Resources
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Glossary
- Acid: any substance that donates H+ ions; A solution that contains more H+ than OH- ions
- Base: any substance that removes free H+ from a solution
- Alkali: any substance that donates OH- ions into a solution; A solution that contains more OH- than H+ ions
- pH: the concentration of hydrogen ions (H+) in a solution
- Acidic: a solution containing excess H+ ions; a solution with a pH less than 7
- Alkaline: a solution containing fewer H+ than OH- ions; a solution with a pH greater than 7
- Neutral: a solution where there are exactly the same number of H+ and OH- ions
- Dissociation: molecules in solution break apart into ions and then re-form again
- Buffer: a molecule that can both accept H+ and donate that H+ ions
- Denaturation: alteration of a molecule's shape and structure leading to loss of function following rearrangement of its atoms
- Neutralisation: combination of an acid and an alkali to form a salt and water
- Salt: a molecule formed by the combination of an acid without its free H+ ions and an alkali without its OH- ions
Resources
| Title/link | Description |
|---|---|
| RLO: The Anatomy of the Liver | Introduction to the external and internal anatomy of the liver. |
| RLO: The Physiology of the Liver | An introduction to liver physiology and its role in metabolism. |
| RLO: Understanding First Pass Metabolism | Description of the first pass metabolism of orally-administered drugs in the liver and gastrointestinal tract |
| RLO: Plasma proteins and drug binding. | Examining the role of plasma proteins in the distribution and retention of drugs in the body |
| RLO: Half-life of Drugs | To understand the half-life of drugs and its relationship with volume of distribution and clearance |
| RLO: The Kidneys and Drug Excretion | Examining the role of the kidneys in the exretion of drugs from the body |
Books and Journals
| Egger M, Davey Smith G, Phillips AN. (1997) Meta-analysis: Principles and Procedures.BMJ;315:1533-1537. |
The Liver and Drug Metabolism - Print summary
This RLO covers role of the liver in drug metabolism.
Learning outcomes
By completing this resource you should be able to describe:
- the stages of metabolism
- factors affecting the metabolism of drugs by the liver.
By completing this resource you should be able to describe:
- the stages of metabolism
- factors affecting the metabolism of drugs by the liver.
This resource was developed by:
Dr Viv Rolfe - content author
Dr Viv Rolfe - developer
Liz Hilton - HTML5 conversion
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