), 1715
CANN, P. A., ROVATI, L. C., SMART, H. L., SPILLER, R. C. and WHORWELL, P. J., 1994. Loxiglumide, a CCK-A antagonist, in irritable bowel syndrome. A pilot multicenter clinical study: Ann N Y Acad Sci 713, 449-50
ATHERTON, J. C., WASHINGTON, N., BRACEWELL, M. A., SUTTON, L. J., GREAVES, J. L., PERKINS, A. C., HAWKEY, C. J. and SPILLER, R. C., 1994. Scintigraphic assessment of the intragastric distribution and gastric emptying of an encapsulated drug: the effect of feeding and of a proton pump inhibitor: Aliment Pharmacol Ther 8(5), 489-94
ATHERTON, J. C. and SPILLER, R. C., 1994. The urea breath test for Helicobacter pylori: Gut 35(6), 723-5
ATHERTON, J. C., HUDSON, N., KIRK, G. E., HAWKEY, C. K. and SPILLER, R. C., 1994. Amoxycillin capsules with omeprazole for the eradication of Helicobacter pylori. Assessment of the importance of antibiotic dose timing in relation to meals: Aliment Pharmacol Ther 8(5), 495-8
SPILLER, R. C., 1994. Irritable bowel or irritable mind? Medical treatment works for those with clear diagnosis: BMJ 309(6969), 1646-7
SPILLER, R. C., 1994. Intestinal absorptive function: Gut 35(1 Suppl), S5-9
SPILLER, R. C., 1994. Pharmacology of dietary fibre: Pharmacol Ther 62(3), 407-27
SPILLER, R. E., JR., 1994. Dispenser tube for stainless steel ligatures: J Clin Orthod 28(3), 142
THOMPSON, L., COCKAYNE, A. and SPILLER, R. C., 1994. Inhibitory effect of polyunsaturated fatty acids on the growth of Helicobacter pylori: a possible explanation of the effect of diet on peptic ulceration: Gut 35(11), 1557-61
BARROW, L., STEED, K. P., SPILLER, R. C., MASKELL, N. A., BROWN, J. K., WATTS, P. J., MELIA, C. D., DAVIES, M. C. and WILSON, C. G., 1993. Quantitative, noninvasive assessment of antidiarrheal actions of codeine using an experimental model of diarrhea in man: Dig Dis Sci 38(6), 996-1003
STEED, K. P., BOHEMEN, E. K., LAMONT, G. M., EVANS, D. F., WILSON, C. G. and SPILLER, R. C., 1993. Proximal colonic response and gastrointestinal transit after high and low fat meals: Dig Dis Sci 38(10), 1793-800
BARROW, L., STEED, K. P., SPILLER, R. C., WATTS, P. J., MELIA, C. D., DAVIES, M. C. and WILSON, C. G., 1992. Scintigraphic demonstration of lactulose-induced accelerated proximal colon transit: Gastroenterology 103(4), 1167-73
PROBERT, C. S., SPILLER, R., ATKINSON, M. and MAYBERRY, J. F., 1991. Achalasia and diet: assessment of the effect of achalasia on the diet of patients and their spouses: Dysphagia 6(3), 145-6
MANSELL, P. I., TATTERSALL, R. B., BALSITIS, M., LOWE, J. and SPILLER, R. C., 1991. Megaduodenum due to hollow visceral myopathy successfully managed by duodenoplasty and feeding jejunostomy: Gut 32(3), 334-7
SPILLER, R., 1990. Management of constipation. 2. When fibre fails: BMJ 300(6731), 1064-5; discussion 1063
PAYNE-JAMES, J. J., SPILLER, R. C., MISIEWICZ, J. J. and SILK, D. B., 1990. Use of ethanol-induced tumor necrosis to palliate dysphagia in patients with esophagogastric cancer: Gastrointest Endosc 36(1), 43-6
SPILLER, R. C., 1990. Feedforward and feedback control mechanisms in the gut. With special emphasis on inhibitory feedback by nutrients in the distal small bowel and colon: Dig Dis 8(4), 189-205
SPILLER, R. E., JR., HELLSTEIN, J. W. and BASQUILL, P. J., 1990. Radiographic support in highly mobile operations: Mil Med 155(10), 486-9
PENAGINI, R., SPILLER, R. C., MISIEWICZ, J. J. and FROST, P. G., 1989. Effect of ileal infusion of glycochenodeoxycholic acid on segmental transit, motility, and flow in the human jejunum and ileum: Gut 30(5), 609-17
GARDNER-MEDWIN, J., SAYER, J., MAHIDA, Y. R. and SPILLER, R. C., 1989. Spontaneous rupture of spleen following streptokinase therapy: Lancet 2(8676), 1398
PENAGINI, R., SPILLER, R. C., MISIEWICZ, J. J., FROST, P. G. and SILK, D. B., 1988. Effect of cholecystectomy on mouth-to-cecum transit of a liquid meal: Dig Dis Sci 33(1), 19-22
SPILLER, R. C., LOVELL, D. and SILK, D. B., 1988. Adult acquired cytomegalovirus infection with gastric and duodenal ulceration: Gut 29(8), 1109-11
SPILLER, R. C., TROTMAN, I. F., ADRIAN, T. E., BLOOM, S. R., MISIEWICZ, J. J. and SILK, D. B., 1988. Further characterisation of the 'ileal brake' reflex in man--effect of ileal infusion of partial digests of fat, protein, and starch on jejunal motility and release of neurotensin, enteroglucagon, and peptide YY: Gut 29(8), 1042-51
SPILLER, R. C., BROWN, M. L. and PHILLIPS, S. F., 1987. Emptying of the terminal ileum in intact humans. Influence of meal residue and ileal motility: Gastroenterology 92(3), 724-9
SPILLER, R. C., FROST, P. F., STEWART, J. S., BLOOM, S. R. and SILK, D. B., 1987. Delayed postprandial plasma bile acid response in coeliac patients with slow mouth-caecum transit: Clin Sci (Lond) 72(2), 217-23
SPILLER, R. C., JONES, B. J. and SILK, D. B., 1987. Jejunal water and electrolyte absorption from two proprietary enteral feeds in man: importance of sodium content: Gut 28(6), 681-7
SPILLER, R. C., LEE, Y. C., EDGE, C., RALPHS, D. N., STEWART, J. S., BLOOM, S. R. and SILK, D. B., 1987. Delayed mouth-caecum transit of a lactulose labelled liquid test meal in patients with steatorrhoea caused by partially treated coeliac disease: Gut 28(10), 1275-82
SPILLER, R. C. and MISIEWICZ, J. J., 1987. Ethanol-induced tumour necrosis for palliation of malignant dysphagia: Lancet 2(8562), 792
SPILLER, R. C., 1986. Where do all the tablets go in 1986?: Gut 27(8), 879-85
SPILLER, R. C., BROWN, M. L. and PHILLIPS, S. F., 1986. Decreased fluid tolerance, accelerated transit, and abnormal motility of the human colon induced by oleic acid: Gastroenterology 91(1), 100-7
SPILLER, R. C., BROWN, M. L., PHILLIPS, S. F. and AZPIROZ, F., 1986. Scintigraphic measurements of canine ileocolonic transit. Direct and indirect effects of eating: Gastroenterology 91(5), 1213-20
KEOHANE, P. P., GRIMBLE, G. K., BROWN, B., SPILLER, R. C. and SILK, D. B., 1985. Influence of protein composition and hydrolysis method on intestinal absorption of protein in man: Gut 26(9), 907-13
SPILLER, W. F. and SPILLER, R. F., 1985. Cryoanesthesia and electrosurgical treatment of benign skin tumors: Cutis 35(6), 551-2
SPILLER, R. C., HIGGINS, B. E., FROST, P. G. and SILK, D. B., 1984. Inhibition of jejunal water and electrolyte absorption by therapeutic doses of clindamycin in man: Clin Sci (Lond) 67(1), 117-20
SPILLER, R. C., TROTMAN, I. F., HIGGINS, B. E., GHATEI, M. A., GRIMBLE, G. K., LEE, Y. C., BLOOM, S. R., MISIEWICZ, J. J. and SILK, D. B., 1984. The ileal brake--inhibition of jejunal motility after ileal fat perfusion in man: Gut 25(4), 365-74
SPILLER, W. F. and SPILLER, R. F., 1984. Treatment of basal cell epithelioma by curettage and electrodesiccation: J Am Acad Dermatol 11(5 Pt 1), 808-14
SHOUSHA, S., SPILLER, R. C. and PARKINS, R. A., 1983. The endoscopically abnormal duodenum in patients with dyspepsia: biopsy findings in 60 cases: Histopathology 7(1), 23-34
KRAWCZYNSKI, M., SPILLER, R. and BORSKI, K., 1983. [Klippel-Feil syndrome associated with renal agenesia and heart defect in an 11-year-old girl]: Wiad Lek 36(18), 1527-31
KEOHANE, P. P., ATTRILL, H., GRIMBLE, G., SPILLER, R., FROST, P. and SILK, D. B., 1983. Enteral nutrition in malnourished patients with hepatic cirrhosis and acute encephalopathy: JPEN J Parenter Enteral Nutr 7(4), 346-50
SPILLER, R. C. and PARKINS, R. A., 1983. Recurrent gastrointestinal bleeding of obscure origin: report of 17 cases and a guide to logical management: Br J Surg 70(8), 489-93
SPILLER, R. C., SHOUSHA, S. and BARRISON, I. G., 1982. Heterotopic gastric tissue in the duodenum: a report of eight cases: Dig Dis Sci 27(10), 880-3
SPILLER, R. C., CATTO, J. V. and KANE, S. P., 1981. Spontaneous dissecting intramural haematoma of the oesophagus: a rare cause of haematemesis and dysphagia: Endoscopy 13(3), 128-30