Learning Objects : Lifelong Application
RLO: Volume of Distribution
Resources
| Title/link | Description |
|---|---|
| RLO: Plasma proteins and drug distribution | Examines the role of plasma proteins in the blood in the distribution and elimination of drugs in the body. |
| RLO: Pharmacokinetic and pharmacodynamic influences of aminoglycoside dosing | Examines how the absorbtion and distribution of aminoglycosides within the body affects the dosing regimens used. |
Glossary
- Extracellular fluid: Fluid which is present outside the cells or between the cells in the tissue. Consists of plasma, interstitial fluid (between cells) and transcellular fluid.
- Lipid solubility: The ability of a drug to cross cell membranes to enter cells/tissues, or to be stored in body fat. The higher the lipid solubility, the more readily this will occur.
- Loading dose: A higher than average dose of drug used initially to rapidly establish a desired level of drug in the body.
- Plasma proteins: Proteins present in the blood plasma which bind drug molecules. The main plasma proteins are albumin, acid-glycoprotein and ß-globulin.
- Plasma volume: The volume of plasma in the circulation.
© 2007 University of Nottingham
The production of this learning object was funded by the Eduserv Foundation
Developer: Lucrezia Herman
Content authors: Joanne Lymn, University of Nottingham and Tim Hills, Nottingham University Hospitals NHS Trust
RLO released: 15 November 2007
Page last updated: 24 March, 2021