Walter Kockenberger

Contact

• workRoom MR14 Sir Peter Mansfield Imaging Centre
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 951 5161
• walter.kockenberger@nottingham.ac.uk

Research Summary

Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI) are important tools in many scientific disciplines, including medical diagnostics, molecular biology, pharmaceutical… read more

Selected Publications

• KARABANOV, A., VAN DER DRIFT, A., EDWARDS, L.J., KUPROV, I. and KÖCKENBERGER, W., 2012. Quantum mechanical simulation of solid effect dynamic nuclear polarisation using Krylov–Bogolyubov time averaging and a restricted state-space Physical Chemistry Chemical Physics. 14(8), 2658-2668
• KARABANOV, A, KUPROV, I, CHARNOCK, GTP, VAN DER DRIFT, A, EDWARDS, LJ and KOECKENBERGER, W, 2011. On The Accuracy Of The State Space Restriction Approximation For Spin Dynamics Simulations Journal Of Chemical Physics. 135(8), -
• LEGGETT, J., HUNTER, R., GRANWEHR, J., PANEK, R., PEREZ-LINDE, A.J., HORSEWILL, A.J., MCMASTER, J., SMITH, G. and KÖCKENBERGER, W., 2010. A dedicated spectrometer for dissolution DNP NMR spectroscopy Physical Chemistry Chemical Physics. 12(22), 5883-5892
• PANEK, R., GRANWEHR, J., LEGGETT, J. and KÖCKENBERGER, W., 2010. Slice-selective single scan proton COSY with dynamic nuclear polarisation Physical Chemistry Chemical Physics. 12(22), 5771-5778

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Current Research

Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI) are important tools in many scientific disciplines, including medical diagnostics, molecular biology, pharmaceutical and material sciences. However, due to fundamental principles that relate to the low energy of interaction between a strong magnetic field and the weak magnetic moment of certain nuclei such as hydrogen, the sensitivity of these techniques is usually low in comparison to other spectroscopic techniques. I am currently involved in the design and testing of an novel spectrometer which will provide much higher sensitivity. The instrument relies on exploiting the interaction between unpaired electrons and nuclear spins in a process called dynamic nuclear polarisation (DNP). The approach is technically very challenging since it requires the accommodation of two iso-centres within a superconductive magnet. The realisation of such a prototype instrument will have strong impact on many research areas since the generation of a much stronger NMR signal will open up a range of novel applications such as NMR microscopy with very high spatial resolution and very fast spectroscopy of the interaction of different nuclei. For instance, it will make micro-imaging and spectroscopic studies on a single cell level possible or it may enable us to perform NMR spectroscopy experiments with very high temporal resolution.

I am also interested in theoretical aspects of DNP and the use of parahydrogen to enhance the NMR signal. In this context I have used principles based on optimal control to design strategies for the distribution of spin polarisation in a system containing more than two coupled spins. Further details of NMR and MRI research projects can be found on the Sir Peter Mansfield Magnetic Resonance Centre webpage. Current Teaching Biomedical Physics (F31AB1) Molecular Biophysics (F32SB3) Computational Physics (F32SC2)

• WISNIEWSKI, DANIEL, KARABANOV, ALEXANDER, LESANOVSKY, IGOR and KOECKENBERGER, WALTER, 2016. Solid effect DNP polarization dynamics in a system of many spins JOURNAL OF MAGNETIC RESONANCE. 264, 30-38
• KARABANOV, ALEXANDER, KWIATKOWSKI, GRZEGORZ, PEROTTO, CARLO U., WISNIEWSKI, DANIEL, MCMASTER, JONATHAN, LESANOVSKY, IGOR and KOCKENBERGER, WALTER, 2016. Dynamic nuclear polarisation by thermal mixing: quantum theory and macroscopic simulations PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 18(43), 30093-30104
• GLASER, STEFFEN J., BOSCAIN, UGO, CALARCO, TOMMASO, KOCH, CHRISTIANE P., KOECKENBERGER, WALTER, KOSLOFF, RONNIE, KUPROV, ILYA, LUY, BURKHARD, SCHIRMER, SOPHIE, SCHULTE-HERBRUEGGEN, THOMAS, SUGNY, DOMINIQUE and WILHELM, FRANK K., 2015. Training Schrodinger's cat: quantum optimal control Strategic report on current status, visions and goals for research in Europe EUROPEAN PHYSICAL JOURNAL D. 69(12),
• KARABANOV, A., WISNIEWSKI, D., LESANOVSKY, I. and KOECKENBERGER, W., 2015. Dynamic Nuclear Polarization as Kinetically Constrained Diffusion PHYSICAL REVIEW LETTERS. 115(2),
• KARABANOV, ALEXANDER, KWIATKOWSKI, GRZEGORZ and KOECKENBERGER, WALTER, 2014. Spin dynamic simulations of solid effect DNP: the role of the relaxation superoperator MOLECULAR PHYSICS. 112(14), 1838-1854
• KWIATKOWSKI, GRZEGORZ, KARABANOV, ALEXANDER and KOECKENBERGER, WALTER, 2014. The Role of the Interaction Frame in the Theoretical Description of Solid Effect Dynamic Nuclear Polarization ISRAEL JOURNAL OF CHEMISTRY. 54(1-2), 184-195
• PEAT, DAVID T., HORSEWILL, ANTHONY J., KOECKENBERGER, WALTER, LINDE, ANGEL J. PEREZ, GADIAN, DAVID G. and OWERS-BRADLEY, JOHN R., 2013. Achievement of high nuclear spin polarization using lanthanides as low-temperature NMR relaxation agents PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 15(20), 7586-7591
• NAPOLITANO, ANTONIO, KOCKENBERGER, WALTER and AUER, DOROTHEE P., 2013. Reliable gamma aminobutyric acid measurement using optimized PRESS at 3 T MAGNETIC RESONANCE IN MEDICINE. 69(6), 1528-1533
• KARABANOV, A., VAN DER DRIFT, A., EDWARDS, L.J., KUPROV, I. and KÖCKENBERGER, W., 2012. Quantum mechanical simulation of solid effect dynamic nuclear polarisation using Krylov–Bogolyubov time averaging and a restricted state-space Physical Chemistry Chemical Physics. 14(8), 2658-2668
• NAPOLITANO A, KOCKENBERGER W and AUER DP, 2012. Reliable gamma aminobutyric acid measurement using optimized PRESS at 3 T. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 69(6), 1528-33
• KARABANOV, ALEXANDER, KWIATKOWSKI, GRZEGORZ and KOECKENBERGER, WALTER, 2012. Quantum Mechanical Simulation of Cross Effect DNP Using Krylov-Bogolyubov Averaging (vol 43, pg 43, 2012) APPLIED MAGNETIC RESONANCE. 43(3), 461-461
• KARABANOV, ALEXANDER, VAN DER DRIFT, ANNIEK, EDWARDS, LUKE J., KUPROV, ILYA and KOECKENBERGER, WALTER, 2012. Quantum mechanical simulation of solid effect dynamic nuclear polarisation using Krylov-Bogolyubov time averaging and a restricted state-space PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 14(8), 2658-2668
• KARABANOV, A, KUPROV, I, CHARNOCK, GTP, VAN DER DRIFT, A, EDWARDS, LJ and KOECKENBERGER, W, 2011. On The Accuracy Of The State Space Restriction Approximation For Spin Dynamics Simulations Journal Of Chemical Physics. 135(8), -
• PANEK, R., GRANWEHR, J., LEGGETT, J. and KÖCKENBERGER, W., 2010. Slice-selective single scan proton COSY with dynamic nuclear polarisation Physical Chemistry Chemical Physics. 12(22), 5771-5778
• LEGGETT, J., HUNTER, R., GRANWEHR, J., PANEK, R., PEREZ-LINDE, A.J., HORSEWILL, A.J., MCMASTER, J., SMITH, G. and KÖCKENBERGER, W., 2010. A dedicated spectrometer for dissolution DNP NMR spectroscopy Physical Chemistry Chemical Physics. 12(22), 5883-5892
• GRANWEHR, J, PANEK, R, LEGGETT, J and KOCKENBERGER, W, 2010. Quantifying The Transfer And Settling In Nmr Experiments With Sample Shuttling Journal Of Chemical Physics. 132(24), -
• KARABANOV, AA, BRETSCHNEIDER, C and KOCKENBERGER, W, 2009. Symmetries Of The Master Equation And Long-Lived States Of Nuclear Spins Journal Of Chemical Physics. 131(20), -
• MATHER, M.L., MORGAN, S.P., WHITE, L.J., TAI, H., KOCKENBERGER, W., HOWDLE, S.M., SHAKESHEFF, K.M. and CROWE, J.A., 2008. Image-based characterisation of foamed polymeric tissue scaffolds Biomedical Materials. 3(1), 015011
• GRANWEHR, J. and KÖCKENBERGER, W., 2008. Multidimensional low-power pulse EPR under DNP conditions Applied Magnetic Resonance. 34(3-4), 355-378
• PRISNER, T and KOCKENBERGER, W, 2008. Dynamic Nuclear Polarization: New Experimental And Methodology Approaches And Applications In Physics, Chemistry, Biology And Medicine
• MORLEY-SMITH, E.R., PIKE, M.J., FINDLAY, K., KÖCKENBERGER, W., HILL, L.M., SMITH, A.M. and RAWSTHORNE, S., 2008. The transport of sugars to developing embryos is not via the bulk endosperm in oilseed rape seeds Plant Physiology. 147(4), 2121-2130
• GRANWEHR, J, LEGGETT, J and KOCKENBERGER, W, 2007. A Low-Cost Implementation Of Epr Detection In A Dissolution Dnp Setup Journal Of Magnetic Resonance. 187(2), 266-276
• JEFFERY, N, DAVIES, K, KOCKENBERGER, W and WILLIAMS, S, 2007. Craniofacial Growth In Fetal Tarsius Bancanus: Brains, Eyes And Nasal Septa Journal Of Anatomy. 210(6), 703-722
• SEEFELDT, HF, VAN DEN BERG, F, KOCKENBERGER, W, ENGELSEN, SB and WOLLENWEBER, B, 2007. Water Mobility In The Endosperm Of High Beta-Glucan Barley Mutants As Studied By Nuclear Magnetic Resonance Imaging Magnetic Resonance Imaging. 25(3), 425-432
• ZHAO, YM, DUNNILL, CW, ZHU, YQ, GREGORY, DH, KOCKENBERGER, W, LI, YH, HU, WB, AHMAD, I and MCCARTNEY, DG, 2007. Low-Temperature Magnetic Properties Of Hematite Nanorods Chemistry Of Materials. 19(4), 916-921
• ANDERSEN, N.S. and KÖCKENBERGER, W., 2005. A simple approach for phase-modulated single-scan 2D NMR spectroscopy Magnetic Resonance in Chemistry: MRC. 43(10), 795-797
• KOCKENBERGER, W., DE PANFILIS, C., SANTORO, D., DAHIYA, P. and RAWSTHORNE, S., 2004. High resolution NMR microscopy of plants and fungi Journal of Microscopy. VOL 214(NUMBER 2), 182-189
• REID, SD, BLAKE, AJ, KOCKENBERGER, W, CLAIRE, WA and LOVE, JB, 2003. Double-Stranded, [4+4] Helicates Of Fe(Ii) And Mn(Ii) Supported By An Extended Dipyrrolide Ligand Dalton Transactions. 4387-4388
• SUTCH, JCD, ROSS, AC, KOCKENBERGER, W, BOWTELL, RW, MACRAE, RJ, STEVENS, HNE and MELIA, CD, 2003. Investigating The Coating-Dependent Release Mechanism Of A Pulsatile Capsule Using Nmr Microscopy Journal Of Controlled Release. 92(3), 341-347
• SINHA, A.K., HOFMANN, M.G., RÖMER, U., KÖCKENBERGER, W., ELLING, L. and ROITSCH, T., 2002. Metabolizable and non-metabolizable sugars activate different signal transduction pathways in tomato Plant Physiology. 128(4), 1480-1489
• HUDSON, AMJ, KOCKENBERGER, W, HEIDENREICH, M, CHANDRAKUMAR, N, KIMMICH, R and BOWTELL, R, 2002. H-1 Detected C-13 Echo Planar Imaging Journal Of Magnetic Resonance. 155(1), 64-71
• KOCKENBERGER, W., 2001. Functional imaging of plants by magnetic resonance experiments Trends in Plant Science. VOL 6(NUMBER 7), 286-292
• KOCKENBERGER, W., 2001. Nuclear magnetic resonance micro-imaging in the investigation of plant cell metabolism Journal of Experimental Botany. 52(356), 641-652
• ROMER, U, NETTELSTROTH, N, KOCKENBERGER, W and ELLING, L, 2001. Characterization Of Recombinant Sucrose Synthase 1 From Potato For The Synthesis Of Sucrose Analogues Advanced Synthesis & Catalysis. 343(6-7), 655-661
• ATSARKIN, A. VADIM and KOECKENBERGER, WALTER, The Different Magnetic Resonance Communities Join Forces for Progress in DNP: an Editorial for the Special Issue on DNP APPLIED MAGNETIC RESONANCE. 43(1-2), 1-2
• KARABANOV, ALEXANDER, KWIATKOWSKI, GRZEGORZ and KOECKENBERGER, WALTER, Quantum Mechanical Simulation of Cross Effect DNP Using Krylov-Bogolyubov Averaging APPLIED MAGNETIC RESONANCE. 43(1-2), 43-58
• GADIAN, DAVID G., PANESAR, KULDEEP S., LINDE, ANGEL J. PEREZ, HORSEWILL, ANTHONY J., KOECKENBERGER, WALTER and OWERS-BRADLEY, JOHN R., Preparation of highly polarized nuclear spin systems using brute-force and low-field thermal mixing PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 14(16), 5397-5402
• BRETSCHNEIDER, CHRISTIAN, KARABANOV, ALEXANDER, NIELSEN, NIELS CHR and KOCKENBERGER, WALTER, Conversion of parahydrogen induced longitudinal two-spin order to evenly distributed single spin polarisation by optimal control pulse sequences. The Journal of chemical physics. 136(9), 094201