Sebastien Serres

Contact

• workRoom D47 School of Life Sciences, The Medical School, Queen’s Medical Centre
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work01158230394
• Sebastien.Serres@nottingham.ac.uk

Biography

My research is interdisciplinary and translational, combining magnetic resonance (MR) imaging and spectroscopy methods, immunohistochemistry and molecular biology. During my work at Oxford, I used these approaches to investigate cellular metabolism, vascular function and inflammatory processes in animal models.

Expertise Summary

- Cell culture and experimental models of neurological disease in rodents (intracerebral, ultrasound-guided intracardiac, intraperitoneal and subcutaneous injections).

- Perfusion, fixation and extractions of cells/tissues for histology, ELISA and biochemical assays, respectively.

- Tissue sectioning and staining (immunohistochemistry and immunofluorescence).

- Electrophysiology, EEG recording, laser speckle contrast imaging.

- Determination of structural and functional changes in vivo and ex vivo using MRI (T1 and T2, diffusion, magnetisation transfer and perfusion weighted MRI, functional and molecular MRI).

- Cellular metabolism measurement in vivo and ex vivo using MRS (¹H, ¹³C and ³¹P).

- Image analysis, MRI/MRS data processing and metabolic modelling.

- Human physiological studies using clinical MR scanner and SpinLab hyperpolarizer.

Research Summary

In collaboration with the Sir Peter Mansfield Imaging Centre, our group is currently involved in the development of a cutting-edge metabolic imaging method- called Dynamic Nuclear Polarisation 13C MR… read more

Recent Publications

• MASIERO, MASSIMO, LI, DEMIN, WHITEMAN, PAT, BENTLEY, CAROL, GREIG, JENNY, HASSANALI, TASNEEM, WATTS, SARAH, STRIBBLING, STEPHEN, YATES, JENNA, BEALING, ELLEN, LI, JI-LIANG, CHILLAKURI, CHANDRAMOULI, SHEPPARD, DEVON, SERRES, SEBASTIEN, SARMIENTO-SOTO, MANUEL, LARKIN, JAMES, SIBSON, NICOLA R, HANDFORD, PENNY A, HARRIS, ADRIAN L and BANHAM, ALISON H, 2019. Development of therapeutic anti-JAGGED1 antibodies for cancer therapy. Molecular cancer therapeutics.
• MILLER, JACK J., GRIST, JAMES T., SERRES, SEBASTIEN, LARKIN, JAMES R., LAU, ANGUS Z., RAY, KEVIN, FISHER, KATHERINE R., HANSEN, ESBEN, TOUGAARD, RASMUS STILLING, NIELSEN, PER MOSE, LINDHARDT, JAKOB, LAUSTSEN, CHRISTOFFER, GALLAGHER, FERDIA A., TYLER, DAMIAN J. and SIBSON, NICOLA, 2018. C-13 Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI SCIENTIFIC REPORTS. 8,
• PEREZ-BALDERAS, F., VAN KASTEREN, S. I., ALJABALI, A. A., WALS, K., SERRES, S., JEFFERSON, A., SARMIENTO SOTO, M., KHRAPITCHEV, A. A., LARKIN, J. R., BRISTOW, C., LEE, S. S., BORT, G., DE SIMONE, F., CAMPBELL, S. J., CHOUDHURY, R. P., ANTHONY, D. C., SIBSON, N. R. and DAVIS, B. G., 2017. Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI: Nat Commun Nat Commun. 8, 14254
• RADUCU, M., FUNG, E., SERRES, S., INFANTE, P., BARBERIS, A., FISCHER, R., BRISTOW, C., THEZENAS, M. L., FINTA, C., CHRISTIANSON, J. C., BUFFA, F. M., KESSLER, B. M., SIBSON, N. R., DI MARCOTULLIO, L., TOFTGARD, R. and D'ANGIOLELLA, V., 2016. SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development: EMBO J EMBO J.

• View all publications

Current Research

In collaboration with the Sir Peter Mansfield Imaging Centre, our group is currently involved in the development of a cutting-edge metabolic imaging method- called Dynamic Nuclear Polarisation ¹³C MR spectroscopy- to investigate metabolic changes associated with brain and musculoskeletal function in health and disease. This approach could revolutionise our understanding of age-related diseases and also provide platform for diagnosis and treatment of disease in the clinic.

Interests:

In brain research:

- How disease-related changes of perivascular cell metabolism (e.g. astrocyte, pericyte and smooth muscle cell) could alter vascular function, and thus normal functioning of the brain.

- How real-time monitoring of metabolic changes could help to optimise and/or develop novel treatment strategies that aim to improve vascular function (e.g. metabolic drug, diet or exercise).

In musculoskeletal research:

- How alteration of cellular energy regeneration during exercise could affect muscular pain and fatigue, and thus quality of life.

- How real-time metabolic monitoring could help to develop and/or guide therapies targeting the effect of peripheral vascular disease on musculoskeletal function.

• MASIERO, MASSIMO, LI, DEMIN, WHITEMAN, PAT, BENTLEY, CAROL, GREIG, JENNY, HASSANALI, TASNEEM, WATTS, SARAH, STRIBBLING, STEPHEN, YATES, JENNA, BEALING, ELLEN, LI, JI-LIANG, CHILLAKURI, CHANDRAMOULI, SHEPPARD, DEVON, SERRES, SEBASTIEN, SARMIENTO-SOTO, MANUEL, LARKIN, JAMES, SIBSON, NICOLA R, HANDFORD, PENNY A, HARRIS, ADRIAN L and BANHAM, ALISON H, 2019. Development of therapeutic anti-JAGGED1 antibodies for cancer therapy. Molecular cancer therapeutics.
• MILLER, JACK J., GRIST, JAMES T., SERRES, SEBASTIEN, LARKIN, JAMES R., LAU, ANGUS Z., RAY, KEVIN, FISHER, KATHERINE R., HANSEN, ESBEN, TOUGAARD, RASMUS STILLING, NIELSEN, PER MOSE, LINDHARDT, JAKOB, LAUSTSEN, CHRISTOFFER, GALLAGHER, FERDIA A., TYLER, DAMIAN J. and SIBSON, NICOLA, 2018. C-13 Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI SCIENTIFIC REPORTS. 8,
• PEREZ-BALDERAS, F., VAN KASTEREN, S. I., ALJABALI, A. A., WALS, K., SERRES, S., JEFFERSON, A., SARMIENTO SOTO, M., KHRAPITCHEV, A. A., LARKIN, J. R., BRISTOW, C., LEE, S. S., BORT, G., DE SIMONE, F., CAMPBELL, S. J., CHOUDHURY, R. P., ANTHONY, D. C., SIBSON, N. R. and DAVIS, B. G., 2017. Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI: Nat Commun Nat Commun. 8, 14254
• RADUCU, M., FUNG, E., SERRES, S., INFANTE, P., BARBERIS, A., FISCHER, R., BRISTOW, C., THEZENAS, M. L., FINTA, C., CHRISTIANSON, J. C., BUFFA, F. M., KESSLER, B. M., SIBSON, N. R., DI MARCOTULLIO, L., TOFTGARD, R. and D'ANGIOLELLA, V., 2016. SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development: EMBO J EMBO J.
• BARDELLA, C., AL-DALAHMAH, O., KRELL, D., BRAZAUSKAS, P., AL-QAHTANI, K., TOMKOVA, M., ADAM, J., SERRES, S., LOCKSTONE, H., FREEMAN-MILLS, L., PFEFFER, I., SIBSON, N., GOLDIN, R., SCHUSTER-BOECKLER, B., POLLARD, P. J., SOGA, T., MCCULLAGH, J. S., SCHOFIELD, C. J., MULHOLLAND, P., ANSORGE, O., KRIAUCIONIS, S., RATCLIFFE, P. J., SZELE, F. G. and TOMLINSON, I., 2016. Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis: Cancer Cell Cancer Cell. 30(4), 578-594
• WANG, Y., BU, F., ROYER, C., SERRES, S., LARKIN, J. R., SOTO, M. S., SIBSON, N. R., SALTER, V., FRITZSCHE, F., TURNQUIST, C., KOCH, S., ZAK, J., ZHONG, S., WU, G., LIANG, A., OLOFSEN, P. A., MOCH, H., HANCOCK, D. C., DOWNWARD, J., GOLDIN, R. D., ZHAO, J., TONG, X., GUO, Y. and LU, X., 2014. ASPP2 controls epithelial plasticity and inhibits metastasis through beta-catenin-dependent regulation of ZEB1: Nat Cell Biol Nat Cell Biol. 16(11), 1092-104
• SOTO, M. S., SERRES, S., ANTHONY, D. C. and SIBSON, N. R., 2014. Functional role of endothelial adhesion molecules in the early stages of brain metastasis: Neuro Oncol Neuro Oncol. 16(4), 540-51
• SERRES, S., O'BRIEN, E. R. and SIBSON, N. R., 2014. Imaging angiogenesis, inflammation, and metastasis in the tumor microenvironment with magnetic resonance imaging: Adv Exp Med Biol Adv Exp Med Biol. 772, 263-83
• SERRES, S., MARTIN, C. J., SARMIENTO SOTO, M., BRISTOW, C., O'BRIEN, E. R., CONNELL, J. J., KHRAPITCHEV, A. A. and SIBSON, N. R., 2014. Structural and functional effects of metastases in rat brain determined by multimodal MRI: Int J Cancer Int J Cancer. 134(4), 885-96
• O'BRIEN, E. R., KERSEMANS, V., TREDWELL, M., CHECA, B., SERRES, S., SOTO, M. S., GOUVERNEUR, V., LEPPERT, D., ANTHONY, D. C. and SIBSON, N. R., 2014. Glial activation in the early stages of brain metastasis: TSPO as a diagnostic biomarker: J Nucl Med J Nucl Med. 55(2), 275-80
• EVANS, M. C., SERRES, S., KHRAPITCHEV, A. A., STOLP, H. B., ANTHONY, D. C., TALBOT, K., TURNER, M. R. and SIBSON, N. R., 2014. T(2)-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS: J Cereb Blood Flow Metab J Cereb Blood Flow Metab. 34(5), 785-93
• SERRES, S., BRISTOW, C., DE PABLOS, R. M., MERKLER, D., SOTO, M. S., SIBSON, N. R. and ANTHONY, D. C., 2013. Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis: J Cereb Blood Flow Metab J Cereb Blood Flow Metab. 33(5), 744-53
• MARDIGUIAN, S., SERRES, S., LADDS, E., CAMPBELL, S. J., WILAINAM, P., MCFADYEN, C., MCATEER, M., CHOUDHURY, R. P., SMITH, P., SAUNDERS, F., WATT, G., SIBSON, N. R. and ANTHONY, D. C., 2013. Anti-IL-17A treatment reduces clinical score and VCAM-1 expression detected by in vivo magnetic resonance imaging in chronic relapsing EAE ABH mice: Am J Pathol Am J Pathol. 182(6), 2071-81
• SERRES, S., SOTO, M. S., HAMILTON, A., MCATEER, M. A., CARBONELL, W. S., ROBSON, M. D., ANSORGE, O., KHRAPITCHEV, A., BRISTOW, C., BALATHASAN, L., WEISSENSTEINER, T., ANTHONY, D. C., CHOUDHURY, R. P., MUSCHEL, R. J. and SIBSON, N. R., 2012. Molecular MRI enables early and sensitive detection of brain metastases: Proc Natl Acad Sci U S A Proc Natl Acad Sci U S A. 109(17), 6674-9
• SERRES, S., MARDIGUIAN, S., CAMPBELL, S. J., MCATEER, M. A., AKHTAR, A., KRAPITCHEV, A., CHOUDHURY, R. P., ANTHONY, D. C. and SIBSON, N. R., 2011. VCAM-1-targeted magnetic resonance imaging reveals subclinical disease in a mouse model of multiple sclerosis: FASEB J FASEB J. 25(12), 4415-22
• VAN KASTEREN, S. I., CAMPBELL, S. J., SERRES, S., ANTHONY, D. C., SIBSON, N. R. and DAVIS, B. G., 2009. Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease: Proc Natl Acad Sci U S A Proc Natl Acad Sci U S A. 106(1), 18-23
• SERRES, S., ANTHONY, D. C., JIANG, Y., CAMPBELL, S. J., BROOM, K. A., KHRAPITCHEV, A. and SIBSON, N. R., 2009. Comparison of MRI signatures in pattern I and II multiple sclerosis models: NMR Biomed NMR Biomed. 22(10), 1014-24
• SERRES, S., ANTHONY, D. C., JIANG, Y., BROOM, K. A., CAMPBELL, S. J., TYLER, D. J., VAN KASTEREN, S. I., DAVIS, B. G. and SIBSON, N. R., 2009. Systemic inflammatory response reactivates immune-mediated lesions in rat brain: J Neurosci J Neurosci. 29(15), 4820-8
• SERRES, S., RAFFARD, G., FRANCONI, J. M. and MERLE, M., 2008. Close coupling between astrocytic and neuronal metabolisms to fulfill anaplerotic and energy needs in the rat brain: J Cereb Blood Flow Metab J Cereb Blood Flow Metab. 28(4), 712-24
• SERRES, S., BEZANCON, E., FRANCONI, J. M. and MERLE, M., 2007. Brain pyruvate recycling and peripheral metabolism: an NMR analysis ex vivo of acetate and glucose metabolism in the rat: J Neurochem J Neurochem. 101(5), 1428-40
• PELLERIN, L., BOUZIER-SORE, A. K., AUBERT, A., SERRES, S., MERLE, M., COSTALAT, R. and MAGISTRETTI, P. J., 2007. Activity-dependent regulation of energy metabolism by astrocytes: an update: Glia Glia. 55(12), 1251-62
• SERRES, S., BEZANCON, E., FRANCONI, J. M. and MERLE, M., 2005. Ex vivo NMR study of lactate metabolism in rat brain under various depressed states: J Neurosci Res J Neurosci Res. 79(1-2), 19-25
• SERRES, S., BEZANCON, E., FRANCONI, J. M. and MERLE, M., 2004. Ex vivo analysis of lactate and glucose metabolism in the rat brain under different states of depressed activity: J Biol Chem J Biol Chem. 279(46), 47881-9
• MIRAUX, S., SERRES, S., THIAUDIERE, E., CANIONI, P., MERLE, M. and FRANCONI, J. M., 2004. Gadolinium-enhanced small-animal TOF magnetic resonance angiography: MAGMA MAGMA. 17(3-6), 348-52
• SERRES, S., BOUYER, J. J., BEZANCON, E., CANIONI, P. and MERLE, M., 2003. Involvement of brain lactate in neuronal metabolism: NMR Biomed NMR Biomed. 16(6-7), 430-9
• BOUZIER-SORE, A. K., SERRES, S., CANIONI, P. and MERLE, M., 2003. Lactate involvement in neuron-glia metabolic interaction: (13)C-NMR spectroscopy contribution: Biochimie Biochimie. 85(9), 841-8